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公开(公告)号：WO02089739A3
公开(公告)日：2003-08-21
申请号：PCT/US0214500
申请日：2002-05-09
Applicant: NEWBIOTICS INC , SERGEEVA MARIA VLADIMIR , DOPPALAPUDI VENKATA RAMANA
Inventor： SERGEEVA MARIA VLADIMIR , DOPPALAPUDI VENKATA RAMANA
CPC classification number: B82Y5/00 , A61K38/00 , A61K47/556 , A61K47/67 , C07K5/0606 , C07K5/06191
Abstract: This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting themicroorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gra m-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. Catarrhalis,E. coli, E. faecalis, H. influenzae and P. aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symtoms of an infection by a Peptide_Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
Abstract translation: 本发明提供了通过使微生物与有效量的本文所述的化合物接触来抑制表达肽脱甲硅烷基化酶的微生物的生长的方法。 该方法抑制革兰氏阳性和阴性微生物的生长，例如金黄色葡萄球菌，表皮葡萄球菌，肺炎克雷伯菌，产气荚膜梭菌，阴沟肠杆菌，卡他莫拉菌， 大肠杆菌，粪肠球菌，流感嗜血杆菌和铜绿假单胞菌。 该方法可以在体外，离体和体内实施。 还提供了一种通过向受试者施用或递送有效量的上述化合物来减轻受试者中表达Peptide_Deformylase的微生物感染症状的方法。
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公开(公告)号：WO2006094269A2
公开(公告)日：2006-09-08
申请号：PCT/US2006/007865
申请日：2006-03-03
Applicant: COVX TECHNOLOGIES IRELAND LIMITED , BRADSHAW, Curt, W. , DOPPALAPUDI, Venkata, Ramana , LAI, Jing-Yu , RIZZO, John
Inventor： BRADSHAW, Curt, W. , DOPPALAPUDI, Venkata, Ramana , LAI, Jing-Yu , RIZZO, John
CPC classification number: C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：WO2004043400A2
公开(公告)日：2004-05-27
申请号：PCT/US0336124
申请日：2003-11-14
Applicant: NEWBIOTICS INC , BALLATORE CARLO , DOPPALAPUDI VENKATA RAMANA , SERGEEVA MARIA V
Inventor： BALLATORE CARLO , DOPPALAPUDI VENKATA RAMANA , SERGEEVA MARIA V
CPC classification number: C07F9/4084 , A61K47/65 , C07F9/4006
Abstract: This invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula (I).
Abstract translation: 本发明提供了使用它们抑制表达肽脱甲酰酶的微生物生长的化合物和方法，该化合物具有通式（I）。
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公开(公告)号：WO2009136352A8
公开(公告)日：2010-11-25
申请号：PCT/IB2009051820
申请日：2009-05-04
Applicant: COVX TECHNOLOGIES IRELAND LTD , DOPPALAPUDI VENKATA RAMANA , LAI JING-YU , LIU BIN , LIU DINGGUO , DESHARNAIS JOEL , BHAT ABHIJIT SURESH , FU YANWEN , OATES BRYAN DOUGLAS , CHEN GANG , BRADSHAW CURT WILLIAM
Inventor： DOPPALAPUDI VENKATA RAMANA , LAI JING-YU , LIU BIN , LIU DINGGUO , DESHARNAIS JOEL , BHAT ABHIJIT SURESH , FU YANWEN , OATES BRYAN DOUGLAS , CHEN GANG , BRADSHAW CURT WILLIAM
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders assoiated with abnormal angiogenesis.
Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供了肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。
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公开(公告)号：WO2009136352A1
公开(公告)日：2009-11-12
申请号：PCT/IB2009/051820
申请日：2009-05-04
Applicant: CovX Technologies Ireland, Ltd. , DOPPALAPUDI, Venkata Ramana , LAI, Jing-Yu , LIU, Bin , LIU, Dingguo , DESHARNAIS, Joel , BHAT, Abhijit Suresh , FU, Yanwen , OATES, Bryan Douglas , GANG, Chen , BRADSHAW, Curt William
Inventor： DOPPALAPUDI, Venkata Ramana , LAI, Jing-Yu , LIU, Bin , LIU, Dingguo , DESHARNAIS, Joel , BHAT, Abhijit Suresh , FU, Yanwen , OATES, Bryan Douglas , GANG, Chen , BRADSHAW, Curt William
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders assoiated with abnormal angiogenesis.
Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供了肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2002089739A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/014500
申请日：2002-05-09
IPC: A61K
CPC classification number: B82Y5/00 , A61K38/00 , A61K47/556 , A61K47/67 , C07K5/0606 , C07K5/06191 , Y02A50/473
Abstract: This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting themicroorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gra m-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. Catarrhalis,E. coli, E. faecalis, H. influenzae and P. aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symtoms of an infection by a Peptide_Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
Abstract translation: 本发明提供了通过使微生物与有效量的本文所述的化合物接触来抑制表达肽脱甲硅烷基化酶的微生物的生长的方法。 该方法抑制革兰氏阳性和阴性微生物的生长，例如金黄色葡萄球菌，表皮葡萄球菌，肺炎克雷伯菌，产气荚膜梭菌，阴沟肠杆菌，卡他莫拉菌， 大肠杆菌，粪肠球菌，流感嗜血杆菌和铜绿假单胞菌。 该方法可以在体外，离体和体内实施。 还提供了一种通过向受试者施用或递送有效量的上述化合物来减轻受试者中表达Peptide_Deformylase的微生物感染症状的方法。
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公开(公告)号：WO2006094269A3
公开(公告)日：2007-01-11
申请号：PCT/US2006007865
申请日：2006-03-03
Applicant: COVX TECHNOLOGIES IRELAND LTD , BRADSHAW CURT W , DOPPALAPUDI VENKATA RAMANA , LAI JING-YU , RIZZO JOHN
Inventor： BRADSHAW CURT W , DOPPALAPUDI VENKATA RAMANA , LAI JING-YU , RIZZO JOHN
CPC classification number: C07K7/02 , A61K38/00 , C07K7/06 , C07K16/40 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
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公开(公告)号：WO03088913A8
公开(公告)日：2005-01-06
申请号：PCT/US0311981
申请日：2003-04-17
Applicant: CELMED ONCOLOGY USA INC , SERGEEVA MARIA V , DOPPALAPUDI VENKATA RAMANA
Inventor： SERGEEVA MARIA V , DOPPALAPUDI VENKATA RAMANA
IPC: A61K47/48 , A61K49/00 , C12Q1/18 , A61K31/4709 , A61K39/02 , C07C69/017 , C07D307/42 , C07D401/04
CPC classification number: C12Q1/18 , A61K47/556 , A61K47/65 , A61K47/67 , A61K49/0004 , B82Y5/00
Abstract: This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, and E. cloacae. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
Abstract translation: 本发明提供了通过使微生物与有效量的本文所述的化合物接触来抑制表达肽脱甲硅烷基化酶的微生物生长的方法。 该方法抑制革兰氏阳性和革兰氏阴性微生物例如金黄色葡萄球菌，表皮葡萄球菌，肺炎克雷伯菌，产气荚膜梭菌和阴沟肠杆菌的生长。 该方法可以在体外，离体和体内实施。 还提供了一种通过向受试者施用或递送有效量的上述化合物来减轻受试者中表达肽变态酶的微生物的感染症状的方法。
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公开(公告)号：WO2004043400A3
公开(公告)日：2004-05-27
申请号：PCT/US2003/036124
申请日：2003-11-14
Applicant: NEWBIOTICS, INC. , BALLATORE, Carlo , DOPPALAPUDI, Venkata, Ramana , SERGEEVA, Maria, V.
Inventor： BALLATORE, Carlo , DOPPALAPUDI, Venkata, Ramana , SERGEEVA, Maria, V.
IPC: C07F9/28
Abstract: This invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula (I).
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公开(公告)号：WO2003088913A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011981
申请日：2003-04-17
Applicant: NEWBIOTICS, INC. , SERGEEVA, Maria, V. , DOPPALAPUDI, Venkata, Ramana
Inventor： SERGEEVA, Maria, V. , DOPPALAPUDI, Venkata, Ramana
IPC: A61K31/4709
Abstract: This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, and E. cloacae. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
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