公开(公告)号：WO2012058645A8

公开(公告)日：2012-06-28

申请号：PCT/US2011058472

申请日：2011-10-28

Applicant: BIOGEN IDEC INC ,  SUNESIS PHARMACEUTICALS INC ,  HOPKINS BRIAN T ,  SCOTT DANIEL ,  CONLON PATRICK ,  JENKINS TRACY J ,  POWELL NOEL ,  GUAN BING ,  CUERVO JULIO H ,  WANG DEPING ,  TAVERAS ART

Inventor： HOPKINS BRIAN T ,  SCOTT DANIEL ,  CONLON PATRICK ,  JENKINS TRACY J ,  POWELL NOEL ,  GUAN BING ,  CUERVO JULIO H ,  WANG DEPING ,  TAVERAS ART

IPC: C07D211/60

CPC classification number: A61K31/553 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/12 ,  C07D403/04 ,  C07D413/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. In certain embodiments, the present invention provides pharmaceutical formulations comprising provided compounds. In certain embodiments, the present invention provides a method of decreasing enzymatic activity of a Tec kinase family member. In some embodiments, such methods include contacting a Tec kinase family member with an effective amount of a Tec kinase family member inhibitor. In certain embodiments, the present invention provides a method of treating a disorder responsive to Tec kinase family inhibition in a subject in need thereof.

Abstract translation: 本发明提供了可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。 在某些实施方案中，本发明提供包含所提供化合物的药物制剂。 在某些实施方案中，本发明提供降低Tec激酶家族成员的酶活性的方法。 在一些实施方案中，这些方法包括使Tec激酶家族成员与有效量的Tec激酶家族成员抑制剂接触。 在某些实施方案中，本发明提供在有需要的受试者中治疗对Tec激酶家族抑制有反应的病症的方法。

公开(公告)号：WO2009006404A2

公开(公告)日：2009-01-08

申请号：PCT/US2008068789

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS INC ,  COSSROW JENNIFER ,  GUAN BING ,  ISHCHENKO ALEXEY ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

Inventor： COSSROW JENNIFER ,  GUAN BING ,  ISHCHENKO ALEXEY ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

IPC: C07D413/12 ,  A61K31/505 ,  A61P35/00 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract translation: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。

公开(公告)号：WO2004058709A1

公开(公告)日：2004-07-15

申请号：PCT/US2003/041360

申请日：2003-12-23

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  GUAN, Bing ,  MINOR, Charles ,  DAI, Mingshi ,  GHOSH, Shomir ,  JENKINS, Tracy, J. ,  LI, Gang ,  BURDI, Douglas, F. ,  BENNETT, Robert, A.

Inventor： GUAN, Bing ,  MINOR, Charles ,  DAI, Mingshi ,  GHOSH, Shomir ,  JENKINS, Tracy, J. ,  LI, Gang ,  BURDI, Douglas, F. ,  BENNETT, Robert, A.

IPC: C07D211/58

CPC classification number: C07D401/12 ,  C07C311/46 ,  C07C311/47 ,  C07C335/16 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/14 ,  C07D211/28 ,  C07D211/58 ,  C07D405/12 ,  C07D413/12

Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I). The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.

Abstract translation: 公开了由结构式（I）表示的CCR8抑制剂。 本文描述了结构式（I）中的变量。 还公开了通过向受试者施用所公开的CCR8抑制剂之一来治疗CCR8介导的病症，特别是哮喘的受试者的方法。

公开(公告)号：WO2011029043A1

公开(公告)日：2011-03-10

申请号：PCT/US2010/047879

申请日：2010-09-03

Applicant: BIOGEN IDEC MA INC. ,  SUNESIS PHARMACEUTICALS, INC. ,  BUI, Minna ,  CONLON, Patrick ,  ERLANSON, Daniel, A. ,  FAN, Junfa ,  GUAN, Bing ,  HOPKINS, Brian, T. ,  ISHCHENKO, Alexey ,  JENKINS, Tracy, J. ,  KUMARAVEL, Gnanasambandam ,  MARCOTTE, Doug ,  POWELL, Noel ,  SCOTT, Daniel ,  TAVERAS, Art ,  WANG, Deping ,  ZHONG, Min

Inventor： BUI, Minna ,  CONLON, Patrick ,  ERLANSON, Daniel, A. ,  FAN, Junfa ,  GUAN, Bing ,  HOPKINS, Brian, T. ,  ISHCHENKO, Alexey ,  JENKINS, Tracy, J. ,  KUMARAVEL, Gnanasambandam ,  MARCOTTE, Doug ,  POWELL, Noel ,  SCOTT, Daniel ,  TAVERAS, Art ,  WANG, Deping ,  ZHONG, Min

IPC: A01N43/42

CPC classification number: C07D473/34 ,  C07D239/70 ,  C07D401/04 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。

公开(公告)号：WO2010078408A1

公开(公告)日：2010-07-08

申请号：PCT/US2009/069795

申请日：2009-12-30

Applicant: BIOGEN IDEC MA INC. ,  SUNESIS PHARMACEUTICALS, INC. ,  CHUAQUI, Claudio ,  COSSROW, Jennifer ,  DOWLING, James ,  GUAN, Bing ,  HOEMANN, Michael ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KABIGTING, Lori ,  KUMARAVEL, Gnanasambandam ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VAN VLOTEN, Kurt ,  VESSELS, Jeffrey ,  XIN, Zhili

Inventor： CHUAQUI, Claudio ,  COSSROW, Jennifer ,  DOWLING, James ,  GUAN, Bing ,  HOEMANN, Michael ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KABIGTING, Lori ,  KUMARAVEL, Gnanasambandam ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VAN VLOTEN, Kurt ,  VESSELS, Jeffrey ,  XIN, Zhili

IPC: C07D261/08 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/12 ,  A61K31/416 ,  A61P35/00 ,  C07D513/04 ,  A61K31/437 ,  A61K31/422 ,  A61K31/428 ,  A61K31/429

CPC classification number: C07D261/08 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

Abstract translation: 本发明提供了可用作Raf蛋白激酶抑制剂的式（I）化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。

公开(公告)号：WO2009006389A2

公开(公告)日：2009-01-08

申请号：PCT/US2008/068762

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS, INC. ,  CHEN, Weirong ,  COSSROW, Jennier ,  FRANKLIN, Lioyd ,  GUAN, Bing ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LANE, Benjamin ,  LITTKE, Adam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

Inventor： CHEN, Weirong ,  COSSROW, Jennier ,  FRANKLIN, Lioyd ,  GUAN, Bing ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LANE, Benjamin ,  LITTKE, Adam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC: C07D417/14 ,  C07D417/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14 ,  C07D403/12 ,  C07D401/12 ,  C07D473/00 ,  A61K31/506 ,  A61P35/00

CPC classification number: C07D417/14 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07F9/65583

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract translation: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。

公开(公告)号：WO2009006404A3

公开(公告)日：2009-01-08

申请号：PCT/US2008/068789

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS, INC. ,  COSSROW, Jennifer ,  GUAN, Bing ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

Inventor： COSSROW, Jennifer ,  GUAN, Bing ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61P35/00 ,  A61K31/505

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy 1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy 2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L 1 is a direct bond of an optionally substituted, straight or branched C 1-6 alkylene chain; L 2 is a direct bond, or is an optionally substituted, straight or branched C 1-6 alkylene chain wherein 1 or 2 methylene units of L 2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO 2 -, -SO 2 N(R)-, -N(R)SO 2 -, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C 1-6 aliphatic group;

公开(公告)号：WO2004058736A1

公开(公告)日：2004-07-15

申请号：PCT/US2003/041199

申请日：2003-12-23

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  DAI, Mingshi ,  JENKINS, Tracy, J. ,  GUAN, Bing ,  GHOSH, Shomir ,  MINOR, Charles

Inventor： DAI, Mingshi ,  JENKINS, Tracy, J. ,  GUAN, Bing ,  GHOSH, Shomir ,  MINOR, Charles

IPC: C07D295/26

CPC classification number: C07D213/42 ,  C07C311/37 ,  C07C311/46 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/14 ,  C07D207/27 ,  C07D209/48 ,  C07D211/28 ,  C07D211/56 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D213/76 ,  C07D213/81 ,  C07D295/13 ,  C07D295/26 ,  C07D307/68 ,  C07D309/08 ,  C07D309/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D451/04

Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I). Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.

Abstract translation: 公开了由结构式（I）表示的CCR8抑制剂。 还公开了包含药学上可接受的载体或稀释剂和由结构式（I）表示的CCR8抑制剂的药物组合物。 还公开了通过向受试者施用CCR8抑制剂来治疗受试者的炎症性疾病的方法。

公开(公告)号：WO2011029046A1

公开(公告)日：2011-03-10

申请号：PCT/US2010/047883

申请日：2010-09-03

Applicant: BIOGEN IDEC MA INC. ,  ERLANSON, Daniel, A. ,  MARCOTTE, Doug ,  KUMARAVEL, Gnanasambandam ,  FAN, Junfa ,  WANG, Deping ,  CUERVO, Julio, H. ,  SILVIAN, Laura ,  POWELL, Noel ,  BUI, Minna ,  HOPKINS, Brian, T. ,  TAVERAS, Art ,  GUAN, Bing ,  CONLON, Patrick ,  ZHONG, Min ,  JENKINS, Tracy, J. ,  SCOTT, Daniel ,  SUNESIS PHARMACEUTICALS, INC. ,  LUGOVSKOY, Alexey, A.

Inventor： ERLANSON, Daniel, A. ,  MARCOTTE, Doug ,  KUMARAVEL, Gnanasambandam ,  FAN, Junfa ,  WANG, Deping ,  CUERVO, Julio, H. ,  SILVIAN, Laura ,  POWELL, Noel ,  BUI, Minna ,  HOPKINS, Brian, T. ,  TAVERAS, Art ,  GUAN, Bing ,  CONLON, Patrick ,  ZHONG, Min ,  JENKINS, Tracy, J. ,  SCOTT, Daniel ,  LUGOVSKOY, Alexey, A.

IPC: A01N43/54 ,  C07D471/04 ,  C07D471/22

CPC classification number: C07D487/14 ,  A61K31/519 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04

Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。

公开(公告)号：WO2009006389A3

公开(公告)日：2009-05-07

申请号：PCT/US2008068762

申请日：2008-06-30

Applicant: SUNESIS PHARMACEUTICALS INC ,  CHEN WEIRONG ,  COSSROW JENNIFER ,  FRANKLIN LIOYD ,  GUAN BING ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LANE BENJAMIN ,  LITTKE ADAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

Inventor： CHEN WEIRONG ,  COSSROW JENNIFER ,  FRANKLIN LIOYD ,  GUAN BING ,  JONES JOHN HOWARD ,  KUMARAVEL GNANASAMBANDAM ,  LANE BENJAMIN ,  LITTKE ADAM ,  LUGOVSKOY ALEXEY ,  PENG HAIRUO ,  POWELL NOEL ,  RAIMUNDO BRIAN ,  TANAKA HIROKO ,  VESSELS JEFFREY ,  WYNN THOMAS ,  XIN ZHILI

IPC: C07D401/12 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

CPC classification number: C07D417/14 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07F9/65583

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract translation: 本发明提供可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。