中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

12 records (took 0.019 seconds)

    MICROSYSTEM SPECTROSCOPY
    1.
    发明申请
    MICROSYSTEM SPECTROSCOPY 审中-公开
    微结构光谱

    公开(公告)号：WO2006125176A8

    公开(公告)日：2007-03-01

    申请号：PCT/US2006019533

    申请日：2006-05-19

    Applicant: HARVARD COLLEGE ,  DAMEAN NICOLAE ,  SIA SAMUEL K ,  LINDER VINCENT ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

    Inventor： DAMEAN NICOLAE ,  SIA SAMUEL K ,  LINDER VINCENT ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

    IPC: G01N33/543 ,  B01L3/00

    CPC classification number: G01N21/255 ,  B01L3/5027 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0256 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/0638 ,  G02B21/0032

    Abstract: The present invention generally relates to systems and methods for acquiring multiple spectra from a sample, for example, a microfluidic sample. In some aspects of the invention, spectra from a series of locations within a sample are recorded and analyzed, and optionally correlated with an image of the sample. The spectra can be obtained by passing a plurality of light beams through a sample, e.g., using an array of microlenses, diffracting the light beams passing through the sample with a transmission grating, before or after passing the light through the sample, and detecting the resulting light, e.g., as an image. The light beams may pass through the sample before or after passing through the transmission grating. The image can appear as an array of discrete spectra, where each spectrum is associated with a region of the sample where a light beam passed through the sample. The spectra can be analyzed to determine information about the region where the light beam passed through the sample. In some cases, the array of microlenses may be movable and/or replaceable with a second array of microlenses. Also, in some instances, the transmission grating may be movable and/or replaceable with a second transmission grating.

    Abstract translation: 本发明一般涉及用于从样品例如微流体样品获取多个光谱的系统和方法。 在本发明的一些方面，记录和分析来自样品中的一系列位置的光谱，并且可选地与样品的图像相关。 可以通过使多个光束通过样品获得光谱，例如使用微透镜阵列，在通过样品之前或之后通过透射光栅衍射穿过样品的光束，并且检测 产生光，例如，作为图像。 光束可以在通过透射光栅之前或之后通过样品。 该图像可以显示为离散光谱阵列，其中每个光谱与光束通过样品的样品区域相关联。 可以分析光谱以确定关于光束通过样品的区域的信息。 在一些情况下，微透镜阵列可以是可移动的和/或可替代的第二阵列的微透镜。 此外，在一些情况下，透射光栅可以是可移动的和/或可以用第二透射光栅代替。

    FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS
    2.
    发明申请
    FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS 审中-公开
    流体结构包括测量和宽频道

    公开(公告)号：WO2006113727A2

    公开(公告)日：2006-10-26

    申请号：PCT/US2006/014583

    申请日：2006-04-19

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  LINDER, Vincent ,  SIA, Samuel, K. ,  WHITESIDES, George, M. ,  NAROVLYANSKY, Max ,  SIEGEL, Adam

    Inventor： LINDER, Vincent ,  SIA, Samuel, K. ,  WHITESIDES, George, M. ,  NAROVLYANSKY, Max ,  SIEGEL, Adam

    IPC: G01N21/59 ,  B01L3/00 ,  G01N33/543 ,  G01N33/553

    CPC classification number: G01N33/54366 ,  B01L3/502746 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0406 ,  G01N21/01 ,  G01N21/82 ,  G01N33/54373

    Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.

    Abstract translation: 本发明一般涉及微流体结构，更具体地涉及包括曲折和宽通道的微流体结构和方法。 微流控系统可以提供用于执行各种反应和分析的有利环境，这是由于与常规系统相比所需的样品和试剂量的减少，操作系统尺寸的减小以及反应时间的减少。 不幸的是，微量流体通道的小尺寸有时会导致在不放大光学器件（例如显微镜或光电倍增管）的情况下检测物质的困难。 一系列紧密包装的微通道，即曲折区域或具有大约毫米数量级的宽通道可以通过创建宽的测量区域来解决这个问题。 尽管本发明主要描述了在微流体芯片上的异源免疫测定中使用曲折和宽通道，但是本发明可用于放大用于其他类型反应和/或测定的光学信号。

    METHODS AND SYSTEMS FOR FORMING BIOCOMPATIBLE MATERIALS
    5.
    发明申请
    METHODS AND SYSTEMS FOR FORMING BIOCOMPATIBLE MATERIALS 审中-公开
    形成生物材料的方法和系统

    公开(公告)号：WO2009043052A1

    公开(公告)日：2009-04-02

    申请号：PCT/US2008/078197

    申请日：2008-09-29

    Applicant: COLUMBIA UNIVERSITY ,  SIA, Samuel, K. ,  GILLETTE, Brian, Michael

    Inventor： SIA, Samuel, K. ,  GILLETTE, Brian, Michael

    IPC: C12N11/00

    CPC classification number: C12N5/0068 ,  C12N11/04 ,  C12N2533/54

    Abstract: Methods and systems forming biocompatible materials are disclosed herein. Forming a biocompatible material may include contacting a liquid, having a linking material, with an adjoining material having embedded therein a nucleating material that causes the linking material to nucleate and grow into the liquid. After a time sufficient to cause the linking material to grow substantially from the nucleating material into a space occupied by the liquid, the liquid may be solidified to form a solid such that the linking material secures the solid to the adjoining material.

    Abstract translation: 本文公开了形成生物相容性材料的方法和系统。 形成生物相容性材料可以包括使具有连接材料的液体与其中嵌入有成核材料的邻接材料接触，所述成核材料使连接材料成核并生长成液体。 在足以使连接材料从成核材料基本上生长成由液体占据的空间的时间之后，液体可以固化以形成固体，使得连接材料将固体固定到邻接的材料上。

    SYSTEMS AND METHODS FOR FORMING PATTERNED EXTRACELLULAR MATRIX MATERIALS
    6.
    发明申请
    SYSTEMS AND METHODS FOR FORMING PATTERNED EXTRACELLULAR MATRIX MATERIALS 审中-公开
    用于形成图案的细胞基质材料的系统和方法

    公开(公告)号：WO2009086535A2

    公开(公告)日：2009-07-09

    申请号：PCT/US2008088486

    申请日：2008-12-29

    Applicant: UNIV COLUMBIA ,  CHEUNG YUK KEE ,  SIA SAMUEL K ,  CHIN CURTIS D ,  GILLETTE BRIAN MICHAEL

    Inventor： CHEUNG YUK KEE ,  SIA SAMUEL K ,  CHIN CURTIS D ,  GILLETTE BRIAN MICHAEL

    IPC: C12N5/08

    CPC classification number: A61L27/60 ,  A61L27/48 ,  A61L27/52

    Abstract: An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold - over clinically relevant size scales - sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via 'contact degradation.' A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.

    Abstract translation: 适用于人造皮肤以及其他结构的基于细胞外基质（ECM）的支架可以使用生物反应器形成，所述生物反应器以在微观和/或纳米尺度上引入在生物反应器中凝胶化的ECM前体的期望结构特征的图案 。 生物反应器可以产生精细图案化的支架 - 通过临床相关的尺寸尺度 - 足够坚固的常规处理。 预成型的基于ECM的支架也可以具有引入其表面的微尺度和/或纳米级结构特征。 基于ECM的支架可以通过经由“接触降解”的微蚀刻和/或重塑形成具有良好限定的结构特征。 表面活化图案可以用于在图案和ECM之间的接触区域降解基于ECM的支架。 生产的基于ECM的支架可以具有有助于宿主组织向内生长的尺寸结构，同时保留天然ECM的纤维结构和配体密度。

    FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS
    7.
    发明申请
    FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS 审中-公开
    流体连接器和微流体系统

    公开(公告)号：WO2008137008A2

    公开(公告)日：2008-11-13

    申请号：PCT/US2008005577

    申请日：2008-05-01

    Applicant: CLAROS DIAGNOSTICS INC ,  LINDER VINCENT ,  STEINMILLER DAVID ,  SIA SAMUEL K

    Inventor： LINDER VINCENT ,  STEINMILLER DAVID ,  SIA SAMUEL K

    IPC: B01L3/00

    CPC classification number: G01N33/54366 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/563 ,  B01L3/565 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/041 ,  B01L2300/0627 ,  B01L2300/0672 ,  B01L2300/0838 ,  B01L2300/0861 ,  B01L2300/12 ,  B01L2400/049 ,  C12Q1/6834 ,  G01N21/6428 ,  G01N33/5302 ,  G01N33/5304 ,  G01N33/5306 ,  G01N33/545 ,  Y10T403/22 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. Prior to connection of the fluid connector and the substrate, the fluid path may be filled with a sample (e.g., blood). The sample may be obtained, for example, by pricking a finger of a user until blood is drawn from the finger into the fluid path (e.g., by capillary forces). Upon connection of the fluidic connector and the channels of the substrate, the sample can pass through a reaction area within the first channel of the substrate. This process can allow components of the sample to interact with components disposed in the reaction area. Afterwards, reagents from the second channel can flow to the reaction area via the fluid path, allowing components in the reaction area to be processed (e.g., amplified to produce detectable signal). Components in the reaction area can then be determined using various methods of detection.

    Abstract translation: 提供了用于在微流体系统中进行分析（例如免疫测定）的流体连接器，方法和装置。 在一些实施例中，具有流体路径的流体连接器用于连接形成在基板中的两个独立通道，以允许两个独立通道之间的流体连通。 可以使用可用于进行分析的试剂（例如，抗体溶液，洗涤缓冲液和扩增试剂）预先填充一个或两个独立通道。 这些试剂可以在使用前长时间（例如1年）存储在基质的通道中。 在连接流体连接器和基底之前，流体路径可以填充有样品（例如血液）。 样品可以例如通过穿刺用户的手指而获得，直到血液从手指拉入流体路径（例如通过毛细血管力）。 在连接流体连接器和衬底的通道时，样品可以通过衬底的第一通道内的反应区域。 该过程可以允许样品的组分与设置在反应区域中的组分相互作用。 之后，来自第二通道的试剂可以经由流体路径流到反应区域，从而允许处理反应区域中的组分（例如，被扩增以产生可检测的信号）。 然后可以使用各种检测方法来确定反应区域中的组分。

    FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS
    8.
    发明申请
    FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS 审中-公开

    公开(公告)号：WO2008137008A3

    公开(公告)日：2008-11-13

    申请号：PCT/US2008/005577

    申请日：2008-05-01

    Applicant: CLAROS DIAGNOSTICS, INC. ,  LINDER, Vincent ,  STEINMILLER, David ,  SIA, Samuel, K.

    Inventor： LINDER, Vincent ,  STEINMILLER, David ,  SIA, Samuel, K.

    IPC: B01L3/00

    Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. Prior to connection of the fluid connector and the substrate, the fluid path may be filled with a sample (e.g., blood). The sample may be obtained, for example, by pricking a finger of a user until blood is drawn from the finger into the fluid path (e.g., by capillary forces). Upon connection of the fluidic connector and the channels of the substrate, the sample can pass through a reaction area within the first channel of the substrate. This process can allow components of the sample to interact with components disposed in the reaction area. Afterwards, reagents from the second channel can flow to the reaction area via the fluid path, allowing components in the reaction area to be processed (e.g., amplified to produce detectable signal). Components in the reaction area can then be determined using various methods of detection.

    MICROSYSTEM SPECTROSCOPY
    9.
    发明申请
    MICROSYSTEM SPECTROSCOPY 审中-公开
    微结构光谱

    公开(公告)号：WO2006125176A1

    公开(公告)日：2006-11-23

    申请号：PCT/US2006/019533

    申请日：2006-05-19

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  DAMEAN, Nicolae ,  SIA, Samuel, K. ,  LINDER, Vincent ,  NAROVLYANSKY, Max ,  WHITESIDES, George, M.

    Inventor： DAMEAN, Nicolae ,  SIA, Samuel, K. ,  LINDER, Vincent ,  NAROVLYANSKY, Max ,  WHITESIDES, George, M.

    IPC: G01N33/543 ,  B01L3/00

    CPC classification number: G01N21/255 ,  B01L3/5027 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0256 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/0638 ,  G02B21/0032

    Abstract: The present invention generally relates to systems and methods for acquiring multiple spectra from a sample, for example, a microfluidic sample. In some aspects of the invention, spectra from a series of locations within a sample are recorded and analyzed, and optionally correlated with an image of the sample. The spectra can be obtained by passing a plurality of light beams through a sample, e.g., using an array of microlenses, diffracting the light beams passing through the sample with a transmission grating, before or after passing the light through the sample, and detecting the resulting light, e.g., as an image. The light beams may pass through the sample before or after passing through the transmission grating. The image can appear as an array of discrete spectra, where each spectrum is associated with a region of the sample where a light beam passed through the sample. The spectra can be analyzed to determine information about the region where the light beam passed through the sample. In some cases, the array of microlenses may be movable and/or replaceable with a second array of microlenses. Also, in some instances, the transmission grating may be movable and/or replaceable with a second transmission grating.

    Abstract translation: 本发明一般涉及用于从样品例如微流体样品获取多个光谱的系统和方法。 在本发明的一些方面，记录和分析来自样品中的一系列位置的光谱，并且可选地与样品的图像相关。 可以通过使多个光束通过样品获得光谱，例如使用微透镜阵列，在通过样品之前或之后通过透射光栅衍射穿过样品的光束，并且检测 产生光，例如，作为图像。 光束可以在通过透射光栅之前或之后通过样品。 该图像可以显示为离散光谱阵列，其中每个光谱与光束通过样品的样品区域相关联。 可以分析光谱以确定关于光束通过样品的区域的信息。 在一些情况下，微透镜阵列可以是可移动的和/或可替代的第二阵列的微透镜。 此外，在一些情况下，透射光栅可以是可移动的和/或可以用第二透射光栅代替。

Patent Agency Ranking