公开(公告)号：WO2008036314A2

公开(公告)日：2008-03-27

申请号：PCT/US2007/020300

申请日：2007-09-19

Applicant: COOK INCORPORATED ,  DEBRUYNE, Michael, P. ,  HOFFA, Andrew, K. ,  MELSHEIMER, Jeffry, S. ,  REEVES, Sarah, E.

Inventor： DEBRUYNE, Michael, P. ,  HOFFA, Andrew, K. ,  MELSHEIMER, Jeffry, S. ,  REEVES, Sarah, E.

IPC: A61F2/82 ,  A61F2/06 ,  A61F2/84

CPC classification number: A61F2/013 ,  A61F2/07 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/011 ,  A61F2002/075 ,  A61F2002/8486 ,  A61F2250/0048

Abstract: The present invention provides apparatus and methods for treating a vascular condition by restoring patency to a vessel while reducing the likelihood that emboli become dislodged into the bloodstream. In a first embodiment, the apparatus comprises a graft having proximal and distal regions, a first support member attached to the distal region of the graft, and a second support member attached to the proximal region of the graft. The first and second support members may comprise first and second stents, respectively. The first stent is deployed distal to a vascular condition, and the second stent is deployed proximal to a vascular condition, such that the graft spans the length of the vascular condition to entrap emboli during treatment of the vascular condition. In an alternative embodiment, the first stent is adapted to be deployed within a vessel at a location distal to the vascular condition, and the graft is adapted to be everted to form a pocket adapted to entrap emboli dislodged during treatment of the vascular condition. The second stent then may be subsequently deployed proximal to the vascular condition, such that emboli trapped within the graft pocket are effectively sealed off from the bloodstream.

Abstract translation: 本发明提供了通过恢复对血管的通畅来治疗血管病变的装置和方法，同时降低栓塞进入血流的可能性。 在第一实施例中，该装置包括具有近端区域和远端区域的移植物，附接到移植物的远侧区域的第一支撑构件和附接到移植物的近端区域的第二支撑构件。 第一和第二支撑构件可以分别包括第一和第二支架。 第一个支架部署在血管状态的远端，第二个支架部署在血管状态附近，使得移植物跨越血管状态的长度，以在治疗血管疾病期间截留栓塞。 在替代实施例中，第一支架适于在位于远离血管状态的位置处的血管内展开，并且移植物适于被转动以形成适于在治疗血管状况期间阻塞栓塞移出的口袋。 然后第二支架随后可以部署在血管状态附近，使得捕获在移植物袋内的栓塞被有效地从血流中密封。

公开(公告)号：WO2005070338A1

公开(公告)日：2005-08-04

申请号：PCT/US2005/002108

申请日：2005-01-18

Applicant: COOK INCORPORATED ,  OSBORNE, Thomas, A. ,  DEBRUYNE, Michael, P. ,  LAD, Ashvin

Inventor： OSBORNE, Thomas, A. ,  DEBRUYNE, Michael, P. ,  LAD, Ashvin

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2002/075 ,  A61F2220/0041 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067

Abstract: An endoluminal prosthetic device is formed by attaching a stent (14) to a graft (12). The stent is a plurality of struts (15) and joints or apices (16) between the struts. At least one apex of the stent may be attached to the graft with at least two stitches (18) sharing a penetration (19) in the graft. This more firmly anchors the stent to the graft, preventing separation of the stent from the graft. By using at least one opening or penetration in the graft for more than one stitch, the number of penetrations or openings in the graft is minimized. This has the advantage of maintaining as much as possible the integrity of the graft while minimizing leakage and complications.

Abstract translation: 通过将支架（14）附接到移植物（12）来形成腔内假体装置。 支架是支柱之间的多个支柱（15）和关节或顶点（16）。 支架的至少一个顶点可以在移植物中具有共享穿透（19）的至少两个针脚（18）附接到移植物。 这更牢固地将支架固定到移植物上，防止支架与移植物分离。 通过在移植物中使用至少一个开口或穿透多于一个针脚，使移植物中的穿孔或开口的数量最小化。 这具有尽可能地保持移植物的完整性同时最小化渗漏和并发症的优点。

公开(公告)号：WO2008036314A3

公开(公告)日：2008-05-15

申请号：PCT/US2007020300

申请日：2007-09-19

Applicant: COOK INC ,  DEBRUYNE MICHAEL P ,  HOFFA ANDREW K ,  MELSHEIMER JEFFRY S ,  REEVES SARAH E

Inventor： DEBRUYNE MICHAEL P ,  HOFFA ANDREW K ,  MELSHEIMER JEFFRY S ,  REEVES SARAH E

IPC: A61F2/82 ,  A61F2/06 ,  A61F2/84

CPC classification number: A61F2/013 ,  A61F2/07 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/011 ,  A61F2002/075 ,  A61F2002/8486 ,  A61F2250/0048

Abstract: The present invention provides apparatus and methods for treating a vascular condition by restoring patency to a vessel while reducing the likelihood that emboli become dislodged into the bloodstream. In a first embodiment, the apparatus comprises a graft having proximal and distal regions, a first support member attached to the distal region of the graft, and a second support member attached to the proximal region of the graft. The first and second support members may comprise first and second stents, respectively. The first stent is deployed distal to a vascular condition, and the second stent is deployed proximal to a vascular condition, such that the graft spans the length of the vascular condition to entrap emboli during treatment of the vascular condition. In an alternative embodiment, the first stent is adapted to be deployed within a vessel at a location distal to the vascular condition, and the graft is adapted to be everted to form a pocket adapted to entrap emboli dislodged during treatment of the vascular condition. The second stent then may be subsequently deployed proximal to the vascular condition, such that emboli trapped within the graft pocket are effectively sealed off from the bloodstream.

Abstract translation: 本发明提供了通过恢复血管通畅同时减少栓塞移位到血流中的可能性来治疗血管病症的装置和方法。 在第一实施例中，该设备包括具有近侧和远侧区域的移植物，附接到移植物的远侧区域的第一支撑构件和附接到移植物的近侧区域的第二支撑构件。 第一支撑构件和第二支撑构件可以分别包括第一支架和第二支架。 第一支架布置在血管状况的远侧，并且第二支架布置在血管状况的近侧，使得移植物跨越血管状况的长度以在血管状况的治疗期间俘获栓塞。 在一个替代实施例中，第一支架适于布置在远离血管状况的位置处的血管内，并且移植物适于外翻以形成适于在治疗血管状况期间俘获栓塞物的囊袋。 随后可以将第二支架配置在血管状态附近，使得被困在移植物袋内的栓子被有效地与血流隔离。

公开(公告)号：WO2005070337A3

公开(公告)日：2005-09-22

申请号：PCT/US2005001830

申请日：2005-01-18

Applicant: COOK INC ,  DEBRUYNE MICHAEL P ,  LAD ASHVIN ,  OSBORNE THOMAS A

Inventor： DEBRUYNE MICHAEL P ,  LAD ASHVIN ,  OSBORNE THOMAS A

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067

Abstract: An endoluminal prosthetic device for placement in a body lumen is formed by stitching stents to a graft. A first or anchoring stent (12) is used for securing a graft made of biocompatible material that forms at least one lumen. There is also a second stent (14). The first and second stents each include a plurality of struts (15, 25) and apices (16, 26) between the struts. At least two of the apices in each of the first and second stents are secured to the graft by stitches (21, 23). A running suture (24) links at least one stitch of the first stent and one stitch of the second stent. The running suture linking the first stent and the second stent adds strength to the stitches and better secures the first stent to the device. The endoluminal prosthetic device may be used in an aortic vessel to treat stenoses or aneurysms.

Abstract translation: 通过将支架缝合到移植物上而形成用于放置在体腔内的腔内假体装置。 第一或锚固支架（12）用于固定由形成至少一个内腔的生物相容性材料制成的移植物。 还有第二支架（14）。 第一和第二支架各自包括在支柱之间的多个支柱（15,25）和顶点（16,26）。 第一和第二支架中的每一个中的至少两个顶点通过针脚（21,23）固定到移植物上。 运行缝合线（24）连接第一支架的至少一个线圈和第二支架的一个线圈。 连接第一支架和第二支架的运行缝合线为线圈增加了强度，并且将第一支架更好地固定到装置。 腔内修复装置可用于主动脉血管以治疗狭窄或动脉瘤。

公开(公告)号：WO2022236057A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/028074

申请日：2022-05-06

Applicant: COOK REGENTEC LLC ,  FISCHER, Frank, J. ,  BENNETT, Jonathan, Lee ,  DEBRUYNE, Michael, P. ,  MELSHEIMER, Jeffrey, S.

Inventor： FISCHER, Frank, J. ,  BENNETT, Jonathan, Lee ,  DEBRUYNE, Michael, P. ,  MELSHEIMER, Jeffrey, S.

IPC: A61M5/32

Abstract: Devices and methods useful for injecting therapeutics into the body of a. patient are illustrated and described herein. In certain aspects, needle assemblies comprising a needle having a needle shaft with one or more side openings and a needle sheath slidably moveable along the needle shaft to selectively expose or cover all or a portion of the one or more side openings are provided. Such assemblies may include an interference fit between the needle sheath and the needle shaft and or a seal positioned around the needle shaft proximal of the plurality of one or more side openings and configured to prevent fluid from leaking between the needle sheath and the needle shaft and beyond a proximal end of the needle sheath.

公开(公告)号：WO2008094504A1

公开(公告)日：2008-08-07

申请号：PCT/US2008/001089

申请日：2008-01-28

Applicant: COOK INCORPORATED ,  BARR, Aaron, P. ,  DEBRUYNE, Michael, P. ,  DITTMAN, Jay, A. ,  HOFFA, Michael, C. ,  MEAD, Jason, A. ,  NICKLESS, Benjamin

Inventor： BARR, Aaron, P. ,  DEBRUYNE, Michael, P. ,  DITTMAN, Jay, A. ,  HOFFA, Michael, C. ,  MEAD, Jason, A. ,  NICKLESS, Benjamin

IPC: A61F2/90 ,  B23K26/00

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0068 ,  Y10T29/49995

Abstract: The invention relates to a method for producing a radially expandable prosthesis by laser cutting a pattern in a tubular member, which member has an outer diameter at least as great as the expanded diameter of the prosthesis. The prosthesis may be a Z-stent which can be cut out to have integral barbs or notches along its struts. The apexes between the struts may be relatively thin.

Abstract translation: 本发明涉及通过激光切割管状构件中的图案来制造可径向扩张的假体的方法，该构件的外径至少与假体的扩大直径一样大。 该假体可以是Z-支架，其可以被切除以沿其支柱具有整体倒钩或凹口。 支柱之间的顶点可能相对较薄。

公开(公告)号：WO2007109257A3

公开(公告)日：2007-11-29

申请号：PCT/US2007006890

申请日：2007-03-20

Applicant: COOK WILLIAM A AUSTRALIA ,  COOK INC ,  COOK WILLIAM EUROP ,  HARTLEY DAVID ERNEST ,  IVANCEV KRANSNODAR ,  DUCKE WERNER D ,  DEBRUYNE MICHAEL P ,  DIAMOND JARETT ,  FRYE MARK R

Inventor： HARTLEY DAVID ERNEST ,  IVANCEV KRANSNODAR ,  DUCKE WERNER D ,  DEBRUYNE MICHAEL P ,  DIAMOND JARETT ,  FRYE MARK R

IPC: A61B17/22

CPC classification number: A61B17/221 ,  A61B2017/00867 ,  A61B2017/2215

Abstract: A medical grasping device (1 ) has an elongate control member (9) with a grasping member ( 17) proximal to its distal tip. An outer sheath (3) with a passageway therethrough surrounds the elongate control member and is relatively movable with respect to the control member. A control assembly (2) disposed at a proximal end of said outer sheath has a fixed handle (5) and a sliding handle (7) and the proximal end of the elongate control member is fixed to the sliding handle to move the control member. The grasping member (17) has a plurality of pre¬ formed wire loops (50, 52, 54, 56) which self-deploy transversely upon emerging from said distal end of said outer sheath. Each wire loop is fastened to substantially opposite sides of the elongate control member so that each of said wire loops is substantially semi-circular upon full deployment and the respective ends (27, 29)of each wire loop extend substantially in opposite directions from the elongate control member.

Abstract translation: 医疗握持装置（1）具有细长的控制构件（9），在其远侧末端附近具有抓握构件（17）。 具有穿过其中的通道的外部护套（3）围绕细长控制构件并且相对于控制构件可相对移动。 设置在所述外护套的近端处的控制组件（2）具有固定手柄（5）和滑动手柄（7），并且所述细长控制构件的近端固定到所述滑动手柄以移动所述控制构件。 抓握构件（17）具有多个预制的线环（50,52,54,56），所述线环在从所述外部护套的所述远端出现时横向自动展开。 每个导线环被紧固到细长控制构件的基本相对的侧面，使得每个所述导线环在完全展开时基本上是半圆形的，并且每个导线环的相应端部（27,29）基本上沿相反方向从细长 控制成员。

公开(公告)号：WO2007109257A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/006890

申请日：2007-03-20

Applicant: WILLIAM A. COOK AUSTRALIA PTY. LTD. ,  COOK INCORPORATED ,  WILLIAM COOK EUROPE APS ,  HARTLEY, David, Ernest ,  IVANCEV, Kransnodar ,  DUCKE, Werner, D. ,  DEBRUYNE, Michael, P. ,  DIAMOND, Jarett ,  FRYE, Mark, R.

Inventor： HARTLEY, David, Ernest ,  IVANCEV, Kransnodar ,  DUCKE, Werner, D. ,  DEBRUYNE, Michael, P. ,  DIAMOND, Jarett ,  FRYE, Mark, R.

CPC classification number: A61B17/221 ,  A61B2017/00867 ,  A61B2017/2215

Abstract: A medical grasping device (1 ) has an elongate control member (9) with a grasping member ( 17) proximal to its distal tip. An outer sheath (3) with a passageway therethrough surrounds the elongate control member and is relatively movable with respect to the control member. A control assembly (2) disposed at a proximal end of said outer sheath has a fixed handle (5) and a sliding handle (7) and the proximal end of the elongate control member is fixed to the sliding handle to move the control member. The grasping member (17) has a plurality of pre¬ formed wire loops (50, 52, 54, 56) which self-deploy transversely upon emerging from said distal end of said outer sheath. Each wire loop is fastened to substantially opposite sides of the elongate control member so that each of said wire loops is substantially semi-circular upon full deployment and the respective ends (27, 29)of each wire loop extend substantially in opposite directions from the elongate control member.

Abstract translation: 医疗把持装置（1）具有细长的控制构件（9），其具有靠近其远端的抓握构件（17）。 具有穿过其的通道的外护套（3）围绕细长控制构件并且可相对于控制构件相对移动。 设置在所述外护套的近端处的控制组件（2）具有固定手柄（5）和滑动手柄（7），并且细长控制构件的近端固定到滑动手柄以移动控制构件。 抓握构件（17）具有多个预先形成的线环（50,52,54,56），其从所述外护套的所述远端出现时横向自动展开。 每个线环被紧固到细长控制构件的基本相对的两侧，使得每个线环在完全展开时基本上为半圆形，并且每个导线环的相应端（27,29）从细长的 控制成员。

公开(公告)号：WO2005115275A1

公开(公告)日：2005-12-08

申请号：PCT/US2005/010847

申请日：2005-03-30

Applicant: COOK INCORPORATED ,  MED INSTITUTE, INCORPORATED ,  BAHLER, Clinton, D. ,  DEBRUYNE, Michael, P. ,  FEARNOT, Neal, E. ,  LEEWOOD, Alan, R. ,  MEAD, Jason, A. ,  OSBORNE, Thomas, A. ,  SUN, Jichao

Inventor： BAHLER, Clinton, D. ,  DEBRUYNE, Michael, P. ,  FEARNOT, Neal, E. ,  LEEWOOD, Alan, R. ,  MEAD, Jason, A. ,  OSBORNE, Thomas, A. ,  SUN, Jichao

IPC: A61F2/06

CPC classification number: A61L27/3633 ,  A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2/915 ,  A61F2002/0086 ,  A61F2002/061 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2002/821 ,  A61F2002/8486 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0039 ,  A61F2250/0065 ,  A61L27/3629

Abstract: An endoluminal device (170) comprises a stent and a tubular graft supported by the stent. The graft has a proximal (174) and a distal opening (176) and comprises a synthetic material and a bioremodelable material. The bioremodelable material is disposed on an exterior surface in at least one band (171) adjacent at least one of the proximal and distal openings.

Abstract translation: 腔内装置（170）包括支架和由支架支撑的管状移植物。 移植物具有近端（174）和远端开口（176），并且包括合成材料和生物可重塑材料。 生物可重构材料设置在邻近近端和远端开口中的至少一个的至少一个带（171）中的外表面上。

公开(公告)号：WO2005070337A2

公开(公告)日：2005-08-04

申请号：PCT/US2005/001830

申请日：2005-01-18

Applicant: COOK INCORPORATED ,  DEBRUYNE, Michael, P. ,  LAD, Ashvin ,  OSBORNE, Thomas, A.

Inventor： DEBRUYNE, Michael, P. ,  LAD, Ashvin ,  OSBORNE, Thomas, A.

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067

Abstract: An endoluminal prosthetic device for placement in a body lumen is formed by stitching stents to a graft. A first or anchoring stent is used for securing a graft made of biocompatible material that forms at least one lumen. There is also a second stent. The first and second stents each include a plurality of struts and apices between the struts. At least two of the apices in each of the first and second stents are secured to the graft by stitches. A running suture links at least one stitch of the first stent and one stitch of the second stent. The running suture linking the first stent and the second stent adds strength to the stitches and better secures the first stent to the device. The endoluminal prosthetic device may be used in an aortic vessel to treat stenoses or aneurysms.

Abstract translation: 通过将支架缝合到移植物上而形成用于放置在体腔内的腔内假体装置。 第一或锚固支架用于固定由形成至少一个腔的生物相容性材料制成的移植物。 还有第二支架。 第一和第二支架各自包括支柱之间的多个支柱和顶点。 第一和第二支架中的每一个中的至少两个顶点通过针迹固定到移植物上。 运行缝合线连接第一支架的至少一个线圈和第二支架的一个线圈。 连接第一支架和第二支架的运行缝合线为线圈增加了强度，并且将第一支架更好地固定到装置。 腔内修复装置可用于主动脉血管以治疗狭窄或动脉瘤。