公开(公告)号：WO2023049791A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/076842

申请日：2022-09-22

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： DECKELBAUM, Richard J. ,  ZIRPOLI, Hylde ,  DAHL, Søren Weis ,  KRALOVEC, Jaroslav A.

IPC: A61K47/54 ,  A61K31/202

Abstract: The invention relates to a bioactive lipid (BAL) composition comprising one or more hydrocarbon-derivatized fatty acids (FAs), which can be an oxygenated, halogenated, amino, amide, nitro, cyano, furanoid, nitroso, isonitrile, or O-substituted derivative of the hydrocarbon-derivatized FA, which are bound to a molecular backbone. In some embodiments, the BALs comprise a specialized pro-resolving mediator (SPMs), eicosanoid, prostanoid, prostaglandin, or endocannabinoid (eCBs) and optionally further comprise omega-3 (n-3) FAs and/or omega-6 (n-6) FAs. In general, the BALs are conjugated to a molecular backbone, preferably a five- or six-carbon monosaccharide, or glycerol. The compositions can be formulated as an emulsion. Preferred BALs can be selected by their performance in one or more cellular assays or animal models. These compositions are useful for tissue or organ protection in a patient, for example in stroke, ischemia, traumatic injury, a neurodegenerative disorder, or organ injury and/or transplant.

公开(公告)号：WO2023039510A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/076179

申请日：2022-09-09

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： STOCKWELL, Brent R. ,  LIU, Hengrui ,  FOROUHAR, Farhad ,  XIA, Xin ,  LIN, Annie ,  WANG, Qian

IPC: A61K31/404 ,  C07D209/08

Abstract: The present disclosure provides, inter alia, compounds to modulate GPX4 activity. Also provided are pharmaceutical compositions containing same compounds. Further provided are methods for treating or ameliorating the effects of a cancer in a subject, methods of modulating GPX activity in a subject, methods of inducing ferroptosis in a cell, and methods for treating or ameliorating the effects of a cancer in a subject using the compounds or composition in combination with other therapeutic agents.

公开(公告)号：WO2023009652A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/038561

申请日：2022-07-27

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： PREINDL, Matthias ,  ZHOU, Liwei ,  EULL, William-Michael ,  JAHNES, Matthew

IPC: H02M7/02 ,  H02M1/12 ,  H02M7/42

Abstract: Disclosed are implementations that include a power converter system and method including an N-phase power converter stage having to an alternating current (AC) side and a direct current (DC) side, with N > 1. The system and method further include an N-phase LC filter comprising one or more capacitors, wherein respective one or more neutral points of the one or more capacitors are electrically connected to a DC negative terminal of a DC source. A control system drives power switching elements of the N-phase power converter stage to convert received power and to output converted power. The control system drives the power switching elements using variable frequency soft switching at a frequency of at least 20 kHz. The power converter may have bidirectional operation to operate in a traction mode to drive a motor or a charging mode to charge a DC source.

公开(公告)号：WO2023009648A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/038556

申请日：2022-07-27

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： PREINDL, Matthias ,  ZHOU, Liwei ,  EULL, William-Michael ,  JAHNES, Matthew

IPC: H02M1/08 ,  H02M1/084 ,  H02M1/02 ,  H02M1/12 ,  H02M1/14 ,  H02M1/16

Abstract: Systems and methods for a high-efficiency power converter incorporating a half-bridge topology with one or more an additional upper capacitor and a drain-source capacitor. The converter includes DC voltage terminals and a DC link capacitor coupled across a positive and negative DC terminal of the DC voltage terminals. The converter further includes a power switching element pair including a high side switch and a low side switch coupled together at a midpoint node. The converter further includes an LC filter having a switch-side inductor, a lower capacitor coupled between a second end of switch- side inductor and the negative DC terminal; and an upper capacitor coupled between the second end of the switch-side inductor and the positive DC terminal. The converter may further include drain-source capacitors coupled across the drain and source terminals of the switches.

公开(公告)号：WO2023004431A2

公开(公告)日：2023-01-26

申请号：PCT/US2022/074075

申请日：2022-07-22

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： HO, David, D. ,  HUANG, Yaoxing ,  LIU, Lihong ,  NAIR, Manoj, S. ,  YU, Jian ,  IKETANI, Sho

IPC: A61K39/42 ,  A61P31/14 ,  C07K16/10 ,  C12N15/13 ,  C12N15/63 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92

Abstract: The subject matter described herein relates to engineered monoclonal antibodies, derived from antibodies isolated from human patients, neutralizing a SARS-CoV-2 virus, its variants, or related coronaviruses.

公开(公告)号：WO2022272263A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/073087

申请日：2022-06-22

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： CREUSOT, Remi J. ,  FIRDESSA FITE, Rebuma ,  POSTIGO FERNANDEZ, Jorge

IPC: A61P37/02 ,  C12N5/071 ,  C12N5/078 ,  C12N5/0783 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  A61P37/00

Abstract: This disclosure describes a nucleic acid construct that contains sequences for an Endotope construct, a STAT1c, and miR142 target sites. In one example, disclosed is composition comprising an Endotope construct and a STAT1 construct including a nucleic acid sequence encoding a constitutively active STAT1 (e.g. STAT1c), wherein the Endotope and the STAT1 constructs each include miR142 target sites. In alternative examples, disclosed is a single construct that includes the Endotope construct and STAT1 construct along with miR142 target sites. The nucleic acid constructs can be packaged into polycationic molecules or liposome to create nanoparticles for efficient cell transfection.

公开(公告)号：WO2022266394A1

公开(公告)日：2022-12-22

申请号：PCT/US2022/033891

申请日：2022-06-16

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES IN THE CITY OF ALBANY ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： PETRUKHIN, Konstantin ,  CIOFFI, Christopher L. ,  WANG, Yuhong ,  MA, Jian-Xing ,  MOISEYEV, Gennadiy

IPC: A61K31/145 ,  C07C317/22 ,  A61P27/02

Abstract: The present disclosure provides a compound having the structure : Formula (I) or Formula (II).

公开(公告)号：WO2022266235A1

公开(公告)日：2022-12-22

申请号：PCT/US2022/033651

申请日：2022-06-15

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： BRIESE, Thomas ,  LIPKIN, Walter, Ian ,  MISHRA, Nischay

IPC: C07K16/10 ,  C07K14/165 ,  A61P31/12

Abstract: The current disclosure provides for polypeptides, single domain antibodies, VHHs and nanobodies which bind to or are directed against the SARS-CoV-2 virus, more specifically the spike protein of the SARS-CoV-2 virus. The disclosed VHHs and nanobodies can comprise a sequence selected from the sequences listed in Table 1 (SEQ ID NOs: 1-60), and fragments, derivatives and homologues thereof. The disclosure further provides for compositions comprising the anti-SARS-CoV-2 polypeptides, single domain antibodies, VHHs and nanobodies, and methods of making and using such for treatment, prevention, detection and diagnosis.

公开(公告)号：WO2022246175A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/030224

申请日：2022-05-20

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： MARGOLIS, Kara ,  ANSORGE, Mark ,  LEONG, Kam W. ,  YANG, Letao ,  ZHU, Yuefei

IPC: A61K31/57 ,  C07J7/00 ,  A61K45/06

Abstract: The present disclosure provides, inter alia, compositions and methods for treating or ameliorating the effect of a disorder such as, e.g., anxiety or depression in a subject, with less or no off- and/or on-target side effects. Also provided are methods for treating such disorder in a pregnant woman.

公开(公告)号：WO2022246003A2

公开(公告)日：2022-11-24

申请号：PCT/US2022/029914

申请日：2022-05-18

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  CORNISH, Virginia ,  CRNKOVIC, Tea ,  RIOS, Davida ,  JAFARIYAN, Amirhossein ,  FANTINI, Marco

Inventor： CORNISH, Virginia ,  CRNKOVIC, Tea ,  RIOS, Davida ,  JAFARIYAN, Amirhossein ,  FANTINI, Marco

IPC: G01N33/566 ,  C12Q1/02 ,  C07K14/37 ,  C07K14/723 ,  C12N15/52 ,  C12R2001/68 ,  C12R2001/865 ,  G01N33/56961 ,  G01N33/56983

Abstract: The present disclosure relates to kits, compositions and methods for detecting fungal species, viruses and/or protein variants in a sample, e.g., a biological sample. For example, but not by way of limitation, the present disclosure provides living yeast biosensors that have been genetically engineered to detect fungal species, viruses and/or protein variants in a sample, e.g., a biological sample.