公开(公告)号：WO2010111485A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028658

申请日：2010-03-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  DICKEY, Burton ,  TUVIM, Michael ,  EVANS, Scott

Inventor： DICKEY, Burton ,  TUVIM, Michael ,  EVANS, Scott

IPC: C12N15/117 ,  A61K38/06 ,  A61K45/06 ,  C07K14/705 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K9/0078 ,  A61K31/7125 ,  A61K38/08 ,  A61K45/06 ,  A61K2039/54 ,  A61K2039/55516 ,  A61K2039/55561 ,  Y02A50/387 ,  Y02A50/481 ,  A61K2300/00

Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a TLR9 agonist and a TLR 2/6 agonist to the individual.

Abstract translation: 本发明的实施方案涉及治疗，抑制或减弱患有发生这种感染或有发展这种感染风险的个体的微生物感染的方法，包括施用有效量的TLR9激动剂和TLR 2/6的步骤 对个体的激动。

公开(公告)号：WO2008085549A2

公开(公告)日：2008-07-17

申请号：PCT/US2007/074760

申请日：2007-07-30

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  DICKEY, Burton, F. ,  TUVIM, Michael ,  CLEMENT, Cecilla, G.

Inventor： DICKEY, Burton, F. ,  TUVIM, Michael ,  CLEMENT, Cecilla, G.

IPC: A61K35/74 ,  A61K39/00

CPC classification number: A61K39/102 ,  A61K31/573 ,  A61K35/74 ,  A61K45/06 ,  A61K2039/544 ,  Y02A50/388 ,  A61K2300/00

Abstract: Embodiments of the invention include compositions, formulations and methods for the enhancement of a subject's biological defenses against infection, for example the subject's innate immunity against infection. Aspects of the invention provide a rapid and temporal enhancement or augmentation of biological defenses against microbial infection.

Abstract translation: 本发明的实施方案包括用于增强受试者针对感染的生物防御的组合物，制剂和方法，例如受试者对感染的先天免疫。 本发明的方面提供了针对微生物感染的生物防御的快速和时间的增强或增加。

公开(公告)号：WO2010030790A3

公开(公告)日：2010-05-20

申请号：PCT/US2009056525

申请日：2009-09-10

Applicant: TEXAS A & M UNIV SYS ,  HOEOEK MAGNUS ,  ZHANG DEKAI ,  GENDRON CHRISTI ,  DICKEY BURTON ,  TUVIM MICHAEL ,  EVANS SCOTT ,  UNIV TEXAS

Inventor： HOOK MAGNUS ,  ZHANG DEKAI ,  GENDRON CHRISTI ,  DICKEY BURTON ,  TUVIM MICHAEL ,  EVANS SCOTT

IPC: A61K38/16

CPC classification number: A61K38/164

Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR polypeptide or peptide or fragment or derivative or analog thereof to the individual.

Abstract translation: 本发明的实施方案涉及治疗，抑制或减弱患有发生这种感染的风险的个体中的微生物感染的方法，其包括施用有效量的StIR多肽或肽或片段或衍生物的步骤 或其类似物。

公开(公告)号：WO2008085549A3

公开(公告)日：2008-09-25

申请号：PCT/US2007074760

申请日：2007-07-30

Applicant: UNIV TEXAS ,  DICKEY BURTON F ,  TUVIM MICHAEL ,  CLEMENT CECILLA G

Inventor： DICKEY BURTON F ,  TUVIM MICHAEL ,  CLEMENT CECILLA G

IPC: A61K35/66 ,  A61K35/74

CPC classification number: A61K39/102 ,  A61K31/573 ,  A61K35/74 ,  A61K45/06 ,  A61K2039/544 ,  A61K2300/00

Abstract: Embodiments of the invention include microbial lysates in the form of compositions, formulations and methods for the enhancement of a subject's biological defenses against infection, for example the subject's innate immunity against infection. Aspects of the invention provide a rapid and temporal enhancement or augmentation of biological defenses against microbial infection.

Abstract translation: 本发明的实施方案包括用于增强受试者针对感染的生物防御的组合物，制剂和方法形式的微生物裂解物，例如受试者针对感染的先天免疫。 本发明的方面提供了针对微生物感染的生物防御的快速和时间的增强或增加。

公开(公告)号：WO2010030790A2

公开(公告)日：2010-03-18

申请号：PCT/US2009/056525

申请日：2009-09-10

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  HOOK, Magnus ,  ZHANG, Dekai ,  GENDRON, Christi ,  DICKEY, Burton ,  TUVIM, Michael ,  EVANS, Scott ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： HOOK, Magnus ,  ZHANG, Dekai ,  GENDRON, Christi ,  DICKEY, Burton ,  TUVIM, Michael ,  EVANS, Scott

IPC: A61K38/16 ,  A61P31/00

CPC classification number: A61K38/164 ,  Y02A50/387

Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR polypeptide or peptide or fragment or derivative or analog thereof to the individual.

Abstract translation: 本发明的实施方案涉及治疗，抑制或减轻患有或有风险发生这种感染的个体中的微生物感染的方法，所述方法包括施用有效量的 StIR多肽或肽或其片段或衍生物或类似物给予个体。