公开(公告)号：WO2010144745A3

公开(公告)日：2011-04-14

申请号：PCT/US2010038229

申请日：2010-06-10

Applicant: CYNVENIO BIOSYSTEMS INC ,  PAGANO PAUL ,  ZHANG YANTING ,  QIAN KAREN ,  SOH HYONGSOK TOM ,  DEMPSEY PAUL W ,  DE FUSCO ANDRE

Inventor： PAGANO PAUL ,  ZHANG YANTING ,  QIAN KAREN ,  SOH HYONGSOK TOM ,  DEMPSEY PAUL W ,  DE FUSCO ANDRE

IPC: G01N35/08 ,  G01N33/487 ,  G01N33/58

CPC classification number: G01N33/54366 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N1/405 ,  G01N33/57407 ,  G01N33/585 ,  G01N35/0098 ,  G01N35/1095 ,  G01N2800/52

Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.

Abstract translation: 本发明一般涉及流体处理，尤其涉及用于颗粒部分的检测，选择，捕集和/或分选的处理流体。 所描述的护套流动装置允许将目标物质与流体样品隔离，同时避免不需要的物质与分离装置的表面的非特异性结合。 描述了细胞，蛋白质和核酸的生物流体处理，检测，分选或选择。 本发明特别用于诊断设置，分析患者的医疗状况，监测和/或调整治疗方案并产生基于细胞的产品。

公开(公告)号：WO2010144745A2

公开(公告)日：2010-12-16

申请号：PCT/US2010/038229

申请日：2010-06-10

Applicant: CYNVENIO BIOSYSTEMS, INC. ,  PAGANO, Paul ,  ZHANG, Yanting ,  QIAN, Karen ,  SOH, Hyongsok Tom ,  DEMPSEY, Paul W. ,  DE FUSCO, Andre

Inventor： PAGANO, Paul ,  ZHANG, Yanting ,  QIAN, Karen ,  SOH, Hyongsok Tom ,  DEMPSEY, Paul W. ,  DE FUSCO, Andre

IPC: G01N35/08 ,  G01N33/487 ,  G01N33/58

CPC classification number: G01N33/54366 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N1/405 ,  G01N33/57407 ,  G01N33/585 ,  G01N35/0098 ,  G01N35/1095 ,  G01N2800/52

Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.

Abstract translation: 本发明一般涉及流体处理，尤其涉及用于颗粒部分的检测，选择，捕集和/或分选的处理流体。 所描述的护套流动装置允许将目标物质与流体样品隔离，同时避免不需要的物质与分离装置的表面的非特异性结合。 描述了细胞，蛋白质和核酸的生物流体处理，检测，分选或选择。 本发明特别用于诊断设置，分析患者的医疗状况，监测和/或调整治疗方案并产生基于细胞的产品。