公开(公告)号：WO2006132640A3

公开(公告)日：2007-04-19

申请号：PCT/US2005020959

申请日：2005-06-14

Applicant: UNIV ARIZONA STATE ,  ROSARIO ROHIT ,  PICRAUX S THOMAS ,  HAYES MARK ,  GUST JOHN DEVENS JR ,  GARCIA ANTONIO A

Inventor： ROSARIO ROHIT ,  PICRAUX S THOMAS ,  HAYES MARK ,  GUST JOHN DEVENS JR ,  GARCIA ANTONIO A

IPC: G01N27/26

CPC classification number: B01L3/502707 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502792 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2300/166 ,  B01L2400/0406 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/082 ,  Y10T137/2076 ,  Y10T137/2191 ,  Y10T137/2224 ,  Y10T428/24612

Abstract: Disclosed are compositions and methods for producing movement of liquid across surfaces.

Abstract translation: 公开了用于在表面上产生液体运动的组合物和方法。

公开(公告)号：WO2005072334A2

公开(公告)日：2005-08-11

申请号：PCT/US2005/002317

申请日：2005-01-24

Applicant: ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ,  GARCIA, Antonio, A. ,  ROSARIO, Rohit ,  GUST, John, Devens, Jr. ,  HAYES, Mark, A. ,  MARQUEZ, Manuel ,  HU, Zhibing ,  CAI, Tong

Inventor： GARCIA, Antonio, A. ,  ROSARIO, Rohit ,  GUST, John, Devens, Jr. ,  HAYES, Mark, A. ,  MARQUEZ, Manuel ,  HU, Zhibing ,  CAI, Tong

IPC: A61K47/34

CPC classification number: C08F2/50 ,  A61K47/34

Abstract: Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.

Abstract translation: 公开了光响应水凝胶。 本文公开的组合物可以通过聚合水凝胶前体和螺吡喃来制备。 所公开的组合物的性质可以通过暴露于光，pH和温度而改变。 还公开了使用所公开的组合物递送药物活性物质的方法。

公开(公告)号：WO2004000446A2

公开(公告)日：2003-12-31

申请号：PCT/US2003/019257

申请日：2003-06-20

Applicant: ARIZONA BOARD OF REGENTS ,  GARCIA, Antonio, A. ,  VUPPU, Anil, K.

Inventor： GARCIA, Antonio, A. ,  VUPPU, Anil, K.

IPC: B01F

CPC classification number: B01F13/0809

Abstract: This invention provides a device and method for rotating magnetically inducible particles suspended in a fluid by rotating a multidirectional magnetic field through the suspended particles. A rare earth magnet is positioned adjacent to the suspended particles and oriented such that the axis of a magnetic field generated by the magnet passes through the suspension. The magnetic flux lines of the magnet's field radiate in multiple directions through the suspended particles, them to form long multidirectional chains. The magnet and the chains of suspended particles are rotated with respect to one another, the axis of the rotation being approximately parallel to the magnetic axis of the multidirectional magnetic field. This causes the particle chains to rotate about the magnetic axis, thus mixing the fluid.

Abstract translation: 本发明提供一种通过使多向磁场通过悬浮颗粒旋转来旋转悬浮在流体中的磁诱导颗粒的装置和方法。 稀土磁体定位成与悬浮颗粒相邻并且定向成使得由磁体产生的磁场的轴线通过悬架。 磁场的磁通线通过悬浮颗粒沿多个方向辐射，形成长的多向链。 磁体和悬浮颗粒的链条相对于彼此旋转，旋转轴线大致平行于多向磁场的磁轴。 这使得颗粒链围绕磁轴旋转，从而混合流体。

公开(公告)号：WO2001098785A3

公开(公告)日：2001-12-27

申请号：PCT/US2001/041037

申请日：2001-06-19

Applicant: ARIZONA BOARD OF REGENTS ,  HAYES, Mark, A. ,  POLSON, Nolan, A. ,  VUPPU, Anil, K. ,  CROWLEY, Timothy, A. ,  GARCIA, Antonio, A.

Inventor： HAYES, Mark, A. ,  POLSON, Nolan, A. ,  VUPPU, Anil, K. ,  CROWLEY, Timothy, A. ,  GARCIA, Antonio, A.

IPC: G01N33/543

Abstract: A microimmunoassay arrangement including paramagnetic particles having labeled antibody held in a microchannel by an external magnetic field provides rapid analysis using small sample volumes.

公开(公告)号：WO0021665A9

公开(公告)日：2000-08-24

申请号：PCT/US9923902

申请日：1999-10-14

Applicant: UNIV ARIZONA ,  GARCIA ANTONIO A ,  BONEN MATTHEW R

Inventor： GARCIA ANTONIO A ,  BONEN MATTHEW R

IPC: G01N33/53 ,  G01N33/543 ,  B01L3/00 ,  B05D5/12 ,  C12Q1/68 ,  G01N33/549 ,  G01N33/553

CPC classification number: G01N33/54393 ,  G01N33/5304

Abstract: The present invention provides bioassay plates having silver ions immobilized thereon, which are useful in immunoassays for detection of antibodies or antigens. Methods of making and using the biossay plates are also provided, as well as an apparatus for making activated bioassay plates.

Abstract translation: 本发明提供了其上固定有银离子的生物测定板，其可用于检测抗体或抗原的免疫测定。 还提供制造和使用生物测定板的方法，以及用于制备活性生物测定板的装置。

公开(公告)号：WO2004000446A3

公开(公告)日：2004-03-25

申请号：PCT/US0319257

申请日：2003-06-20

Applicant: UNIV ARIZONA ,  GARCIA ANTONIO A ,  VUPPU ANIL K

Inventor： GARCIA ANTONIO A ,  VUPPU ANIL K

IPC: B01F20060101 ,  B01F13/08

CPC classification number: B01F13/0809

Abstract: A device and method for rotating magnetically inducible particles (204) suspended in a fluid by rotating a multidirectional magnetic field through the suspended particles. A rare earth magnet (502) is positioned adjacent to the suspended particles and oriented such that the axis of a magnetic field generated by the magnet passes through the suspension. The magnetic flux lines of the magnet's field radiate in multiple directions through the suspended particles, them to form long multidirectional chains (601). The magnet and the chains of suspended particles (601) are rotated with respect to one another, the axis of the rotation (503) being approximately parallel to the magnetic axis of the multidirectional magnetic field. This causes the particle chains (601) to rotate about the magnetic axis, thus mixing the fluid.

Abstract translation: 一种用于通过旋转多向磁场通过悬浮颗粒旋转悬浮在流体中的磁诱导颗粒（204）的装置和方法。 稀土磁体（502）定位成与悬浮颗粒相邻并且定向成使得由磁体产生的磁场的轴线穿过悬架。 磁场的磁通线通过悬浮颗粒沿多个方向辐射，形成长的多向链（601）。 磁体和悬浮颗粒链（601）相对于彼此旋转，旋转轴（503）大致平行于多方向磁场的磁轴。 这使得颗粒链（601）围绕磁轴旋转，从而混合流体。

公开(公告)号：WO0189985A3

公开(公告)日：2002-03-28

申请号：PCT/US0116764

申请日：2001-05-23

Applicant: UNIV ARIZONA ,  HAYES MARK A ,  GARCIA ANTONIO A ,  POLSON NOLAN A

Inventor： HAYES MARK A ,  GARCIA ANTONIO A ,  POLSON NOLAN A

IPC: B81B1/00 ,  H01F1/00 ,  H01F1/44 ,  B03C1/00

CPC classification number: H01F1/44 ,  B81B1/00 ,  H01F1/0018 ,  Y10T137/2191

Abstract: A method for assembling a pattern of structures in a microchannel comprises providing a colloid of paramagnetic particles in a microchannel and applying an axially uniform magnetic field thereto.

Abstract translation: 在微通道中组装结构图案的方法包括在微通道中提供顺磁性粒子的胶体并向其施加轴向均匀的磁场。

公开(公告)号：WO2011034678A1

公开(公告)日：2011-03-24

申请号：PCT/US2010/045692

申请日：2010-08-17

Applicant: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ,  GARCIA, Antonio, A. ,  SCHNEIDER, John

Inventor： GARCIA, Antonio, A. ,  SCHNEIDER, John

IPC: G01N21/00

CPC classification number: G01N21/82 ,  G01N21/49 ,  G01N33/5304 ,  G01N33/536 ,  G01N33/54346 ,  G01N2021/035

Abstract: This invention relates to the use of thermodynamically incompatible surfaces in agglutination assays for the express purpose of using the sample as a key component of the detection instrument. Specifically, the invention relates to formation of a lense and a virtual container for rapid mixing via thermal energy by a sample liquid disposed on a superhydrophobic surfaces, and a subsequent specific analyte or overall protein concentration assay using particles agglutination for use in the industrial, environmental, and clinical laboratory test fields.

Abstract translation: 本发明涉及在凝集测定中使用热力学不相容的表面，以便将样品用作检测仪器的关键组分。 具体地说，本发明涉及用于通过设置在超疏水表面上的样品液体通过热能快速混合的透镜和虚拟容器的形成，以及随后使用用于工业环境中的颗粒凝集物的特定分析物或总体蛋白质浓度测定 ，临床实验室检测领域。

公开(公告)号：WO2007101174A3

公开(公告)日：2007-09-07

申请号：PCT/US2007/062842

申请日：2007-02-27

Applicant: ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ,  HERNANDEZ, Sonia, Melle ,  GOMEZ, Ana, N. ,  PICRAUX, S., Thomas ,  GUST, John, Devens ,  HAYES, Mark ,  LINDSAY, Solitaire ,  GARCIA, Antonio, A. ,  WANG, Joseph ,  VAZQUEZ-ALVAREZ, Terannie

Inventor： HERNANDEZ, Sonia, Melle ,  GOMEZ, Ana, N. ,  PICRAUX, S., Thomas ,  GUST, John, Devens ,  HAYES, Mark ,  LINDSAY, Solitaire ,  GARCIA, Antonio, A. ,  WANG, Joseph ,  VAZQUEZ-ALVAREZ, Terannie

IPC: B32B9/00

Abstract: Disclosed are devices and methods for moving and controlling droplets of fluids on hydrophobic surfaces through the use of magnetic fields. For example, droplets can be moved, immobilized, dispensed, coalesced, and/or divided. Also disclosed is a digital magnetofluidic device comprising a hydrophobic surface; a magnetically active fluid droplet in contact with the surface; and a magnetic field coupled with at least a portion of the droplet. Also disclosed is a digital isoelectric focusing method using the devices and methods. Also disclosed are digital microelectrochemical detection methods and digital microelectrochemical reaction methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：WO2007101174A2

公开(公告)日：2007-09-07

申请号：PCT/US2007062842

申请日：2007-02-27

Applicant: UNIV ARIZONA STATE ,  HERNANDEZ SONIA MELLE ,  GOMEZ ANA N ,  PICRAUX S THOMAS ,  GUST JOHN DEVENS ,  HAYES MARK ,  LINDSAY SOLITAIRE ,  GARCIA ANTONIO A ,  WANG JOSEPH ,  VAZQUEZ-ALVAREZ TERANNIE

Inventor： HERNANDEZ SONIA MELLE ,  GOMEZ ANA N ,  PICRAUX S THOMAS ,  GUST JOHN DEVENS ,  HAYES MARK ,  LINDSAY SOLITAIRE ,  GARCIA ANTONIO A ,  WANG JOSEPH ,  VAZQUEZ-ALVAREZ TERANNIE

CPC classification number: B01F13/0071 ,  B01F13/0077 ,  B01L3/502792 ,  B01L2300/0822 ,  B01L2300/166 ,  B01L2400/043 ,  B01L2400/0448

Abstract: Disclosed are devices and methods for moving and controlling droplets of fluids on hydrophobic surfaces through the use of magnetic fields. For example, droplets can be moved, immobilized, dispensed, coalesced, and/or divided. Also disclosed is a digital magnetofluidic device comprising a hydrophobic surface; a magnetically active fluid droplet in contact with the surface; and a magnetic field coupled with at least a portion of the droplet. Also disclosed is a digital isoelectric focusing method using the devices and methods. Also disclosed are digital microelectrochemical detection methods and digital microelectrochemical reaction methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract translation: 公开了通过使用磁场来移动和控制疏水表面上的流体液滴的装置和方法。 例如，液滴可以被移动，固定，分配，聚结和/或分割。 还公开了包括疏水表面的数字磁流体装置; 与表面接触的磁性活性流体液滴; 以及与液滴的至少一部分耦合的磁场。 还公开了使用这些装置和方法的数字等电聚焦方法。 还公开了数字微电化学检测方法和数字微电化学反应方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。