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公开(公告)号：WO2007073567A2
公开(公告)日：2007-06-28
申请号：PCT/US2006062580
申请日：2006-12-22
Applicant: IQ CORP , US NAVY , JACKSON H M FOUND MILITARY MED , HERMAN GROEN , MATECZUN AI , CHAPMAN GAIL , BAILLIE LES , GOLDMAN STANLEY , ALBRECHT MARK
Inventor： HERMAN GROEN , MATECZUN AI , CHAPMAN GAIL , BAILLIE LES , GOLDMAN STANLEY , ALBRECHT MARK
CPC classification number: A61K39/40 , A61K39/07 , A61K39/395 , A61K2039/5254 , A61K2039/545 , A61K2039/55505 , A61K2039/55516 , A61K2300/00
Abstract: The present invention provides methods and compositions of enhancing the immune response to an antigen.
Abstract translation: 本发明提供增强对抗原的免疫应答的方法和组合物。
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2.发明申请METHODS AND COMPOSITIONS FOR DEVELOPING SPORE DISPLAY SYSTEMS FOR MEDICINAL AND INDUSTRIAL APPLICATIONS 审中-公开开发用于药物和工业应用的孢子展示系统的方法和组合物
公开(公告)号：WO0200232A3
公开(公告)日：2002-06-20
申请号：PCT/US0120372
申请日：2001-06-26
Applicant: MAXYGEN INC , GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
Inventor： GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
IPC: A61K39/385 , A61K48/00 , A61P37/00 , C07K14/14 , C07K14/24 , C12Q1/02 , G01N33/532 , A61K39/00 , A61K35/72 , A61K35/74
CPC classification number: C07K14/005 , A61K39/385 , A61K48/00 , A61K2039/523 , A61K2039/541 , A61K2039/6006 , A61K2039/6031 , C07K14/24 , C12N2720/12322 , C12Q1/02 , G01N33/532
Abstract: Compositions and methods for utilizing spore systems for medicinal and industrial protein applications are provided. Compositions comprise spores that produce and/or display carbohydrates, proteins, and nucleic acids of interest. Such spores are useful as therapeutic or prophylactic agents or vaccines against a broad spectrum of immunogens and bacterial and viral pathogens. Additionally, spore systems are useful in production, packaging, delivery, and presentation of polypeptides and/or nucleic acids for industrial catalysts, medical applications, and diagnostic applications.
Abstract translation: 提供了用于医药和工业蛋白质应用的孢子系统的组合物和方法。 组合物包含产生和/或展示感兴趣的碳水化合物，蛋白质和核酸的孢子。 这种孢子可用作针对广谱免疫原和细菌和病毒病原体的治疗剂或预防剂或疫苗。 此外，孢子系统可用于工业催化剂，医学应用和诊断应用的多肽和/或核酸的生产，包装，递送和递呈。
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公开(公告)号：WO2007050103A3
公开(公告)日：2009-04-09
申请号：PCT/US2005043141
申请日：2005-11-29
Applicant: PHYLLOM LLC , LIBS JOHN , GOLDMAN STANLEY
Inventor： LIBS JOHN , GOLDMAN STANLEY
IPC: C12N1/20
Abstract: The present invention provides recombinant bacteria strains, such as Bacillus or Clostridium strains, lacking one or more genes commonly used for selecting recombinants (i.e., selection marker genes). More particularly, the present invention provides recombinant bacteria strains, containing one or more additional copies of its own gene or genes and/or one or more foreign genes artificially inserted in the host chromosomal DNA or extra-chromosomal DNA (e.g., a plasmid) without any selection marker gene or genes, such as an antibiotic resistance gene of any foreign origin. This allows for the introduction of the resultant recombinant Bacillus or Clostridium strain into the environment or into animals or humans without any contaminating selection marker gene. The recombinant strain, while lacking detrimental genes such as selection marker genes, may contain one or more desirable genes such as genes encoding insecticidal proteins or antigens for immunizing animals and humans. The present invention also provides methods for producing the recombinant bacterial strains.
Abstract translation: 本发明提供了重组细菌菌株，例如芽孢杆菌属或梭菌属菌株，缺乏通常用于选择重组体的一种或多种基因（即选择标记基因）。 更具体地，本发明提供了重组细菌菌株，其含有一个或多个本身的基因或基因的另外的拷贝，和/或人造地插入宿主染色体DNA或染色体外DNA（例如质粒）中的一个或多个外来基因，而没有 任何选择标记基因或基因，例如任何外来来源的抗生素抗性基因。 这允许将所得到的重组芽孢杆菌或梭菌属菌株引入环境中或将其引入动物或人体中而没有任何污染选择标记基因。 重组菌株虽然缺乏有害基因如选择标记基因，但可含有一个或多个所需基因，例如编码杀虫蛋白的基因或用于免疫动物和人的抗原。 本发明还提供了生产重组细菌菌株的方法。
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4.发明申请
公开(公告)号：WO2006012366A3
公开(公告)日：2006-09-28
申请号：PCT/US2005025788
申请日：2005-07-20
Applicant: PHYLLOM LLC , GOLDMAN STANLEY , LIBS JOHN
Inventor： GOLDMAN STANLEY , LIBS JOHN
CPC classification number: A01N63/02 , C07K14/325 , C07K2319/00 , C07K2319/035
Abstract: The invention provides isolated nucleic acid and amino acid sequences for Bacillus thuringiensis (Bt) spore outer coat protein and exosporium protein genes fusion proteins containing such proteins. The invention further includes methods for using the genes to construct expression cassettes, expression vectors, and recombinant Bt strains that have exogenous proteins attached to their spores. The exogenous proteins attached to the surface of recombinant Bt spores may provide insecticidal, enzymatic, or antigenic activity. The invention also provides for compositions made from the recombinant Bt strains and methods for fermenting and using the recombinant Bt strains produced by the invention.
Abstract translation: 本发明提供了苏云金芽孢杆菌（Bt）孢子外壳蛋白的分离的核酸和氨基酸序列以及含有这些蛋白质的外孢菌蛋白基因融合蛋白。 本发明还包括使用这些基因构建表达盒，表达载体和具有附着于其孢子上的外源蛋白质的重组Bt菌株的方法。 附着于重组Bt孢子表面的外源蛋白可提供杀虫，酶促或抗原活性。 本发明还提供了由重组Bt菌株制备的组合物以及发酵和使用本发明生产的重组Bt菌株的方法。
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Patent Agency Ranking
公开(公告)号：WO2007050103A2
公开(公告)日：2007-05-03
申请号：PCT/US2005/043141
申请日：2005-11-29
Applicant: PHYLLOM LLC , LIBS, John , GOLDMAN, Stanley
Inventor： LIBS, John , GOLDMAN, Stanley
Abstract: The present invention provides recombinant bacteria strains, such as Bacillus or Clostridium strains, lacking one or more genes commonly used for selecting recombinants (i.e., selection marker genes). More particularly, the present invention provides recombinant bacteria strains, containing one or more additional copies of its own gene or genes and/or one or more foreign genes artificially inserted in the host chromosomal DNA or extra-chromosomal DNA (e.g., a plasmid) without any selection marker gene or genes, such as an antibiotic resistance gene of any foreign origin. This allows for the introduction of the resultant recombinant Bacillus or Clostridium strain into the environment or into animals or humans without any contaminating selection marker gene. The recombinant strain, while lacking detrimental genes such as selection marker genes, may contain one or more desirable genes such as genes encoding insecticidal proteins or antigens for immunizing animals and humans. The present invention also provides methods for producing the recombinant bacterial strains.
Abstract translation: 本发明提供了重组细菌菌株，如芽孢杆菌属（Bacillus）或梭菌属（Clostridium），缺乏一种或多种通常用于选择重组体的基因（即选择标记基因）。 更具体地，本发明提供了重组细菌菌株，其含有一个或多个本身的基因或基因的另外的拷贝，和/或人造地插入宿主染色体DNA或染色体外DNA（例如，质粒）中的一个或多个外来基因，没有 任何选择标记基因或基因，例如任何外来来源的抗生素抗性基因。 这允许将所得重组芽孢杆菌或梭菌属菌株引入环境中或将其引入动物或人体中而没有任何污染选择标记基因。 重组菌株虽然缺乏有害基因如选择标记基因，但可含有一个或多个所需基因，例如编码杀虫蛋白的基因或用于免疫动物和人的抗原。 本发明还提供了生产重组细菌菌株的方法。
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公开(公告)号：WO2007073567A3
公开(公告)日：2007-06-28
申请号：PCT/US2006/062580
申请日：2006-12-22
Applicant: IQ CORPORATION , THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY , HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE , HERMAN, Groen , MATECZUN, Ai , CHAPMAN, Gail , BAILLIE, Les , GOLDMAN, Stanley , ALBRECHT, Mark
Inventor： HERMAN, Groen , MATECZUN, Ai , CHAPMAN, Gail , BAILLIE, Les , GOLDMAN, Stanley , ALBRECHT, Mark
Abstract: The present invention provides methods and compositions of enhancing the immune response to an antigen.
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7.发明申请
公开(公告)号：WO0151663A3
公开(公告)日：2002-06-13
申请号：PCT/US0101056
申请日：2001-01-10
Applicant: MAXYGEN INC , BASS STEVEN H , DAVIS S CHRISTOPHER , PATTEN PHILLIP A , TOBIN MATTHEW , MINSHULL JEREMY , WELCH MARK , GUSTAFSSON CLAES , CARR BRIAN , JENNE STEPHANE , RAILLARD SUN AI , CRAMERI ANDREAS , STEMMER WILLEM P C , EMIG ROBIN , LONGCHAMP PASCAL , GOLDMAN STANLEY , GIVER LORRAINE J , AFFHOLTER JOSEPH A
Inventor： BASS STEVEN H , DAVIS S CHRISTOPHER , PATTEN PHILLIP A , TOBIN MATTHEW , MINSHULL JEREMY , WELCH MARK , GUSTAFSSON CLAES , CARR BRIAN , JENNE STEPHANE , RAILLARD SUN AI , CRAMERI ANDREAS , STEMMER WILLEM P C , EMIG ROBIN , LONGCHAMP PASCAL , GOLDMAN STANLEY , GIVER LORRAINE J , AFFHOLTER JOSEPH A
CPC classification number: C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
Abstract translation: 提供了用于多样化生成和筛选的集成系统和方法。 该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。
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8.发明申请
公开(公告)号：WO2006012366A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/025788
申请日：2005-07-20
Applicant: PHYLLOM LLC , GOLDMAN, Stanley , LIBS, John
Inventor： GOLDMAN, Stanley , LIBS, John
CPC classification number: A01N63/02 , C07K14/325 , C07K2319/00 , C07K2319/035
Abstract: The invention provides isolated nucleic acid and amino acid sequences for Bacillus thuringiensis (Bt) spore outer coat protein and exosporium protein genes fusion proteins containing such proteins. The invention further includes methods for using the genes to construct expression cassettes, expression vectors, and recombinant Bt strains that have exogenous proteins attached to their spores. The exogenous proteins attached to the surface of recombinant Bt spores may provide insecticidal, enzymatic, or antigenic activity. The invention also provides for compositions made from the recombinant Bt strains and methods for fermenting and using the recombinant Bt strains produced by the invention.
Abstract translation: 本发明提供了用于苏云金芽孢杆菌（Bt）孢子外壳蛋白和含有这种蛋白质的外源蛋白基因融合蛋白的分离的核酸和氨基酸序列。 本发明还包括使用该基因构建表达盒，表达载体和具有附着于其孢子的外源蛋白的重组Bt菌株的方法。 附着于重组Bt孢子表面的外源蛋白可提供杀虫，酶促或抗原活性。 本发明还提供了由重组Bt菌株制备的组合物以及用于发酵和使用本发明生产的重组Bt菌株的方法。
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9.发明申请METHODS AND COMPOSITIONS FOR DEVELOPING SPORE DISPLAY SYSTEMS FOR MEDICINAL AND INDUSTRIAL APPLICATIONS 审中-公开用于开发用于医药和工业应用的SPORE显示系统的方法和组合
公开(公告)号：WO0200232A9
公开(公告)日：2004-05-13
申请号：PCT/US0120372
申请日：2001-06-26
Applicant: MAXYGEN INC , GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
Inventor： GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
IPC: A61K39/385 , A61K48/00 , A61P37/00 , C07K14/14 , C07K14/24 , C12Q1/02 , G01N33/532 , A61K39/00 , A61K35/72 , A61K35/74
CPC classification number: C07K14/005 , A61K39/385 , A61K48/00 , A61K2039/523 , A61K2039/541 , A61K2039/6006 , A61K2039/6031 , C07K14/24 , C12N2720/12322 , C12Q1/02 , G01N33/532
Abstract: Compositions and methods for utilizing spore systems for medicinal and industrial protein applications are provided. Compositions comprise spores that produce and/or display carbohydrates, proteins, and nucleic acids of interest. Such spores are useful as therapeutic or prophylactic agents or vaccines against a broad spectrum of immunogens and bacterial and viral pathogens. Additionally, spore systems are useful in production, packaging, delivery, and presentation of polypeptides and/or nucleic acids for industrial catalysts, medical applications, and diagnostic applications.
Abstract translation: 提供了用于药用和工业蛋白质应用的孢子体系的组合物和方法。 组合物包含产生和/或显示目标碳水化合物，蛋白质和核酸的孢子。 这样的孢子可用作针对广谱免疫原和细菌和病毒病原体的治疗或预防剂或疫苗。 此外，孢子系统在生产，包装，递送和呈递用于工业催化剂，医疗应用和诊断应用的多肽和/或核酸方面是有用的。
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