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    SUGAR-LINKER-DRUG CONJUGATES
    1.
    发明申请
    SUGAR-LINKER-DRUG CONJUGATES 审中-公开
    糖链接药物联合使用

    公开(公告)号：WO2014145109A1

    公开(公告)日：2014-09-18

    申请号：PCT/US2014/029793

    申请日：2014-03-14

    Applicant: ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY

    Inventor： HECHT, Sidney ,  PAUL, Rakesh ,  TANG, Chenhong ,  MADATHIL, Manikandadas ,  BHATTACHARYA, Chandraball

    IPC: A61K31/7042

    CPC classification number: A61K47/549 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/7042

    Abstract: The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using thern are also provided.

    Abstract translation: 本公开涉及式[A-B-] n-L-D的糖接头 - 药物偶联物，其中A是糖; B是间隔基，n是选自1至3的整数; L是连接基团，D是具有选自伯胺或仲胺，羟基，巯基，羧基，醛和酮的化学反应性官能团的药物。 还提供了包含缀合物的药物组合物和使用方法。

    CIRCUITS AND METHODS FOR PHOTOVOLTAIC INVERTERS
    5.
    发明申请
    CIRCUITS AND METHODS FOR PHOTOVOLTAIC INVERTERS 审中-公开
    光伏逆变器的电路和方法

    公开(公告)号：WO2014004575A1

    公开(公告)日：2014-01-03

    申请号：PCT/US2013/047707

    申请日：2013-06-25

    Applicant: ARIZONA BOARD OF REGENTS, for and on behalf of ARIZONA STATE UNIVERSITY

    Inventor： AYYANAR, Rajapandian

    IPC: H02M7/00 ,  H02M7/42

    CPC classification number: H02M7/537 ,  H02J3/383 ,  H02J3/385 ,  H02M1/15 ,  H02M7/48 ,  H02M7/487 ,  Y02E10/563 ,  Y02E10/58

    Abstract: Circuits and methods for photovoltaic inverters are provided. In some embodiments, a power inverter circuit is provided, the inverter comprising: an input terminal for a direct current source coupled to a first conductor; a first side of a capacitor coupled to the input terminal; a second input terminal for the direct current source coupled to first sides of a first switch and second switch; a second side of the capacitor coupled to first sides of a third switch and fourth switch; a first side of a first inductor coupled to the first input terminal, the first side of the capacitor and the first conductor; a second side of the first inductor coupled to second sides of the first switch and third switch; and a first side of a second inductor coupled to a second conductor, and second sides of the second switch and fourth switch.

    Abstract translation: 提供光伏逆变器的电路和方法。 在一些实施例中，提供了一种功率逆变器电路，所述逆变器包括：用于耦合到第一导体的直流电源的输入端子; 耦合到输入端的电容器的第一侧; 用于直流电源的第二输入端，耦合到第一开关和第二开关的第一侧; 电容器的第二侧耦合到第三开关和第四开关的第一侧; 耦合到第一输入端子的第一电感器的第一侧，电容器的第一侧和第一导体; 所述第一电感器的第二侧耦合到所述第一开关和第三开关的第二侧; 以及耦合到第二导体的第二电感器的第一侧和第二开关和第四开关的第二侧。

    SYSTEMS, METHODS, AND MEDIA FOR UPDATING A CLASSIFIER
    7.
    发明申请
    SYSTEMS, METHODS, AND MEDIA FOR UPDATING A CLASSIFIER 审中-公开
    用于更新分类器的系统，方法和媒体

    公开(公告)号：WO2013116865A1

    公开(公告)日：2013-08-08

    申请号：PCT/US2013/024675

    申请日：2013-02-04

    Applicant: ARIZONA BOARD OF REGENTS, for and on behalf of, ARIZONA STATE UNIVERSITY

    Inventor： LIANG, Jianming ,  WU, Hong ,  XUE, Wenzhe ,  TAJBAKHSH, Nima

    IPC: G06F15/18 ,  G06K9/00 ,  G06F9/02

    CPC classification number: G06N99/005 ,  G06F19/321 ,  G06K9/6256 ,  G06K9/6267 ,  G06N5/043 ,  G06N5/046 ,  G16H50/20

    Abstract: Systems, methods, and media for updating a classifier are provided, in some embodiments, systems for updating a classifier are provided, the systems comprising: a hardware processor that is configured to: receive a sample; for each of a first plurality of weak learners, classify the sample using the weak learner, determine an outcome of the classification, and determine an updated error rate of the weak learner based on the outcome of the classification and at least one of: (i) a count of positive samples used to update the classifier, and (ii) a count of negative samples used to update the classifier; select a first weak learner from the first plurality of weak learners based on the updated error rate of the first weak learner; and update tire classifier based on the first weak learner.

    Abstract translation: 提供了用于更新分类器的系统，方法和媒体，在一些实施例中，提供了用于更新分类器的系统，所述系统包括：硬件处理器，其被配置为：接收样本; 对于第一多个弱学习者中的每一个，使用弱学习者对样本进行分类，确定分类的结果，并且基于分类的结果确定弱学习者的更新错误率，并且至少一个：（i ）用于更新分类器的正样本的计数，以及（ii）用于更新分类器的负样本的计数; 基于第一弱势学习者的更新错误率，从第一批弱势学习者中选出第一位弱势学习者; 并基于第一个弱学习者更新轮胎分选机。

    ALUMINUM-BASED METAL-AIR BATTERIES
    8.
    发明申请
    ALUMINUM-BASED METAL-AIR BATTERIES 审中-公开
    铝基金属电池

    公开(公告)号：WO2013106122A2

    公开(公告)日：2013-07-18

    申请号：PCT/US2012/060581

    申请日：2012-10-17

    Applicant: ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： FRIESEN, Cody A. ,  MARTINEZ, Jose Antonio Bautista

    IPC: H01M12/06 ,  H01M12/00

    CPC classification number: H01M4/38 ,  H01M12/02 ,  H01M12/06 ,  H01M12/08 ,  H01M2300/0002 ,  H01M2300/0028 ,  Y02E60/128 ,  Y10T29/49108

    Abstract: Provided in one embodiment is an electrochemical cell, comprising: (i) a plurality of electrodes, comprising a fuel electrode that comprises aluminum and an air electrode that absorbs gaseous oxygen, the electrodes being operable in a discharge mode wherein the aluminum is oxidized at the fuel electrode and oxygen is reduced at the air electrode, and (ii) an ionically conductive medium, comprising an organic solvent; wherein during non-use of the cell, the organic solvent promotes formation of a protective interface between the aluminum of the fuel electrode and the ionically conductive medium, and wherein at an onset of the discharge mode, at least some of the protective interface is removed from the aluminum to thereafter permit oxidation of the aluminum during the discharge mode.

    Abstract translation: 在一个实施方案中提供了一种电化学电池，包括：（i）多个电极，包括包含铝的燃料电极和吸收气态氧的空气电极，所述电极可在放电模式下操作，其中铝在 燃料电极和氧在空气电极处被还原，和（ii）离子导电介质，包括有机溶剂; 其中在不使用所述电池期间，所述有机溶剂促进在所述燃料电极的铝与所述离子传导介质之间形成保护界面，并且其中在所述放电模式开始时，至少一些所述保护界面被去除 从铝到其后允许铝在放电模式下的氧化。

    CONTROLLED STIMULATION DELIVERY FROM NEUROSTIMULATOR
    9.
    发明申请
    CONTROLLED STIMULATION DELIVERY FROM NEUROSTIMULATOR 审中-公开
    来自神经细胞的控制性刺激

    公开(公告)号：WO2013071290A1

    公开(公告)日：2013-05-16

    申请号：PCT/US2012/064820

    申请日：2012-11-13

    Applicant: ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： TOWE, Bruce, C. ,  GULICK, Daniel

    IPC: A61N1/18 ,  A61N1/36 ,  A61N1/05 ,  A61N7/00 ,  A61N5/00

    CPC classification number: A61N1/3787 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N5/045

    Abstract: A system for providing neurostimulation includes an external device ("external exciter") and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.

    Abstract translation: 用于提供神经刺激的系统包括外部装置（“外部激励器”）和植入装置。 外部激励器包括对植入装置进行感应供电的能量源。 这种外部激励器的实例包括具有以下至少一种的装置：超声换能器，射频（RF）发射器和太阳能电池。 植入装置包括将其最大能量输出限制到预定饱和阈值的电路，使得来自外部激励器的过量刺激不会使植入装置的输出超过饱和阈值。 然后对外部激励器的输出信号进行脉冲宽度调制，以从植入装置产生期望量的输出刺激，以刺激生物电可兴奋的组织达到期望的水平。

    SYSTEMS METHODS, AND MEDIA FOR POLICY-BASED MONITORING AND CONTROLLING OF APPLICATIONS
    10.
    发明申请
    SYSTEMS METHODS, AND MEDIA FOR POLICY-BASED MONITORING AND CONTROLLING OF APPLICATIONS 审中-公开
    系统方法和基于政策监测和应用控制的媒体

    公开(公告)号：WO2013025785A1

    公开(公告)日：2013-02-21

    申请号：PCT/US2012/050913

    申请日：2012-08-15

    Applicant: ARIZONA BOARD OF REGENTS, for and on behalf of, ARIZONA STATE UNIVERSITY ,  AHN, Gail-Joon

    Inventor： AHN, Gail-Joon

    IPC: G06F21/00

    CPC classification number: G06F21/629 ,  G06F21/53 ,  G06F21/552 ,  G06F21/57 ,  G06F2221/2139

    Abstract: Systems, methods, and media for policy-based monitoring and controlling of applications are provided. Methods for policy-based monitoring and controlling of applications are provided, the methods comprising: providing a policy engine that: receives system policies and user policies; determines whether any violations and/or conflicts exist between the system policies and the user policies; and determines whether the system policies and/or user policies are violated during an installation, launch, and/or execution of an application; and providing a user interface to alert a user of violations during the installation, launch, and/or execution of the application.

    Abstract translation: 提供了用于基于策略的监控和应用程序控制的系统，方法和媒体。 提供了用于基于策略的监视和控制应用的方法，所述方法包括：提供：接收系统策略和用户策略的策略引擎; 确定系统策略和用户策略之间是否存在任何违规和/或冲突; 并且确定在应用的安装，启动和/或执行期间是否违反了系统策略和/或用户策略; 以及提供用户界面以在安装，启动和/或执行应用程序期间提醒用户违规。

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