公开(公告)号：WO2014121330A1

公开(公告)日：2014-08-14

申请号：PCT/AU2014/000088

申请日：2014-02-06

申请人： HATCH ASSOCIATES PTY LTD ,  FRASER, Robert John ,  JOHNSTON, Timothy George ,  ROBINSON, Douglas John ,  WHITE, Mathew George

发明人： FRASER, Robert John ,  JOHNSTON, Timothy George ,  ROBINSON, Douglas John ,  WHITE, Mathew George

IPC分类号： C25D21/04 ,  C25C7/00

CPC分类号： C25D21/04 ,  C25C7/00

摘要： An acid mist control apparatus (10) for the control of acid mist emissions in an electrolytic cell, the apparatus comprising: an elongate hood (12) having longitudinal edges (14), an upper surface (16) and a lower surface (18); and a receiving aperture (20), wherein the receiving aperture (20) is adapted to receive therethrough an anode (22) of an electrolytic cell.

摘要翻译： 一种用于控制电解池中酸雾排放的酸雾控制装置（10），该装置包括：具有纵向边缘（14），上表面（16）和下表面（18）的细长罩（12） ; 和接收孔（20），其中所述接收孔（20）适于通过其中的电解池的阳极（22）接收。

公开(公告)号：WO2007109324A3

公开(公告)日：2008-11-27

申请号：PCT/US2007007025

申请日：2007-03-21

申请人： XENON PHARMACEUTICALS INC ,  FRASER ROBERT A ,  SHERRINGTON ROBIN ,  MACDONALD MARCIA L ,  SAMUELS MARK ,  NEWMAN SCOTT ,  FU JIAN-MIN ,  KAMBOJ RAJENDER

发明人： FRASER ROBERT A ,  SHERRINGTON ROBIN ,  MACDONALD MARCIA L ,  SAMUELS MARK ,  NEWMAN SCOTT ,  FU JIAN-MIN ,  KAMBOJ RAJENDER

IPC分类号： C12Q1/68 ,  C12N15/113 ,  C12P21/02

CPC分类号： C12Q1/6883 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/5088 ,  G01N33/574 ,  G01N33/6872 ,  G01N33/9486 ,  G01N2500/04 ,  G01N2800/2842

摘要： The present invention relates to the discovery that mutations in Nav1.7 are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the Nav1.7 gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for Nav1.7, and are useful in the treatment of pain and other Nav1.7-mediated disorders. The invention discloses potent and selective small molecule inhibitors of Nay1.7 and also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.

摘要翻译： 本发明涉及Nav1.7突变是人类先天性疼痛（CIP）的原因的发现。 本发明还涉及使用Nav1.7基因及其表达产物的方法，用于筛选和鉴定对Nav1.7具有选择性的治疗剂，包括小有机化合物，并且可用于治疗疼痛和其他Nav1 .7介导的疾病。 本发明公开了Nay1.7的有效和选择性的小分子抑制剂，并且还涉及使用这些化合物来治疗或改善此类疾病的方法。

公开(公告)号：WO2008121859A1

公开(公告)日：2008-10-09

申请号：PCT/US2008058728

申请日：2008-03-28

申请人： XENON PHARMACEUTICALS INC ,  KAMBOJ RAJENDER ,  FRASER ROBERT ,  FU JIANMIN ,  KODUMURU VISHNUMURTHY ,  SADALAPURE KASHINATH

发明人： KAMBOJ RAJENDER ,  FRASER ROBERT ,  FU JIANMIN ,  KODUMURU VISHNUMURTHY ,  SADALAPURE KASHINATH

IPC分类号： A61K31/165 ,  A61K31/166 ,  A61K31/381 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/24

CPC分类号： A61K31/165 ,  A61K31/166 ,  A61K31/381

摘要： This invention is directed to compounds of formula (I): wherein , , n, r, q, R1, R2, R3 and R4 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

摘要翻译： 本发明涉及式（I）化合物：其中，n，r，q，R 1，R 2，R 3和R 4如本文所定义，为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，包含该化合物的药物组合物和使用该化合物和药物组合物用于治疗和/或预防钠通道介导的疾病或病症例如疼痛的方法。

公开(公告)号：WO2008060789A3

公开(公告)日：2008-07-24

申请号：PCT/US2007081247

申请日：2007-10-12

申请人： XENON PHARMACEUTICALS INC ,  CHAFEEV MIKHAIL ,  CHOWDHURY SULTAN ,  FRASER ROBERT ,  FU JIANMIN ,  KAMBOJ RAJENDER ,  HOU DUANJIE ,  LIU SHIFENG ,  SEID BAGHERZADEH MEHRAN ,  SVIRIDOV SERGUEI ,  SUN SHAOYI ,  SUN JIANYU ,  CHAKKA NAGASREE ,  HSIEH TOM ,  RAINA VANDNA

发明人： CHAFEEV MIKHAIL ,  CHOWDHURY SULTAN ,  FRASER ROBERT ,  FU JIANMIN ,  KAMBOJ RAJENDER ,  HOU DUANJIE ,  LIU SHIFENG ,  SEID BAGHERZADEH MEHRAN ,  SVIRIDOV SERGUEI ,  SUN SHAOYI ,  SUN JIANYU ,  CHAKKA NAGASREE ,  HSIEH TOM ,  RAINA VANDNA

IPC分类号： A61K31/437 ,  A61K31/407 ,  A61P3/06 ,  A61P13/08 ,  A61P17/04 ,  A61P35/00

CPC分类号： A61K31/407 ,  A61K31/437

摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.

摘要翻译： 本发明涉及使用式（I）的螺 - 羟吲哚化合物的方法：其中k，j，Q，R 1，R 2a，R 2b，2b R 2c，R 2d，R 3a，R 3b，R 3c， R 3和R 3如本文所定义，为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，用于治疗和/或预防高胆固醇血症，良性前列腺增生，瘙痒症和癌症。

公开(公告)号：WO2008046083A2

公开(公告)日：2008-04-17

申请号：PCT/US2007081319

申请日：2007-10-12

申请人： XENON PHARMACEUTICALS INC ,  CHAFEEV MIKHAIL ,  CHAKKA NAGASREE ,  CHOWDHURY SULTAN ,  FRASER ROBERT ,  FU JIANMIN ,  HOU DUANJIE ,  HSIEH TOM ,  KAMBOJ RAJENDER ,  LIU SHIFENG ,  RAINA VANDNA ,  SEID BAGHERZADEH MEHRAN ,  SUN JIANYU ,  SUN SHAOYI ,  SVIRIDOV SERGUEI

发明人： CHAFEEV MIKHAIL ,  CHAKKA NAGASREE ,  CHOWDHURY SULTAN ,  FRASER ROBERT ,  FU JIANMIN ,  HOU DUANJIE ,  HSIEH TOM ,  KAMBOJ RAJENDER ,  LIU SHIFENG ,  RAINA VANDNA ,  SEID BAGHERZADEH MEHRAN ,  SUN JIANYU ,  SUN SHAOYI ,  SVIRIDOV SERGUEI

CPC分类号： A61K31/404

摘要： This invention is directed to methods of using oxindole compounds for the treatment and/or prevention of diseases or conditions such as hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.

摘要翻译： 本发明涉及使用羟吲哚化合物治疗和/或预防高胆固醇血症，良性前列腺增生症，瘙痒症和癌症等疾病或病症的方法。

公开(公告)号：WO2008046082A2

公开(公告)日：2008-04-17

申请号：PCT/US2007/081318

申请日：2007-10-12

申请人： XENON PHARMACEUTICALS INC. ,  CHAFEEV, Mikhail ,  CHOWDHURY, Sultan ,  FRASER, Robert ,  FU, Jianmin ,  KAMBOJ, Rajender ,  LIU, Shifeng ,  RAINA, Vandna ,  SEID BAGHERZADEH, Mehran ,  SUN, Jianyu ,  SVIRIDOV, Serguei

发明人： CHAFEEV, Mikhail ,  CHOWDHURY, Sultan ,  FRASER, Robert ,  FU, Jianmin ,  KAMBOJ, Rajender ,  LIU, Shifeng ,  RAINA, Vandna ,  SEID BAGHERZADEH, Mehran ,  SUN, Jianyu ,  SVIRIDOV, Serguei

CPC分类号： A61K31/438

摘要： This invention is directed to the use of heterocyclic compounds for the treatment and/or prevention of diseases or conditions such as hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.

摘要翻译： 本发明涉及杂环化合物用于治疗和/或预防高胆固醇血症，良性前列腺增生症，瘙痒症和癌症等疾病或病症的用途。

公开(公告)号：WO2008033599A2

公开(公告)日：2008-03-20

申请号：PCT/US2007/072468

申请日：2007-06-29

申请人： THE GLAD PRODUCTS COMPANY ,  DORSEY, Robert, T. ,  FRASER, Robert, W. ,  MACK-ROBLES, Nancy, M. ,  BROERING, Shaun, T. ,  TOERNER, Karin, L.

发明人： DORSEY, Robert, T. ,  FRASER, Robert, W. ,  MACK-ROBLES, Nancy, M. ,  BROERING, Shaun, T. ,  TOERNER, Karin, L.

IPC分类号： B65D30/02

CPC分类号： B65F1/0006

摘要： The bag for receiving refuse may include a bag body, the bag body including an inside surface, an outside surface, and a rim defining a mouth. The bag may also include a first strip of material disposed on the inside surface of the bag body proximate the rim. The strip may include an inside surface, an outside surface that faces the inside surface of the body, a top edge, and a bottom edge. The bag may also include a front wall, a back wall, and a hem, the hem including a drawstring. The strip may include a printed design. The design could be letters, numbers, pictures, writing, or any other design. When the bag is inserted into a trash receptacle such that the rim of the bag is folded over the rim of the receptacle, the printed design is visible from outside the receptacle.

公开(公告)号：WO2008008644A3

公开(公告)日：2008-01-17

申请号：PCT/US2007/072476

申请日：2007-06-29

申请人： THE GLAD PRODUCTS COMPANY ,  BROERING, Shaun, T. ,  TOERNER, Karin, L. ,  FRASER, Robert, W. ,  SNORECK, Charles, B.

发明人： BROERING, Shaun, T. ,  TOERNER, Karin, L. ,  FRASER, Robert, W. ,  SNORECK, Charles, B.

IPC分类号： B65D33/28

摘要： The bag for receiving refuse may include a bag body, the bag body including an inside surface, an outside surface, and a rim defining a mouth. The bag may also include a first strip of material disposed on the inside surface of the bag body proximate the rim. The strip may include an inside surface, an outside surface that faces the inside surface of the body, a top edge, and a bottom edge. The bag may also include a front wall, a back wall, and a hem, the hem including a drawstring. The strip may include a printed design. The design could be letters, numbers, pictures, writing, or any other design. When the bag is inserted into a trash receptacle such that the rim of the bag is folded over the rim of the receptacle, the printed design is visible from outside the receptacle.

公开(公告)号：WO2008008640A2

公开(公告)日：2008-01-17

申请号：PCT/US2007/072460

申请日：2007-06-29

申请人： THE GLAD PRODUCTS COMPANY ,  DORSEY, Robert, T. ,  FRASER, Robert, W. ,  MACK-ROBLES, Nancy, M. ,  BROERING, Shaun, T. ,  TOERNER, Karin, L.

发明人： DORSEY, Robert, T. ,  FRASER, Robert, W. ,  MACK-ROBLES, Nancy, M. ,  BROERING, Shaun, T. ,  TOERNER, Karin, L.

IPC分类号： B65D65/22

CPC分类号： B65F1/0006

摘要： The bag for receiving refuse may include a bag body, the bag body including an inside surface, an outside surface, and a rim defining a mouth. The bag may also include a first strip of material disposed on the inside surface of the bag body proximate the rim. The strip may include an inside surface, an outside surface that faces the inside surface of the body, a top edge, and a bottom edge. The bag may also include a front wall, a back wall, and a hem, the hem including a drawstring. The strip may include a printed design. The design could be letters, numbers, pictures, writing, or any other design. When the bag is inserted into a trash receptacle such that the rim of the bag is folded over the rim of the receptacle, the printed design is visible from outside the receptacle.

摘要翻译： 用于接收垃圾的袋子可以包括袋子主体，袋子主体包括内表面，外表面和限定口的边缘。 袋子还可以包括布置在靠近边缘的袋体的内表面上的第一条材料。 条带可以包括内表面，面向主体的内表面的外表面，顶部边缘和底部边缘。 该包还可以包括前壁，后壁和下摆，下摆包括拉绳。 该条可以包括印刷设计。 设计可以是字母，数字，图片，文字或任何其他设计。 当将袋子插入垃圾容器中使得袋子的边缘折叠在容器的边缘上时，从容器外部可以看到印刷图案。

公开(公告)号：WO2006113875A3

公开(公告)日：2007-05-10

申请号：PCT/US2006014887

申请日：2006-04-20

申请人： XENON PHARMACEUTICALS INC ,  CHAFEEV MIKHAIL ,  CHOWDHURY SULTAN ,  FRASER ROBERT ,  FU JIANMIN ,  KAMBOJ RAJENDER ,  BAGHERZADEH MEHRAN SEID ,  SVIRIDOV SERGUEI ,  RAINA VANDNA ,  LIU SHIFENG ,  SUN JIANYU

发明人： CHAFEEV MIKHAIL ,  CHOWDHURY SULTAN ,  FRASER ROBERT ,  FU JIANMIN ,  KAMBOJ RAJENDER ,  BAGHERZADEH MEHRAN SEID ,  SVIRIDOV SERGUEI ,  RAINA VANDNA ,  LIU SHIFENG ,  SUN JIANYU

IPC分类号： C07D471/04 ,  A61K31/44 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D405/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： The current invention is directed to 2-Pyrrolidone derivatives of formula (I); Due to their interaction with voltage-gated sodium channels these compounds are useful for the treatment of inflammatory conditions and pain.

摘要翻译： 本发明涉及式（I）的2-吡咯烷酮衍生物; 由于它们与电压门控钠通道的相互作用，这些化合物可用于治疗炎性疾病和疼痛。