公开(公告)号：WO1998010055A1

公开(公告)日：1998-03-12

申请号：PCT/JP1997003016

申请日：1997-08-29

Applicant: KANEKA CORPORATION ,  YAMASHITA, Kenji ,  FUKUCHI, Takeshi ,  NISHINO, Tomoko

Inventor： KANEKA CORPORATION

IPC: C12N05/00

CPC classification number: C12N5/0636 ,  A61K2035/122 ,  C12M25/00 ,  C12N2501/23 ,  C12N2501/515 ,  C12N2501/599

Abstract: A method for inducing immunosuppressive cells by culturing human cells with the use of a culturing device having an affinity for proteins, and the device to be used therefor. The use of the method and the device makes it possible to efficiently induce immunosuppressive cells by fixed culture and thus provide an efficient therapeutic system with little side effect for diseases accompanied by the abnormal acceleration in immune systems.

Abstract translation: 通过使用对蛋白质具有亲和力的培养装置培养人细胞来诱导免疫抑制细胞的方法，以及用于其的装置。 通过使用该方法和装置，可以通过固定培养有效地诱导免疫抑制细胞，从而为免疫系统异常加速的疾病提供对副作用很小的有效治疗系统。

公开(公告)号：WO1996033217A1

公开(公告)日：1996-10-24

申请号：PCT/JP1996001039

申请日：1996-04-15

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  YAMASHITA, Kenji ,  NIWA, Hideo ,  OKAZAKI, Takeshi ,  FUKUCHI, Takeshi ,  OHARA, Takaaki ,  NISHINO, Tomoko ,  KAKUTANI, Tetsu

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C07K14/705

CPC classification number: C07K14/70528 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

Abstract: A novel cell adhesion protein having the effect of suppressing various immunological reactions and its analogs; a process for producing the same; an immunosuppressive agent containing the same; and another immunosuppressive agent containing as the active ingredient immunosuppressive cells obtained by incubating human cells in the presence of the cell adhesion protein. These immunosuppressive agents have potent immunosuppressive effects with little side effects.

Abstract translation: 具有抑制各种免疫反应及其类似物作用的新型细胞粘附蛋白; 其制造方法; 含有该免疫抑制剂的免疫抑制剂; 和含有作为活性成分的免疫抑制剂，其通过在细胞粘附蛋白的存在下培养人细胞而获得的免疫抑制细胞。 这些免疫抑制剂具有很强的免疫抑制作用，副作用很小。