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公开(公告)号：WO2011137288A3
公开(公告)日：2011-12-22
申请号：PCT/US2011034451
申请日：2011-04-29
Applicant: UNIV OHIO STATE , CROCE CARLO M , VOLINIA STEFANO
Inventor： CROCE CARLO M , VOLINIA STEFANO
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: Methods for identification of cancer variations in miRNA networks, including comparing normal to cancer networks by generating a comprehensive miRNA alteration map in cancer, and superimposing DNA variations onto expression data, databases containing the same and uses thereof are disclosed.
Abstract translation: 用于鉴定miRNA网络中的癌症变异的方法，包括通过在癌症中产生全面的miRNA改变图，以及将DNA变异叠加在表达数据上，比较正常与癌症网络的方法，包含其的数据库及其用途。
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2.发明申请MATERIALS AND METHODS RELATED TO MODULATION OF MISMATCH REPAIR AND GENOMIC STABILITY BY MIR-155 审中-公开与MIR-155相关的调制修复和基因稳定性的材料与方法
公开(公告)号：WO2011119553A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029348
申请日：2011-03-22
Applicant: THE OHIO STATE UNIVERSITY , CROCE, Carlo, M. , VALERI, Nicola
Inventor： CROCE, Carlo, M. , VALERI, Nicola
CPC classification number: C12N15/113 , C12N15/1137 , C12N2310/113 , C12N2310/141 , C12N2310/3231
Abstract: The present invention provides materials and methods related to modulation of mismatch and genomic stability by miR-155.
Abstract translation: 本发明提供了通过miR-155调节失配和基因组稳定性的材料和方法。
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3.发明申请MICRORNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PRONOSIS AND TREATMENT OF PROSTATE RELATED DISORDERS 审中-公开基于MICRORNA的方法和组合物用于诊断，预后和治疗前列腺相关疾病
公开(公告)号：WO2009108860A8
公开(公告)日：2011-01-27
申请号：PCT/US2009035470
申请日：2009-02-27
Applicant: UNIV OHIO STATE RES FOUND , US GOV HEALTH & HUMAN SERV , CROCE CARLO M , AMBS STEFAN
Inventor： CROCE CARLO M , AMBS STEFAN
IPC: C12Q1/68
CPC classification number: C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/1135 , C12N15/1137 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12N2320/31 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of prostate associated disorders are disclosed.
Abstract translation: 公开了用于诊断，预后和/或治疗前列腺相关疾病的方法和组合物。
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4.发明申请MICRORNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF OVARIAN CANCER 审中-公开用于诊断和治疗OVARIAN癌症的基于微阵列的方法和组合物
公开(公告)号：WO2010065156A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/038214
申请日：2009-03-25
Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , COHN, David, E. , RESNICK, Kimberly , ALDER, Hansjuerg , CROCE, Carlo, M.
Inventor： COHN, David, E. , RESNICK, Kimberly , ALDER, Hansjuerg , CROCE, Carlo, M.
CPC classification number: C12N15/1138 , A61K31/7105 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/136 , C12Q2600/178
Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed.
Abstract translation: 公开了用于诊断，预后和/或治疗卵巢癌的方法和组合物。
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5.发明申请MICRORNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) 审中-公开基于MICRORNA的方法和组合物用于诊断，预防和治疗急性髓性白血病（AML）
公开(公告)号：WO2008094545A2
公开(公告)日：2008-08-07
申请号：PCT/US2008001157
申请日：2008-01-29
Applicant: UNIV OHIO STATE RES FOUND , CROCE CARLO M
Inventor： CROCE CARLO M
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
Abstract translation: 本发明提供用于急性骨髓性白血病（AML）的诊断，预后和治疗的新方法和组合物。 本发明还提供鉴定抗AML剂的方法。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2007109236A3
公开(公告)日：2008-04-24
申请号：PCT/US2007006824
申请日：2007-03-19
Applicant: UNIV OHIO STATE RES FOUND , CROCE CARLO M , GARZON RAMIRO , CALIN GEORGE A
Inventor： CROCE CARLO M , GARZON RAMIRO , CALIN GEORGE A
IPC: A61K31/105
CPC classification number: C12N15/1135 , A61K31/7105 , A61K45/06 , C12N15/113 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents.
Abstract translation: 本发明提供了用于诊断，预后和治疗癌症和骨髓增生性疾病的新颖方法和组合物。 本发明还提供鉴定抗癌剂的方法。
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7.发明申请MICRO-RNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER-RELATED DISEASES 审中-公开用于诊断和治疗结肠癌相关疾病的基于微RNA的方法和组合物
公开(公告)号：WO2008008430A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015892
申请日：2007-07-12
Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , CROCE, Carlo, M. , HARRIS, Curtis, C. , SCHETTER, Aaron, J.
Inventor： CROCE, Carlo, M. , HARRIS, Curtis, C. , SCHETTER, Aaron, J.
IPC: C12Q1/68
CPC classification number: C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , Y10T436/143333
Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
Abstract translation: 本发明提供了用于诊断和治疗结肠癌的新型方法和组合物。 本发明还提供鉴定肿瘤发生抑制剂的方法。
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8.发明申请MICRORNA EXPRESSION ABNORMALITIES IN PANCREATIC ENDOCRINE AND ACINAR TUMORS 审中-公开胰腺内分泌和腹腔内肿瘤微阵列异常表达异常
公开(公告)号：WO2007081680A3
公开(公告)日：2007-12-27
申请号：PCT/US2007000024
申请日：2007-01-03
Applicant: UNIV OHIO STATE RES FOUND , CROCE CARLO M , CALIN GEORGE A
Inventor： CROCE CARLO M , CALIN GEORGE A
CPC classification number: C12Q1/6886 , A61N1/30 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/57438
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent.
Abstract translation: 本发明提供了用于诊断，预后和治疗胰腺癌的新方法和组合物。 本发明还提供鉴定抗胰腺癌剂的方法。
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9.发明申请MICRORNA EXPRESSION ABNORMALITIES IN PANCREATIC ENDOCRINE AND ACINAR TUMORS 审中-公开微管蛋白在胰腺内分泌和腺瘤肿瘤中的表达异常
公开(公告)号：WO2007081680A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000024
申请日：2007-01-03
Inventor： CROCE, Carlo, M. , CALIN, George, A.
IPC: A61N1/30
CPC classification number: C12Q1/6886 , A61N1/30 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/57438
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent.
Abstract translation: 本发明提供了用于胰腺癌的诊断，预后和治疗的新方法和组合物。 本发明还提供了鉴定抗胰腺癌剂的方法。
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10.发明申请DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES 审中-公开诊断和治疗位于或接近癌相关染色体特征的微小RNA
公开(公告)号：WO2005078139A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/004865
申请日：2005-02-09
Applicant: THOMAS JEFFERSON UNIVERSITY , CROCE, Carlo, M. , LIU, Chang-Gong , CALIN, George, A.
Inventor： CROCE, Carlo, M. , LIU, Chang-Gong , CALIN, George, A.
IPC: C12Q1/68
CPC classification number: C12N15/1135 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N7/00 , C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/31 , C12N2310/32 , C12N2310/33 , C12N2710/16143 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
Abstract: MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused by these cancer-associated chromosomal features can affect the expression of the miR genes) located in close proximity to that chromosomal feature. Evaluation of miR gene expression can therefore be used to indicate the presence of a cancercausing chromosomal lesion in a subject. As the change in miR gene expression level caused by a cancer-associated chromosomal feature may also contribute to cancerigenesis, a given cancer fan be treated by restoring the level of miR gene expression to normal.
Abstract translation: MicroRNA基因与涉及不同癌症病因的染色体特征高度相关。 由这些与癌症相关的染色体特征引起的细胞的基因组结构或染色体结构的扰动可影响位于该染色体特征附近的miR基因的表达。 因此，miR基因表达的评估可用于指示受试者中存在癌症染色体损伤。 由于由癌症相关的染色体特征引起的miR基因表达水平的变化也可能导致癌发生，通过将miR基因表达水平恢复至正常来治疗给定的癌症风扇。
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