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    ASSAY FOR IDENTIFYING AGENTS THAT MODULATE EPIGENETIC SILENCING, AND AGENTS IDENTIFIED THEREBY
    3.
    发明申请
    ASSAY FOR IDENTIFYING AGENTS THAT MODULATE EPIGENETIC SILENCING, AND AGENTS IDENTIFIED THEREBY 审中-公开
    用于识别调节沉默剂的试剂的测定和鉴定的试剂

    公开(公告)号：WO2009134418A3

    公开(公告)日：2010-01-21

    申请号：PCT/US2009002677

    申请日：2009-04-30

    Applicant: FOX CHASE CANCER CT ,  KATZ RICHARD A ,  SKALKA ANNA MARIE

    Inventor： KATZ RICHARD A ,  SKALKA ANNA MARIE

    IPC: C12Q1/68 ,  C12N5/00

    CPC classification number: C12N15/111 ,  C12N2320/12

    Abstract: A high throughput RNAi-based assay for identify factors involved in maintaining epigenetic silencing is disclosed. The assay measures reactivation of a silent reporter gene in cells, resulting from RNAi-based knockdown of target mRNA. RNAi-based screening of these silent reporter cells has identified known enzymes that place or remove epigenetic marks on histones, as well as non-enzymatic proteins that function in silencing or in transfer of marks during S-phase. In addition, the screen has been used to identify a number of novel gene products involved in epigenetic silencing, which are also disclosed.

    Abstract translation: 公开了用于识别维持表观遗传学沉默的因素的高通量RNAi测定。 该测定法测定细胞中无声报道基因的再活化，由基于RNAi的靶mRNA敲低引起。 这些无声报道细胞的基于RNAi的筛选已经鉴定了在组蛋白中放置或除去表观遗传标记的已知酶，以及在S期期间沉默或转移标记的非酶蛋白质。 此外，该屏幕已经用于鉴定参与表观遗传学沉默的许多新的基因产物，这也被公开。

    TARGET DESIGN FOR HIGH-POWER LASER ACCELERATED IONS
    7.
    发明申请
    TARGET DESIGN FOR HIGH-POWER LASER ACCELERATED IONS 审中-公开
    大功率激光加速离子的目标设计

    公开(公告)号：WO2006086084A2

    公开(公告)日：2006-08-17

    申请号：PCT/US2005046838

    申请日：2005-12-22

    Applicant: FOX CHASE CANCER CT ,  FOURKAL EUGENE S ,  VELTCHEV LAVOR ,  MA CHANG MING

    Inventor： FOURKAL EUGENE S ,  VELTCHEV LAVOR ,  MA CHANG MING

    IPC: C12Q1/68

    CPC classification number: H01J27/24 ,  G21B1/19 ,  H01L21/268 ,  Y02E30/16

    Abstract: Methods for designing a laser-accelerated ion beam are disclosed. The methods include modeling a system including a heavy ion layer, an electric field, and high energy light positive ions having a maximum light positive ion energy, correlating physical parameters of the heavy ion layer, the electric field, and the maximum light positive ion energy using the model, and varying the parameters of the heavy ion layer to optimize the energy distribution of the high energy light positive ions. One method includes analyzing the acceleration of light positive ions, for example protons, through interaction of a high-power laser pulse with a double-layer target using two-dimensional particle-in-cell (PIC) simulations and a one-dimensional analytical model. The maximum energy acquired by the accelerated light positive ions, e.g., protons, in this model depends on the physical characteristics of the heavy-ion layer-the electron-ion mass ratio and effective charge state of the ions. The hydrodynamic equations for both electron and heavy ion species solved and the test-particle approximation for the protons is applied. It was found that the heavy ion motion modifies the longitudinal electric field distribution, thus changing the acceleration conditions for the light positive ions.

    Abstract translation: 公开了设计激光加速离子束的方法。 所述方法包括对包括重离子层，电场和具有最大的光正离子能量的高能量的光正离子进行建模，将重离子层的物理参数，电场和最大的光正离子能量相关联 使用该模型，改变重离子层的参数，以优化高能光阳离子的能量分布。 一种方法包括通过使用二维粒子单元（PIC）模拟的高功率激光脉冲与双层靶的相互作用来分析光正离子（例如质子）的加速度，以及一维分析模型 。 在该模型中由加速的光正离子（例如质子）获得的最大能量取决于重离子层的物理特性 - 离子的电子 - 离子质量比和有效电荷状态。 解决了电子和重离子物质的流体动力学方程，并应用质子的测试粒子近似。 发现重离子运动改变纵向电场分布，从而改变光正离子的加速条件。

    METHODS FOR SCREENING FOR INHIBITORS OF AUTOINHIBITED PROTEINS
    8.
    发明申请
    METHODS FOR SCREENING FOR INHIBITORS OF AUTOINHIBITED PROTEINS 审中-公开
    筛选自限性蛋白抑制剂的方法

    公开(公告)号：WO2006029337A3

    公开(公告)日：2006-05-04

    申请号：PCT/US2005032195

    申请日：2005-09-09

    Applicant: FOX CHASE CANCER CT ,  CHERNOFF JONATHAN ,  PETERSON JEFFREY R

    Inventor： CHERNOFF JONATHAN ,  PETERSON JEFFREY R

    IPC: C12Q1/00 ,  A01N61/00 ,  C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/485 ,  G01N2500/00

    Abstract: Methods for obtaining highly target-specific inhibitory compounds are disclosed. These inhibitory compounds provide for the preservation of a native, non-activated form of an autoinhibited molecule, such as a protein or enzyme. The inhibitory compounds are further described as essentially free of inhibitory activity for non-native forms of an autoinhibited molecule of interest. By way of example, such autoinhibited molecules of interest include proteins and enzymes, such as the p-21-activated kinases (Paks) and the Rho-activated proteins. The inhibitory compounds act by binding to a distinct, autoinhibitory domain of an autoinhibited molecule (protein), and thereby stabilize an autoinhibited conformation of the molecule (protein). Preparations, including pharmaceutical preparations, compromising a composition enriched for the inhibitory compounds are also disclosed.

    Abstract translation: 公开了获得高度靶特异性抑制化合物的方法。 这些抑制性化合物提供了天然非活化形式的自抑制分子如蛋白质或酶的保存。 抑制性化合物被进一步描述为基本上不存在对非天然形式的自动抑制的感兴趣的分子的抑制活性。 举例来说，此类自抑制感兴趣的分子包括蛋白质和酶，例如p-21激活的激酶（Paks）和Rho激活的蛋白质。 抑制性化合物通过与自动抑制分子（蛋白质）的不同自动抑制结构域结合起作用，从而稳定分子（蛋白质）的自动抑制构象。 还公开了包含药物制剂的制剂，这些制剂损害了富含抑制性化合物的组合物。

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