公开(公告)号：WO2010111485A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028658

申请日：2010-03-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  DICKEY, Burton ,  TUVIM, Michael ,  EVANS, Scott

Inventor： DICKEY, Burton ,  TUVIM, Michael ,  EVANS, Scott

IPC: C12N15/117 ,  A61K38/06 ,  A61K45/06 ,  C07K14/705 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K9/0078 ,  A61K31/7125 ,  A61K38/08 ,  A61K45/06 ,  A61K2039/54 ,  A61K2039/55516 ,  A61K2039/55561 ,  Y02A50/387 ,  Y02A50/481 ,  A61K2300/00

Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a TLR9 agonist and a TLR 2/6 agonist to the individual.

Abstract translation: 本发明的实施方案涉及治疗，抑制或减弱患有发生这种感染或有发展这种感染风险的个体的微生物感染的方法，包括施用有效量的TLR9激动剂和TLR 2/6的步骤 对个体的激动。

公开(公告)号：WO2009114428A1

公开(公告)日：2009-09-17

申请号：PCT/US2009/036404

申请日：2009-03-06

Applicant: VISIOGEN, INC. ,  TSAI, George ,  NGUYEN, Tuan, Anh ,  NGUYEN, Phu, H. ,  EVANS, Scott

Inventor： TSAI, George ,  NGUYEN, Tuan, Anh ,  NGUYEN, Phu, H. ,  EVANS, Scott

IPC: A61F2/16

CPC classification number: A61F2/1675 ,  A61F2/1629 ,  A61F2/1648 ,  A61F2/1678 ,  A61F2002/1683 ,  A61F2250/0021 ,  A61F2250/0025

Abstract: An injector (900) for inserting an intraocular lens (930, 980) into an eye includes a lumen (910). The lumen (910, 960) can include a terminal portion (912, 962) at a distal end (916, 966) and a proximal portion (914, 964) juxtaposed with the terminal portion (912, 962). An injector plunger (920, 970) can be disposed within the lumen (910, 960) for generating a driving force (944, 994) on the intraocular lens (930, 980). The injector (900) can include a lens frictional force (942) that has a first value when the lens (930, 980) is at a first location (Ll) within the proximal portion (914, 964) and a second value when the lens (930, 980) is a,t a second location (L2) within the terminal portion (912, 962). The first value can be smaller than the second value.

Abstract translation: 用于将眼内透镜（930,980）插入眼睛的注射器（900）包括内腔（910）。 管腔（910,960）可以包括在远端（916,966）处的端子部分（912，962）和与端子部分（912,962）并置的近端部分（914,964）。 注射器柱塞（920,970）可以设置在内腔（910,960）内，用于在眼内透镜（930,980）上产生驱动力（944,944）。 注射器（900）可以包括透镜摩擦力（942），当透镜（930,980）位于近端部分（914,964）内的第一位置（L1）时具有第一值，并且当第 透镜（930,980）是端子部分（912,962）内的第二位置（L2）。 第一个值可以小于第二个值。

公开(公告)号：WO2007016533A9

公开(公告)日：2007-07-12

申请号：PCT/US2006029852

申请日：2006-07-31

Applicant: VISIOGEN INC ,  NGUYEN TUAN ANH ,  ZADNO-AZIZI GHOLAM-REZA ,  EVANS SCOTT ,  PORTNEY VALDEMAR

Inventor： NGUYEN TUAN ANH ,  ZADNO-AZIZI GHOLAM-REZA ,  EVANS SCOTT ,  PORTNEY VALDEMAR

IPC: A61F2/16

CPC classification number: A61F2/1613 ,  A61F2/1627 ,  A61F2/1629 ,  A61F2/1632 ,  A61F2/1648

Abstract: An accommodating intraocular lens (100) implantable in an eye. The lens comprises an anterior portion having an anterior biasing element and an anterior optic having refractive power (106). The lens further comprises a posterior portion having a posterior biasing element and a posterior optic having refractive power (118). The anterior optic and the posterior optic are relatively moveable in response to action of the ciliary muscle to change the separation between the optics and the refractive power of the lens. The lens has an aberration-inducing force characteristic of about 70 mg to about 115 mg to allow aberration-inducing relative movement of the optics when the lens is in the eye, thereby adding optical aberration to the lens which increases depth of focus of the lens. In one variation, the lens has an aberration-inducing force characteristic of 70 mg to 115 mg. Related methods are also disclosed.

Abstract translation: 一种可植入眼睛的适应性眼内透镜（100）。 透镜包括具有前偏置元件的前部和具有屈光力的前光学元件（106）。 透镜还包括具有后偏置元件的后部部分和具有屈光力的后光学元件（118）。 前视神经和后视镜相对于睫状肌的作用相对移动以改变光学元件与透镜屈光力之间的分离。 透镜具有约70mg至约115mg的像差诱导力特征，以允许当透镜在眼睛中时像差引起的光学元件的相对运动，从而增加透镜的光学像差，从而增加透镜的焦深的光学像差 。 在一个变型中，透镜具有70mg至115mg的像差诱导力特征。 还公开了相关方法。

公开(公告)号：WO2007016533A3

公开(公告)日：2007-02-08

申请号：PCT/US2006/029852

申请日：2006-07-31

Applicant: VISIOGEN, INC. ,  NGUYEN, Tuan, Anh ,  ZADNO-AZIZI, Gholam-Reza ,  EVANS, Scott ,  PORTNEY, Valdemar

Inventor： NGUYEN, Tuan, Anh ,  ZADNO-AZIZI, Gholam-Reza ,  EVANS, Scott ,  PORTNEY, Valdemar

IPC: A61F2/16

Abstract: An accommodating intraocular lens (100) implantable in an eye. The lens comprises an anterior portion having an anterior biasing element and an anterior optic having refractive power (106). The lens further comprises a posterior portion having a posterior biasing element and a posterior optic having refractive power (118). The anterior optic and the posterior optic are relatively moveable in response to action of the ciliary muscle to change the separation between the optics and the refractive power of the lens. The lens has an aberration-inducing force characteristic of about 70 mg to about 115 mg to allow aberration-inducing relative movement of the optics when the lens is in the eye, thereby adding optical aberration to the lens which increases depth of focus of the lens. In one variation, the lens has an aberration-inducing force characteristic of 70 mg to 115 mg. Related methods are also disclosed.

公开(公告)号：WO2006020268A3

公开(公告)日：2006-10-05

申请号：PCT/US2005025490

申请日：2005-07-19

Applicant: EBERLE DESIGN INC ,  EVANS SCOTT R

Inventor： EVANS SCOTT R

IPC: G01N19/00

CPC classification number: G08G1/07 ,  G05B23/0272 ,  G08G1/095

Abstract: A malfunction management unit (MMU) includes advanced diagnostic and set-up capabilities accessed through a display-based user interface. In general, the MMU is capable of displaying (1) monitor status information, wherein the monitor status information includes information relating to the status of at least a portion of the input signals; and (2) diagnostic information, wherein the diagnostic information includes an indication of fault type, an indication of faulty signals, and troubleshooting information associated with said fault type and relevant faulty signals. The diagnostic information includes a textual interpretation of the results of a field check analysis.

Abstract translation: 故障管理单元（MMU）包括通过基于显示的用户界面访问的高级诊断和设置功能。 通常，MMU能够显示（1）监视状态信息，其中监视状态信息包括与至少一部分输入信号的状态有关的信息; （2）诊断信息，其中诊断信息包括故障类型的指示，故障信号的指示以及与所述故障类型和相关故障信号相关联的故障排除信息。 诊断信息包括对现场检查分析结果的文本解释。

公开(公告)号：WO2005104995A3

公开(公告)日：2006-02-23

申请号：PCT/US2005012032

申请日：2005-04-12

Applicant: VISIOGEN ,  NGUYEN TUAN ANH ,  EVANS SCOTT ,  ZADNO-AZIZI GHOLAM-REZA

Inventor： NGUYEN TUAN ANH ,  EVANS SCOTT ,  ZADNO-AZIZI GHOLAM-REZA

IPC: A61F2/16

CPC classification number: A61F2/1616 ,  A61F2/1629 ,  A61F2/1648

Abstract: An accommodating intraocular lens (200, 300, 400) has an anterior portion (102) including an anterior viewing element (106) and an anterior biasing element (108) connected to the anterior viewing element (106). A posterior portion (104) has a posterior viewing element (118) and a posterior biasing element (120) connected to the posterior viewing element (118). The anterior and posterior biasing elements (108, 120) are connected at first and second apices (112, 116). First and second distending members (134, 136) are connected to the posterior portion (104). The first and second distending members (134, 136) extend to locations significantly anterior of an anterior side of the posterior viewing element (118).

Abstract translation: 容纳人工晶状体（200,300,400）具有前部（102），其包括前观察元件（106）和连接到前观察元件（106）的前偏置元件（108）。 后部部分（104）具有后观察元件（118）和连接到后观察元件（118）的后偏置元件（120）。 前和后偏置元件（108,120）在第一和第二顶点（112,116）处连接。 第一和第二扩张构件（134,136）连接到后部（104）。 第一和第二扩张构件（134,136）延伸到在后观察元件（118）的前侧的显着前方的位置。

公开(公告)号：WO2004073560A9

公开(公告)日：2004-10-14

申请号：PCT/US2004004033

申请日：2004-02-11

Applicant: VISIOGEN INC ,  AYTON IAN ,  EVANS SCOTT ,  NGUYEN TUAN

Inventor： EVANS SCOTT ,  NGUYEN TUAN

IPC: A61F2/16

CPC classification number: A61F2/1678 ,  A61F2/1648 ,  A61F2250/0021

Abstract: Disclosed is an apparatus for compacting an intraocular lens. The apparatus comprises a lens compactor having a first configuration for retaining the intraocular lens in an unstressed condition and a second configuration in which the compactor stresses the lens into an at least partially compacted condition without advancing the lens along an injection axis of the compactor. The compactor accomplishes this by applying a compacting force in a direction generally orthogonal to the optical axis of the lens. The compactor is responsive to a compactor actuator that is movable by a user to change the compactor from the first configuration to the second configuration. Additional apparatus and methods are disclosed as well.

Abstract translation: 公开了一种用于压紧人工晶状体的装置。 该设备包括具有用于将人工晶状体保持在未受力状态的第一构造的透镜压缩器和其中压实器将透镜压缩到至少部分压实状态而不使压缩器沿着压实器的注射轴线前进的第二构造。 压实机通过在大致垂直于透镜光轴的方向上施加压实力来实现这一点。 压实机响应于压实机致动器，该压实机致动器可由使用者移动以将压实机从第一构造变为第二构造。 另外的设备和方法也被公开。

公开(公告)号：WO02098483A3

公开(公告)日：2003-05-08

申请号：PCT/US0217086

申请日：2002-05-31

Applicant: ALSIUS CORP ,  TZENG ELBERT ,  ADZICH WESLEY A K A VASO ,  BARKER PETER ,  POMPA HORTENSIA ,  EVANS SCOTT

Inventor： TZENG ELBERT ,  ADZICH WESLEY A K A VASO ,  BARKER PETER ,  POMPA HORTENSIA ,  EVANS SCOTT

IPC: A61F7/12 ,  A61F7/00

CPC classification number: A61F7/12 ,  A61F2007/126

Abstract: A heat exchange catheter (14) has a catheter body (300) with a working fluid supply lumen (38) extending therethrough, and terminating in a helical heat exchange tube (36) that exits the body and extends proximally back along the catheter body. Working fluid flows through the heat exchange tube to exchange heat with the central venous system of a patient when the catheter body is properly placed in the patient.

Abstract translation: 热交换导管（14）具有导管主体（300），其具有延伸穿过其中的工作流体供应腔（38），并且终止于离开身体并沿导管主体向近侧延伸的螺旋形热交换管（36）。 当导管主体适当地放置在患者体内时，工作流体流过热交换管以与患者的中心静脉系统进行热交换。

公开(公告)号：WO0149236A2

公开(公告)日：2001-07-12

申请号：PCT/US0100058

申请日：2001-01-03

Applicant: ALSIUS CORP ,  LASERSOHN JACK W ,  WORTHEN WILLIAM J ,  EVANS SCOTT M ,  WINTER SUZANNE C ,  BALDING DAVID P

Inventor： LASERSOHN JACK W ,  WORTHEN WILLIAM J ,  EVANS SCOTT M ,  WINTER SUZANNE C ,  BALDING DAVID P

IPC: A61B18/00 ,  A61F7/00 ,  A61F7/12 ,  A61H31/00 ,  A61M1/36 ,  A61M5/44 ,  A61N1/39 ,  A61H

CPC classification number: A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61H31/006 ,  A61H2201/0214 ,  A61M1/369 ,  A61M5/44 ,  A61M16/0465 ,  A61M16/10 ,  A61N1/39 ,  A61N1/3962

Abstract: A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient's body temperature using one or more cooling catheters positioned in the central venous system of the patient and/or particularly cooling the patient's brain temperature using a catheter advanced into the aortic arch or into the carotid artery whereby a bolus of cold saline solution is introduced into the blood supplied to the brain to lower the brain temperature quickly, and further cooling or maintaining the brain temperature at a desired level by pumping coolant in a closed circuit formation between the catheter and the coolant source to remove heat from the blood supplied to the patient's brain.

Abstract translation: 用于治疗心脏骤停的方法包括使患者去纤维化和/或使患者通风和/或施用心脏骤停药物如肾上腺素来复苏患者，然后使用位于中心静脉中的一个或多个冷却导管来冷却患者的体温 系统和/或特别是使用进入主动脉弓或进入颈动脉的导管特别冷却患者的脑温度，由此将大量冷盐水溶液引入供应给脑的血液中以迅速降低脑温度，并且 通过在导管和冷却剂源之间的封闭回路形成中泵送冷却剂以便从供应给患者的大脑的血液中除去热量来进一步冷却或保持脑温度达到所需水平。

公开(公告)号：WO1997004657A1

公开(公告)日：1997-02-13

申请号：PCT/US1996012436

申请日：1996-07-29

Applicant: MICRO THERAPEUTICS, INC. ,  GREFF, Richard, J. ,  JONES, Michael, L. ,  EVANS, Scott

Inventor： MICRO THERAPEUTICS, INC.

IPC: A01N59/08

CPC classification number: A61L24/08 ,  A61K49/0414 ,  A61K49/0419 ,  A61L24/001 ,  A61L24/046 ,  A61L24/06 ,  A61L2430/36 ,  C08L29/04 ,  C08L1/26

Abstract: Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent characterized by having an average particle size of less than about 10 mu m. In another embodiment, the biocompatible polymer in these compositions is replaced with a biocompatible prepolymer.

Abstract translation: 公开了用于栓塞血管的新型组合物，其特别适用于通过导管递送治疗血管病变。 在一个实施方案中，本发明的组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性水不溶性造影剂，其特征在于平均粒度小于约10μm。 在另一个实施方案中，这些组合物中的生物相容性聚合物被生物相容性预聚物代替。