公开(公告)号：WO2011066391A3

公开(公告)日：2011-10-06

申请号：PCT/US2010058009

申请日：2010-11-24

Applicant: DIFUSION TECHNOLOGIES INC ,  CRUDDEN JOSEPH J ,  JOHNS DERRICK

Inventor： CRUDDEN JOSEPH J ,  JOHNS DERRICK

IPC: A61L27/14 ,  A61L27/04 ,  A61L27/10 ,  A61L27/54

CPC classification number: A61L27/54 ,  A61L27/10 ,  A61L27/18 ,  A61L27/443 ,  A61L27/446 ,  A61L27/56 ,  A61L2202/21 ,  A61L2300/104 ,  A61L2300/404 ,  C08L71/12 ,  C08L71/00

Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

Abstract translation: 公开了用抗微生物金属阳离子后载荷陶瓷颗粒的方法。 在某些实施方案中，后加载颗粒是沸石，其中沸石已经结合到树脂中，并且该组合用作可植入装置。 在某些实施方案中，聚合物是热塑性聚合物，例如聚芳醚醚酮（PEEK）。 在某些实施方案中，抗微生物活性的来源包括沸石中所含的离子交换阳离子。 在某些实施方案中，公开了通过控制通过离子交换通过装在装置中的沸石的某些阳离子的递送来向装置赋予抗微生物活性的方法。

公开(公告)号：WO2014152653A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/027581

申请日：2014-03-14

Applicant: DIFUSION TECHNOLOGIES, INC.

Inventor： CRUDDEN, Joseph J.

IPC: A61L2/00 ,  A61L2/04

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2300/62 ,  C08L71/12

Abstract: Methods of post-charging ammonium ions into ceramic particles having antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite.

Abstract translation: 公开了将铵离子带入具有抗微生物金属阳离子的陶瓷颗粒中的方法。 在某些实施方案中，后加载颗粒是沸石，其中沸石已经结合到树脂中，并且该组合用作可植入装置。 在某些实施方案中，聚合物是热塑性聚合物，例如聚芳醚醚酮（PEEK）。 在某些实施方案中，抗微生物活性的来源包括沸石中所含的离子交换阳离子。

公开(公告)号：WO2011072212A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/059868

申请日：2010-12-10

Applicant: DIFUSION TECHNOLOGIES, INC. ,  CRUDDEN, Joseph J. ,  HAFIZ, Jami ,  DEATON, James E. ,  PEPPER, John R. ,  JOHNS, Derrick

Inventor： CRUDDEN, Joseph J. ,  HAFIZ, Jami ,  DEATON, James E. ,  PEPPER, John R. ,  JOHNS, Derrick

IPC: A61L27/14 ,  A61L27/04 ,  A61L27/50 ,  A61L27/56 ,  B29C45/00 ,  B29B7/18

CPC classification number: B29C45/0013 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404 ,  B29B13/022 ,  B29B13/06 ,  B29C43/003 ,  B29C43/26 ,  B29C43/32 ,  B29C43/52 ,  B29C45/0001 ,  B29C45/0005 ,  B29C45/0053 ,  B29K2071/00 ,  B29K2105/0011 ,  B29K2105/04 ,  B29K2105/12 ,  B29K2105/16 ,  B29K2307/04 ,  B29K2505/14 ,  B29K2709/02 ,  B29K2995/0056 ,  B29K2995/0072 ,  B29L2031/7532 ,  Y10T29/4998 ,  C08L71/12 ,  C08L71/00

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract translation: 公开了具有抗微生物特性的可植入式医疗装置，优选具有PEEK的方法。 通过将含有抗微生物金属阳离子的陶瓷颗粒结合到熔融的PEEK树脂中来产生抗微生物效果，随后允许其冷却并且通过注射成型，切割和机械加工或其它技术实现其最终形状。

公开(公告)号：WO2011140416A3

公开(公告)日：2011-11-10

申请号：PCT/US2011/035468

申请日：2011-05-06

Applicant: DIFUSION TECHNOLOGIES, INC. ,  GHISELLI, Gary ,  WHANG, Peter ,  HAFIZ, Jami ,  CRUDDEN, Joseph ,  JOHNS, Derrick W.

Inventor： GHISELLI, Gary ,  WHANG, Peter ,  HAFIZ, Jami ,  CRUDDEN, Joseph ,  JOHNS, Derrick W.

IPC: A61L27/14 ,  A61L27/10 ,  A61L27/50 ,  A61F2/44 ,  A61L27/30

Abstract: Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.

公开(公告)号：WO2011140416A2

公开(公告)日：2011-11-10

申请号：PCT/US2011035468

申请日：2011-05-06

Applicant: DIFUSION TECHNOLOGIES INC ,  GHISELLI GARY ,  WHANG PETER ,  HAFIZ JAMI ,  CRUDDEN JOSEPH ,  JOHNS DERRICK W

Inventor： GHISELLI GARY ,  WHANG PETER ,  HAFIZ JAMI ,  CRUDDEN JOSEPH ,  JOHNS DERRICK W

IPC: A61L27/14 ,  A61F2/44 ,  A61L27/10 ,  A61L27/30 ,  A61L27/50

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/4455 ,  A61F2210/0071 ,  A61L27/446 ,  A61L27/54 ,  A61L2300/404 ,  C08L71/12

Abstract: Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.

Abstract translation: 诸如矫形植入物的装置由热塑性树脂如聚芳醚醚酮（PEEK）组成，并且包括诸如沸石的陶瓷物质以增强其亲水性。 陶瓷种类可以是表面涂层，可以掺入或嵌入到热塑性树脂中，或者可以是表面涂层，也可以掺入或嵌入树脂中。 在某些实施方案中，陶瓷物质是引入装置中的沸石，特别是在装置的暴露表面，并且没有抗微生物金属离子。 手术中将该装置引入体内。

公开(公告)号：WO2011066391A2

公开(公告)日：2011-06-03

申请号：PCT/US2010/058009

申请日：2010-11-24

Applicant: DIFUSION TECHNOLOGIES, INC. ,  CRUDDEN, Joseph J. ,  JOHNS, Derrick

Inventor： CRUDDEN, Joseph J. ,  JOHNS, Derrick

IPC: A61L27/14 ,  A61L27/10 ,  A61L27/04 ,  A61L27/54

CPC classification number: A61L27/54 ,  A61L27/10 ,  A61L27/18 ,  A61L27/443 ,  A61L27/446 ,  A61L27/56 ,  A61L2202/21 ,  A61L2300/104 ,  A61L2300/404 ,  C08L71/12 ,  C08L71/00

Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

Abstract translation: 公开了用抗微生物金属阳离子后加载陶瓷颗粒的方法。 在某些实施方案中，后负载颗粒是沸石，其中沸石已经掺入到树脂中并且该组合用作可植入装置。 在某些实施方案中，聚合物是热塑性聚合物，例如聚芳醚醚酮（PEEK）。 在某些实施方案中，抗微生物活性的来源包括包含在沸石中的可离子交换的阳离子。 在某些实施方案中，公开了通过控制经由掺入装置中的沸石的离子交换来输送某些阳离子来赋予装置抗微生物活性的方法。

公开(公告)号：WO2014152649A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/027576

申请日：2014-03-14

Applicant: DIFUSION TECHNOLOGIES, INC.

Inventor： CRUDDEN, Joseph J.

IPC: A61L2/00 ,  A61L2/04

CPC classification number: A61L27/18 ,  A61L2/238 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2300/62 ,  C08L71/00

Abstract: Methods for imparting antimicrobial properties to polymers using ceramics, preferably zeolites, as a cation cage, to deliver and dose one or more antimicrobial cations. Polymer containing antimicrobial metal ions is contacted with a strong acid or a suitable solvent, such as by immersion, dipping, spraying, etc. After contacting with the acid for a sufficient amount of time, the article can be washed and further processed in a conventional manner. Suitable polymers include thermoplastic resins, especially polyaryletherketones such as polyetheretherketone (PEEK) and polyetherketoneketone (PEKK). Suitable acids include sulfuric acid, nitric acid, mixtures thereof, glacial acetic acid, citric acid solution, and phosphoric acid, particularly in combination with nitric and sulfuric acid.

Abstract translation: 使用陶瓷优选沸石作为阳离子笼的聚合物赋予抗微生物性能以递送和剂量一种或多种抗微生物阳离子的方法。 含有抗微生物金属离子的聚合物与强酸或合适的溶剂接触，例如通过浸渍，浸渍，喷涂等。在与酸接触足够的时间后，可以用常规方法洗涤并进一步加工制品 方式。 合适的聚合物包括热塑性树脂，特别是聚芳醚酮如聚醚醚酮（PEEK）和聚醚酮酮（PEKK）。 合适的酸包括硫酸，硝酸，其混合物，冰醋酸，柠檬酸溶液和磷酸，特别是与硝酸和硫酸组合。

公开(公告)号：WO2011072212A3

公开(公告)日：2011-11-17

申请号：PCT/US2010059868

申请日：2010-12-10

Applicant: DIFUSION TECHNOLOGIES INC ,  CRUDDEN JOSEPH J ,  HAFIZ JAMI ,  DEATON JAMES E ,  PEPPER JOHN R ,  JOHNS DERRICK

Inventor： CRUDDEN JOSEPH J ,  HAFIZ JAMI ,  DEATON JAMES E ,  PEPPER JOHN R ,  JOHNS DERRICK

IPC: A61L27/14 ,  A61L27/04 ,  A61L27/50 ,  A61L27/56 ,  B29B7/18 ,  B29C45/00

CPC classification number: B29C45/0013 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404 ,  B29B13/022 ,  B29B13/06 ,  B29C43/003 ,  B29C43/26 ,  B29C43/32 ,  B29C43/52 ,  B29C45/0001 ,  B29C45/0005 ,  B29C45/0053 ,  B29K2071/00 ,  B29K2105/0011 ,  B29K2105/04 ,  B29K2105/12 ,  B29K2105/16 ,  B29K2307/04 ,  B29K2505/14 ,  B29K2709/02 ,  B29K2995/0056 ,  B29K2995/0072 ,  B29L2031/7532 ,  Y10T29/4998 ,  C08L71/12 ,  C08L71/00

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract translation: 公开了制造具有抗微生物特性的可植入医疗装置的方法，优选用PEEK制造。 通过将含有抗微生物金属阳离子的陶瓷颗粒结合到熔融的PEEK树脂中产生抗微生物效果，随后使其冷却并通过注射成型，切割和机械加工或其他技术达到其最终形状。

公开(公告)号：WO2010114827A1

公开(公告)日：2010-10-07

申请号：PCT/US2010/029180

申请日：2010-03-30

Applicant: DIFUSION TECHNOLOGIES, INC. ,  JOHNS, Derrick ,  GECK, Matthew ,  WHANG, Peter ,  HAFIZ, Jami

Inventor： JOHNS, Derrick ,  GECK, Matthew ,  WHANG, Peter ,  HAFIZ, Jami

IPC: A61K9/00

CPC classification number: A61L27/446 ,  A61L27/025 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02

Abstract: Medical implants such as bone graft substitutes that include one or more cations are delivered in a local environment to promote osteogenesis. Zeolite loaded with a metal cation in combination with an implant such as a bone graft substitute can be used as an implant in the body to regulate protein transcription and translation. Also disclosed are methods of promoting osteogenesis in a patient in need thereof, methods for modulating bone formation and mineralization by implanting in a patient a medical implant comprising ion-exchangeable cations, and methods of regulating BMP gene expression in bone cells in a patient by controlling the delivery of certain cations through ion- exchange via a zeolite incorporated in a bone substitute implanted in a patient so that BMP gene expression can be upregulated or downregulated appropriately.

Abstract translation: 包括一种或多种阳离子在内的医用植入物例如骨移植物替代物在局部环境中递送以促进成骨。 负载有金属阳离子与植入物如骨移植物替代物组合的沸石可以用作体内的植入物以调节蛋白质转录和翻译。 还公开了在有需要的患者中促进成骨的方法，通过在患者体内植入包括可离子交换的阳离子的医疗植入物来调节骨形成和矿化的方法，以及通过控制来调节患者骨细胞中的BMP基因表达的方法 通过离子交换通过掺入植入患者的骨替代物中的沸石递送某些阳离子，使得BMP基因表达可以适当地上调或下调。