公开(公告)号：WO2011087644A1

公开(公告)日：2011-07-21

申请号：PCT/US2010/059680

申请日：2010-12-09

Applicant: COOK MEDICAL TECHNOLOGIES LLC ,  ROEDER, Blayne, A. ,  LEEWOOD, Alan, R.

Inventor： ROEDER, Blayne, A. ,  LEEWOOD, Alan, R.

IPC: A61F2/90 ,  A61F2/06 ,  A61F2/82

CPC classification number: A61F2/848 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2220/0016 ,  A61F2220/0058

Abstract: An implantable medical support frame (104) having a central longitudinally extending axis is expandable from a collapsed configuration having a first diameter to an expanded configuration having a second diameter. The frame also includes an anchoring mechanism with an elongate member (110). At least a portion of the elongate member is slidably disposed within a retaining structure when the frame is in the collapsed configuration. When the frame expands from the collapsed configuration to the expanded configuration, a portion of the elongate member is advanced out of the retaining structure such that the portion of the elongate member protrudes radially outward of the frame at an angle to the axis, thereby forming an anchor. A length of the protruding portion of the anchor increases as the frame expands from the collapsed configuration to the expanded configuration.

Abstract translation: 具有中心纵向延伸轴线的可植入医疗支撑框架（104）从具有第一直径的收缩构造可扩展至具有第二直径的扩张构型。 框架还包括具有细长构件（110）的锚固机构。 当框架处于折叠构型时，细长构件的至少一部分可滑动地设置在保持结构内。 当框架从折叠构型膨胀到扩展构型时，细长构件的一部分从保持结构中推出，使得细长构件的该部分以与轴线成一定角度的径向向外突出地突出，从而形成 锚。 锚的突出部分的长度随着框架从折叠构型扩展到扩展构型而增加。

公开(公告)号：WO2008030488A3

公开(公告)日：2008-03-13

申请号：PCT/US2007/019389

申请日：2007-09-06

Applicant: MED INSTITUTE, INC. ,  COOK INCORPORATED ,  LEEWOOD, Alan, R. ,  GREWE, David, D. ,  HIATT, Mark ,  RAGHEB, Anthony, O. ,  VOORHEES, III, William, D. ,  ROEDER, Blayne, A. ,  PURDY, James, D.

Inventor： LEEWOOD, Alan, R. ,  GREWE, David, D. ,  HIATT, Mark ,  RAGHEB, Anthony, O. ,  VOORHEES, III, William, D. ,  ROEDER, Blayne, A. ,  PURDY, James, D.

IPC: A61F2/86 ,  A61F2/84

Abstract: Various stent structures are provided with improved axial and torsional flexibility. One type of stent structure includes multiple segmented stent structures connected to each other by biodegradable interconnectors. A delivery system adapted to delivery the multiple segmented stents is also described. Another type of stent structure includes biodegradable connectors that are incorporated into a framework of non-biodegradable interconnecting members that form the support structure of the stent. The biodegradable connectors in both stent structures degrade or are absorbed after the stent is deployed. Stabilizing elements may be provided to the stent structures to supplement the stiffness of the stent with stability during loading and deployment.

公开(公告)号：WO2007098232A3

公开(公告)日：2007-11-15

申请号：PCT/US2007004563

申请日：2007-02-20

Applicant: MED INST INC ,  ROEDER BLAYNE A ,  LEEWOOD ALAN R

Inventor： ROEDER BLAYNE A ,  LEEWOOD ALAN R

IPC: A61F2/04

CPC classification number: A61F2/966 ,  A61F2/06 ,  A61F2/82 ,  A61F2/95 ,  A61F2/97 ,  A61F2002/041 ,  A61F2002/044 ,  A61F2002/9517

Abstract: A device for delivering and deploying a radially expandable prosthesis is disclosed and comprises a proximal prosthesis release mechanism (24) having a first resistance and a distal prosthesis release mechanism (22) having a second resistance. The device further comprises an actuation mechanism (27) for actuating the distal and proximal release mechanisms in a single coordinated movement and a biasing compensator (60) for regulating the relationship between the first resistance and the second resistance. Additional aspects of the invention include devices and methods for delivering and deploying a radially expandable prosthesis.

Abstract translation: 公开了用于递送和展开径向可扩张的假体的装置，并且包括具有第一阻力的近端假体释放机构（24）和具有第二阻力的远侧假体释放机构（22）。 该装置还包括用于在单个协调运动中致动远侧和近侧释放机构的致动机构（27）和用于调节第一阻力和第二阻力之间的关系的偏置补偿器（60）。 本发明的另外的方面包括用于递送和展开径向可扩张假体的装置和方法。

公开(公告)号：WO2006138547A1

公开(公告)日：2006-12-28

申请号：PCT/US2006/023464

申请日：2006-06-15

Applicant: MED INSTITUTE, INC ,  LEEWOOD, Alan, R. ,  ROEDER, Blayne, A.

Inventor： LEEWOOD, Alan, R. ,  ROEDER, Blayne, A.

IPC: A61F2/92 ,  A61F2/00

CPC classification number: A61F2/915 ,  A61F2230/0013 ,  A61F2250/0036

Abstract: A strut, or beam, is provided for intraluminal devices. Strain which is introduced into a stent or other intraluminal device is distributed more evenly along the length of the improved strut by maintaining a substantially constant strain level along the length of an end portion. This may increase fatigue life or improve the performance of devices using the improved strut. The strain along the length of the end portion may be maintained substantially constant by varying a section property of the strut, including the width, thickness, cross-sectional area, material property or other characteristic of the end portion.

Abstract translation: 为管腔内装置提供支柱或梁。 通过沿着端部的长度保持基本恒定的应变水平，被引入支架或其他管腔内装置的应变沿着改进的支柱的长度更均匀地分布。 这可能会增加疲劳寿命或提高使用改进支柱的设备的性能。 通过改变支柱的截面性能，包括端部的宽度，厚度，横截面面积，材料特性或其他特性，沿端部长度的应变可以保持基本恒定。

公开(公告)号：WO2005115275A1

公开(公告)日：2005-12-08

申请号：PCT/US2005/010847

申请日：2005-03-30

Applicant: COOK INCORPORATED ,  MED INSTITUTE, INCORPORATED ,  BAHLER, Clinton, D. ,  DEBRUYNE, Michael, P. ,  FEARNOT, Neal, E. ,  LEEWOOD, Alan, R. ,  MEAD, Jason, A. ,  OSBORNE, Thomas, A. ,  SUN, Jichao

Inventor： BAHLER, Clinton, D. ,  DEBRUYNE, Michael, P. ,  FEARNOT, Neal, E. ,  LEEWOOD, Alan, R. ,  MEAD, Jason, A. ,  OSBORNE, Thomas, A. ,  SUN, Jichao

IPC: A61F2/06

CPC classification number: A61L27/3633 ,  A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2/915 ,  A61F2002/0086 ,  A61F2002/061 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2002/821 ,  A61F2002/8486 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0039 ,  A61F2250/0065 ,  A61L27/3629

Abstract: An endoluminal device (170) comprises a stent and a tubular graft supported by the stent. The graft has a proximal (174) and a distal opening (176) and comprises a synthetic material and a bioremodelable material. The bioremodelable material is disposed on an exterior surface in at least one band (171) adjacent at least one of the proximal and distal openings.

Abstract translation: 腔内装置（170）包括支架和由支架支撑的管状移植物。 移植物具有近端（174）和远端开口（176），并且包括合成材料和生物可重塑材料。 生物可重构材料设置在邻近近端和远端开口中的至少一个的至少一个带（171）中的外表面上。

公开(公告)号：WO2012051532A3

公开(公告)日：2012-12-13

申请号：PCT/US2011056365

申请日：2011-10-14

Applicant: COOK MEDICAL TECHNOLOGIES LLC ,  CHUTER TIMOTHY A M ,  BROCKER DAVID ,  DIERKING WILLIAM K ,  LEEWOOD ALAN R ,  ROEDER BLAYNE A ,  CHARLEBOIS STEVEN J ,  SWIFT RICHARD A ,  GOPALAKRISHNAMURTHY SHARATH ,  HUSER MATTHEW S

Inventor： CHUTER TIMOTHY A M ,  BROCKER DAVID ,  DIERKING WILLIAM K ,  LEEWOOD ALAN R ,  ROEDER BLAYNE A ,  CHARLEBOIS STEVEN J ,  SWIFT RICHARD A ,  GOPALAKRISHNAMURTHY SHARATH ,  HUSER MATTHEW S

IPC: A61F2/06 ,  A61F2/82 ,  A61F2/86

CPC classification number: A61F2/89 ,  A61F2/07 ,  A61F2/848 ,  A61F2/852 ,  A61F2/856 ,  A61F2/915 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91541 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/006

Abstract: Various stent-graft systems for treatment of medical conditions are disclosed. In one embodiment, an exemplary stent-graft system may be used for endovascular treatment of a thoracic aortic aneurysm. The stent-graft system (800) comprises proximal (802) and distal (822) components, each comprising a graft (805, 825) having proximal and distal ends, where upon deployment the proximal and distal components at least partially overlap with one another to provide a fluid passageway therebetween. The proximal component comprises a proximal stent (804) having a plurality of proximal and distal apices connected by a plurality of generally straight portions, where a radius of curvature of at least one of the proximal apices greater than the radius of H is curvature of at least one of the distal apices. The distal component comprises a proximal z- stent (830a) coupled to the graft (825), where the proximal end of the graft comprises at least a scallop (845) formed therein that generally follows the shape of the proximal z- stent. Further, the distal component may comprise at least one z- stent (834) coupled to the distal end of the graft and extending distally therefrom that reduces proximal migration of the distal component.

Abstract translation: 公开了用于治疗医疗状况的各种支架移植物系统。 在一个实施方案中，示例性支架移植物系统可用于胸主动脉瘤的血管内治疗。 支架移植系统（800）包括近端（802）和远侧部件（822），每个部件包括具有近端和远端的移植物（805,825），其中在展开时，近端和远端部件至少部分地彼此重叠 以在其间提供流体通道。 近端部件包括近端支架（804），其具有通过多个大体上直的部分连接的多个近端和远端顶点，其中近端顶点中的至少一个的曲率半径大于H的半径为曲率 至少一个远端顶点。 远侧部件包括联接到移植物（825）的近端支架（830a），其中移植物的近端包括至少形成在其中的扇形齿（845），其大致遵循近端z-支架的形状。 此外，远侧部件可以包括联接到移植物的远端并从其远端延伸的至少一个z支架（834），其减少远侧部件的近端迁移。

公开(公告)号：WO2010077808A1

公开(公告)日：2010-07-08

申请号：PCT/US2009/067848

申请日：2009-12-14

Applicant: MED INSTITUTE, INC. ,  LEEWOOD, Alan, R. ,  YANG, Shuo ,  DIERKING, William, K. ,  SWIFT, Richard, A. ,  ROEDER, Blayne, A.

Inventor： LEEWOOD, Alan, R. ,  YANG, Shuo ,  DIERKING, William, K. ,  SWIFT, Richard, A. ,  ROEDER, Blayne, A.

IPC: A61F2/02 ,  A61F2/06

CPC classification number: A61F2/02 ,  A61F2/07 ,  A61F2/848 ,  A61F2002/8483 ,  A61F2220/0016

Abstract: A barb for anchoring an implantable medical device to a body vessel comprises a thin-walled body portion for engagement with a structural element of an implantable medical device and a penetrating element extending from the body portion. The body portion has a longitudinal axis. The penetrating element includes a tip portion for anchoring into tissue and a base portion between the tip portion and the body portion. In a deployed configuration of the barb, the base portion curves away from the longitudinal axis at a first curvature and the tip portion curves toward the longitudinal axis at a second curvature which is opposite in sign from the first.

Abstract translation: 用于将可植入医疗装置固定到体内容器的倒钩包括用于与可植入医疗装置的结构元件和从身体部分延伸的穿透元件接合的薄壁主体部分。 主体部分具有纵向轴线。 穿透元件包括用于锚定到组织​​中的尖端部分和在顶端部分和主体部分之间的基部。 在倒钩的展开构造中，基部以第一曲率远离纵向轴线弯曲，并且尖端部分以与第一曲面相反的第二曲率朝向纵向轴线弯曲。

公开(公告)号：WO2010027450A1

公开(公告)日：2010-03-11

申请号：PCT/US2009/004940

申请日：2009-09-02

Applicant: MED INSTITUTE, INC. ,  LEEWOOD, Alan, R. ,  YANG, Shuo

Inventor： LEEWOOD, Alan, R. ,  YANG, Shuo

IPC: A61F2/90

CPC classification number: A61F2/90 ,  A61F2/07 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054

Abstract: The present invention provides a stent having less invasive ends and improved radial force. In one embodiment, the stent comprises a series of proximal apices disposed at a proximal end of the stent, a series of distal apices disposed at a distal end of the stent, and at least one angled strut segment disposed between the proximal and distal apices of the stent. At least one apex of the stent may comprise multiple curved portions. In one example, the radius of curvature of one of the curved portions is significantly greater, for example, at least 10 times greater, than each of the other radii of curvature of the apex. The curved portion having the significantly greater radius of curvature may be configured to engage a vessel wall in a less invasive manner.

Abstract translation: 本发明提供一种具有较小侵入性末端和改善的径向力的支架。 在一个实施例中，支架包括设置在支架的近端处的一系列近端顶点，设置在支架远端的一系列远侧顶点，以及设置在支架近端和远端顶点之间的至少一个成角度的支柱段 支架 支架的至少一个顶点可以包括多个弯曲部分。 在一个示例中，一个弯曲部分的曲率半径比顶点的其他曲率半径的每一个显着地大得多，例如大至少10倍。 具有明显更大的曲率半径的弯曲部分可以被构造成以较小的侵入方式接合血管壁。

公开(公告)号：WO2007142935B1

公开(公告)日：2008-02-14

申请号：PCT/US2007012684

申请日：2007-05-30

Applicant: COOK INC ,  MED INST INC ,  FEARNOT NEIL E ,  LEEWOOD ALAN R ,  PAUL RAM H ,  ROEDER BLAYNE A ,  VOORHEES WILLIAM D

Inventor： FEARNOT NEIL E ,  LEEWOOD ALAN R ,  PAUL RAM H ,  ROEDER BLAYNE A ,  VOORHEES WILLIAM D

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2475 ,  A61F2220/005 ,  A61F2220/0058

Abstract: A self-expanding or otherwise expandable artificial valve prostheses for deployment within a body passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame, a supporting member and a valve leaflet. The portion of the valve leaflet is supported by the supporting member and is positioned away from the wall of the body passageway when the device is deployed within the body passageway.

Abstract translation: 用于展开在身体通道（例如患者的血管或导管）内的自膨胀或其他可膨胀的人造瓣膜假体。 瓣膜假体包括具有外框架，支撑构件和瓣膜小叶的支撑结构。 瓣膜小叶的部分由支撑构件支撑，并且当装置展开在身体通道内时，其被定位成远离身体通道的壁。

公开(公告)号：WO2007142935A1

公开(公告)日：2007-12-13

申请号：PCT/US2007/012684

申请日：2007-05-30

Applicant: COOK INCORPORATED ,  MED INSTITUTE, INCORPORATED ,  FEARNOT, Neil, E. ,  LEEWOOD, Alan, R. ,  PAUL, Ram, H. ,  ROEDER, Blayne, A. ,  VOORHEES, William, D.

Inventor： FEARNOT, Neil, E. ,  LEEWOOD, Alan, R. ,  PAUL, Ram, H. ,  ROEDER, Blayne, A. ,  VOORHEES, William, D.

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2475 ,  A61F2220/005 ,  A61F2220/0058

Abstract: A self-expanding or otherwise expandable artificial valve prostheses for deployment within a body passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame, a supporting member and a valve leaflet. The portion of the valve leaflet is supported by the supporting member and is positioned away from the wall of the body passageway when the device is deployed within the body passageway.

Abstract translation: 用于展开在身体通道（例如患者的血管或导管）内的自膨胀或其他可膨胀的人造瓣膜假体。 瓣膜假体包括具有外框架，支撑构件和瓣膜小叶的支撑结构。 瓣膜小叶的部分由支撑构件支撑，并且当装置展开在身体通道内时，其被定位成远离身体通道的壁。