公开(公告)号：WO2009102633A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033380

申请日：2009-02-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052

Abstract: The present disclosure relates to compounds of structure (I), compositions and Methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及结构（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法的化合物。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102325A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053779

申请日：2008-02-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  A61P31/00 ,  A61K31/41

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds Formule (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in. the treatment of HCV infection.

Abstract translation: 本公开涉及化合物（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和在治疗HCV感染中使用这些化合物的方法。

公开(公告)号：WO2008021928A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075545

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4439 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：WO2008021927A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075544

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D401/14 ,  C07D403/14 ,  A61P31/12 ,  A61K31/4025 ,  A61K31/4178

CPC classification number: C07D233/64 ,  A61K31/4178 ,  A61K45/06 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07F5/025 ,  C07F7/0812

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102694A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033646

申请日：2009-02-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  A61K31/517 ,  A61P31/00

CPC classification number: C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), their compositions and their use in the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，其组合物及其在治疗丙型肝炎病毒（HCV）感染中的用途。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102318A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053638

申请日：2008-02-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

IPC: C07D403/10 ,  C07D403/14 ,  A61K31/4164 ,  A61P31/22

CPC classification number: C07D403/14 ,  C07D233/64 ,  C07D403/10

Abstract: The present disclosure relates to (4-4' -diimidazolyl) biphenyls compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及（4-4'-二咪唑基）联苯组合物和治疗丙型肝炎病毒（HCV）感染的方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021936A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075553

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/501 ,  A61K31/506 ,  A61K31/497 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2010039793A1

公开(公告)日：2010-04-08

申请号：PCT/US2009/058970

申请日：2009-09-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BELEMA, Makonen ,  NGUYEN, Van N. ,  SERRANO-WU, Michael ,  ST. LAURENT, Denis R. ,  QIU, Yuping ,  DING, Min ,  MEANWELL, Nicholas A. ,  SNYDER, Lawrence B.

Inventor： BELEMA, Makonen ,  NGUYEN, Van N. ,  SERRANO-WU, Michael ,  ST. LAURENT, Denis R. ,  QIU, Yuping ,  DING, Min ,  MEANWELL, Nicholas A. ,  SNYDER, Lawrence B.

IPC: C07D207/16 ,  C07C233/62 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D401/12 ,  C07D487/08 ,  C07D401/14 ,  C07D403/14 ,  A61K31/401 ,  A61K31/4015 ,  A61P31/14

CPC classification number: C07D207/16 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/47 ,  A61K31/5377 ,  A61K31/70 ,  A61K31/7088 ,  C07C233/62 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D487/08

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：WO2010017401A1

公开(公告)日：2010-02-11

申请号：PCT/US2009/053019

申请日：2009-08-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BELEMA, Makonen ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  KAKARLA, Ramesh ,  LI, Guo ,  LOPEZ, Omar, D. ,  NGUYEN, Van, N. ,  KAPUR, Jayne ,  QIU, Yuping ,  ROMINE, Jeffrey, Lee ,  ST. LAURENT, Denis, R. ,  SERRANO-WU, Michael ,  SNYDER, Lawrence, B. ,  YANG, Fukang

Inventor： BELEMA, Makonen ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  KAKARLA, Ramesh ,  LI, Guo ,  LOPEZ, Omar, D. ,  NGUYEN, Van, N. ,  KAPUR, Jayne ,  QIU, Yuping ,  ROMINE, Jeffrey, Lee ,  ST. LAURENT, Denis, R. ,  SERRANO-WU, Michael ,  SNYDER, Lawrence, B. ,  YANG, Fukang

IPC: C07D235/20 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/12 ,  C07D409/14

CPC classification number: C07D235/20 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102568A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/032830

申请日：2009-02-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

IPC: C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。