公开(公告)号：WO2008130647A1

公开(公告)日：2008-10-30

申请号：PCT/US2008/005054

申请日：2008-04-18

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF) ,  JAMES, Susan, P. ,  OLDINSKI, Rachael, Kurkowski

Inventor： JAMES, Susan, P. ,  OLDINSKI, Rachael, Kurkowski

IPC: A61K38/38 ,  A61P27/02

CPC classification number: C08F255/02 ,  C08B37/0063 ,  C08B37/0072 ,  C08G81/02

Abstract: A new copolymer synthesized from a glycosaminoglycan (GAG) such as hyaluronan/ hyaluronic acid (HA), chondroitin sulfates, derma tan sulfates, keratan sulfates, heparan sulfate, and heparin, and an anhydride functionalized hydrophobic polymer, i.e., any polyolefin which has been 'functionalized' (grafted onto the backbone or incorporated into the backbone) with anhydride functional groups, such as maleic anhydride-graft-polyethylene, (or, maleated polyethylene), maleic anhydride-graft-polystyrene, maleic anhydride-graft-polypropylene, etc. The functionalized polyolefin may be a polyolefin backbone to which the anhydride functional groups have been grafted, or otherwise incorporated with the backbone. Also, a unique synthesis technique combines a modified GAG with a graft polyolefin, resulting in a unique copolymer with its constituents by-and-large covalently bound to each other.

Abstract translation: 由糖胺聚糖（GAG）如透明质酸/透明质酸（HA），硫酸软骨素，硫酸皮肤素，硫酸角质素，硫酸乙酰肝素和肝素合成的新共聚物，以及酸酐官能化的疏水性聚合物，即任何已经被 马来酸酐接枝聚乙烯（或马来酸化聚乙烯），马来酸酐接枝 - 聚苯乙烯，马来酸酐 - 接枝 - 聚丙烯等的酸酐官能团“官能化”（接枝到骨架上或并入骨架中） 官能化聚烯烃可以是聚酐主链，酸酐官能团已经被接枝或以其它方式与主链结合。 此外，独特的合成技术将改性的GAG与接枝聚烯烃结合在一起，形成独特的共聚物，其组成物彼此共价结合。

公开(公告)号：WO2009131983A1

公开(公告)日：2009-10-29

申请号：PCT/US2009/041214

申请日：2009-04-21

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION ,  JAMES, Susan, P. ,  ZHANG, Min ,  BEAUREGARD, Guy ,  OLDINSKI, Rachael, Kurkowski

Inventor： JAMES, Susan, P. ,  ZHANG, Min ,  BEAUREGARD, Guy ,  OLDINSKI, Rachael, Kurkowski

IPC: C08J7/04 ,  C08J9/40 ,  C09D105/00 ,  C08L5/08 ,  C08F8/12 ,  C08B37/00 ,  C08J3/24 ,  C08L101/00

CPC classification number: C08J3/246 ,  A61L31/048 ,  C08B37/00 ,  C08B37/0072 ,  C08J9/42 ,  C08J2323/06 ,  C08J2405/08 ,  C08L5/08 ,  Y10T428/249953 ,  C08L2666/02 ,  C08L101/00 ,  C08L2666/26

Abstract: An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.

Abstract translation: 具有缠结的外层材料，其包含掩蔽的亲水性客体和疏水性聚合物主体的混合物，其中客体的分子彼此交联。 在某些情况下，使用客人的复合物可能是理想的或甚至是必需的。 在与客体混合之前，可以制备主体共混物以包括疏水性聚合物主体和马来酸化的疏水性共主体的物理共混物（优选为酸酐官能化的疏水性聚合物，由此使官能化的聚合物与该官能化的聚合物相同） 为主机选择）。 客体和宿主或宿主 - 共同宿主混合物的混合包括物理缠结，不管其是否还包括通过其间的初次键合（例如，化学/共价键合）的交联。 还有一种制造具有这种缠结的外层材料的方法，包括以下步骤：暂时掩蔽客体的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内，与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主体或主体混合物的混合物（无论是溶液，粉末状，颗粒状等）形式进行; 接下来，进行客人与其自身的交联; 然后，将该混合物模塑到外层中，该主体与主体有或没有额外的交联。