公开(公告)号：WO1997016439A1

公开(公告)日：1997-05-09

申请号：PCT/HU1996000064

申请日：1996-11-01

申请人： BIOREX KUTATO ÉS FEJLESZTO RT. ,  VIGH, László ,  LITERATI NAGY, Péter ,  SZILBEREKY, Jeno"e; ,  ÜRÖGDI, László ,  JEDNAKOVITS, Andrea ,  JASZLITS, László ,  BIRO, Katalin ,  MARVANYOS, Ede ,  BARABAS, Mihály ,  HEGEDÜS, Erzsébet ,  KORANYI, László ,  KÜRTHY, Mária ,  BALOGH, Gábor ,  HORVATH, Ibolya ,  TÖRÖK, Zsolt ,  UDVARDY, Éva ,  DORMAN, György ,  MEDZIHRADSZKY, Dénes ,  MÉZES, Bea ,  KOVACS, Eszter ,  DUDA, Erno"e; ,  FARKAS, Beatrix ,  GLATZ, Attila

发明人： BIOREX KUTATO ÉS FEJLESZTO RT.

IPC分类号： C07D333/38

CPC分类号： C07D213/78 ,  C07C259/02 ,  C07C259/18 ,  C07C275/64 ,  C07C279/18 ,  C07C2601/14 ,  C07D213/89 ,  C07D215/54 ,  C07D217/26 ,  C07D295/088 ,  C07D307/68 ,  C07D333/38 ,  C07D409/12 ,  C07D413/04

摘要： A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

摘要翻译： 提供了增加细胞分子伴侣表达和/或提高细胞中分子伴侣活性的方法。 所述方法包括用有效量的某种羟胺衍生物处理暴露于生理应激的细胞，所述生理应激诱导细胞表达分子伴侣以增加应激。 或者，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前向细胞施用羟胺衍生物。 优选地，施用羟胺衍生物的细胞是真核细胞。 羟胺衍生物对应于式（I）或（II）。 本发明还提供了落入式（I）和（II）范围内的新型羟胺衍生物以及包含所述化合物的药物和/或化妆品组合物。