公开(公告)号：WO2021133984A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066959

申请日：2020-12-23

申请人： LUNGLIFE AI ,  TAHVILIAN, Shahram ,  BADEN, Lara ,  GRAMAJO-LEVENTON, Daniel ,  REED, Rebecca ,  GARWARE, Bhushan ,  SAVADIKAR, Chimney ,  PALKAR, Anurag ,  PAGANO, Paul

发明人： TAHVILIAN, Shahram ,  BADEN, Lara ,  GRAMAJO-LEVENTON, Daniel ,  REED, Rebecca ,  GARWARE, Bhushan ,  SAVADIKAR, Chimney ,  PALKAR, Anurag ,  PAGANO, Paul

IPC分类号： G06T7/00 ,  G01N33/68 ,  G01N21/64 ,  G01N33/574 ,  C12Q2563/107 ,  G01N21/6458 ,  G01N33/57423 ,  G01N33/6893 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/20084 ,  G06T2207/30024 ,  G06T2207/30096 ,  G06T2207/30242 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/136 ,  G06T7/155 ,  G06T7/194 ,  G06T7/90

摘要： In some embodiments, a non-transitory processor-readable medium stores code representing instructions to be executed by a processor. The code includes code to cause the processor to receive a plurality of sets of images associated with a sample treated with fluorescence in situ hybridization (FISH) probes. Each image from that set of images is associated with a different focal length using a fluorescence microscope. Each FISH probe can selectively bind to a unique location on chromosomal DNA in the sample. The code further causes the processor to identify cell nuclei in the images. The code further causes the processor to apply a convolutional neural network (CNN) to each set of images. The CNN is configured to identify a probe indication from a plurality of probe indications for that set of images. The code further causes the processor to identify the sample as containing circulating tumor cells.

公开(公告)号：WO2011112810A1

公开(公告)日：2011-09-15

申请号：PCT/US2011/027898

申请日：2011-03-10

申请人： PAGANO, Paul, J.

发明人： PAGANO, Paul, J.

IPC分类号： A61B17/70

CPC分类号： A61B17/7059 ,  A61B17/8004 ,  A61B17/8061

摘要： A cervical fixation system for repairing odontoid fractures includes securing an anterior plate to caudal portion of C2 body below the odontoid neck. The anterior plate houses lag screw within a posterior shaft. A cannulated fixation device crosses the fracture site with fixation into the cephalad fragment. The lag screw can be pulled caudally into the plate with a compression screw to apply a compression force across the fracture site.

摘要翻译： 用于修复牙质骨折的子宫颈固定系统包括将前板固定在牙体颈部下方的C2体尾部。 前板在后轴内容纳螺钉。 插管固定装置穿过骨折部位，固定在头骨碎片中。 拉伸螺钉可以用压缩螺钉尾部拉到板中，以在断裂部位上施加压缩力。

公开(公告)号：WO2010144747A2

公开(公告)日：2010-12-16

申请号：PCT/US2010/038231

申请日：2010-06-10

申请人： CYNVENIO BIOSYSTEMS, INC. ,  TUREWICZ, Marek ,  PAGANO, Paul ,  DE FUSCO, Andre ,  SAUVAGEAU, David

发明人： TUREWICZ, Marek ,  PAGANO, Paul ,  DE FUSCO, Andre ,  SAUVAGEAU, David

IPC分类号： G01N35/08 ,  G01N33/487 ,  G01N1/38

CPC分类号： G01N21/11 ,  B01L3/50273 ,  B01L3/505 ,  B01L9/527 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N21/03 ,  G01N2021/0346 ,  G01N2021/0364

摘要： Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in conventional fluid sample devices. Flexible cartridge devices are particularly advantageous in control of fluid handling, rapid adaptation to a number of configurations by the end user, multiple uses for a single configuration, and in cost and ease of manufacture.

摘要翻译： 描述了用于流体样品处理的柔性袋和柔性盒装置，制造和使用的相关方法，相关的制造系统和相关的仪器系统。 柔性袋通过克服复杂仪器，专用设备的需求以及常规流体样品设备中相对较高的成本而在各种领域中提供广泛的优点。 灵活的墨盒装置在流体处理的控制，终端用户对许多配置的快速适应，单一配置的多种用途以及成本和易于制造方面特别有利。

公开(公告)号：WO2009026566A1

公开(公告)日：2009-02-26

申请号：PCT/US2008/074107

申请日：2008-08-22

申请人： CYNVENIO BIOSYSTEMS, LLC ,  CHANG-YEN, David, A. ,  DARABI, Jafar ,  ZHANG, Yanting ,  SOH, Hyongsok, T. ,  PAGANO, Paul

发明人： CHANG-YEN, David, A. ,  DARABI, Jafar ,  ZHANG, Yanting ,  SOH, Hyongsok, T. ,  PAGANO, Paul

IPC分类号： B03C1/28 ,  B03C1/01

CPC分类号： B03C1/288 ,  B03C1/01 ,  B03C2201/26

摘要： A system for sorting and trapping magnetic target species includes a microfluidic trapping module designed to receive and then temporarily hold magnetic particles in place within the module. The magnetic particles flowing into the module are trapped there while the other sample components (non-magnetic) continuously flow through and out of the station, thereby separating and concentrating the species captured on the magnetic particles. The magnetic particles and/or their payloads may be released and separately collected at an outlet after the sample passes through the trapping module.

摘要翻译： 用于分类和捕获磁性目标物种的系统包括微流体捕获模块，其被设计成接收然后临时将磁性颗粒保持在模块内的适当位置。 流入模块的磁性颗粒被捕获在一起，而其他样品组分（非磁性）连续流过和流出站，从而分离和浓缩捕获在磁性颗粒上的物质。 在样品通过捕集模块之后，磁性颗粒和/或其有效载荷可以在出口处被释放并分开收集。

公开(公告)号：WO2009129415A1

公开(公告)日：2009-10-22

申请号：PCT/US2009/040866

申请日：2009-04-16

申请人： CYNVENIO BIOSYSTEMS, LLC ,  CHANG-YEN, David, A. ,  DARABI, Jafar ,  ZHANG, Yanting ,  PAGANO, Paul ,  GLUCK, Frederick, W.

发明人： CHANG-YEN, David, A. ,  DARABI, Jafar ,  ZHANG, Yanting ,  PAGANO, Paul ,  GLUCK, Frederick, W.

IPC分类号： G01N27/00

CPC分类号： G01N35/0098 ,  G01N2035/00544

摘要： A system for sorting and trapping magnetic target species includes a microfluidic chamber designed to receive and then temporarily hold magnetic particles in place within the module. A pre-processing module may mix a sample and magnetic particles to cause certain species in the sample to be labeled. The microfluidic chamber may include a mechanism to move magnetic particles within the chamber. A post-processing module or the microfluidic chamber may be used to separate the labeled species from the magnetic particles by adding a release reagent. The magnetic particles and/or their payloads may be released and separately collected at an outlet of the chamber or the post-processing module.

摘要翻译： 用于分类和捕获磁性目标物种的系统包括微流体室，其设计成接收然后临时将磁性颗粒保持在模块内的适当位置。 预处理模块可以混合样品和磁性颗粒以使样品中的某些物质被标记。 微流体室可以包括在室内移动磁性颗粒的机构。 可以使用后处理模块或微流体室来通过添加释放试剂将标记物质与磁性颗粒分离。 磁性颗粒和/或其有效载荷可以被释放并且分别收集在腔室或后处理模块的出口处。

公开(公告)号：WO2003061715A1

公开(公告)日：2003-07-31

申请号：PCT/US2003/001710

申请日：2003-01-21

申请人： PHARMACIA & UPJOHN COMPANY ,  GIBSON, John, Kenneth ,  FORD, Charles, W. ,  PAGANO, Paul, J.

发明人： GIBSON, John, Kenneth ,  FORD, Charles, W. ,  PAGANO, Paul, J.

IPC分类号： A61L2/16

CPC分类号： A61K31/42 ,  A61L2/16 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/404 ,  A61L2400/18

摘要： A method for preventing medical device-associated microorganism infection includes the steps of providing a medical device and incorporating an effective amount of an oxazolidinone compound, such as linezolid, into the medical device.

摘要翻译： 用于预防医疗器械相关微生物感染的方法包括提供医疗装置并将有效量的恶唑烷酮化合物（如利奈唑胺）并入医疗装置的步骤。

公开(公告)号：WO2010144747A3

公开(公告)日：2011-03-03

申请号：PCT/US2010038231

申请日：2010-06-10

申请人： CYNVENIO BIOSYSTEMS INC ,  TUREWICZ MAREK ,  PAGANO PAUL ,  DE FUSCO ANDRE ,  SAUVAGEAU DAVID

发明人： TUREWICZ MAREK ,  PAGANO PAUL ,  DE FUSCO ANDRE ,  SAUVAGEAU DAVID

IPC分类号： G01N35/08 ,  G01N1/38 ,  G01N33/487

CPC分类号： G01N21/11 ,  B01L3/50273 ,  B01L3/505 ,  B01L9/527 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N21/03 ,  G01N2021/0346 ,  G01N2021/0364

摘要： Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in conventional fluid sample devices. Flexible cartridge devices are particularly advantageous in control of fluid handling, rapid adaptation to a number of configurations by the end user, multiple uses for a single configuration, and in cost and ease of manufacture.

摘要翻译： 描述了用于流体样品处理的柔性袋和柔性盒装置，制造和使用的相关方法，相关的制造系统和相关的仪器系统。 柔性袋通过克服复杂仪器，专用设备的需求以及常规流体样品设备中相对较高的成本而在各种领域中提供广泛的优点。 灵活的墨盒装置在流体处理的控制，终端用户对许多配置的快速适应，单一配置的多种用途以及成本和易于制造方面特别有利。

公开(公告)号：WO2009117611A3

公开(公告)日：2009-09-24

申请号：PCT/US2009/037714

申请日：2009-03-19

申请人： CYNVENIO BIOSYSTEMS, LLC ,  CHANG-YEN, David, A. ,  DARABI, Jafar ,  ZHANG, Yanting ,  PAGANO, Paul

发明人： CHANG-YEN, David, A. ,  DARABI, Jafar ,  ZHANG, Yanting ,  PAGANO, Paul

IPC分类号： B01D35/06 ,  B03C1/30 ,  C02F1/48

摘要： A system for sorting and trapping magnetic target species includes a microfluidic trapping chamber designed to receive and then temporarily hold magnetic particles in place within the module. An external magnetic source moves relatives to the fluid chamber as the magnetic particles flow the device in the fluidic medium. The magnetic particles flowing into the module are trapped there while the other sample components (non-magnetic) continuously flow through and out of the station, thereby separating and concentrating the species captured on the magnetic particles. The magnetic particles and/or their payloads may be released and separately collected at an outlet after the sample passes through the trapping module.

公开(公告)号：WO2005079686A1

公开(公告)日：2005-09-01

申请号：PCT/US2005/003720

申请日：2005-02-07

申请人： SDGI HOLDINGS, INC. ,  PAGANO, Paul, J.

发明人： PAGANO, Paul, J.

IPC分类号： A61B17/88

CPC分类号： A61B17/8811 ,  A61B17/025 ,  A61B17/3417 ,  A61B17/3468 ,  A61B17/3472 ,  A61B17/8858 ,  A61B2017/0256 ,  A61B2090/034 ,  A61B2090/0801

摘要： Instrumentation and method for treatment of a spinal structure, comprising an elongate member (22) including a deformable distal portion (22a) having an initial configuration for placement within the spinal structure and a deformed configuration wherein the distal portion (22a) is outwardly deformed to form a cavity (C) in the spinal structure. The elongate member (22, 122) comprises a cannula member (32) and an actuator member (30) that is removably positioned within the cannula member (32) and configured to transition the deformable distal portion (22a) from the initial configuration toward the deformed configuration. The actuator member (30) is selectively removed from the cannula member (32) to provide a passageway (60) for delivery of a material (M) into the cavity (C) formed in the spinal structure.

摘要翻译： 用于治疗脊柱结构的仪器和方法，包括细长构件（22），所述细长构件（22）包括具有用于放置在所述脊柱结构内的初始构型的可变形远端部分（22a）和变形构造，其中所述远端部分（22a）向外变形 在脊柱结构中形成腔（C）。 细长构件（22,122）包括套管构件（32）和致动器构件（30），其被可移除地定位在套管构件（32）内并且构造成使可变形远侧部分（22a）从初始构型朝向 变形配置。 致动器构件（30）从套管构件（32）中选择性地移除，以提供用于将材料（M）输送到形成在脊柱结构中的空腔（C）中的通道（60）。

公开(公告)号：WO2009117611A2

公开(公告)日：2009-09-24

申请号：PCT/US2009037714

申请日：2009-03-19

申请人： CYNVENIO BIOSYSTEMS LLC ,  CHANG-YEN DAVID A ,  DARABI JAFAR ,  ZHANG YANTING ,  PAGANO PAUL

发明人： CHANG-YEN DAVID A ,  DARABI JAFAR ,  ZHANG YANTING ,  PAGANO PAUL

IPC分类号： C12M1/00

CPC分类号： C12M47/04

摘要： A system for sorting and trapping magnetic target species includes a microfluidic trapping chamber designed to receive and then temporarily hold magnetic particles in place within the module. An external magnetic source moves relatives to the fluid chamber as the magnetic particles flow the device in the fluidic medium. The magnetic particles flowing into the module are trapped there while the other sample components (non-magnetic) continuously flow through and out of the station, thereby separating and concentrating the species captured on the magnetic particles. The magnetic particles and/or their payloads may be released and separately collected at an outlet after the sample passes through the trapping module.

摘要翻译： 用于分类和捕获磁性目标物种的系统包括微流体捕获室，其设计成接收然后临时将磁性颗粒保持在模块内的适当位置。 当磁性颗粒将流体介质中的装置流动时，外部磁源将亲属移动到流体室。 流入模块的磁性颗粒被捕获在一起，而其他样品组分（非磁性）连续流过和流出站，从而分离和浓缩捕获在磁性颗粒上的物质。 在样品通过捕集模块之后，磁性颗粒和/或其有效载荷可以在出口处被释放并分开收集。