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    METHOD OF MAKING A MICROMOULD AND A MICROMOULDED ARTICLE
    1.
    发明申请
    METHOD OF MAKING A MICROMOULD AND A MICROMOULDED ARTICLE 审中-公开
    制作微型和微型文章的方法

    公开(公告)号：WO2006135794A3

    公开(公告)日：2007-02-22

    申请号：PCT/US2006022570

    申请日：2006-06-08

    Applicant: 3M INNOVATIVE PROPERTIES CO ,  FREDERICKSON FRANKLYN L ,  FERGUSON DENNIS E

    Inventor： FREDERICKSON FRANKLYN L ,  FERGUSON DENNIS E

    IPC: B81C1/00 ,  B29C33/00

    CPC classification number: B81C99/009 ,  B29C33/00 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

    Abstract: The present invention is directed to a method of forming a mold for use in making molded articles having a plurality of microprojections. Additionally, the present invention provides a method of forming a molded article having a plurality of microprojections. In one aspect, a mold workpiece is provided, a tool having a tip with a shape corresponding to the microprojection, wherein the hardness of the tool is greater than that of the mold workpiece, is pressed into the mold workpiece and removed, thereby creating a mold with a microprojection cavity suitable for use in making the molded article.

    Abstract translation: 本发明涉及一种形成用于制造具有多个微喷射体的模制品的模具的方法。 另外，本发明提供了形成具有多个微喷射体的成型品的方法。 一方面，提供了模具工件，具有具有对应于微喷射体的形状的尖端的工具，其中刀具的硬度大于模具工件的硬度，被压入模具工件并移除，从而形成 具有适合用于制造模制品的微型喷射腔的模具。

    METHOD OF MAKING A MOLD AND MOLDED ARTICLE
    2.
    发明申请
    METHOD OF MAKING A MOLD AND MOLDED ARTICLE 审中-公开
    制作模具和模制品的方法

    公开(公告)号：WO2006135794A2

    公开(公告)日：2006-12-21

    申请号：PCT/US2006/022570

    申请日：2006-06-08

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FREDERICKSON, Franklyn, L. ,  FERGUSON, Dennis, E.

    Inventor： FREDERICKSON, Franklyn, L. ,  FERGUSON, Dennis, E.

    IPC: B81C1/00 ,  B29C33/00

    CPC classification number: B81C99/009 ,  B29C33/00 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

    Abstract: The present invention is directed to a method of forming a mold for use in making molded articles having a plurality of microprojections. Additionally, the present invention provides a method of forming a molded article having a plurality of microprojections. In one aspect, a mold workpiece is provided, a tool having a tip with a shape corresponding to the microprojection, wherein the hardness of the tool is greater than that of the mold workpiece, is pressed into the mold workpiece and removed, thereby creating a mold with a microprojection cavity suitable for use in making the molded article.

    Abstract translation: 本发明涉及一种形成用于制造具有多个微喷射体的模制品的模具的方法。 另外，本发明提供了形成具有多个微喷射体的成型品的方法。 一方面，提供了模具工件，具有具有对应于微喷射体的形状的尖端的工具，其中刀具的硬度大于模具工件的硬度，被压入模具工件并移除，从而形成 具有适合用于制造模制品的微型喷射腔的模具。

    MICRONEEDLE ARRAY APPLICATOR AND RETAINER
    3.
    发明申请
    MICRONEEDLE ARRAY APPLICATOR AND RETAINER 审中-公开
    MICRONEEDLE ARRAY应用程序和保留器

    公开(公告)号：WO2006055802A1

    公开(公告)日：2006-05-26

    申请号：PCT/US2005/041870

    申请日：2005-11-18

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  RINGSRED, Ted K., ,  FREDERICKSON, Franklyn L.,

    Inventor： RINGSRED, Ted K., ,  FREDERICKSON, Franklyn L.,

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2025/0253 ,  A61M2025/026 ,  A61M2037/0023

    Abstract: An applicator that has an elastic band to snap a microneedle array against the skin with a predetermined force and velocity. The microneedle array, which may be pre-loaded with drug(s), is attached to the elastic band such that the band can be secured in place (e.g., wrapped around a person's arm), pulled away from the arm, and released from a suitable distance so that the microneedle array snaps back against the arm with sufficient force to cause the intended amount of penetration of the microneedles. Also, a microneedle application device that has an elastic band, a microneedle device, and means for attaching the band to the microneedle device.

    Abstract translation: 具有弹性带的敷贴器，用于以预定的力和速度将微针阵列卡扣在皮肤上。 可以预先装载药物的微针阵列附接到弹性带，使得带可以固定在适当位置（例如，缠绕在人的手臂上），从臂拉出并从臂释放 适当的距离，使得微针阵列以足够的力以相反的方式向后靠靠在臂上以引起微针的预期穿透量。 此外，具有弹性带的微针施加装置，微针装置以及用于将带附着到微针装置的装置。

    LOW-PROFILE MICRONEEDLE ARRAY APPLICATOR
    4.
    发明申请
    LOW-PROFILE MICRONEEDLE ARRAY APPLICATOR 审中-公开
    低轮廓麦克风阵列应用者

    公开(公告)号：WO2006055795A1

    公开(公告)日：2006-05-26

    申请号：PCT/US2005/041854

    申请日：2005-11-18

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CANTOR, Adam, S. ,  FREDERICKSON, Franklyn, L. ,  JOHNSON, Peter, R. ,  RINGSRED, Ted, R.

    Inventor： CANTOR, Adam, S. ,  FREDERICKSON, Franklyn, L. ,  JOHNSON, Peter, R. ,  RINGSRED, Ted, R.

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023

    Abstract: An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

    Abstract translation: 用于将微针阵列（10）施用于哺乳动物的施加器（100）。 特别地，一种用于将微针装置（120）施加到皮肤表面的施加装置，所述皮肤表面包括具有附接到所述微针装置的凸起中心区域（115）的柔性片（110）和在所述柔性片的周边处或附近的支撑构件 其中所述柔性片被构造成使得其将在与所述片材的主平面正交的方向上进行逐步运动。

    DEVICE FOR APPLYING A MICRONEEDLE ARRAY
    5.
    发明申请
    DEVICE FOR APPLYING A MICRONEEDLE ARRAY 审中-公开
    用于应用麦克风阵列的设备

    公开(公告)号：WO2007124411A1

    公开(公告)日：2007-11-01

    申请号：PCT/US2007/067063

    申请日：2007-04-20

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  SIMONS, John, K. ,  FREDERICKSON, Franklyn, L.

    Inventor： SIMONS, John, K. ,  FREDERICKSON, Franklyn, L.

    IPC: A61N1/30 ,  A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

    Abstract: A device (100) for applying a microneedle array to a skin surface. The device comprises a base (120) defining a skin contacting plane, an array component having a skin facing side comprising a microneedle array, and at least one connecting member (140) having a first portion affixed through a first hinge (142) to the base and a second portion affixed to the array component. The connecting member has a first equilibrium position with the microneedle array in a recessed position within the device and a second equilibrium position with the microneedle array positioned so as to be able to contact a skin surface.

    Abstract translation: 一种用于将微针阵列施加到皮肤表面的装置（100）。 该装置包括限定皮肤接触平面的基部（120），具有面向皮肤的侧面的阵列部件，其包括微针阵列，以及至少一个连接部件（140），第一部分通过第一铰链（142）固定到 基部和固定到阵列部件的第二部分。 连接构件具有第一平衡位置，其中微针阵列处于装置内的凹陷位置，并且第二平衡位置与微针阵列定位成能够接触皮肤表面。

    MICRONEEDLE ARRAY APPLICATOR DEVICE
    6.
    发明申请
    MICRONEEDLE ARRAY APPLICATOR DEVICE 审中-公开

    公开(公告)号：WO2007002521A3

    公开(公告)日：2007-06-21

    申请号：PCT/US2006024671

    申请日：2006-06-23

    Applicant: 3M INNOVATIVE PROPERTIES CO ,  FREDERICKSON FRANKLYN L ,  JOHNSON MICHAEL D

    Inventor： FREDERICKSON FRANKLYN L ,  JOHNSON MICHAEL D

    IPC: A61N1/30 ,  A61B17/20 ,  A61M37/00

    CPC classification number: A61M5/158 ,  A61B17/205 ,  A61M37/0015 ,  A61M2005/1585 ,  A61M2037/0023

    Abstract: An applicator device (20) including a housing (22), an impactor (62) for impacting a microneedle array and accelerating the microneedle array toward the target site, wherein the impactor is capable of moving along an arcuate path to move the microneedle array toward the target site. Also, an applicator device including a housing, a patch applicator pivotally supported by the housing, and a torsion spring. The patch applicator has a retaining portion (40) and a patch contacting portion (70), and the patch contacting portion is capable of moving along a substantially arcuate path between a first position and a second position. The torsion spring is capable of biasing the patch applicator relative to the housing.

    Abstract translation: 一种涂抹器装置（20），包括壳体（22），用于冲击微针阵列并将微针阵列加速朝向目标部位的冲击器（62），其中冲击器能够沿着弧形路径移动以将微针阵列朝向 目标网站。 而且，包括壳体，由壳体可枢转地支撑的贴片施加器和扭转弹簧的施加器装置。 贴片施加器具有保持部分（40）和贴片接触部分（70），并且贴片接触部分能够沿第一位置和第二位置之间的大致弧形路径移动。 扭转弹簧能够相对于壳体偏置贴片施加器。

    MICRONEEDLE ARRAY APPLICATOR DEVICE AND METHOD OF ARRAY APPLICATION
    10.
    发明申请
    MICRONEEDLE ARRAY APPLICATOR DEVICE AND METHOD OF ARRAY APPLICATION 审中-公开

    公开(公告)号：WO2007002521A2

    公开(公告)日：2007-01-04

    申请号：PCT/US2006/024671

    申请日：2006-06-23

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FREDERICKSON, Franklyn, L., ,  JOHNSON, Michael, D.,

    Inventor： FREDERICKSON, Franklyn, L., ,  JOHNSON, Michael, D.,

    IPC: A61N1/30 ,  A61M37/00 ,  A61B17/20

    CPC classification number: A61M5/158 ,  A61B17/205 ,  A61M37/0015 ,  A61M2005/1585 ,  A61M2037/0023

    Abstract: An applicator device including a housing, an impactor for impacting a microneedle array and accelerating the microneedle array toward the target site, wherein the impactor is capable of moving along an arcuate path to move the microneedle array toward the target site. Also, an applicator device including a housing, a patch applicator pivotally supported by the housing, and a torsion spring. The patch applicator has a retaining portion and a patch contacting portion, and the patch contacting portion is capable of moving along a substantially arcuate path between a first position and a second position. The torsion spring is capable of biasing the patch applicator relative to the housing.

    Abstract translation: 一种涂抹器装置，包括壳体，用于冲击微针阵列的冲击器，并且将微针阵列加速到目标位置，其中冲击器能够沿着弧形路径移动以将微针阵列移向目标位置。 而且，包括壳体，由壳体可枢转地支撑的贴片施加器和扭转弹簧的施加器装置。 贴片施加器具有保持部分和贴片接触部分，并且贴片接触部分能够沿第一位置和第二位置之间的大致弧形路径移动。 扭转弹簧能够相对于壳体偏置贴片施加器。

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