公开(公告)号：WO2008021936A3

公开(公告)日：2008-04-17

申请号：PCT/US2007075553

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/501 ,  A61K31/497 ,  A61K31/506 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds of formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021928A3

公开(公告)日：2008-03-27

申请号：PCT/US2007075545

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A and B are selected from phenyl and a six-membered heteroaromatic ring containing one, two or three nitrogen atoms; provided that at least one of A and B is other than phenyl, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）化合物或其药学上可接受的盐，其中A和B选自苯基和含有一个，两个或三个氮原子的六元杂芳环; 条件是A和B中的至少一个不是苯基，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2010017401A1

公开(公告)日：2010-02-11

申请号：PCT/US2009/053019

申请日：2009-08-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BELEMA, Makonen ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  KAKARLA, Ramesh ,  LI, Guo ,  LOPEZ, Omar, D. ,  NGUYEN, Van, N. ,  KAPUR, Jayne ,  QIU, Yuping ,  ROMINE, Jeffrey, Lee ,  ST. LAURENT, Denis, R. ,  SERRANO-WU, Michael ,  SNYDER, Lawrence, B. ,  YANG, Fukang

Inventor： BELEMA, Makonen ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  KAKARLA, Ramesh ,  LI, Guo ,  LOPEZ, Omar, D. ,  NGUYEN, Van, N. ,  KAPUR, Jayne ,  QIU, Yuping ,  ROMINE, Jeffrey, Lee ,  ST. LAURENT, Denis, R. ,  SERRANO-WU, Michael ,  SNYDER, Lawrence, B. ,  YANG, Fukang

IPC: C07D235/20 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/12 ,  C07D409/14

CPC classification number: C07D235/20 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102568A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/032830

申请日：2009-02-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

IPC: C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021927A3

公开(公告)日：2008-05-29

申请号：PCT/US2007075544

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  WANG GAN ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  WANG GAN ,  HAMANN LAWRENCE G

IPC: C07D401/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61P31/12 ,  C07D403/14

CPC classification number: C07D233/64 ,  A61K31/4178 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure relates to a compound of Formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102633A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033380

申请日：2009-02-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052

Abstract: The present disclosure relates to compounds of structure (I), compositions and Methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及结构（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法的化合物。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102325A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053779

申请日：2008-02-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  A61P31/00 ,  A61K31/41

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds Formule (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in. the treatment of HCV infection.

Abstract translation: 本公开涉及化合物（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和在治疗HCV感染中使用这些化合物的方法。

公开(公告)号：WO2008021928A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075545

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4439 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：WO2008021927A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075544

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D401/14 ,  C07D403/14 ,  A61P31/12 ,  A61K31/4025 ,  A61K31/4178

CPC classification number: C07D233/64 ,  A61K31/4178 ,  A61K45/06 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07F5/025 ,  C07F7/0812

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2011082077A1

公开(公告)日：2011-07-07

申请号：PCT/US2010/061855

申请日：2010-12-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LOPEZ, Omar D. ,  ST. LAURENT, Denis R. ,  GOODRICH, Jason ,  ROMINE, Jeffrey Lee ,  SERRANO-WU, Michael ,  YANG, Fukang ,  KAKARLA, Ramesh ,  YANG, Xuejie ,  QIU, Yuping ,  SNYDER, Lawrence B.

Inventor： LOPEZ, Omar D. ,  ST. LAURENT, Denis R. ,  GOODRICH, Jason ,  ROMINE, Jeffrey Lee ,  SERRANO-WU, Michael ,  YANG, Fukang ,  KAKARLA, Ramesh ,  YANG, Xuejie ,  QIU, Yuping ,  SNYDER, Lawrence B.

IPC: C07D231/12 ,  C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/341 ,  A61K31/381 ,  A61K31/41 ,  A61P31/14

CPC classification number: A61K31/415 ,  A61K31/4196 ,  A61K31/4245 ,  C07D231/12 ,  C07D233/58 ,  C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D249/12 ,  C07D263/32 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。