公开(公告)号：WO2009006404A2

公开(公告)日：2009-01-08

申请号：PCT/US2008068789

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS INC ,  COSSROW JENNIFER ,  GUAN BING ,  ISHCHENKO ALEXEY ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

Inventor： COSSROW JENNIFER ,  GUAN BING ,  ISHCHENKO ALEXEY ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

IPC: C07D413/12 ,  A61K31/505 ,  A61P35/00 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract translation: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。

公开(公告)号：WO2009006404A3

公开(公告)日：2009-01-08

申请号：PCT/US2008/068789

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS, INC. ,  COSSROW, Jennifer ,  GUAN, Bing ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

Inventor： COSSROW, Jennifer ,  GUAN, Bing ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61P35/00 ,  A61K31/505

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy 1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy 2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L 1 is a direct bond of an optionally substituted, straight or branched C 1-6 alkylene chain; L 2 is a direct bond, or is an optionally substituted, straight or branched C 1-6 alkylene chain wherein 1 or 2 methylene units of L 2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO 2 -, -SO 2 N(R)-, -N(R)SO 2 -, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C 1-6 aliphatic group;

公开(公告)号：WO2009006389A3

公开(公告)日：2009-05-07

申请号：PCT/US2008068762

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS INC ,  CHEN WEIRONG ,  COSSROW JENNIFER ,  FRANKLIN LIOYD ,  GUAN BING ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LANE BENJAMIN ,  LITTKE ADAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

Inventor： CHEN WEIRONG ,  COSSROW JENNIFER ,  FRANKLIN LIOYD ,  GUAN BING ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LANE BENJAMIN ,  LITTKE ADAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

IPC: C07D401/12 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

CPC classification number: C07D417/14 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07F9/65583

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract translation: 本发明提供可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。

公开(公告)号：WO2009006389A8

公开(公告)日：2009-03-26

申请号：PCT/US2008068762

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS INC ,  CHEN WEIRONG ,  COSSROW JENNIFER ,  FRANKLIN LIOYD ,  GUAN BING ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LANE BENJAMIN ,  LITTKE ADAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

Inventor： CHEN WEIRONG ,  COSSROW JENNIFER ,  FRANKLIN LIOYD ,  GUAN BING ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LANE BENJAMIN ,  LITTKE ADAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

IPC: C07D401/12 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

CPC classification number: C07D417/14 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07F9/65583

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract translation: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。

公开(公告)号：WO2010078408A1

公开(公告)日：2010-07-08

申请号：PCT/US2009/069795

申请日：2009-12-30

Applicant: BIOGEN IDEC MA INC. ,  SUNESIS PHARMACEUTICALS, INC. ,  CHUAQUI, Claudio ,  COSSROW, Jennifer ,  DOWLING, James ,  GUAN, Bing ,  HOEMANN, Michael ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KABIGTING, Lori ,  KUMARAVEL, Gnanasambandam ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VAN VLOTEN, Kurt ,  VESSELS, Jeffrey ,  XIN, Zhili

Inventor： CHUAQUI, Claudio ,  COSSROW, Jennifer ,  DOWLING, James ,  GUAN, Bing ,  HOEMANN, Michael ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KABIGTING, Lori ,  KUMARAVEL, Gnanasambandam ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VAN VLOTEN, Kurt ,  VESSELS, Jeffrey ,  XIN, Zhili

IPC: C07D261/08 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/12 ,  A61K31/416 ,  A61P35/00 ,  C07D513/04 ,  A61K31/437 ,  A61K31/422 ,  A61K31/428 ,  A61K31/429

CPC classification number: C07D261/08 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

Abstract translation: 本发明提供了可用作Raf蛋白激酶抑制剂的式（I）化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。