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    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION IN EXTRACORPOREAL MEMBRANE OXYGENATION
    6.
    发明申请
    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION IN EXTRACORPOREAL MEMBRANE OXYGENATION 审中-公开
    新型流体管理系统，用于精确连续超声波在超声波膜氧化

    公开(公告)号：WO2008154376A2

    公开(公告)日：2008-12-18

    申请号：PCT/US2008/066108

    申请日：2008-06-06

    Applicant: GEORGIA TECH RESEARCH CORPORATION ,  FORTENBERRY, James, D. ,  YOGANATHAN, Ajit, P. ,  SUCOSKY, Philippe ,  DASI, Lakshmi, Prasad ,  PADEN, Matthew, L.

    Inventor： FORTENBERRY, James, D. ,  YOGANATHAN, Ajit, P. ,  SUCOSKY, Philippe ,  DASI, Lakshmi, Prasad ,  PADEN, Matthew, L.

    IPC: A61K35/14

    CPC classification number: A61M1/3448 ,  A61M1/1698 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3666

    Abstract: A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

    Abstract translation: 一种用于体外膜氧合（ECMO）中精确连续静脉血液滤过（CWH）的流体管理的新型系统和方法。 流体管理或CWH系统是自动化的并且被配置为作为独立单元操作，并且可以容易地与ECMO系统集成。 流体管理系统能够在超滤液去除和更换流体输送之间产生完美或负向的流体平衡。 流体管理系统可以在护理从新生儿到成人的患者所需的一系列流量范围内实现电解质置换。 最后，新颖的流体管理系统保持患者的安全，在手术过程中保持不育，操作方便，并且足够紧凑以适应病人的床位。

    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION
    7.
    发明申请
    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION 审中-公开
    新型流体管理系统，用于精确的连续HEMOFILTRATION

    公开(公告)号：WO2008154376A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2008066108

    申请日：2008-06-06

    Applicant: GEORGIA TECH RES INST ,  FORTENBERRY JAMES D ,  YOGANATHAN AJIT P ,  SUCOSKY PHILIPPE ,  DASI LAKSHMI PRASAD ,  PADEN MATTHEW L

    Inventor： FORTENBERRY JAMES D ,  YOGANATHAN AJIT P ,  SUCOSKY PHILIPPE ,  DASI LAKSHMI PRASAD ,  PADEN MATTHEW L

    IPC: A61M1/02 ,  B01D61/00

    CPC classification number: A61M1/3448 ,  A61M1/1698 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3666

    Abstract: A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

    Abstract translation: 一种用于体外膜氧合（ECMO）中精确连续静脉血液滤过（CWH）的流体管理的新型系统和方法。 流体管理或CWH系统是自动化的并且被配置为作为独立单元操作，并且可以容易地与ECMO系统集成。 流体管理系统能够在超滤液去除和更换流体输送之间产生完美或负向的液体平衡。 流体管理系统可以在护理从新生儿到成人的患者所需的一定范围的流速下实现电解质置换。 最后，新颖的流体管理系统保持患者的安全，在手术过程中维持不育，操作方便，并且足够紧凑以适合患者的床。

    ANATOMICAL CONNECTION
    8.
    发明申请
    ANATOMICAL CONNECTION 审中-公开
    解剖学连接

    公开(公告)号：WO2005094521A3

    公开(公告)日：2007-06-14

    申请号：PCT/US2005009835

    申请日：2005-03-23

    Applicant: GEORGIA TECH RES INST ,  SOERENSEN DENNIS DAM ,  DASI LAKSHMI PRASAD ,  PEKKAN KEREM ,  DE JULIEN DE ZELICOURT DIANE ,  YOGANATHAN AJIT P

    Inventor： SOERENSEN DENNIS DAM ,  DASI LAKSHMI PRASAD ,  PEKKAN KEREM ,  DE JULIEN DE ZELICOURT DIANE ,  YOGANATHAN AJIT P

    IPC: A61F2/04 ,  A61F2/06 ,  A61M5/00 ,  F16L41/00 ,  F17D3/00

    CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/0058 ,  Y10T137/87249

    Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.

    Abstract translation: 用于全肺静脉连接（TCPC）的装置，以优化其血流动力学。 虽然目前的单心室心脏修复方案是选择，但TCPC已经将术后死亡率降低到更简单类型的先天性心脏病修复水平，Fontan患者仍然遭受严重的长期并发症。 恢复氧合和脱氧血液之间重要分离的TCPC程序也导致剩余的单个心室的工作量增加，因为它现在负责通过全身和肺循环泵送血液。 本设备通过更改手术创建的TCPC设计来减少此工作负载。 改善的流体力学和减少的连接部位的能量消耗转化为较少的单一心室的工作和改善的脱氧血液转运到肺部，这可能反过来有助于改善术后结果和生活质量。

    ANATOMICAL CONNECTION
    9.
    发明申请
    ANATOMICAL CONNECTION 审中-公开
    解剖学连接

    公开(公告)号：WO2005094521A2

    公开(公告)日：2005-10-13

    申请号：PCT/US2005/009835

    申请日：2005-03-23

    Applicant: GEORGIA TECH RESEARCH CORPORATION ,  SOERENSEN, Dennis, Dam ,  DASI, Lakshmi, Prasad ,  PEKKAN, Kerem ,  DE JULIEN DE ZELICOURT, Diane ,  YOGANATHAN, Ajit, P.

    Inventor： SOERENSEN, Dennis, Dam ,  DASI, Lakshmi, Prasad ,  PEKKAN, Kerem ,  DE JULIEN DE ZELICOURT, Diane ,  YOGANATHAN, Ajit, P.

    IPC: A61F2/04 ,  A61F2/06

    CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/0058 ,  Y10T137/87249

    Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.

    Abstract translation: 用于全肺静脉连接（TCPC）的装置，以优化其血流动力学。 虽然目前的单心室心脏修复方案是选择，但TCPC已经将术后死亡率降低到更简单类型的先天性心脏病修复水平，Fontan患者仍然遭受严重的长期并发症。 恢复氧合和脱氧血液之间重要分离的TCPC程序也导致剩余的单个心室的工作量增加，因为它现在负责通过全身和肺循环泵送血液。 本设备通过更改手术创建的TCPC设计来减少此工作负载。 改善的流体力学和减少的连接部位的能量消耗转化为较少的单一心室的工作和改善的脱氧血液转运到肺部，这可能反过来有助于改善术后结果和生活质量。

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