公开(公告)号：WO2013089665A1

公开(公告)日：2013-06-20

申请号：PCT/US2011/064428

申请日：2011-12-12

Applicant: CORNING CABLE SYSTEMS LLC ,  GEORGE, Jacob ,  NG'OMA, Anthony ,  RUFFIN, Alranzo B. ,  SAUER, Michael

Inventor： GEORGE, Jacob ,  NG'OMA, Anthony ,  RUFFIN, Alranzo B. ,  SAUER, Michael

IPC: H04W88/08 ,  H04B10/12

CPC classification number: H04B10/25759 ,  H04W88/085

Abstract: Extremely High Frequency (EHF) distributed antenna systems and related components and methods are disclosed. In one embodiment, a base unit for distributing EHF modulated data signals to a RAU(s) is provided. The base unit includes a downlink data source input configured to receive downlink electrical data signal(s) from a data source. The base unit also includes an E-O converter configured to convert downlink electrical data signal(s) into downlink optical data signal(s). The base unit also includes an oscillator configured to generate an electrical carrier signal at a center frequency in the EHF band. The base unit also includes a modulator configured to combine the downlink optical data signal(s) with the electrical carrier signal to form downlink modulated optical signal(s) comprising a downlink optical data signal(s) modulated at the center frequency of the electrical carrier signal. The modulator is further configured to send the downlink modulated optical signal to the RAU(s).

Abstract translation: 公开了极高频（EHF）分布式天线系统及相关组件和方法。 在一个实施例中，提供了用于将EHF调制数据信号分配给RAU的基本单元。 基本单元包括被配置为从数据源接收下行链路电数据信号的下行链路数据源输入。 基本单元还包括被配置为将下行链路电数据信号转换为下行链路光数据信号的E-O转换器。 基本单元还包括被配置为在EHF频带中以中心频率产生电载波信号的振荡器。 基本单元还包括调制器，其被配置为将下行链路光数据信号与电载波信号组合以形成下行链路调制的光信号，所述下行链路调制光信号包括以电载波的中心频率调制的下行链路光数据信号 信号。 调制器还被配置为将下行链路调制的光信号发送到RAU。

公开(公告)号：WO2011146985A1

公开(公告)日：2011-12-01

申请号：PCT/AU2011/000627

申请日：2011-05-25

Applicant: THE UNIVERSITY OF SYDNEY ,  WESTERN SYDNEY LOCAL HEALTH NETWORK ,  MURDOCH UNIVERSITY ,  SUPPIAH, Vijayaprakash ,  BOOTH, David ,  STEWART, Graeme ,  GEORGE, Jacob ,  GAUDIERI, Silvana ,  MALLAL, Simon

Inventor： SUPPIAH, Vijayaprakash ,  BOOTH, David ,  STEWART, Graeme ,  GEORGE, Jacob ,  GAUDIERI, Silvana ,  MALLAL, Simon

IPC: C12Q1/68 ,  G01N33/48

CPC classification number: C12Q1/707 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present invention provides a method for accurately determining the likelihood that a subject will respond to treatment with an immunomodulatory composition comprising detecting homozygosity for HLA-C2 alleles or at least two markers one of which is a marker for an HLA-C allele and one of which is a marker for an IL28B allele, and processes for selecting suitable subjects for therapy or for continued therapy, and for providing appropriate therapy to subjects, based on the assay results.

Abstract translation: 本发明提供了一种准确地确定受试者对免疫调节组合物治疗反应的可能性的方法，所述免疫调节组合物包括检测HLA-C2等位基因的纯合子或至少两个标记，其中一个是HLA-C等位基因的标记， 其是IL28B等位基因的标记，以及用于选择合适的受试者进行治疗或继续治疗的方法，以及基于测定结果为受试者提供适当的治疗。

公开(公告)号：WO2011072336A8

公开(公告)日：2011-08-18

申请号：PCT/AU2010001695

申请日：2010-12-16

Applicant: UNIV SYDNEY ,  SYDNEY WEST AREA HEALTH SERVICE ,  VAN DER POORTEN DAVID ,  DOUGLAS MARK ,  GEORGE JACOB

Inventor： VAN DER POORTEN DAVID ,  DOUGLAS MARK ,  GEORGE JACOB

IPC: A61P31/14 ,  A61K31/16 ,  A61K38/00

CPC classification number: A61K31/16 ,  A61K45/06 ,  G01N33/5767 ,  G01N2500/10 ,  A61K2300/00

Abstract: The invention relates to agents for the treatment of hepatitis C virus infection. More specifically, the invention relates to antagonists of cannabinoid type 1 receptor signalling pathway proteins and their use for the treatment of hepatitis C virus infection.

Abstract translation: 本发明涉及用于治疗丙型肝炎病毒感染的药剂。 更具体地，本发明涉及大麻素1型受体信号通路蛋白的拮抗剂及其用于治疗丙型肝炎病毒感染的用途。

公开(公告)号：WO2011072336A1

公开(公告)日：2011-06-23

申请号：PCT/AU2010/001695

申请日：2010-12-16

Applicant: THE UNIVERSITY OF SYDNEY ,  SYDNEY WEST AREA HEATH SERVICE ,  VAN DER POORTEN, David ,  DOUGLAS, Mark ,  GEORGE, Jacob

Inventor： VAN DER POORTEN, David ,  DOUGLAS, Mark ,  GEORGE, Jacob

IPC: A61P31/14 ,  A61K31/16 ,  A61K38/00

CPC classification number: A61K31/16 ,  A61K45/06 ,  G01N33/5767 ,  G01N2500/10 ,  A61K2300/00

Abstract: The invention relates to agents for the treatment of hepatitis C virus infection. More specifically, the invention relates to antagonists of cannabinoid type 1 receptor signalling pathway proteins and their use for the treatment of hepatitis C virus infection.

Abstract translation: 本发明涉及用于治疗丙型肝炎病毒感染的药剂。 更具体地说，本发明涉及大麻素1型受体信号传导途径蛋白的拮抗剂及其用于治疗丙型肝炎病毒感染的用途。

公开(公告)号：WO2010086854A1

公开(公告)日：2010-08-05

申请号：PCT/IL2010/000073

申请日：2010-01-28

Applicant: THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER ,  GEORGE, Jacob ,  KEREN, Gad

Inventor： GEORGE, Jacob ,  KEREN, Gad

IPC: C07K16/24 ,  C07K14/52 ,  A61K39/00

CPC classification number: C07K16/24 ,  A61K38/13 ,  A61K38/215 ,  A61K2039/505 ,  A61K2300/00

Abstract: The present invention is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. The invention thus provides pharmaceutical compositions comprising specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. The invention also provides specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing the antibodies of the invention.

Abstract translation: 本发明是基于以下发现：通过多克隆或单克隆抗体抑制嗜酸性粒细胞趋化因子-2在诸如类风湿性关节炎，实验性自身免疫性脑脊髓炎（EAE），结肠炎，糖尿病和动脉粥样硬化的炎性疾病的动物模型中具有显着的保护作用。 因此，本发明提供了药物组合物，其包含单独使用或与其它治疗剂组合用于治疗炎性，自身免疫性和心血管疾病的特异性抗 - 嗜酸性粒细胞趋化因子2抗体。 本发明还提供了具体的抗嗜酸性粒细胞趋化因子受体激动剂-2单克隆抗体，以及利用本发明的抗体的治疗方法。

公开(公告)号：WO2010051337A1

公开(公告)日：2010-05-06

申请号：PCT/US2009/062478

申请日：2009-10-29

Applicant: CORNING INCORPORATED ,  GEORGE, Jacob ,  HARIHARA, Parasuram P ,  SHEN, Min

Inventor： GEORGE, Jacob ,  HARIHARA, Parasuram P ,  SHEN, Min

IPC: B28B11/24 ,  C04B38/00 ,  F26B3/347 ,  H05B6/64 ,  H05B6/78

CPC classification number: H05B6/78 ,  B28B11/241 ,  B28B11/243 ,  C04B2235/606 ,  F26B3/347 ,  F26B2210/02 ,  H05B6/6447 ,  H05B2206/046 ,  Y02P40/63

Abstract: Methods and apparatus for drying ceramic green bodies include providing one or more ceramic green bodies in a microwave heating chamber operatively connected to a microwave source and a PLC. The total mass of the ceramic green bodies present in the microwave heating chamber is determined. Microwave energy is generated with the microwave source and transmitted from the microwave source to the microwave heating chamber. A transmitted power of the microwave energy transmitted from the microwave source to the microwave heating chamber is measured with power sensors. The reflected power of reflected microwave energy reflected back from the microwave heating chamber is also measured. The power of the microwave energy transmitted from the microwave source to the microwave heating chamber is adjusted based on the total mass of ceramic green bodies present in the microwave heating chamber, the measured transmitted power and the measured reflected power.

Abstract translation: 用于干燥陶瓷生坯体的方法和设备包括在可操作地连接到微波源和PLC的微波加热室中提供一个或多个陶瓷生坯体。 确定存在于微波加热室中的陶瓷生坯的总质量。 微波能量由微波源产生并从微波源传输到微波加热室。 使用功率传感器测量从微波源传输到微波加热室的微波能量的发射功率。 还测量了从微波加热室反射回来的反射微波能量的反射功率。 基于微波加热室中存在的陶瓷生坯的总质量，测量的透射功率和测量的反射功率，调节从微波源传输到微波加热室的微波能量的功率。

公开(公告)号：WO2009147679A1

公开(公告)日：2009-12-10

申请号：PCT/IL2009/000563

申请日：2009-06-04

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  KLOOG, Yoel ,  GEORGE, Jacob ,  KEREN, Gad ,  RANDO, Rakefet

Inventor： KLOOG, Yoel ,  GEORGE, Jacob ,  KEREN, Gad ,  RANDO, Rakefet

IPC: A61K31/60 ,  A61K31/192 ,  A61P9/10

CPC classification number: A61K31/192 ,  A61K31/60

Abstract: Disclosed are methods for reducing the extent of myocardial ischemia/reperfusion injury, comprising administering to a human prior to reperfusion of the ischemic myocardium or pre-angioplasty, coronary artery bypass surgery, or thrombolytic therapy an effective amount of FTS, or various analogs thereof, or a pharmaceutically acceptable salt thereof. Methods of treating ischemia/reperfusion injury, comprising administering to a human after reperfusion of the ischemic myocardium or post-angioplasty, coronary artery bypass surgery, or thrombolytic therapy an effective amount of FTS, or various analogs thereof, or a pharmaceutically acceptable salt thereof are also disclosed.

Abstract translation: 公开了减少心肌缺血/再灌注损伤程度的方法，包括在缺血心肌的再灌注或预血管成形术，冠状动脉搭桥手术或溶栓治疗之前对人施用有效量的FTS或其各种类似物， 或其药学上可接受的盐。 治疗缺血/再灌注损伤的方法，包括在缺血心肌再灌注后或后血管成形术，冠状动脉旁路手术或血栓溶解治疗中向人施用有效量的FTS或其各种类似物或其药学上可接受的盐是 也披露。

公开(公告)号：WO2009005741A3

公开(公告)日：2009-06-25

申请号：PCT/US2008008061

申请日：2008-06-27

Applicant: CORNING INC ,  BRUNDAGE KEVIN R ,  GEORGE JACOB ,  VILENO ELIZABETH M

Inventor： BRUNDAGE KEVIN R ,  GEORGE JACOB ,  VILENO ELIZABETH M

IPC: H05B6/72

CPC classification number: H05B6/701 ,  B28B11/241 ,  B28B11/243 ,  F26B3/347 ,  F26B15/12 ,  F26B2210/02 ,  H05B6/705

Abstract: A microwave applicator assembly (100) includes a microwave applicator (102) that excites TE modes and provides a generally circular heating pattern in a lossy dielectric material. The microwave applicator has a processing chamber bounded by a circumferential wall (110) in which a plurality of indents (102) are formed. The microwave applicator assembly (100) may further include a feed waveguide (120) coupled to the microwave applicator (102) for inputting microwaves into the processing chamber. The microwave applicator assembly (100) may further include one or more choking sections in communication with the processing chamber (104) to enhance heating efficiency and reduce microwave leakage.

Abstract translation: 微波施加器组件（100）包括微波施加器（102），其激发TE模式并且在有损介质材料中提供大致圆形的加热图案。 微波施加器具有由周向壁（110）限定的处理室，其中形成有多个凹口（102）。 微波施加器组件（100）还可以包括耦合到微波施加器（102）的馈入波导（120），用于将微波输入到处理室中。 微波施加器组件（100）还可以包括与处理室（104）连通的一个或多个阻塞部分，以提高加热效率并减少微波泄漏。

公开(公告)号：WO2009048506A1

公开(公告)日：2009-04-16

申请号：PCT/US2008/010878

申请日：2008-09-19

Applicant: CORNING CABLE SYSTEMS LLC ,  EASTON, Martyn, N. ,  GEORGE, Jacob ,  SAUER, Michael ,  THELEN, Dean, M. ,  ZENTENO, Luis, A.

Inventor： EASTON, Martyn, N. ,  GEORGE, Jacob ,  SAUER, Michael ,  THELEN, Dean, M. ,  ZENTENO, Luis, A.

IPC: H04B10/12

CPC classification number: H04B10/25752

Abstract: A radio-over-fiber (RoF) hybrid wired/wireless transponder is disclosed that is configured to provide both wireless and wired communication between a hybrid head-end and one or more client devices. The hybrid transponder includes optical-to-electrical (O/E) and electrical-to-optical (E/O) conversion capability and is configured to frequency multiplex/demultiplex electrical "wired" signals and electrical "wireless" signals. The electrical wireless signals are wirelessly communicated to the client device(s) via a multiple- input/multiple-output (MIMO) antenna system within a cellular coverage area. The electrical wired signals are communicated to the client device(s) via a wireline cable that plugs into a wireline cable port on the transponder. The hybrid RoF system includes a hybrid head-end capable of transmitting and receiving wired and wireless optical signals, and an optical fiber cable that is optically coupled to the hybrid head-end and to at least one hybrid transponder. Drop-down transponder configurations that allow for easy wired and wireless connectivity between the client device(s) to the transponder(s) are also disclosed.

Abstract translation: 公开了一种无线电光纤（RoF）混合有线/无线应答器，其被配置为在混合头端与一个或多个客户端设备之间提供无线和有线通信。 混合转发器包括光电（O / E）和电 - 光（E / O）转换能力，并且被配置为频率复用/解复用电“有线”信号和电“无线”信号。 无线电信号通过蜂窝覆盖区域内的多输入/多输出（MIMO）天线系统无线地传送到客户端设备。 电接线信号通过有线电缆传送到客户端设备，该有线电缆插入应答器上的有线电缆端口。 混合RoF系统包括能够发送和接收有线和无线光信号的混合头端，以及光耦合到混合头端和至少一个混合转发器的光纤电缆。 还公开了允许在客户端设备与应答器之间简单的有线和无线连接的下拉式应答器配置。

公开(公告)号：WO2008021442A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/018154

申请日：2007-08-15

Applicant: CORNING CABLE SYSTEMS LLC ,  GEORGE, Jacob ,  SAUER, Michael ,  ZENTENO, Luis A.

Inventor： GEORGE, Jacob ,  SAUER, Michael ,  ZENTENO, Luis A.

IPC: H04B10/00

CPC classification number: H04B10/25759 ,  H04B10/25754

Abstract: The radio-over-fiber (RoF) transponder includes a converter unit adapted to convert RF electrical signals into optical signals and vice versa, and an antenna system electrically coupled to the converter unit. The antenna system includes first and second Z-shaped patch antenna elements formed on an antenna substrate. These patches are adapted to respectively transmit and receive radio-frequency (RF) electromagnetic radiation at a first frequency fA (e.g., 2.4 GHz) over a first picocell. The antenna system also includes a square patch antenna element formed atop the antenna substrate surface between the first and second Z-shaped patch antenna elements. The square patch antenna is adapted to transmit and receive RF electromagnetic radiation at a second frequency fB (e.g., 5.2 GHz) over a second picocell substantially co-located with the first picocell. One or more spaced-apart transponders can be supported by one or more optical fibers to form an array of picocells.

Abstract translation: 无线电光纤（RoF）应答器包括转换器单元，其适于将RF电信号转换成光信号，反之亦然，以及电耦合到转换器单元的天线系统。 天线系统包括形成在天线基板上的第一和第二Z形贴片天线元件。 这些贴片适于在第一微微小区上以第一频率fA（例如，2.4GHz）分别发射和接收射频（RF）电磁辐射。 天线系统还包括形成在第一和第二Z形贴片天线元件之间的天线基板表面顶部的方形贴片天线元件。 方形贴片天线适于在与第一微微小区基本共位的第二微微小区上以第二频率fB（例如，5.2GHz）发射和接收RF电磁辐射。 一个或多个间隔开的应答器可以由一个或多个光纤支撑以形成微微小区阵列。