公开(公告)号：WO2004087061A2

公开(公告)日：2004-10-14

申请号：PCT/US2004009417

申请日：2004-03-26

Applicant: OXIGENE INC ,  UNIV BAYLOR ,  PINNEY KEVIN G ,  MOCHARLA VANI P ,  CHEN ZHI ,  GARNER CHARLES M ,  GHATAK ANJAN ,  HADIMANI MALLINATH ,  KESSLER JIMMY ,  DORSEY JAMES M ,  EDVARDSON KLAUS ,  CHAPLIN DAVID J ,  PREZIOSO JOSEPH ,  JELINEK CHRISTOPHER

Inventor： PINNEY KEVIN G ,  MOCHARLA VANI P ,  CHEN ZHI ,  GARNER CHARLES M ,  GHATAK ANJAN ,  HADIMANI MALLINATH ,  KESSLER JIMMY ,  DORSEY JAMES M ,  EDVARDSON KLAUS ,  CHAPLIN DAVID J ,  PREZIOSO JOSEPH ,  JELINEK CHRISTOPHER

IPC: A61K20060101 ,  A61K31/075 ,  C07C41/00 ,  C07C43/215 ,  C07C43/23 ,  C07C45/51 ,  C07C45/64 ,  C07C49/84 ,  C07C205/45 ,  C07C217/84 ,  C07C217/94 ,  C07C225/22 ,  C07D233/54 ,  C07D307/80 ,  C07D307/81 ,  C07D333/56 ,  C07D333/64 ,  C07F9/12 ,  C07F9/18 ,  C07F9/24 ,  C07F9/655 ,  C07F9/6553 ,  A61K

CPC classification number: C07C43/23 ,  A61K31/075 ,  A61K31/66 ,  C07C43/215 ,  C07C45/512 ,  C07C45/64 ,  C07C45/673 ,  C07C49/755 ,  C07C49/84 ,  C07C205/37 ,  C07C205/45 ,  C07C217/84 ,  C07C217/94 ,  C07C223/06 ,  C07C225/22 ,  C07C237/08 ,  C07C2602/08 ,  C07C2602/10 ,  C07D307/80 ,  C07D307/81 ,  C07D333/56 ,  C07D333/64 ,  C07F9/12 ,  C07F9/18 ,  C07F9/247 ,  C07F9/65517 ,  C07F9/655354

Abstract: A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

Abstract translation: 已经发现了一组不同的微管蛋白结合剂，其在结构上通常通过能够维持适于分子识别微管蛋白的芳基 - 芳基，伪pi堆叠距离的半刚性分子框架来表征。 在酚类或氨基形式中，这些配体可进一步官能化以制备能够显示肿瘤细胞脉管系统的选择性靶向和破坏的磷酸酯，磷酸盐，氨基磷酸酯和其它前体药物。

公开(公告)号：WO2004087061A3

公开(公告)日：2004-10-14

申请号：PCT/US2004/009417

申请日：2004-03-26

Applicant: OXIGENE, INC. ,  BAYLOR UNIVERSITY ,  PINNEY, Kevin, G. ,  MOCHARLA, Vani, P. ,  CHEN, Zhi ,  GARNER, Charles, M. ,  GHATAK, Anjan ,  HADIMANI, Mallinath ,  KESSLER, Jimmy ,  DORSEY, James, M. ,  EDVARDSON, Klaus ,  CHAPLIN, David, J. ,  PREZIOSO, Joseph ,  JELINEK, Christopher

Inventor： PINNEY, Kevin, G. ,  MOCHARLA, Vani, P. ,  CHEN, Zhi ,  GARNER, Charles, M. ,  GHATAK, Anjan ,  HADIMANI, Mallinath ,  KESSLER, Jimmy ,  DORSEY, James, M. ,  EDVARDSON, Klaus ,  CHAPLIN, David, J. ,  PREZIOSO, Joseph ,  JELINEK, Christopher

IPC: C07C41/00

Abstract: A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

公开(公告)号：WO2004087061B1

公开(公告)日：2005-05-12

申请号：PCT/US2004009417

申请日：2004-03-26

Applicant: OXIGENE INC ,  UNIV BAYLOR ,  PINNEY KEVIN G ,  MOCHARLA VANI P ,  CHEN ZHI ,  GARNER CHARLES M ,  GHATAK ANJAN ,  HADIMANI MALLINATH ,  KESSLER JIMMY ,  DORSEY JAMES M ,  EDVARDSON KLAUS ,  CHAPLIN DAVID J ,  PREZIOSO JOSEPH ,  JELINEK CHRISTOPHER

Inventor： PINNEY KEVIN G ,  MOCHARLA VANI P ,  CHEN ZHI ,  GARNER CHARLES M ,  GHATAK ANJAN ,  HADIMANI MALLINATH ,  KESSLER JIMMY ,  DORSEY JAMES M ,  EDVARDSON KLAUS ,  CHAPLIN DAVID J ,  PREZIOSO JOSEPH ,  JELINEK CHRISTOPHER

IPC: A61K20060101 ,  A61K31/075 ,  C07C41/00 ,  C07C43/215 ,  C07C43/23 ,  C07C45/51 ,  C07C45/64 ,  C07C49/84 ,  C07C205/45 ,  C07C217/84 ,  C07C217/94 ,  C07C225/22 ,  C07D233/54 ,  C07D307/80 ,  C07D307/81 ,  C07D333/56 ,  C07D333/64 ,  C07F9/12 ,  C07F9/18 ,  C07F9/24 ,  C07F9/655 ,  C07F9/6553

CPC classification number: C07C43/23 ,  A61K31/075 ,  A61K31/66 ,  C07C43/215 ,  C07C45/512 ,  C07C45/64 ,  C07C45/673 ,  C07C49/755 ,  C07C49/84 ,  C07C205/37 ,  C07C205/45 ,  C07C217/84 ,  C07C217/94 ,  C07C223/06 ,  C07C225/22 ,  C07C237/08 ,  C07C2602/08 ,  C07C2602/10 ,  C07D307/80 ,  C07D307/81 ,  C07D333/56 ,  C07D333/64 ,  C07F9/12 ,  C07F9/18 ,  C07F9/247 ,  C07F9/65517 ,  C07F9/655354

Abstract: A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

Abstract translation: 已经发现了各种各样的微管蛋白结合剂，其结构特征在于一般意义上是能够维持适于分子识别微管蛋白的芳基 - 芳基，伪π层叠距离的半刚性分子框架。 在酚类或氨基形式中，这些配体可进一步官能化以制备能够显示肿瘤细胞脉管系统的选择性靶向和破坏的磷酸酯，磷酸盐，氨基磷酸酯和其它前体药物。

公开(公告)号：WO1997015642A1

公开(公告)日：1997-05-01

申请号：PCT/US1996016632

申请日：1996-10-18

Applicant: BAYLOR UNIVERSITY ,  GARNER, Charles, M.

Inventor： BAYLOR UNIVERSITY

IPC: C10L01/18

CPC classification number: C10L1/1824 ,  B01D17/00 ,  C10L7/02 ,  Y10S210/925 ,  Y10S516/917 ,  Y10S516/924 ,  Y10S588/901

Abstract: The present invention generally relates to the formation of organic gels by dissolving organic gelling agents in organic solvents. The aryl cyclohexanol gelling agents employed in this invention are not structurally related to previously known gellation agents and they exhibit potent gellation activity, for example, from 0.2 - 5 %, by weight, of gelling agent, which is able to immobilize a variety of organic solvents. The gels formed range from optically transparent to slightly translucent, and complete fluidity can be restored by either increasing the temperature (reversible) or by chemical treatment (irreversible).

Abstract translation: 本发明一般涉及通过将有机胶凝剂溶解在有机溶剂中形成有机凝胶。 本发明中使用的芳基环己醇胶凝剂在结构上不与先前已知的凝胶剂相关，并且它们显示出有效的凝胶化活性，例如0.2-5重量％的胶凝剂，其能够固定各种有机 溶剂。 形成的凝胶范围从光学透明到略微半透明，并且可以通过增加温度（可逆）或通过化学处理（不可逆）来恢复完全的流动性。