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    SYSTEMS FOR IMPLANTING AND USING A CONDUIT WITHIN A TISSUE WALL
    1.
    发明申请
    SYSTEMS FOR IMPLANTING AND USING A CONDUIT WITHIN A TISSUE WALL 审中-公开
    用于在一个组织墙上嵌入和使用一个管道的系统

    公开(公告)号：WO2012106422A3

    公开(公告)日：2012-10-18

    申请号：PCT/US2012023476

    申请日：2012-02-01

    Applicant: GEORGIA TECH RES INST ,  UNIV EMORY ,  JIMENEZ JORGE H ,  YOGANATHAN AJIT P ,  WEST SETH ,  THOURANI VINOD

    Inventor： JIMENEZ JORGE H ,  YOGANATHAN AJIT P ,  WEST SETH ,  THOURANI VINOD

    IPC: A61B17/11 ,  A61F2/06

    CPC classification number: A61B17/3423 ,  A61B17/00234 ,  A61B17/0218 ,  A61B2017/00252 ,  A61B2017/3425 ,  A61F2/064 ,  A61M1/1008 ,  A61M1/3659 ,  A61M27/002

    Abstract: Various embodiments of the present invention provide a conduit system including an outer lumen ( 810 ), an inner lumen ( 805 ), and an attaching device ( 820 ). In other embodiments, a multiple access port device adapted for communication with at least one of an outer lumen, an inner lumen, or an attaching device of a conduit system is provided. In yet other embodiments, a system including an inner lumen that is collapsible is provided. Means for closing a conduit system are also provided, including a plug for insertion through an attaching device and a variable radius coiled member associated with an attaching device.

    Abstract translation: 本发明的各种实施例提供一种包括外腔（810），内腔（805）和附接装置（820）的导管系统。 在其他实施例中，提供了适于与管道系统的外腔，内腔或附接装置中的至少一个通信的多通道端口装置。 在其他实施例中，提供了包括可折叠的内腔的系统。 还提供了用于封闭导管系统的装置，包括用于插入通过附接装置的插头和与附接装置相关联的可变半径盘绕构件。

    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION
    2.
    发明申请
    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION 审中-公开
    新型流体管理系统，用于精确的连续HEMOFILTRATION

    公开(公告)号：WO2008154376A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2008066108

    申请日：2008-06-06

    Applicant: GEORGIA TECH RES INST ,  FORTENBERRY JAMES D ,  YOGANATHAN AJIT P ,  SUCOSKY PHILIPPE ,  DASI LAKSHMI PRASAD ,  PADEN MATTHEW L

    Inventor： FORTENBERRY JAMES D ,  YOGANATHAN AJIT P ,  SUCOSKY PHILIPPE ,  DASI LAKSHMI PRASAD ,  PADEN MATTHEW L

    IPC: A61M1/02 ,  B01D61/00

    CPC classification number: A61M1/3448 ,  A61M1/1698 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3666

    Abstract: A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

    Abstract translation: 一种用于体外膜氧合（ECMO）中精确连续静脉血液滤过（CWH）的流体管理的新型系统和方法。 流体管理或CWH系统是自动化的并且被配置为作为独立单元操作，并且可以容易地与ECMO系统集成。 流体管理系统能够在超滤液去除和更换流体输送之间产生完美或负向的液体平衡。 流体管理系统可以在护理从新生儿到成人的患者所需的一定范围的流速下实现电解质置换。 最后，新颖的流体管理系统保持患者的安全，在手术过程中维持不育，操作方便，并且足够紧凑以适合患者的床。

    ANATOMICAL CONNECTION
    3.
    发明申请
    ANATOMICAL CONNECTION 审中-公开
    解剖学连接

    公开(公告)号：WO2005094521A3

    公开(公告)日：2007-06-14

    申请号：PCT/US2005009835

    申请日：2005-03-23

    Applicant: GEORGIA TECH RES INST ,  SOERENSEN DENNIS DAM ,  DASI LAKSHMI PRASAD ,  PEKKAN KEREM ,  DE JULIEN DE ZELICOURT DIANE ,  YOGANATHAN AJIT P

    Inventor： SOERENSEN DENNIS DAM ,  DASI LAKSHMI PRASAD ,  PEKKAN KEREM ,  DE JULIEN DE ZELICOURT DIANE ,  YOGANATHAN AJIT P

    IPC: A61F2/04 ,  A61F2/06 ,  A61M5/00 ,  F16L41/00 ,  F17D3/00

    CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/0058 ,  Y10T137/87249

    Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.

    Abstract translation: 用于全肺静脉连接（TCPC）的装置，以优化其血流动力学。 虽然目前的单心室心脏修复方案是选择，但TCPC已经将术后死亡率降低到更简单类型的先天性心脏病修复水平，Fontan患者仍然遭受严重的长期并发症。 恢复氧合和脱氧血液之间重要分离的TCPC程序也导致剩余的单个心室的工作量增加，因为它现在负责通过全身和肺循环泵送血液。 本设备通过更改手术创建的TCPC设计来减少此工作负载。 改善的流体力学和减少的连接部位的能量消耗转化为较少的单一心室的工作和改善的脱氧血液转运到肺部，这可能反过来有助于改善术后结果和生活质量。

    ANATOMICAL CONNECTION
    4.
    发明申请
    ANATOMICAL CONNECTION 审中-公开
    解剖学连接

    公开(公告)号：WO2005094521A2

    公开(公告)日：2005-10-13

    申请号：PCT/US2005/009835

    申请日：2005-03-23

    Applicant: GEORGIA TECH RESEARCH CORPORATION ,  SOERENSEN, Dennis, Dam ,  DASI, Lakshmi, Prasad ,  PEKKAN, Kerem ,  DE JULIEN DE ZELICOURT, Diane ,  YOGANATHAN, Ajit, P.

    Inventor： SOERENSEN, Dennis, Dam ,  DASI, Lakshmi, Prasad ,  PEKKAN, Kerem ,  DE JULIEN DE ZELICOURT, Diane ,  YOGANATHAN, Ajit, P.

    IPC: A61F2/04 ,  A61F2/06

    CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/0058 ,  Y10T137/87249

    Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.

    Abstract translation: 用于全肺静脉连接（TCPC）的装置，以优化其血流动力学。 虽然目前的单心室心脏修复方案是选择，但TCPC已经将术后死亡率降低到更简单类型的先天性心脏病修复水平，Fontan患者仍然遭受严重的长期并发症。 恢复氧合和脱氧血液之间重要分离的TCPC程序也导致剩余的单个心室的工作量增加，因为它现在负责通过全身和肺循环泵送血液。 本设备通过更改手术创建的TCPC设计来减少此工作负载。 改善的流体力学和减少的连接部位的能量消耗转化为较少的单一心室的工作和改善的脱氧血液转运到肺部，这可能反过来有助于改善术后结果和生活质量。

    ANNULOPLASTY RINGS AND METHODS FOR HEART VALVE REPAIR
    8.
    发明申请
    ANNULOPLASTY RINGS AND METHODS FOR HEART VALVE REPAIR 审中-公开
    环形瓣环和心脏瓣膜修复方法

    公开(公告)号：WO2009126629A1

    公开(公告)日：2009-10-15

    申请号：PCT/US2009/039777

    申请日：2009-04-07

    Applicant: GEORGIA TECH RESEARCH CORPORATION ,  MURALIDHAR, Sai ,  YOGANATHAN, Ajit, P. ,  THOURANI, Vinod, H. ,  JIMENEZ, Jorge, H.

    Inventor： MURALIDHAR, Sai ,  YOGANATHAN, Ajit, P. ,  THOURANI, Vinod, H. ,  JIMENEZ, Jorge, H.

    IPC: A61F2/24

    CPC classification number: A61F2/2448 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2230/0023 ,  A61F2230/0063 ,  A61F2230/0095 ,  A61F2250/0004

    Abstract: An annuloplasty ring, configured for implantation in the annulus of a heart valve, comprising multiple segments each of which are geometrically shaped from a three dimensional perspective to conform to the anatomic shape of the valve annulus. In one embodiment, the annuloplasty ring is configured to facilitate a reduction of tension on heart valve tissue and eliminate a substantial portion of potential pressure or force that may be applied to the atrioventricular node by the annuloplasty ring when implanted. In another embodiment, at the annuloplasty ring is configured to include an assembly that facilitates selective adjustment of a segment's respective length and/or shape. The adjustment of the length of one of the ring segment's results in an adjustment of at least one angle between at least one set of other ring segments, thereby causing an adjustment to the geometric characteristics of the ring.

    Abstract translation: 瓣膜成形术环，构造成用于植入心脏瓣膜的环中，包括多个部分，每个部分从三维透视几何形状形成，以符合瓣膜环的解剖形状。 在一个实施例中，瓣膜成形术环被配置为有助于降低心脏瓣膜组织上的张力，并且消除植入时由瓣环成形术环施加到房室结的可能的压力或力的大部分。 在另一个实施例中，在瓣环成形术环被配置为包括便于对片段相应长度和/或形状进行选择性调节的组件。 调节环段中的一个的长度导致至少一组其它环段之间的至少一个角度的调整，从而调整环的几何特性。

    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION IN EXTRACORPOREAL MEMBRANE OXYGENATION
    9.
    发明申请
    NOVEL FLUID MANAGEMENT SYSTEM FOR ACCURATE CONTINUOUS HEMOFILTRATION IN EXTRACORPOREAL MEMBRANE OXYGENATION 审中-公开
    新型流体管理系统，用于精确连续超声波在超声波膜氧化

    公开(公告)号：WO2008154376A2

    公开(公告)日：2008-12-18

    申请号：PCT/US2008/066108

    申请日：2008-06-06

    Applicant: GEORGIA TECH RESEARCH CORPORATION ,  FORTENBERRY, James, D. ,  YOGANATHAN, Ajit, P. ,  SUCOSKY, Philippe ,  DASI, Lakshmi, Prasad ,  PADEN, Matthew, L.

    Inventor： FORTENBERRY, James, D. ,  YOGANATHAN, Ajit, P. ,  SUCOSKY, Philippe ,  DASI, Lakshmi, Prasad ,  PADEN, Matthew, L.

    IPC: A61K35/14

    CPC classification number: A61M1/3448 ,  A61M1/1698 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3666

    Abstract: A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

    Abstract translation: 一种用于体外膜氧合（ECMO）中精确连续静脉血液滤过（CWH）的流体管理的新型系统和方法。 流体管理或CWH系统是自动化的并且被配置为作为独立单元操作，并且可以容易地与ECMO系统集成。 流体管理系统能够在超滤液去除和更换流体输送之间产生完美或负向的流体平衡。 流体管理系统可以在护理从新生儿到成人的患者所需的一系列流量范围内实现电解质置换。 最后，新颖的流体管理系统保持患者的安全，在手术过程中保持不育，操作方便，并且足够紧凑以适应病人的床位。

    SYSTEMS AND METHODS FOR ENABLING HEART VALVE REPLACEMENT
    10.
    发明申请
    SYSTEMS AND METHODS FOR ENABLING HEART VALVE REPLACEMENT 审中-公开
    用于启动心脏瓣膜置换的系统和方法

    公开(公告)号：WO2007100410A3

    公开(公告)日：2007-12-21

    申请号：PCT/US2006062199

    申请日：2006-12-15

    Applicant: GEORGIA TECH RES INST ,  YOGANATHAN AJIT P ,  JIMENEZ JORGE HERNAN

    Inventor： YOGANATHAN AJIT P ,  JIMENEZ JORGE HERNAN

    IPC: A61F2/24

    CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2002/8483 ,  A61F2002/9528 ,  A61F2250/0059 ,  A61F2250/006

    Abstract: The present invention descrbes a cardiac prothetic system (400) comprising: an anchoring conduit (200) having a harbour (415), the harbour including a first releasably engaging component (515); a temporary valve (305) and a heart valve prosthesis (420) having a second releasably engaging component (445) enabled to be securely coupled and uncoupled from the first releasably engaging component (515) of the harbour (415).

    Abstract translation: 本发明描述一种心脏假想系统（400），包括：具有港口（415）的锚固管道（200），所述港口包括第一可释放地接合的部件（515）; 临时阀（305）和具有第二可释放接合部件（445）的心脏瓣膜假体（420）能够牢固地联接并离开港口（415）的第一可释放接合部件（515）。

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