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1.发明申请NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER 审中-公开用于治疗代谢性疾病和癌症的新型麻醉药
公开(公告)号：WO2016081599A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061342
申请日：2015-11-18
发明人： JIN, Shengkan , AUGERI, David, J. , KIMBALL, David, S. , LIU, Peng , TAO, Hanlin , ZENG, Xiangang
IPC分类号： A61K31/16 , A61K31/44 , C07D277/62
CPC分类号： A61K31/166 , A61K31/155 , A61K31/428 , A61K31/437 , A61K31/47 , A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/505 , A61K45/06 , C07D213/78 , C07D215/42 , C07D219/04 , C07D237/20 , C07D239/42 , C07D239/557 , C07D241/24 , C07D277/56 , C07D277/62 , C07D277/68 , A61K2300/00
摘要： 2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.
摘要翻译： 2-羟基 - 苯甲酰苯胺化合物及其衍生物，其组合物，以及通过解偶联线粒体治疗代谢疾病和癌症的方法。
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2.发明申请SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS 审中-公开用于治疗心脏病的SPHINGOSINE-1-PHOSPATE受体调节剂
公开(公告)号：WO2016053855A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/052611
申请日：2015-09-28
IPC分类号： C09B11/00
CPC分类号： C07D471/04 , C07C255/63 , C07D211/16 , C07D213/38 , C07D213/40 , C07D213/55 , C07D213/61 , C07D213/75 , C07D213/78 , C07D213/80 , C07D215/12 , C07D217/18 , C07D235/14 , C07D237/08 , C07D239/26 , C07D239/30 , C07D241/16 , C07D241/42 , C07D249/08 , C07D263/32 , C07D263/58 , C07D271/06 , C07D271/10 , C07D285/12 , C07D309/06 , C07D309/14 , C07D333/20 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C09B55/002 , C09B55/005 , C09B55/007
摘要： The invention provides compounds effective as sphingosine-1 -phosphate receptor modulators for treatment of cardiopulmonary diseases, such as hypertension (including malignant hypertension), angina, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, dysrhythmias, cardiomyothopy (including hypertropic cardiomyothopy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolus, pulmonary hypertension, mesothelioma, ventricular conduction abnormalities, complete heart block, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.
摘要翻译： 本发明提供了用于治疗心肺疾病如高血压（包括恶性高血压），心绞痛，心肌梗塞，心律失常，充血性心力衰竭，冠心病，动脉粥样硬化，心绞痛，心律失常的心肌病的鞘氨醇-1-磷酸受体调节剂有效的化合物 ，心肌肥厚（包括高血压心肌病），心力衰竭，心脏骤停，支气管炎，哮喘，慢性阻塞性肺疾病，囊性纤维化，咳嗽，肺气肿，胸膜炎，肺纤维化，肺炎，肺栓塞，肺动脉高压，间皮瘤，心室传导异常 心脏阻塞，成人呼吸窘迫综合征，败血症综合征，特发性肺纤维化，硬皮病，系统性硬化，腹膜后纤维化，预防瘢痕疙瘩形成或肝硬化。
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3.发明申请PYRIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开吡咯烷酮衍生物及其在治疗，改善或预防病毒性疾病中的应用
公开(公告)号：WO2014108407A1
公开(公告)日：2014-07-17
申请号：PCT/EP2014/050166
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles
IPC分类号： C07D213/78 , A61K31/4412 , A61P43/00
CPC分类号： C07D213/81 , A61K31/4412 , A61K45/06 , C07D213/78 , C07D213/79
摘要： The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof (II), which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式（II）的化合物，其任选呈药学上可接受的盐，溶剂化物，多晶型物，共价，共结晶，前药，互变异构体，外消旋物，对映异构体或非对映异构体或其混合物的形式（II）， 其可用于治疗，预防或预防病毒性疾病。 此外，公开了具体的组合疗法。
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公开(公告)号：WO2008106692A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/055724
申请日：2008-03-03
申请人： NOVARTIS VACCINES AND DIAGNOSTICS, INC. , BURGER, Matthew , LINDVALL, Mika , HAN, Wooseok , LAN, Jiong , NISHIGUCHI, Gisele , SHAFER, Cynthia , BELLAMACINA, Cornelia , HUH, Kay , ATALLAH, Gordana , MCBRIDE, Christopher , ANTONIOS-MCCREA, William, Jr. , ZAVOROTINSKAYA, Tatiana , WALTER, Annette , GARCIA, Pablo
发明人： BURGER, Matthew , LINDVALL, Mika , HAN, Wooseok , LAN, Jiong , NISHIGUCHI, Gisele , SHAFER, Cynthia , BELLAMACINA, Cornelia , HUH, Kay , ATALLAH, Gordana , MCBRIDE, Christopher , ANTONIOS-MCCREA, William, Jr. , ZAVOROTINSKAYA, Tatiana , WALTER, Annette , GARCIA, Pablo
IPC分类号： C07D213/78 , C07D401/12 , C07D239/28 , A61K31/44 , A61P35/00
CPC分类号： C07D401/12 , C07D213/78 , C07D239/28
摘要： New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase- mediated disorder, such as cancer.
摘要翻译： 提供了抑制人或动物受试者中与肿瘤发生相关的激酶活性的新化合物，组合物和方法。 在某些实施方案中，化合物和组合物有效抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的疾病，例如癌症。
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公开(公告)号：WO2007130823A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/067370
申请日：2007-04-25
申请人： ASTRAZENECA AB , NPS PHARMACEUTICALS, INC. , ISAAC, Methvin , SLASSI, Abdelmalik , EDWARDS, Louise , XIN, Tao , WÅLLBERG, Andreas , STEFANAC, Tomislav
发明人： ISAAC, Methvin , SLASSI, Abdelmalik , EDWARDS, Louise , XIN, Tao , WÅLLBERG, Andreas , STEFANAC, Tomislav
IPC分类号： C07D413/14 , A61K31/4439 , A61P25/02 , A61P25/22 , A61P1/00
CPC分类号： C07D207/16 , C07D207/08 , C07D207/09 , C07D213/78 , C07D213/79 , C07D413/04 , C07D413/14
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
摘要翻译： 本发明涉及新化合物，其制备方法，它们在治疗中的应用和包含新化合物的药物组合物。
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6.发明申请PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE 审中-公开作为HISTONE脱乙酰基酶抑制剂的吡啶和吡啶衍生物
公开(公告)号：WO2007082874A1
公开(公告)日：2007-07-26
申请号：PCT/EP2007/050371
申请日：2007-01-16
申请人： JANSSEN PHARMACEUTICA N.V. , MARCONNET-DECRANE, Laurence, Françoise, Bernadette , GAURRAND, Sandrine, Françoise, Dominique , ANGIBAUD, Patrick, René
发明人： MARCONNET-DECRANE, Laurence, Françoise, Bernadette , GAURRAND, Sandrine, Françoise, Dominique , ANGIBAUD, Patrick, René
IPC分类号： C07D239/42 , C07D409/14 , C07D403/12 , A61K31/506 , A61P35/00
CPC分类号： A61K31/496 , A61K45/06 , C07D213/78 , C07D213/82 , C07D239/42 , C07D403/12 , C07D409/14 , Y02A50/411
摘要： This invention comprises the novel compounds of formula (I) wherein R 1 , R 2 , R 3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R 1，R 2，R 3和X具有确定的含义，具有组蛋白脱乙酰酶 抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：WO2007044085A3
公开(公告)日：2007-06-28
申请号：PCT/US2006019359
申请日：2006-05-19
发明人： CHOWDHURY SULTAN
IPC分类号： C07D213/78 , A61K31/44 , A61K31/501 , A61P3/00 , C07D237/24 , C07D401/04 , C07D401/06 , C07D401/08 , C07D417/06
CPC分类号： C07D237/24 , C07D213/78 , C07D401/04 , C07D401/06 , C07D401/08 , C07D417/06
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where J, K, L, M, W, V, R 2 and R 3 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了治疗哺乳动物，优选人的SCD介导的疾病或病症的方法，其中所述方法包括给予有需要的哺乳动物式（I）化合物：其中J，K，L，M，W ，V，R 2和R 3在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：WO2007044085A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/019359
申请日：2006-05-19
发明人： CHOWDHURY, Sultan
IPC分类号： C07D213/78 , C07D237/24 , C07D401/04 , C07D401/06
CPC分类号： C07D237/24 , C07D213/78 , C07D401/04 , C07D401/06 , C07D401/08 , C07D417/06
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where J, K, L, M, W, V, R 2 and R 3 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中J，K，L，M，W ，V，R 2和R 3在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：WO2006089953A1
公开(公告)日：2006-08-31
申请号：PCT/EP2006/060270
申请日：2006-02-24
IPC分类号： C07D333/44 , C07D213/16 , C07D239/42 , A61K38/36 , A61K47/22
CPC分类号： C07D213/78 , A61K9/0019 , A61K9/08 , A61K9/127 , A61K47/22 , C07D213/16 , C07D239/42 , C07D333/44 , C07D409/12
摘要： The invention relates to novel compounds with formula I and their use in stabilization of Factor Vila or other Factor VII polypeptides, particularly in aqueous liquid compositions thereof.
摘要翻译： 本发明涉及具有式I的新化合物及其在因子VIIa或其他因子VII多肽的稳定中的用途，特别是在其水性液体组合物中。
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10.发明申请5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS 审中-公开5-取代的-4'-（取代的苯基）！用于MEK抑制剂的氨基-2-吡啶酮衍生物
公开(公告)号：WO2005000818A1
公开(公告)日：2005-01-06
申请号：PCT/IB2004/002060
申请日：2004-06-18
申请人： WARNER-LAMBERT COMPANY LLC , BLACK, Shannon, Leigh , KAUFMAN, Michael, David , ORTWINE, Daniel, Fred , PLUMMER, Mark, Stephen , QUIN, John, III , REWCASTLE, Gordon, William , SHAHRIPOUR, Aurash, Bavarsad , SPICER, Julie, Ann , WHITEHEAD, Christopher, Emil
发明人： BLACK, Shannon, Leigh , KAUFMAN, Michael, David , ORTWINE, Daniel, Fred , PLUMMER, Mark, Stephen , QUIN, John, III , REWCASTLE, Gordon, William , SHAHRIPOUR, Aurash, Bavarsad , SPICER, Julie, Ann , WHITEHEAD, Christopher, Emil
IPC分类号： C07D213/78
CPC分类号： C07D213/78 , C07D213/80 , C07D213/82 , C07D213/87 , C07D401/12 , C07D413/04
摘要： The present invention relates to 5-substituted-4-(substituted) phenylamino-2-pyridone derivatives of formula (I), pharmaceutical compositions and methods of use thereof as MEK inhibitors. Formula (I) wherein W is formula (II), formula (III), formula (IV), or formula (V); and R 1-5 and Z are as defined in the claims.
摘要翻译： 本发明涉及式（I）的5-取代-4-（取代）苯基氨基-2-吡啶酮衍生物，药物组合物及其用作MEK抑制剂的方法。 式（I）其中W是式（II），式（III），式（IV）或式（V）; R1-5和Z如权利要求中所定义。
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