公开(公告)号：WO2011015453A1

公开(公告)日：2011-02-10

申请号：PCT/EP2010/060557

申请日：2010-07-21

Applicant: IMA LIFE S.R.L. ,  VAN VEEN, Johannes ,  DAMEN, Franciscus Antonius ,  SCHAEPMAN, Alexander Clemens Henricus Josef ,  JONGENELEN, Florentinus Adriaan Cornelius Marie

Inventor： VAN VEEN, Johannes ,  DAMEN, Franciscus Antonius ,  SCHAEPMAN, Alexander Clemens Henricus Josef ,  JONGENELEN, Florentinus Adriaan Cornelius Marie

IPC: F26B5/06 ,  F26B25/00

CPC classification number: F26B5/06 ,  B65G47/82 ,  F26B25/001

Abstract: Method for transfer of containers, such as vials (101), between a freeze dryer (1) that is located at a first location and a separate transport vehicle (30) that is mobile with respect to the freeze dryer, wherein the freeze dryer (1) comprises a freeze dryer housing (2) with an access opening (11) towards an inner freeze drying chamber (10) inside the freeze dryer housing (2), multiple shelves (21-24) that are arranged spaced apart above each other inside the freeze dryer chamber (10) and each provided with a horizontally extending first flat supporting surface (25) for supporting the containers, wherein the mobile transport vehicle (30) comprises a mobile undercarriage (31) supporting a storage housing (33) with an access opening (40) towards an inner storage chamber (39), a carrier provided with a second flat supporting surface (58) for supporting the containers inside the storage housing (33), and a container shifter (60) for pushing out containers away from the second flat supporting surface (58) in a pushing out direction parallel to the second flat supporting surface (58).

Abstract translation: 用于在位于第一位置的冷冻干燥机（1）和可相对于第一位置移动的单独运输车辆（30）之间传送诸如小瓶（101）的容器的方法， 其中所述冷冻干燥机（1）包括具有朝向所述冷冻干燥机壳体（2）内的内部冷冻干燥室（10）的进入开口（11）的冷冻干燥机壳体（2），多个搁架（21-24） （30）包括移动式底架（31），所述移动式底架在所述冷冻干燥器室（10）内彼此间隔开地布置并且各自设置有用于支撑所述容器的水平延伸的第一平坦支撑表面（25），其中所述移动式运输车辆 支撑具有朝向内部存储室（39）的进入开口（40）的存储壳体（33），设置有用于支撑存储壳体（33）内的容器的第二平坦支撑表面（58）的载体，以及容器 （60），用于将容器从第二端推出 d平坦支撑表面（58）沿平行于第二平坦支撑表面（58）的推出方向移动。

公开(公告)号：WO2007144206A2

公开(公告)日：2007-12-21

申请号：PCT/EP2007/005436

申请日：2007-06-14

Applicant: THE BOC GROUP PLC ,  BRUKER BIOSPIN GMBH ,  CORVER, Josef, Antonius, Willem, Maria ,  SCHMALBEIN, Klaus-Dieter ,  MAIER, Diether, C. ,  KAMLOWSKI, Andreas ,  DAMEN, Franciscus, Antonius

Inventor： CORVER, Josef, Antonius, Willem, Maria ,  SCHMALBEIN, Klaus-Dieter ,  MAIER, Diether, C. ,  KAMLOWSKI, Andreas ,  DAMEN, Franciscus, Antonius

IPC: G01R33/44

CPC classification number: G01N24/085

Abstract: A method is described for determining a characteristic, such as the mass, of each of a plurality of samples. The method comprises the steps of providing a plurality of coil elements each for surrounding a respective sample, causing the samples to enter an interrogation zone, each sample being surrounded by a respective coil element when it is located within the interrogation zone, applying a magnetic field in a first direction in the interrogation zone for creating in a pre-polarised state a net nuclear magnetisation of a nuclear spin species within a sample located in the interrogation zone, applying, by each coil element surrounding a respective sample located in the interrogation zone, an RF field in a second direction for temporarily changing the net nuclear magnetisation of the nuclear spin species in the sample, detecting RF energy emitted from that sample as the net nuclear magnetisation of the nuclear spin species in the sample relaxes, and, from the detected RF energy, determining the characteristic of each sample located in the interrogation zone.

Abstract translation: 描述了一种用于确定多个样本中的每一个的特征（例如质量）的方法。 该方法包括以下步骤：提供多个线圈元件，每个线圈元件用于围绕相应的样品，使得样品进入询问区域，每个样品在位于询问区域内时由相应的线圈元件围绕，施加磁场 在询问区中的第一方向上，用于在预极化状态下产生位于询问区内的样品内的核自旋物质的净核磁化，由围绕位于询问区中的相应样品的每个线圈元件施加， 用于临时改变样品中核自旋物质的净核磁化的第二方向的RF场，当样品中的核自旋物质的净核磁化松弛时，检测从该样品发射的RF能量，并且从检测到的 RF能量，确定位于询问区的每个样本的特征。

公开(公告)号：WO2006043020A1

公开(公告)日：2006-04-27

申请号：PCT/GB2005/003684

申请日：2005-09-23

Applicant: THE BOC GROUP PLC ,  DAMEN, Franciscus, Antonius ,  VAN DER VELDEN, Harms

Inventor： DAMEN, Franciscus, Antonius ,  VAN DER VELDEN, Harms

IPC: B65G47/14 ,  B65G47/68

CPC classification number: B65G47/682 ,  B65G2201/0244

Abstract: A conveying system comprises a rotating surface (18); a first conveyor for conveying upright articles (16) towards a transfer device for transferring articles from the first conveyor (12) to the rotating surface (18), the transfer device comprising a guide surface (24) moving at a substantially constant speed towards the rotating surface and extending obliquely over the first conveyor (12) and the rotating surface (18); a second conveyor (66); and a curved guide surface (38) for guiding articles transferred to the rotating surface (18) towards the outer periphery thereof for subsequent transfer to the second conveyer.

Abstract translation: 输送系统包括旋转表面（18）; 用于将直立物品（16）输送到用于将物品从第一传送器（12）转移到旋转表面（18）的传送装置的第一传送器，所述传送装置包括以基本上恒定的速度移动的引导表面（24） 旋转表面并倾斜地延伸到第一传送器（12）和旋转表面（18）上方; 第二输送机（66）; 以及弯曲的引导表面（38），用于将被转移到所述旋转表面（18）的物品朝向其外周引导，以便随后转移到所述第二输送器。

公开(公告)号：WO2005121671A1

公开(公告)日：2005-12-22

申请号：PCT/GB2005/002191

申请日：2005-06-06

Applicant: THE BOC GROUP PLC ,  DAMEN, Franciscus, Antonius

Inventor： DAMEN, Franciscus, Antonius

IPC: F26B5/06

CPC classification number: F26B25/003 ,  F26B5/06 ,  F26B25/001

Abstract: A freeze dryer (10) comprises a chamber (12) having a rectangular slot through which vials (86) are inserted into the chamber (12). An assembly for loading and/or unloading the chamber (12) comprises a transfer bar (42) extending across the slot. The bar (42) is pivotally attached at each end to first and second flat springs (46, 48), each spring being wound on a respective rotatably mounted spool (50, 52) located proximate the slot. Drive means are provided for synchronously rotating the spools (50, 52) to effect movement of the bar (42) into or out from the chamber (12) and for selectively rotating the spools (50, 52) to raise or lower the bar (52).

Abstract translation: 冷冻干燥器（10）包括具有矩形狭槽的腔室（12），小瓶（86）通过该狭槽插入腔室12。 用于装载和/或卸载腔室（12）的组件包括延伸穿过狭槽的转移杆（42）。 杆（42）在每一端枢转地附接到第一和第二弹簧（46,48），每个弹簧缠绕在位于槽附近的相应的可旋转地安装的线轴（50,52）上。 提供驱动装置用于同步旋转卷轴（50,52）以实现杆（42）进入或离开室（12）的运动，并且用于选择性地旋转卷轴（50,52）以升高或降低杆 52）。

公开(公告)号：WO2005090210A1

公开(公告)日：2005-09-29

申请号：PCT/GB2005/000781

申请日：2005-03-01

Applicant: THE BOC GROUP PLC ,  DAMEN, Franciscus, Antonius

Inventor： DAMEN, Franciscus, Antonius

IPC: B65G47/84

CPC classification number: B65G47/846 ,  B65G29/00

Abstract: A conveyor system (10) comprises a star wheel (32) for receiving articles (14) from a first conveyor (12) and dispatching the articles to a second conveyor. The star wheel comprises first and second segments (44, 46) each having a perimeter adapted to receive articles to be conveyed. A first shaft (52) rotates the first segment (44) about an axis, and a second shaft (60) rotates the second segment (46) about the axis. In one embodiment, a torsion spring (64) resiliently connects the shafts (52, 60) together. The first shaft (52) is connected to a first drive for rotating the first and second shafts (52, 60) together about the axis. The second shaft (60) is connected to a clutch (72) arrangement for selectively connecting the second shaft (60) to a second drive for rotating the second shaft about the axis at a different speed from the first shaft, for example, in the event that the first drive is switched off. This enables the second segment (46) to continue to rotate during deceleration of the first segment and thereby to continue to convey articles to the second conveyor. The clutch arrangement (72) disconnects the second segment (46) from the second drive before it clashes with the first segment (44) or any articles (14) conveyed thereby, the torsion spring (64) automatically returning the second segment (46) to a predetermined position relative to the first segment (44) for subsequent rotation with the first segment when the first drive is switched on again.

Abstract translation: 输送机系统（10）包括星轮（32），用于从第一输送机（12）接收物品（14）并将物品分送到第二输送机。 星形轮包括第一和第二段（44,46），每个段具有适于接纳待传送物品的周长。 第一轴（52）使第一段（44）围绕轴线旋转，并且第二轴（60）围绕轴线旋转第二段（46）。 在一个实施例中，扭簧（64）将轴（52,60）弹性连接在一起。 第一轴（52）连接到第一驱动器，用于使第一和第二轴（52,60）绕轴线一起旋转。 第二轴（60）连接到用于选择性地将第二轴（60）连接到第二驱动器的离合器（72），该第二驱动器用于以与第一轴不同的速度围绕轴线旋转第二轴，例如在 事件第一个驱动器被关闭。 这使得第二段（46）能够在第一段的减速期间继续旋转，从而继续将物品输送到第二输送机。 离合器装置（72）在其与第一段（44）或由其输送的任何物品（14）发生冲突之前将第二段（46）与第二驱动装置断开，扭力弹簧（64）自动返回第二段（46） 当第一驱动器再次接通时，相对于第一段（44）到达预定位置以随后与第一段旋转。

公开(公告)号：WO2007144206A3

公开(公告)日：2008-04-24

申请号：PCT/EP2007005436

申请日：2007-06-14

Applicant: BOC GROUP PLC ,  BRUKER BIOSPIN GMBH ,  CORVER JOSEF ANTONIUS WILLEM M ,  SCHMALBEIN KLAUS-DIETER ,  MAIER DIETHER C ,  KAMLOWSKI ANDREAS ,  DAMEN FRANCISCUS ANTONIUS

Inventor： CORVER JOSEF ANTONIUS WILLEM M ,  SCHMALBEIN KLAUS-DIETER ,  MAIER DIETHER C ,  KAMLOWSKI ANDREAS ,  DAMEN FRANCISCUS ANTONIUS

IPC: G01R33/44

CPC classification number: G01N24/085

Abstract: A method is described for determining a characteristic, such as the mass, of each of a plurality of samples. The method comprises the steps of providing a plurality of coil elements each for surrounding a respective sample, causing the samples to enter an interrogation zone, each sample being surrounded by a respective coil element when it is located within the interrogation zone, applying a magnetic field in a first direction in the interrogation zone for creating in a pre-polarised state a net nuclear magnetisation of a nuclear spin species within a sample located in the interrogation zone, applying, by each coil element surrounding a respective sample located in the interrogation zone, an RF field in a second direction for temporarily changing the net nuclear magnetisation of the nuclear spin species in the sample, detecting RF energy emitted from that sample as the net nuclear magnetisation of the nuclear spin species in the sample relaxes, and, from the detected RF energy, determining the characteristic of each sample located in the interrogation zone.

Abstract translation: 描述了一种用于确定多个样本中的每一个的特征（例如质量）的方法。 该方法包括以下步骤：提供多个线圈元件，每个线圈元件用于围绕相应的样品，使得样品进入询问区域，每个样品在位于询问区域内时由相应的线圈元件围绕，施加磁场 在询问区中的第一方向上，用于在预极化状态下产生位于询问区内的样品内的核自旋物质的净核磁化，由围绕位于询问区中的相应样品的每个线圈元件施加， 用于临时改变样品中核自旋物质的净核磁化的第二方向的RF场，当样品中的核自旋物质的净核磁化松弛时，检测从该样品发射的RF能量，并且从检测到的 RF能量，确定位于询问区的每个样本的特征。

公开(公告)号：WO2008003509A1

公开(公告)日：2008-01-10

申请号：PCT/EP2007/006005

申请日：2007-07-02

Applicant: THE BOC GROUP PLC ,  DAMEN, Franciscus, Antonius ,  VUGTS, Jan ,  VAN VEEN, Johannes ,  CORVER, Josef, Antonius, Willem, Maria

Inventor： DAMEN, Franciscus, Antonius ,  VUGTS, Jan ,  VAN VEEN, Johannes ,  CORVER, Josef, Antonius, Willem, Maria

IPC: F26B5/06

CPC classification number: F26B5/06

Abstract: A freeze dryer (10) comprises a chamber (12) housing a plate (22) from which a plurality of shelves (20) is suspended. The shelves (20) are suspended from the plate (22) by links (28) carrying stops (38) upon which the shelves (20) rest to form a stack of vertically spaced shelves. Shelf support surfaces (200) are movable relative to the chamber (12) between adjacent shelves (20) in the stack. As the shelf stack is lowered within the chamber, the movement of the uppermost of these adjacent shelves is checked by the shelf support surfaces (200) so that, with further lowering of the shelf stack, the spacing between the adjacent shelves (20) increases. This can enable a pusher bar to fit between these two shelves to remove containers from, or load containers on to, the lowermost of these two shelves.

Abstract translation: 冷冻干燥器（10）包括容纳多个搁架（20）的板（22）的室（12）。 架子（20）通过承载着架子（38）的连杆（28）从板（22）悬挂，搁架（20）搁在其上以形成一叠垂直间隔的货架。 搁架支撑表面（200）可相对于堆叠中的相邻货架（20）之间的室（12）移动。 当货架在室内下降时，搁板支撑表面（200）检查这些相邻货架中最上面的运动，使得随着搁板堆的进一步降低，相邻货架（20）之间的间隔增加 。 这可以使推杆安装在这两个货架之间以从这两个货架的最下面移除容器，或将货物装载到这两个货架的最下面。

公开(公告)号：WO2005121672A1

公开(公告)日：2005-12-22

申请号：PCT/GB2005/002209

申请日：2005-06-06

Applicant: THE BOC GROUP PLC ,  DAMEN, Franciscus, Antonius

Inventor： DAMEN, Franciscus, Antonius

IPC: F26B5/06

CPC classification number: F26B5/06 ,  F26B25/001

Abstract: A freeze dryer (10) comprises a chamber (12) having a rectangular slot through which vials are inserted into the chamber (12). An assembly for loading the chamber (12) comprises a bar (32) extending across the slot to engage vials to be inserted into the chamber (12). The bar (32) is attached to a mechanism (34) for moving the bar (32) laterally into and out from the chamber (12). In a retracted position of the bar (32), at least part of the mechanism (34) is wound around a sprocket (106). Rotation of the sprocket (106) unwinds the mechanism (34) to move the bar (32) into the chamber (12).

Abstract translation: 冷冻干燥器（10）包括具有矩形狭槽的腔室（12），小瓶通过该狭槽插入腔室（12）中。 用于装载室（12）的组件包括延伸穿过狭槽的杆（32），以接合待插入腔室（12）的小瓶。 杆（32）附接到用于使杆（32）横向移入和移出腔室（12）的机构（34）。 在杆（32）的缩回位置中，机构（34）的至少一部分围绕链轮（106）缠绕。 链轮（106）的旋转解除机构（34）以使杆（32）移动到腔室（12）中。

公开(公告)号：WO2011015453A8

公开(公告)日：2011-03-31

申请号：PCT/EP2010060557

申请日：2010-07-21

Applicant: IMA LIFE SRL ,  VAN VEEN JOHANNES ,  DAMEN FRANCISCUS ANTONIUS ,  SCHAEPMAN ALEXANDER CLEMENS HENRICUS JOSEF ,  JONGENELEN FLORENTINUS ADRIAAN CORNELIS MARIE

Inventor： VAN VEEN JOHANNES ,  DAMEN FRANCISCUS ANTONIUS ,  SCHAEPMAN ALEXANDER CLEMENS HENRICUS JOSEF ,  JONGENELEN FLORENTINUS ADRIAAN CORNELIS MARIE

IPC: F26B5/06 ,  F26B25/00

CPC classification number: F26B5/06 ,  B65G47/82 ,  F26B25/001

Abstract: Method for transfer of containers, such as vials (101), between a freeze dryer (1) that is located at a first location and a separate transport vehicle (30) that is mobile with respect to the freeze dryer, wherein the freeze dryer (1) comprises a freeze dryer housing (2) with an access opening (11) towards an inner freeze drying chamber (10) inside the freeze dryer housing (2), multiple shelves (21-24) that are arranged spaced apart above each other inside the freeze dryer chamber (10) and each provided with a horizontally extending first flat supporting surface (25) for supporting the containers, wherein the mobile transport vehicle (30) comprises a mobile undercarriage (31) supporting a storage housing (33) with an access opening (40) towards an inner storage chamber (39), a carrier provided with a second flat supporting surface (58) for supporting the containers inside the storage housing (33), and a container shifter (60) for pushing out containers away from the second flat supporting surface (58) in a pushing out direction parallel to the second flat supporting surface (58).

Abstract translation: 在位于第一位置的冷冻干燥器（1）和可相对于冷冻干燥器移动的单独的运输车辆（30）之间转运诸如小瓶（101）的容器的方法，其中所述冷冻干燥器 冷冻干燥器壳体（2）包括在冷冻干燥器壳体（2）内部具有朝向内部冷冻干燥室（10）的进入开口（11）的冷冻干燥器壳体，彼此间隔开地布置的多个搁架（21-24） 在所述冷冻干燥器室（10）内部并且每个设置有用于支撑所述容器的水平延伸的第一平坦支撑表面（25），其中所述移动式运输车辆（30）包括支撑储存壳体（33）的移动式起落架（31） 朝向内部存储室（39）的进入开口（40），设置有用于将容器支撑在储存壳体（33）内的第二扁平支撑表面（58）的托架和用于推出容器的容器移位器（60） 远离第二个平面支撑 （58）在平行于第二平坦支撑表面（58）的推出方向上。

公开(公告)号：WO2007131760A1

公开(公告)日：2007-11-22

申请号：PCT/EP2007/004272

申请日：2007-05-11

Applicant: THE BOC GROUP PLC ,  CORVER, Josef, Antonius, Willem, Maria ,  DAMEN, Franciscus, Antonius

Inventor： CORVER, Josef, Antonius, Willem, Maria ,  DAMEN, Franciscus, Antonius

IPC: F26B5/06 ,  F26B25/00

CPC classification number: F26B5/06 ,  F26B25/001

Abstract: A loading system for a freeze dryer (10) or the like comprises a plurality of transfer frames (36) each for surrounding a batch of containers to be loaded into the freeze dryer (10). A transport table (60) is moveable between a table loading position at which a loaded transfer frame (36) is moved on to the transport table, and a chamber loading position. A moveable bridge plate is positioned between a shelf (20) of the freeze dryer (10) and the chamber loading position to receive a first loaded transfer frame (36) from the transport table (60). The transfer frames (36) are provided with at least one connecting member to enable the first transfer frame to be connected to a second transfer frame when the transport table (60), bearing the second transfer frame, is returned to the chamber loading position. The first and second transfer frames (36) are then moved on to the shelf (20) of the freeze dryer (10).

Abstract translation: 用于冷冻干燥器（10）等的装载系统包括多个传送框架（36），每个传送框架围绕要装入冷冻干燥机（10）的一批容器。 传送台（60）可以在装载的传送框架（36）移动到传送台的台装载位置和室装载位置之间移动。 可移动桥板被定位在冷冻干燥器（10）的搁板（20）和室装载位置之间，以从传送台（60）接收第一加载传送框架（36）。 传送框架（36）设置有至少一个连接构件，以使得当承载第二传送框架的传送台（60）返回到室装载位置时，能够将第一传送框架连接到第二传送框架。 然后将第一和第二转移框架（36）移动到冷冻干燥器（10）的搁板（20）上。