公开(公告)号：WO2010150281A2

公开(公告)日：2010-12-29

申请号：PCT/IN2010/000428

申请日：2010-06-22

申请人： PANACEA BIOTEC LTD. ,  JAIN, Rajesh ,  TREHAN, Sanjay ,  DAS, Jagattaran ,  KAUR, Gurmeet ,  KANWAR, Sandeep ,  SINGH, Nishan ,  NANDA, Gurmeet Kaur ,  MAGADI, Sitaram Kumar ,  SHARMA, Sudhir Kumar

发明人： JAIN, Rajesh ,  TREHAN, Sanjay ,  DAS, Jagattaran ,  KAUR, Gurmeet ,  KANWAR, Sandeep ,  SINGH, Nishan ,  NANDA, Gurmeet Kaur ,  MAGADI, Sitaram Kumar ,  SHARMA, Sudhir Kumar

IPC分类号： C07D221/22 ,  C07D401/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D471/04 ,  C07D491/08 ,  A61K31/46 ,  A61K31/496 ,  A61K31/498 ,  A61K31/5355 ,  A61K31/551 ,  C07D487/04 ,  A61P25/00 ,  A61P31/00

CPC分类号： C07D221/22 ,  C07D209/52 ,  C07D401/10 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08

摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.

摘要翻译： 本发明涉及式（I）的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。

公开(公告)号：WO2008143649A2

公开(公告)日：2008-11-27

申请号：PCT/US2007024843

申请日：2007-12-04

申请人： REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  TAKHI MOHAMED ,  DAS JAGATTARAN ,  IQBAL JAVED ,  SELVAKUMAR NATESAN ,  KANDEPU SREENIVAS ,  KUMAR M SITARAM

发明人： TAKHI MOHAMED ,  DAS JAGATTARAN ,  IQBAL JAVED ,  SELVAKUMAR NATESAN ,  KANDEPU SREENIVAS ,  KUMAR M SITARAM

IPC分类号： C07D413/02

CPC分类号： C07D413/14 ,  C07D417/14

摘要： The present invention relates to novel oxazolidinone compounds of formula (I) with antibacterial activity, their pharmaceutically acceptable salts, their stereoisomers, their prodrugs, pharmaceutical compositions comprising the same and to their use as therapeutic agents

摘要翻译： 本发明涉及具有抗菌活性的式（I）的恶唑烷酮化合物，其药学上可接受的盐，其立体异构体，其前药，包含它们的药物组合物及其作为治疗剂的用途

公开(公告)号：WO2005082892A2

公开(公告)日：2005-09-09

申请号：PCT/IB2005/000343

申请日：2005-02-11

申请人： DR. REDDY'S LABORATORIES LTD. ,  DAS, Jagattaran ,  TAKHI, Mohamed ,  NATESAN, Selvakumar ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram Kumar ,  KANDEPU, Sreenivas

发明人： DAS, Jagattaran ,  TAKHI, Mohamed ,  NATESAN, Selvakumar ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram Kumar ,  KANDEPU, Sreenivas

IPC分类号： C07D403/00

CPC分类号： C07D403/06 ,  C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

摘要： The present invention relates to novel triazole compounds of formula (I), where all symbols are as defined in the detailed description; their pharmaceutically acceptable salts their stereosiomers thereof, their prodrugs, their rotamers, their pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.

摘要翻译： 本发明涉及新的式（I）三唑化合物，其中所有符号如详细描述中所定义; 其药学上可接受的盐，它们的立体异构体，它们的前药，它们的旋转异构体，它们含有它们的药物组合物。 本发明还涉及制备上述新化合物的方法。

公开(公告)号：WO2005035528A2

公开(公告)日：2005-04-21

申请号：PCT/IB2004/003360

申请日：2004-10-14

申请人： Dr. Reddy's Laboratories Ltd. ,  NATESAN, Selvakumar ,  DAS, Jagattaran ,  TAKHI, Mohamed ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram, Kumar ,  KANDEPU, Sreenivas

发明人： NATESAN, Selvakumar ,  DAS, Jagattaran ,  TAKHI, Mohamed ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram, Kumar ,  KANDEPU, Sreenivas

IPC分类号： C07D403/10

CPC分类号： C07D401/14 ,  C07D403/10

摘要： The present invention relates to novel triazole compounds of formula (I), their prodrugs, their pharmaceutically acceptable salts and their stereoisomers thereof. The present invention also relates to a process for the preparation of the novel compound of the formula (I).

摘要翻译： 本发明涉及式（I）的新型三唑化合物，其前药，其药学上可接受的盐及其立体异构体。 本发明还涉及制备式（I）的新型化合物的方法。

公开(公告)号：WO2004106329A2

公开(公告)日：2004-12-09

申请号：PCT/IB2004001811

申请日：2004-06-03

申请人： REDDYS LAB LTD DR ,  MOHAMED TAKHI ,  DAS JAGATTARAN ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR

发明人： MOHAMED TAKHI ,  DAS JAGATTARAN ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR

IPC分类号： A61P31/04 ,  C07D405/10 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D405/00

CPC分类号： C07D405/10 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14

摘要： The present invention provides novel triazole compounds of formula (I), their pharmaceutically acceptable salts and their pharmaceutical compositions, where all symbols are as defined in the specification

摘要翻译： 本发明提供新的式（I）三唑化合物，其药学上可接受的盐及其药物组合物，其中所有符号如说明书中所定义

公开(公告)号：WO2012042539A3

公开(公告)日：2012-05-31

申请号：PCT/IN2011000669

申请日：2011-09-27

申请人： PANACEA BIOTEC LTD ,  JAIN RAJESH ,  TREHAN SANJAY ,  DAS JAGATTARAN ,  SINGH NISHAN ,  SHARMA SUDHIR KUMAR

发明人： JAIN RAJESH ,  TREHAN SANJAY ,  DAS JAGATTARAN ,  SINGH NISHAN ,  SHARMA SUDHIR KUMAR

IPC分类号： C07D209/52 ,  A61K31/403 ,  A61P25/00

CPC分类号： C07D209/52 ,  A61K31/403 ,  A61K45/06

摘要： The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention further provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more disorders of the central and/or peripheral nervous system, preferably by modulating neurological and/or psychiatric targets (GPCR and/or non-GPCR).

摘要翻译： 本发明涉及式I的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。 本发明还提供包含式I化合物的药物组合物和治疗或预防中枢和/或周围神经系统的一种或多种病症的方法，优选通过调节神经和/或精神病学靶标（GPCR和/或非GPCR） 。

公开(公告)号：WO2011070592A3

公开(公告)日：2011-06-16

申请号：PCT/IN2010/000796

申请日：2010-12-09

申请人： PANACEA BIOTEC LTD. ,  JAIN, Rajesh ,  TREHAN, Sanjay ,  THUNGATHURTHI, Sastry V.R.S. ,  NANDA, Gurmeet, Kaur ,  DAS, Jagattaran ,  MAGADI, Sitaram, Kumar ,  SHARMA, Sudhir, Kumar

发明人： JAIN, Rajesh ,  TREHAN, Sanjay ,  THUNGATHURTHI, Sastry V.R.S. ,  NANDA, Gurmeet, Kaur ,  DAS, Jagattaran ,  MAGADI, Sitaram, Kumar ,  SHARMA, Sudhir, Kumar

IPC分类号： C07H15/203 ,  C07D309/10

摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2). The invention also relates to the use of compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof, for the manufacture of a medicament for the prophylaxis, amelioration and/or treatment of conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2) and the related diseases, disorders and conditions, in a subject in need thereof.

公开(公告)号：WO2009118765A3

公开(公告)日：2010-10-28

申请号：PCT/IN2009000202

申请日：2009-03-27

申请人： PANACEA BIOTEC LTD ,  KESSAR SATINDER VIR ,  KULKARNI SHRINIVAS KRISHNARAO ,  JAIN RAJESH ,  TREHAN SANJAY ,  MAGADI SITARAM KUMAR ,  DAS JAGATTARAN ,  KAUR GURMEET ,  SINGH KAMAL NAIN ,  LATA SNEH ,  DHIR ASHISH

发明人： KESSAR SATINDER VIR ,  KULKARNI SHRINIVAS KRISHNARAO ,  JAIN RAJESH ,  TREHAN SANJAY ,  MAGADI SITARAM KUMAR ,  DAS JAGATTARAN ,  KAUR GURMEET ,  SINGH KAMAL NAIN ,  LATA SNEH ,  DHIR ASHISH

IPC分类号： C07D217/16 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D409/04 ,  C07D409/06 ,  C07D411/12 ,  C07D413/12

CPC分类号： C07D217/16 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D409/04 ,  C07D409/06 ,  C07D411/12 ,  C07D413/12

摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention further provides pharmaceutical compositions comprising compounds of Formula (I) and methods of treating or preventing one or more disorders of the central and/or peripheral nervous system that are responsive to inhibition of biogenic amines, in particular one or more, or any combination of serotonin, norepinephrine and dopamine.

摘要翻译： 本发明涉及式（I）的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成式（I）的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。 本发明进一步提供药物组合物，其包含式（I）化合物和治疗或预防中枢和/或周围神经系统的一种或多种疾病，所述疾病对抑制生物胺特别是一种或多种或任何 5-羟色胺，去甲肾上腺素和多巴胺的组合。

公开(公告)号：WO2010058423A9

公开(公告)日：2010-05-27

申请号：PCT/IN2009/000658

申请日：2009-11-18

申请人： PANACEA BIOTEC LTD. ,  JAIN, Rajesh ,  TREHAN, Sanjay ,  DAS, Jagattaran ,  KANWAR, Sandeep ,  MAGADI, Sitaram, Kumar ,  SHARMA, Sudhir, Kumar

发明人： JAIN, Rajesh ,  TREHAN, Sanjay ,  DAS, Jagattaran ,  KANWAR, Sandeep ,  MAGADI, Sitaram, Kumar ,  SHARMA, Sudhir, Kumar

IPC分类号： C07D413/10 ,  C07D413/14

摘要： The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.

公开(公告)号：WO2005082892A3

公开(公告)日：2006-03-23

申请号：PCT/IB2005000343

申请日：2005-02-11

申请人： REDDYS LAB LTD DR ,  DAS JAGATTARAN ,  TAKHI MOHAMED ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

发明人： DAS JAGATTARAN ,  TAKHI MOHAMED ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

IPC分类号： C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

CPC分类号： C07D403/06 ,  C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

摘要： The present invention relates to novel triazole compounds of formula (I), where all symbols are as defined in the detailed description; their pharmaceutically acceptable salts their stereosiomers thereof, their prodrugs, their rotamers, their pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.

摘要翻译： 本发明涉及新的式（I）三唑化合物，其中所有符号如详细描述中所定义; 其药学上可接受的盐，它们的立体异构体，它们的前药，它们的旋转异构体，它们含有它们的药物组合物。 本发明还涉及制备上述新化合物的方法。