公开(公告)号：WO2009086535A3

公开(公告)日：2009-07-09

申请号：PCT/US2008/088486

申请日：2008-12-29

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  CHEUNG, Yuk Kee ,  SIA, Samuel, K. ,  CHIN, Curtis, D. ,  GILLETTE, Brian, Michael

Inventor： CHEUNG, Yuk Kee ,  SIA, Samuel, K. ,  CHIN, Curtis, D. ,  GILLETTE, Brian, Michael

IPC: A61K35/12

Abstract: An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold - over clinically relevant size scales - sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via 'contact degradation.' A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.

公开(公告)号：WO2009043052A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/078197

申请日：2008-09-29

Applicant: COLUMBIA UNIVERSITY ,  SIA, Samuel, K. ,  GILLETTE, Brian, Michael

Inventor： SIA, Samuel, K. ,  GILLETTE, Brian, Michael

IPC: C12N11/00

CPC classification number: C12N5/0068 ,  C12N11/04 ,  C12N2533/54

Abstract: Methods and systems forming biocompatible materials are disclosed herein. Forming a biocompatible material may include contacting a liquid, having a linking material, with an adjoining material having embedded therein a nucleating material that causes the linking material to nucleate and grow into the liquid. After a time sufficient to cause the linking material to grow substantially from the nucleating material into a space occupied by the liquid, the liquid may be solidified to form a solid such that the linking material secures the solid to the adjoining material.

Abstract translation: 本文公开了形成生物相容性材料的方法和系统。 形成生物相容性材料可以包括使具有连接材料的液体与其中嵌入有成核材料的邻接材料接触，所述成核材料使连接材料成核并生长成液体。 在足以使连接材料从成核材料基本上生长成由液体占据的空间的时间之后，液体可以固化以形成固体，使得连接材料将固体固定到邻接的材料上。

公开(公告)号：WO2009086535A2

公开(公告)日：2009-07-09

申请号：PCT/US2008088486

申请日：2008-12-29

Applicant: UNIV COLUMBIA ,  CHEUNG YUK KEE ,  SIA SAMUEL K ,  CHIN CURTIS D ,  GILLETTE BRIAN MICHAEL

Inventor： CHEUNG YUK KEE ,  SIA SAMUEL K ,  CHIN CURTIS D ,  GILLETTE BRIAN MICHAEL

IPC: C12N5/08

CPC classification number: A61L27/60 ,  A61L27/48 ,  A61L27/52

Abstract: An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold - over clinically relevant size scales - sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via 'contact degradation.' A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.

Abstract translation: 适用于人造皮肤以及其他结构的基于细胞外基质（ECM）的支架可以使用生物反应器形成，所述生物反应器以在微观和/或纳米尺度上引入在生物反应器中凝胶化的ECM前体的期望结构特征的图案 。 生物反应器可以产生精细图案化的支架 - 通过临床相关的尺寸尺度 - 足够坚固的常规处理。 预成型的基于ECM的支架也可以具有引入其表面的微尺度和/或纳米级结构特征。 基于ECM的支架可以通过经由“接触降解”的微蚀刻和/或重塑形成具有良好限定的结构特征。 表面活化图案可以用于在图案和ECM之间的接触区域降解基于ECM的支架。 生产的基于ECM的支架可以具有有助于宿主组织向内生长的尺寸结构，同时保留天然ECM的纤维结构和配体密度。