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    AUTOMATED IMAGING AND ANALYSIS OF THE HEMAGGLUTINATION INHIBITION ASSAY (HAI)
    1.
    发明申请
    AUTOMATED IMAGING AND ANALYSIS OF THE HEMAGGLUTINATION INHIBITION ASSAY (HAI) 审中-公开
    HEMAGGLUTION抑制测定（HAI）自动成像与分析

    公开(公告)号：WO2016018940A1

    公开(公告)日：2016-02-04

    申请号：PCT/US2015/042527

    申请日：2015-07-28

    Applicant: SANOFI PASTEUR VAXDESIGN CORPORATION

    Inventor： NGUYEN, Michael ,  PARKHILL, Robert

    IPC: C40B30/04 ,  C12Q1/70 ,  G01N33/53

    CPC classification number: G01N33/543 ,  B01L9/52 ,  B01L9/523 ,  G01N33/5304 ,  G01N35/025 ,  G01N35/028 ,  G01N2333/11 ,  G01N2469/10

    Abstract: A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.

    Abstract translation: 一种系统和方法提供了高通量测定凝集态。 该系统包括一个旋转台和多个板倾斜台。 该系统还包括一个或多个光路，其定位成以倾斜和/或直立构型对整个板阵列进行成像。 该系统优选地包括图像分析软件，以分析测试孔阵列的图像，并基于图像分析确定每个孔的凝集状态。

    APPARATUS AND METHODS FOR CELLULAR ANALYSIS
    3.
    发明申请
    APPARATUS AND METHODS FOR CELLULAR ANALYSIS 审中-公开
    细胞分析的装置和方法

    公开(公告)号：WO2014186228A4

    公开(公告)日：2015-01-22

    申请号：PCT/US2014037508

    申请日：2014-05-09

    Applicant: DEKA CHIRANJIT

    Inventor： DEKA CHIRANJIT

    IPC: G01N33/48 ,  G01N33/50 ,  G01N33/80

    CPC classification number: G01N15/1459 ,  G01N15/1404 ,  G01N15/1425 ,  G01N15/1436 ,  G01N33/5094 ,  G01N33/5304 ,  G01N33/56966 ,  G01N33/56972 ,  G01N33/80 ,  G01N35/00 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486

    Abstract: Disclosed are apparatus and methods for analyzing bodily fluids, such as blood samples, using an integrated hematology analyzer and flow cytometer system. Under the present approach, an integrated system may operate as a closed fluidic system or an open fluidic system, and may selectively perform automated hematologic protocols, flow cytometer protocols, and custom protocols. Such apparatus may, for example, identify and enumerate multiple cell types in whole blood based on cellular morphology, analyze cellular immunoassays using antibodies labeled to cells, and also detect low abundant analytes in whole blood as well as serum and other bodily fluids not attached to cells using bead-based immunoassay methods. The system may include a fluid handling system to control sample flow, an optical transducer that includes a flow cell, optical detectors for light scatter and/or fluorescence, and also an illumination source.

    Abstract translation: 公开了使用综合血液分析仪和流式细胞仪系统分析体液如血液样品的装置和方法。 在目前的方法下，集成系统可以作为闭合流体系统或开放流体系统运行，并且可以选择性地执行自动化血液学方案，流式细胞仪协议和定制协议。 这样的装置可以例如基于细胞形态来识别和列举全血中的多种细胞类型，使用标记到细胞上的抗体分析细胞免疫测定，并且还检测全血中的低丰度分析物以及未附着于血液的血清和其他体液 细胞使用基于珠的免疫测定方法。 该系统可以包括用于控制样品流的流体处理系统，包括流动池的光学换能器，用于光散射和/或荧光的光学检测器以及照明源。

    IN-VITRO CONTACT LENS TESTING
    5.
    发明申请
    IN-VITRO CONTACT LENS TESTING 审中-公开
    IN-VITRO接触式镜头测试

    公开(公告)号：WO2014052128A1

    公开(公告)日：2014-04-03

    申请号：PCT/US2013/060432

    申请日：2013-09-18

    Applicant: GOOGLE INC.

    Inventor： LIU, Zenghe ,  ETZKORN, James

    IPC: G01N33/48 ,  G01N33/50 ,  G01N33/53

    CPC classification number: G01N33/528 ,  B01J2219/00612 ,  B01J2219/00621 ,  G01N21/6486 ,  G01N21/75 ,  G01N33/5304 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/62 ,  G01N33/66 ,  G01N33/92 ,  G01N33/98 ,  G01N2333/46 ,  Y10T436/144444

    Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

    Abstract translation: 介绍了用于测试分析物的隐形眼镜的隐形眼镜测试仪器和方法。 一方面，提供了一种装置，其包括构造成保持一个或多个隐形眼镜的壳体，以及设置在壳体内并包括试剂的测试室，所述试剂被配置为响应于存在预定的 放置在测试室中的隐形眼镜上或其内的生物标志物，其中化学反应产生与生成生物标志物的个体的状态信息相关的已知结果。

    MICROCANTILEVER SENSOR WITH BIMORPH ACTUATION AND PIEZORESISTIVE READ - OUT
    7.
    发明申请
    MICROCANTILEVER SENSOR WITH BIMORPH ACTUATION AND PIEZORESISTIVE READ - OUT 审中-公开
    微分器传感器具有双向激励和PIEZORESISTIVE READ-OUT

    公开(公告)号：WO2012160393A1

    公开(公告)日：2012-11-29

    申请号：PCT/GB2012/051196

    申请日：2012-05-25

    Applicant: MICROVISK LIMITED ,  DJAKOV, Vladislav ,  DUNN, Richard

    Inventor： DJAKOV, Vladislav ,  DUNN, Richard

    IPC: G01N27/12 ,  C12Q1/00 ,  G01N33/543 ,  B82Y15/00

    CPC classification number: G01N33/5304 ,  G01N27/128 ,  G01N29/022 ,  G01N33/54373 ,  G01N33/5438

    Abstract: There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterise a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample. There is also provided a method for measuring at least one thermal property of a fluid medium sample, and a fluid medium sample reaction detection apparatus.

    Abstract translation: 提供了一种使用热特征来监测流体介质样品中的一个或多个指定反应的方法，包括提供至少一个微悬臂传感器，所述微悬臂传感器包括具有不同热膨胀系数的至少两种材料，以及 具有集成在其中的加热器和压阻传感器，校准至少一个微悬臂响应于热变化以形成校准的微悬臂梁响应特性，启动流体介质样品中的指定反应，将加热器与一个或多个 电脉冲以在微悬臂中引起发热，对集成的压阻传感器的输出进行采样，以在流体介质中指定的反应期间表征微悬臂梁的响应，并从校准的微悬臂梁响应特性中减去 采样输出以确定t中的一个或多个指定反应的特性 他流体介质样品。 还提供了一种用于测量流体介质样品的至少一种热性质和流体介质样品反应检测装置的方法。

    USE OF SUPERHYDROPHOBIC SURFACES FOR LIQUID AGGLUTINATION ASSAYS
    10.
    发明申请
    USE OF SUPERHYDROPHOBIC SURFACES FOR LIQUID AGGLUTINATION ASSAYS 审中-公开
    超声波表面用于液体分析测定

    公开(公告)号：WO2011034678A1

    公开(公告)日：2011-03-24

    申请号：PCT/US2010/045692

    申请日：2010-08-17

    Applicant: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ,  GARCIA, Antonio, A. ,  SCHNEIDER, John

    Inventor： GARCIA, Antonio, A. ,  SCHNEIDER, John

    IPC: G01N21/00

    CPC classification number: G01N21/82 ,  G01N21/49 ,  G01N33/5304 ,  G01N33/536 ,  G01N33/54346 ,  G01N2021/035

    Abstract: This invention relates to the use of thermodynamically incompatible surfaces in agglutination assays for the express purpose of using the sample as a key component of the detection instrument. Specifically, the invention relates to formation of a lense and a virtual container for rapid mixing via thermal energy by a sample liquid disposed on a superhydrophobic surfaces, and a subsequent specific analyte or overall protein concentration assay using particles agglutination for use in the industrial, environmental, and clinical laboratory test fields.

    Abstract translation: 本发明涉及在凝集测定中使用热力学不相容的表面，以便将样品用作检测仪器的关键组分。 具体地说，本发明涉及用于通过设置在超疏水表面上的样品液体通过热能快速混合的透镜和虚拟容器的形成，以及随后使用用于工业环境中的颗粒凝集物的特定分析物或总体蛋白质浓度测定 ，临床实验室检测领域。

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