公开(公告)号：WO2005064349A2

公开(公告)日：2005-07-14

申请号：PCT/US2004/042455

申请日：2004-12-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CARTER, Chad, J. ,  DODGE, Larry, H. ,  GASON, Samuel, J. ,  JOHNSTON, Raymond, P. ,  SMITH, Jeffrey, D. ,  WOOD, Kenneth, B.

Inventor： CARTER, Chad, J. ,  DODGE, Larry, H. ,  GASON, Samuel, J. ,  JOHNSTON, Raymond, P. ,  SMITH, Jeffrey, D. ,  WOOD, Kenneth, B.

IPC: G01N35/00

CPC classification number: G01N29/022 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/523 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/0683 ,  B01L2400/086 ,  B01L2400/088 ,  C07C311/51 ,  C07D207/46 ,  C07D275/06 ,  G01N29/222 ,  G01N29/2462 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02881 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: Detection cartridges and associated components, as well as methods of using the same that provide sample materials to a sensor for detection are disclosed. Among the components that may be used in connection with the detection cartridges of the present invention are, e.g., input modules, fluid flow front control features, and volumetric flow rate control features. The modules may include one or more chambers containing different constituents for mixing and/or delivery into a detection cartridge.

Abstract translation: 公开了检测盒和相关组件，以及将样品材料提供给用于检测的传感器的使用方法。 可以与本发明的检测盒结合使用的部件可以是例如输入模块，流体流前端控制特征和体积流量控制特征。 模块可以包括一个或多个包含用于混合和/或递送到检测盒中的不同组分的室。

公开(公告)号：WO2006062848A1

公开(公告)日：2006-06-15

申请号：PCT/US2005/043769

申请日：2005-12-05

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CARTER, Chad J., ,  FREDERICKSON, Franklyn L. ,  HANSEN, Richard G., ,  HART, John R., ,  LANDIN, Donald T., ,  TOKIE, Jeffrey H., ,  WIRTANEN, David J.,

Inventor： CARTER, Chad J., ,  FREDERICKSON, Franklyn L. ,  HANSEN, Richard G., ,  HART, John R., ,  LANDIN, Donald T., ,  TOKIE, Jeffrey H., ,  WIRTANEN, David J.,

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023

Abstract: A medical device (20) is provided that is suitable for use in the delivery of active component into or through the skin. The medical device comprises: an extension member (22) having a first major surface (24) and a second major surface (26), the first major surface comprising a first portion and a second portion; an array retaining member (28) extending from the first portion of the first major surface of the extension member, the array retaining member comprising an array surface (30) having at least one microneedle (32) extending from the array surface; and pressure sensitive adhesive (34) disposed on the second portion of the first major surface of the extension member to facilitate the adhesive attachment of the device to mammalian skin when the at least one microneedle is inserted through the stratum corneum.

Abstract translation: 提供了适用于将活性成分输送入皮肤或通过皮肤的医疗装置（20）。 医疗装置包括：具有第一主表面（24）和第二主表面（26）的延伸构件（22），所述第一主表面包括第一部分和第二部分; 阵列保持构件（28），其从所述延伸构件的所述第一主表面的第一部分延伸，所述阵列保持构件包括具有从所述阵列表面延伸的至少一个微针（32）的阵列表面（30） 以及设置在延伸构件的第一主表面的第二部分上的压敏粘合剂（34），以便当至少一个微针穿过角质层时，便于将装置粘附到哺乳动物皮肤上。

公开(公告)号：WO2005075973A3

公开(公告)日：2005-08-18

申请号：PCT/US2004/042662

申请日：2004-12-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CARTER, Chad, J. ,  DAVID, Moses, M. ,  DODGE, Larry, H. ,  FREE, M., Benton ,  GASON, Samuel, J. ,  HUIZINGA, John, S. ,  JOHNSTON, Raymond, P. ,  LAKSHMI, Brinda, B. ,  MACH, Patrick, A. ,  MARTIN, Larry, G. ,  PEKUROVSKY, Mikhail, L. ,  SCHABERG, Mark, S. ,  SMITH, Jeffrey, D. ,  WOOD, Kenneth, B. ,  XU, Wenyuan

Inventor： CARTER, Chad, J. ,  DAVID, Moses, M. ,  DODGE, Larry, H. ,  FREE, M., Benton ,  GASON, Samuel, J. ,  HUIZINGA, John, S. ,  JOHNSTON, Raymond, P. ,  LAKSHMI, Brinda, B. ,  MACH, Patrick, A. ,  MARTIN, Larry, G. ,  PEKUROVSKY, Mikhail, L. ,  SCHABERG, Mark, S. ,  SMITH, Jeffrey, D. ,  WOOD, Kenneth, B. ,  XU, Wenyuan

IPC: G01N29/02

Abstract: Detection systems and methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g ., a surface acoustic wave sensor such as, e.g ., a shear horizontal surface acoustic wave sensor ( e.g ., a LSH-SAW sensor). A variety of techniques for modifying the effective mass of the target biological analytes in sample material are disclosed, including fractionating or disassembling the target biological analytes in the sample material ( e.g ., lysing the target biological analyte), adding a detectable mass to the target biological analyte or enhancing coupling of the target biological analyte ( e.g ., through the use of magnetic particles), exposing the sample material to a reagent that causes a change in at least detectable physical property in the sample material if the target biological analyte is present ( e.g ., a change in viscous, elastic, and/or viscoelastic properties), etc.

公开(公告)号：WO2005123173A1

公开(公告)日：2005-12-29

申请号：PCT/US2005/020283

申请日：2005-06-09

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FREDERICKSON, Franklyn, L. ,  CARTER, Chad, J. ,  KUMAR, Kanta ,  SEMONICK, Michael, A. ,  WORTMAN, David, L.

Inventor： FREDERICKSON, Franklyn, L. ,  CARTER, Chad, J. ,  KUMAR, Kanta ,  SEMONICK, Michael, A. ,  WORTMAN, David, L.

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61B17/205 ,  A61M2037/0023

Abstract: A patch application device wherein the patch is retained in position within the collar until delivery through contact of at least one obstruction inside the collar with a portion of an adhesive on the front surface (e.g., microneedle-containing surface) of the patch. The collar and patch can be used to form separate replaceable cartridges, and the combination can be provided as a kit.

Abstract translation: 一种补片应用装置，其中补片保持在套环内的适当位置，直到通过颈圈内的至少一个阻塞件与贴片前表面（例如，包含微针的表面）上的粘合剂的一部分接触而递送。 套环和贴片可以用于形成单独的可替换的盒，并且组合可以作为套件提供。

公开(公告)号：WO2005064349A3

公开(公告)日：2005-11-10

申请号：PCT/US2004042455

申请日：2004-12-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  CARTER CHAD J ,  DODGE LARRY H ,  GASON SAMUEL J ,  JOHNSTON RAYMOND P ,  SMITH JEFFREY D ,  WOOD KENNETH B

Inventor： CARTER CHAD J ,  DODGE LARRY H ,  GASON SAMUEL J ,  JOHNSTON RAYMOND P ,  SMITH JEFFREY D ,  WOOD KENNETH B

IPC: B01L3/00 ,  C07C311/51 ,  C07D207/46 ,  C07D275/06 ,  G01N29/02 ,  G01N33/543

CPC classification number: G01N29/022 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/523 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/0683 ,  B01L2400/086 ,  B01L2400/088 ,  C07C311/51 ,  C07D207/46 ,  C07D275/06 ,  G01N29/222 ,  G01N29/2462 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02881 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: Detection cartridges and associated components, as well as methods of using the same that provide sample materials to a sensor for detection are disclosed. Among the components that may be used in connection with the detection cartridges of the present invention are, e.g., input modules, fluid flow front control features, and volumetric flow rate control features. The modules may include one or more chambers containing different constituents for mixing and/or delivery into a detection cartridge.

Abstract translation: 公开了检测盒和相关部件，以及使用其提供样品材料到传感器进行检测的方法。 结合本发明的检测盒可以使用的部件有例如输入模块，流体流动前端控制特征和体积流量控制特征。 模块可以包括一个或多个腔室，其含有用于混合和/或输送到检测盒中的不同成分。

公开(公告)号：WO2005082596A1

公开(公告)日：2005-09-09

申请号：PCT/US2005/005466

申请日：2005-02-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  BOONE, Mary, R. ,  CARTER, Chad, J. ,  FREDERICKSON, Franklyn, L.

Inventor： BOONE, Mary, R. ,  CARTER, Chad, J. ,  FREDERICKSON, Franklyn, L.

IPC: B29C45/37

CPC classification number: B29C45/372 ,  A61B17/205 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C33/3842 ,  B29C33/3857 ,  B29C33/42 ,  B29C45/2669 ,  B29C45/37 ,  B29C45/561 ,  B29C45/73 ,  B29C2045/0094 ,  B29C2045/7393 ,  B29L2031/753 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C99/0085 ,  C25D1/10

Abstract: A method of manufacturing a moldable microneedle array (54) is described comprising providing a negative mold insert (44) characterized by a negative image of microneedle topography wherein at least one negative image of a microneedle is characterized by an aspect ratio of between about 2 to 1 and about 5 to 1. The negative mold insert (44) is used to define a structured surface of a negative mold cavity (42). Molten plastic material is injected into the heated negative mold cavity. The molten plastic material is subsequently cooled and detached from the mold insert to provide a molded microneedle array (54). One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin.

Abstract translation: 描述了一种制造可模制微针阵列（54）的方法，其包括提供负模具插入物（44），其特征在于微针形地形图的负像，其中微针的至少一个负像的特征在于纵横比在大约2至 负模具插入件（44）用于限定阴模腔（42）的结构化表面。 将熔融塑料材料注入加热的阴模腔中。 随后将熔融的塑料材料冷却并从模具插入件中分离以提供模制的微针阵列（54）。 使用本发明的微针阵列的一种方式是涉及皮肤渗透以递送药物或其它物质和/或通过皮肤提取血液或组织的方法。

公开(公告)号：WO2005075973A2

公开(公告)日：2005-08-18

申请号：PCT/US2004042662

申请日：2004-12-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  CARTER CHAD J ,  DAVID MOSES M ,  DODGE LARRY H ,  FREE M BENTON ,  GASON SAMUEL J ,  HUIZINGA JOHN S ,  JOHNSTON RAYMOND P ,  LAKSHMI BRINDA B ,  MACH PATRICK A ,  MARTIN LARRY G ,  PEKUROVSKY MIKHAIL L ,  SCHABERG MARK S ,  SMITH JEFFREY D ,  WOOD KENNETH B ,  XU WENYUAN

Inventor： CARTER CHAD J ,  DAVID MOSES M ,  DODGE LARRY H ,  FREE M BENTON ,  GASON SAMUEL J ,  HUIZINGA JOHN S ,  JOHNSTON RAYMOND P ,  LAKSHMI BRINDA B ,  MACH PATRICK A ,  MARTIN LARRY G ,  PEKUROVSKY MIKHAIL L ,  SCHABERG MARK S ,  SMITH JEFFREY D ,  WOOD KENNETH B ,  XU WENYUAN

IPC: B01L3/00 ,  C07C311/51 ,  C07D207/46 ,  C07D275/06 ,  G01N29/02 ,  G01N33/543

CPC classification number: G01N29/022 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/523 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/0683 ,  B01L2400/086 ,  B01L2400/088 ,  C07C311/51 ,  C07D207/46 ,  C07D275/06 ,  G01N29/222 ,  G01N29/2462 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02881 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: Detection systems and methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). A variety of techniques for modifying the effective mass of the target biological analytes in sample material are disclosed, including fractionating or disassembling the target biological analytes in the sample material (e.g., lysing the target biological analyte), adding a detectable mass to the target biological analyte or enhancing coupling of the target biological analyte (e.g., through the use of magnetic particles), exposing the sample material to a reagent that causes a change in at least detectable physical property in the sample material if the target biological analyte is present (e.g., a change in viscous, elastic, and/or viscoelastic properties), etc.

Abstract translation: 公开了使用由传感器产生的声 - 机械能来检测样品材料内目标生物分析物的检测系统和方法。 声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。 公开了用于改变样品材料中目标生物分析物的有效质量的各种技术，包括分离或分解样品材料中的目标生物分析物（例如，裂解靶生物分析物），向目标生物体中加入可检测的物质 分析物或增强靶生物分析物的耦合（例如，通过使用磁性颗粒），如果存在目标生物分析物，将样品材料暴露于导致样品材料中至少可检测的物理性质变化的试剂（例如 ，粘性，​​弹性和/或粘弹性的变化）等

公开(公告)号：WO2005065765A1

公开(公告)日：2005-07-21

申请号：PCT/US2004/041732

申请日：2004-12-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CARTER, Chad, J.

Inventor： CARTER, Chad, J.

IPC: A61M37/00

CPC classification number: A61B17/205 ,  A61B2010/008 ,  A61B2017/00473 ,  A61B2017/00477 ,  A61M5/002 ,  A61M37/0015 ,  A61M2037/0023

Abstract: A medical device is described, comprising an array (10) comprising microstructures (12) configured to penetrate the stratum corneum upon impact, and a connection member (20) affixed to the array in a one piece construction, the connection member configured to reversibly connect the medical device to an applicator. The medical devices of the invention may be used in methods requiring the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin. In use, it is generally desirable to provide the microstructures at a height sufficient to penetrate the stratum corneum. A medical kit is also described, comprising the foregoing medical device and a tray (34) configured to hold the medical device.

Abstract translation: 描述了包括阵列（10）的阵列（10），所述阵列（10）包括构造成在冲击时穿透所述角质层的微结构（12）和连接构件（20），所述连接构件（20）以单件结构固定到所述阵列，所述连接构件被配置为可逆地连接 将医疗装置用于敷贴器。 本发明的医疗装置可以用于需要穿透皮肤以递送药物或其它物质和/或通过皮肤提取血液或组织的方法。 在使用中，通常希望在足以穿透角质层的高度处提供微结构。 还描述了包括前述医疗装置和被配置为保持医疗装置的托盘（34）的医疗套件。

公开(公告)号：WO2005066621A1

公开(公告)日：2005-07-21

申请号：PCT/US2004/042663

申请日：2004-12-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CARTER, Chad, J. ,  FREE, M., Benton ,  HUIZINGA, John, S. ,  JOHNSTON, Raymond, P.

Inventor： CARTER, Chad, J. ,  FREE, M., Benton ,  HUIZINGA, John, S. ,  JOHNSTON, Raymond, P.

IPC: G01N29/02

CPC classification number: H05K3/325 ,  G01N29/022 ,  G01N29/222 ,  G01N29/2462 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0423 ,  H01L24/80 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01068 ,  H01L2924/014 ,  H05K2201/0314 ,  H05K2201/09072 ,  H05K2201/10083 ,  H05K2203/1147

Abstract: The invention is directed to a surface acoustic wave sensor assembly that makes use of a Z-axis conductive layer, such as a Z-axis conductive elastomer, or the like. In particular, a Z-axis conductive elastomer couples a circuit layer to a surface acoustic wave (SAW) sensor in order to form a SAW sensor assembly. For example, a plurality of electrical contacts of the circuit layer can be coupled to a plurality of electrodes of the SAW sensor via the Z-axis conductive elastomer. The Z-axis conductive elastomer provides electrical coupling between the electrical contacts and the electrodes, and also forms a hermetic barrier between the circuit layer and the SAW sensor. In addition, elastic properties of the Z-axis conductive elastomer may reduce pressure exerted on the SAW sensor during use.

Abstract translation: 本发明涉及利用诸如Z轴导电弹性体等Z轴导电层的表面声波传感器组件。 特别地，Z轴导电弹性体将电路层耦合到声表面波（SAW）传感器，以形成SAW传感器组件。 例如，电路层的多个电触点可以通过Z轴导电弹性体耦合到SAW传感器的多个电极。 Z轴导电弹性体在电触点和电极之间提供电耦合，并且还在电路层和SAW传感器之间形成气密屏障。 此外，Z轴导电弹性体的弹性特性可减少在使用过程中施加在SAW传感器上的压力。