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    MODULATION OF T CELL SIGNALING THRESHOLD AND T CELL SENSITIVITY TO ANTIGENS
    2.
    发明申请
    MODULATION OF T CELL SIGNALING THRESHOLD AND T CELL SENSITIVITY TO ANTIGENS 审中-公开
    T细胞信号传递阈值和T细胞对抗原的敏感性调节

    公开(公告)号：WO2008057234A3

    公开(公告)日：2008-11-06

    申请号：PCT/US2007022601

    申请日：2007-10-24

    Applicant: UNIV LELAND STANFORD JUNIOR ,  LI QI-JING ,  CHEN CHANG-ZHENG ,  DAVIS MARK M ,  CHAU JACQUELINE

    Inventor： LI QI-JING ,  CHEN CHANG-ZHENG ,  DAVIS MARK M ,  CHAU JACQUELINE

    IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

    CPC classification number: C12N15/113 ,  A61K39/00 ,  A61K2039/57 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  G01N33/5041 ,  G01N33/505 ,  G01N2500/02 ,  G01N2800/24 ,  C12N2310/3521

    Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ~22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

    Abstract translation: MicroRNA（miRNA）是一类多样且丰富的〜22核苷酸（nt）内源性调控RNA，通过在转录后水平控制基因表达来在动物细胞中发挥各种作用。 证明成熟T细胞中miR-181a表达的增加导致T细胞活化的显着增加并增强T细胞对肽抗原的敏感性。 此外，具有较高miR-181a表达的T细胞母细胞对拮抗剂成为反应性的。 miR-181a对抗原歧视的作用部分通过抑制T细胞受体（TCR）信号传导途径中多种负调节因子的表达来实现，包括PTPN22和双特异性磷酸酶DUSP5和DUSP6。 这导致TCR信号传导阈值的降低，从而在数量和质量上增强T细胞对抗原的敏感性。

    MODULATION OF T CELL SIGNALING THRESHOLD AND T CELL SENSITIVITY TO ANTIGENS
    3.
    发明申请
    MODULATION OF T CELL SIGNALING THRESHOLD AND T CELL SENSITIVITY TO ANTIGENS 审中-公开
    T细胞信号传导调控和T细胞对抗原的敏感性

    公开(公告)号：WO2008057234A9

    公开(公告)日：2008-07-17

    申请号：PCT/US2007022601

    申请日：2007-10-24

    Applicant: UNIV LELAND STANFORD JUNIOR ,  LI QI-JING ,  CHEN CHANG-ZHENG ,  DAVIS MARK M ,  CHAU JACQUELINE

    Inventor： LI QI-JING ,  CHEN CHANG-ZHENG ,  DAVIS MARK M ,  CHAU JACQUELINE

    IPC: A61K48/00 ,  C12N15/113

    CPC classification number: C12N15/113 ,  A61K39/00 ,  A61K2039/57 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  G01N33/5041 ,  G01N33/505 ,  G01N2500/02 ,  G01N2800/24 ,  C12N2310/3521

    Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ~22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

    Abstract translation: 微RNA（miRNA）是一种多样且丰富的〜22个核苷酸（nt）内源性调控RNA，通过控制转录后水平的基因表达在动物细胞中发挥各种作用。 在成熟T细胞中增加的miR-181a表达显示导致T细胞活化的显着增加并增加T细胞对肽抗原的敏感性。 此外，具有较高miR-181a表达的T细胞爆发成为对拮抗剂的反应性。 miR-181a对抗原鉴别的影响部分通过抑制T细胞受体（TCR）信号通路中多种负调节因子的表达，包括PTPN22和双重特异性磷酸酶DUSP5和DUSP6来实现。 这导致TCR信号阈值的降低，从而定量和定性地增强T细胞对抗原的敏感性。

    MODULATION OF T CELL SIGNALING THRESHOLD AND T CELL SENSITIVITY TO ANTIGENS
    4.
    发明申请
    MODULATION OF T CELL SIGNALING THRESHOLD AND T CELL SENSITIVITY TO ANTIGENS 审中-公开
    T细胞信号传递阈值和T细胞对抗原的敏感性调节

    公开(公告)号：WO2008057234A2

    公开(公告)日：2008-05-15

    申请号：PCT/US2007/022601

    申请日：2007-10-24

    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  LI, Qi-Jing ,  CHEN, Chang-Zheng ,  DAVIS, Mark, M. ,  CHAU, Jacqueline

    Inventor： LI, Qi-Jing ,  CHEN, Chang-Zheng ,  DAVIS, Mark, M. ,  CHAU, Jacqueline

    IPC: A61K48/00

    CPC classification number: C12N15/113 ,  A61K39/00 ,  A61K2039/57 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  G01N33/5041 ,  G01N33/505 ,  G01N2500/02 ,  G01N2800/24 ,  C12N2310/3521

    Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ~22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

    Abstract translation: microRNA（miRNA）是一类多样且丰富的〜22核苷酸（nt）内源调节RNA，其通过在转录后水平控制基因表达来在动物细胞中发挥各种作用。 证明成熟T细胞中miR-181a表达的增加导致T细胞活化的显着增加并增强T细胞对肽抗原的敏感性。 此外，具有较高miR-181a表达的T细胞母细胞对拮抗剂成为反应性的。 miR-181a对抗原歧视的作用部分通过抑制T细胞受体（TCR）信号传导途径中多种负调节因子的表达来实现，包括PTPN22和双特异性磷酸酶DUSP5和DUSP6。 这导致TCR信号传导阈值的降低，从而在数量和质量上增强T细胞对抗原的敏感性。

    THE USE OF MOFS IN PRESSURE SWING ADSORPTION
    5.
    发明申请
    THE USE OF MOFS IN PRESSURE SWING ADSORPTION 审中-公开
    MOFS在压力振荡吸收中的应用

    公开(公告)号：WO2007111738B1

    公开(公告)日：2008-02-21

    申请号：PCT/US2006062038

    申请日：2006-12-13

    Applicant: UOP LLC ,  DAVIS MARK M ,  LOW JOHN J

    Inventor： DAVIS MARK M ,  LOW JOHN J

    IPC: B01J29/06

    CPC classification number: B01D53/047 ,  B01D2253/20 ,  B01D2253/204 ,  B01D2253/306 ,  B01D2253/308 ,  B01D2256/24 ,  B01D2256/245 ,  B01D2257/504 ,  B01D2259/40081 ,  Y02C10/08

    Abstract: A pressure swing adsorption process for removing light hydrocarbons from a hydrogen stream wherein the process passes the hydrogen stream over a metal organic framework material at a high adsorption pressure, generating an effluent stream with reduced hydrocarbon content. The process then reduces the pressure over the metal organic framework material and releases the hydrocarbon From the material, and generates a stream having hydrocarbons. Further, the process uses multiple adsorption beds comprising the metal organic framework material and cycles the pressures sequentially through the beds to produce a continuous process.

    Abstract translation: 一种用于从氢气流中除去轻烃的变压吸附方法，其中所述方法在高吸附压力下使氢气流过金属有机骨架材料，产生具有降低的烃含量的流出物流。 然后，该方法降低金属有机骨架材料上的压力并从该材料中释放出烃，并产生具有烃的料流。 此外，该方法使用包含金属有机骨架材料的多个吸附床，并且顺序地通过床循环压力以产生连续过程。

    THE USE OF MOFS IN PRESSURE SWING ADSORPTION
    6.
    发明申请
    THE USE OF MOFS IN PRESSURE SWING ADSORPTION 审中-公开
    MOFS在压力摆动吸附中的应用

    公开(公告)号：WO2007111738A3

    公开(公告)日：2008-01-10

    申请号：PCT/US2006062038

    申请日：2006-12-13

    Applicant: UOP LLC ,  DAVIS MARK M ,  LOW JOHN J

    Inventor： DAVIS MARK M ,  LOW JOHN J

    IPC: B01J29/06

    CPC classification number: B01D53/047 ,  B01D2253/20 ,  B01D2253/204 ,  B01D2253/306 ,  B01D2253/308 ,  B01D2256/24 ,  B01D2256/245 ,  B01D2257/504 ,  B01D2259/40081 ,  Y02C10/08

    Abstract: A pressure swing adsorption process for removing light hydrocarbons from a hydrogen stream wherein the process passes the hydrogen stream over a metal organic framework material at a high adsorption pressure, generating an effluent stream with reduced hydrocarbon content. The process then reduces the pressure over the metal organic framework material and releases the hydrocarbon From the material, and generates a stream having hydrocarbons. Further, the process uses multiple adsorption beds comprising the metal organic framework material and cycles the pressures sequentially through the beds to produce a continuous process.

    Abstract translation: 一种用于从氢气流中除去轻质烃的变压吸附方法，其中该方法在高吸附压力下使氢气流在金属有机骨架材料上通过，产生烃含量降低的流出物流。 然后该方法降低金属有机骨架材料上的压力并从材料释放烃，并产生具有烃的物流。 此外，该方法使用多个包含金属有机骨架材料的吸附床，并使压力顺序地循环通过床以产生连续过程。

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