公开(公告)号：WO2008021936A3

公开(公告)日：2008-04-17

申请号：PCT/US2007075553

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/501 ,  A61K31/497 ,  A61K31/506 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds of formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021928A3

公开(公告)日：2008-03-27

申请号：PCT/US2007075545

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A and B are selected from phenyl and a six-membered heteroaromatic ring containing one, two or three nitrogen atoms; provided that at least one of A and B is other than phenyl, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）化合物或其药学上可接受的盐，其中A和B选自苯基和含有一个，两个或三个氮原子的六元杂芳环; 条件是A和B中的至少一个不是苯基，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102568A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/032830

申请日：2009-02-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

IPC: C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021927A3

公开(公告)日：2008-05-29

申请号：PCT/US2007075544

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  WANG GAN ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  WANG GAN ,  HAMANN LAWRENCE G

IPC: C07D401/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61P31/12 ,  C07D403/14

CPC classification number: C07D233/64 ,  A61K31/4178 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure relates to a compound of Formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102694A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033646

申请日：2009-02-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  A61K31/517 ,  A61P31/00

CPC classification number: C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), their compositions and their use in the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，其组合物及其在治疗丙型肝炎病毒（HCV）感染中的用途。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102318A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053638

申请日：2008-02-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

IPC: C07D403/10 ,  C07D403/14 ,  A61K31/4164 ,  A61P31/22

CPC classification number: C07D403/14 ,  C07D233/64 ,  C07D403/10

Abstract: The present disclosure relates to (4-4' -diimidazolyl) biphenyls compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及（4-4'-二咪唑基）联苯组合物和治疗丙型肝炎病毒（HCV）感染的方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021936A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075553

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/501 ,  A61K31/506 ,  A61K31/497 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008144380A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/063689

申请日：2008-05-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

IPC: C07D413/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/40 ,  A61P31/12

CPC classification number: C07D413/14 ,  C07D403/04 ,  C07D403/14

Abstract: The present disclosure relates to compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein A and B are each phenyl; D and E are each five-membered aromatic rings containing one, two, or three i hcteroatoms independently selected from nitrogen, oxygen, and sulfur; provided that ', at least one of D and E is other than imidazole; compositions and methods for the treatment of Hepatitis C virus (HCV) inf ection. Also disclosed are pharmaceutical compositions containing such compounds and methods f or using these compounds in the treatment of HCV inf ection.

Abstract translation: 本公开涉及下式（I）的化合物或其药学上可接受的盐，其中A和B各自为苯基; D和E分别是含有独立地选自氮，氧和硫的一个，两个或三个独立原子的五元芳环; 条件是'，D和E中的至少一个不是咪唑; 用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和f或使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2007041616A1

公开(公告)日：2007-04-12

申请号：PCT/US2006/038731

申请日：2006-10-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Tao ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  JAMES, Clint A. ,  RUEDIGER, Edward H. ,  PEARCE, Bradley C.

Inventor： WANG, Tao ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  JAMES, Clint A. ,  RUEDIGER, Edward H. ,  PEARCE, Bradley C.

IPC: C07D209/12 ,  C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D471/04 ,  C07F5/02 ,  A61K31/395 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07D471/04 ,  C07D209/12 ,  C07D209/18 ,  C07D401/04 ,  C07D401/12 ,  C07D409/04 ,  C07D417/04 ,  C07F5/025

Abstract: This disclosure provides compounds of Formula (I) as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine diamide derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS. Formula (I) wherein: X is selected from the group consisting of formulae (II, III, IV and V); Y is formula (VI); Z is formula (VII).

Abstract translation: 本公开内容提供了本文所述的具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的吲哚和氮杂吲哚哌嗪二酰胺衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。 式（I）其中：X选自式（II，III，IV和V）; Y是式（VI）; Z是式（VII）。

公开(公告)号：WO2010138488A1

公开(公告)日：2010-12-02

申请号：PCT/US2010/036033

申请日：2010-05-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LAVOIE, Rico ,  JAMES, Clint A. ,  RUEDIGER, Edward H.

Inventor： LAVOIE, Rico ,  JAMES, Clint A. ,  RUEDIGER, Edward H.

IPC: C07D413/10 ,  C07D413/14 ,  C07D403/10 ,  C07D403/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D413/10 ,  C07D403/10 ,  C07D403/14 ,  C07D413/14

Abstract: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.