公开(公告)号：WO2008021936A3

公开(公告)日：2008-04-17

申请号：PCT/US2007075553

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/501 ,  A61K31/497 ,  A61K31/506 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds of formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021928A3

公开(公告)日：2008-03-27

申请号：PCT/US2007075545

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A and B are selected from phenyl and a six-membered heteroaromatic ring containing one, two or three nitrogen atoms; provided that at least one of A and B is other than phenyl, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）化合物或其药学上可接受的盐，其中A和B选自苯基和含有一个，两个或三个氮原子的六元杂芳环; 条件是A和B中的至少一个不是苯基，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008144380A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/063689

申请日：2008-05-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

IPC: C07D413/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/40 ,  A61P31/12

CPC classification number: C07D413/14 ,  C07D403/04 ,  C07D403/14

Abstract: The present disclosure relates to compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein A and B are each phenyl; D and E are each five-membered aromatic rings containing one, two, or three i hcteroatoms independently selected from nitrogen, oxygen, and sulfur; provided that ', at least one of D and E is other than imidazole; compositions and methods for the treatment of Hepatitis C virus (HCV) inf ection. Also disclosed are pharmaceutical compositions containing such compounds and methods f or using these compounds in the treatment of HCV inf ection.

Abstract translation: 本公开涉及下式（I）的化合物或其药学上可接受的盐，其中A和B各自为苯基; D和E分别是含有独立地选自氮，氧和硫的一个，两个或三个独立原子的五元芳环; 条件是'，D和E中的至少一个不是咪唑; 用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和f或使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2007002214A2

公开(公告)日：2007-01-04

申请号：PCT/US2006024172

申请日：2006-06-20

Applicant: SQUIBB BRISTOL MYERS CO ,  GERRITZ SAMUEL ,  ZHAI WEIXU ,  SHI SHUHAO ,  ZHU SHIRONG ,  GOOD ANDREW C ,  THOMPSON LORIN A III

Inventor： GERRITZ SAMUEL ,  ZHAI WEIXU ,  SHI SHUHAO ,  ZHU SHIRONG ,  GOOD ANDREW C ,  THOMPSON LORIN A III

CPC classification number: C07D275/03 ,  C07D231/14 ,  C07D261/18 ,  C07D413/12

Abstract: There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 . R 3 , R 4 and R 5 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by Beta-secretase and, more specifically, inhibit the production of ABeta-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to Beta-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

Abstract translation: 提供一系列式（I）的取代酰基胍或立体异构体; 或其药学上可接受的盐，其中R 1，R 2。 R 3，R 4和R 5如本文所定义，其药物组合物和使用方法。 这些化合物通过β-分泌酶抑制淀粉样蛋白前体蛋白（APP）的加工，更具体地，抑制ABeta肽的产生。 本公开涉及可用于治疗与β-淀粉样蛋白产生相关的神经系统疾病的化合物，例如阿尔茨海默病和受抗淀粉样蛋白活性影响的其它病症。

公开(公告)号：WO2009102694A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033646

申请日：2009-02-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  A61K31/517 ,  A61P31/00

CPC classification number: C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), their compositions and their use in the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，其组合物及其在治疗丙型肝炎病毒（HCV）感染中的用途。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102318A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053638

申请日：2008-02-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  WANG, Gan ,  HAMANN, Lawrence, G.

IPC: C07D403/10 ,  C07D403/14 ,  A61K31/4164 ,  A61P31/22

CPC classification number: C07D403/14 ,  C07D233/64 ,  C07D403/10

Abstract: The present disclosure relates to (4-4' -diimidazolyl) biphenyls compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及（4-4'-二咪唑基）联苯组合物和治疗丙型肝炎病毒（HCV）感染的方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021936A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075553

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/501 ,  A61K31/506 ,  A61K31/497 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102633A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033380

申请日：2009-02-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052

Abstract: The present disclosure relates to compounds of structure (I), compositions and Methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及结构（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法的化合物。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102325A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053779

申请日：2008-02-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  A61P31/00 ,  A61K31/41

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds Formule (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in. the treatment of HCV infection.

Abstract translation: 本公开涉及化合物（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和在治疗HCV感染中使用这些化合物的方法。

公开(公告)号：WO2008021928A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075545

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4439 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.