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    TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE
    1.
    发明申请
    TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE 审中-公开
    在头发护理中使用史蒂芬或衍生物

    公开(公告)号：WO2012010624A2

    公开(公告)日：2012-01-26

    申请号：PCT/EP2011/062425

    申请日：2011-07-20

    申请人： DSM IP ASSETS B.V. ,  GORALCZYK, Regina ,  GRAEUB, Remo ,  MAYNE-MECHAN, Annis Olivia ,  PIUSSI, Jenny ,  RIEGER, Henry ,  MOHAJERI, Hasan

    发明人： GORALCZYK, Regina ,  GRAEUB, Remo ,  MAYNE-MECHAN, Annis Olivia ,  PIUSSI, Jenny ,  RIEGER, Henry ,  MOHAJERI, Hasan

    IPC分类号： A61K8/365 ,  A61K8/60 ,  A61Q5/00 ,  A61Q7/00

    CPC分类号： A61K8/365 ,  A61Q5/00 ,  A61Q5/002 ,  A61Q5/006 ,  A61Q5/06 ,  A61Q5/065 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q17/00

    摘要： The present invention relates to the use of steviol and/or isosteviol, or a salt, ester, a diester, or an ether thereof as depicted in formula (I), wherein R1 is hydrogen (H) or a saturated, straight or branched C 1 -C 8 alkyl group non substituted or substituted with up to 3 hydroxyl-, alkoxy- amino-, alkylamino- or dialkylamino- groups, R2 is independently a saturated, straight or branched C 1 -C 8 alkyl group, -O-C 1 -C 8 alkyl group, -OH group, a -O-C(O)-C 1 -C 8 alkyl, or, -COO(C 1 -C 8 alkyl) group, R3 is independently CH 2 , O, or CH-(C 1 -C 7 alkyl), wherein the enhancement of the appearance of hair is selected from the group consisting of: restoring hair color and delaying the onset of greyness in hair, lessening hair loss, restoring hair growth after the onset of baldness has occurred, increasing the thickness of hair, counteracting age-associated hair thinning, preventing premature hair loss, or delaying the onset or severity of age-associated hair loss and thinning, maintaining of the natural hair color, increasing hair shininess, glossiness or volume.

    摘要翻译： 本发明涉及式（I）所示的甜菊醇和/或异雄甾烯或其盐，酯，二酯或其醚的用途，其中R 1是氢（H）或饱和的直链或支链C1 未被取代或被至多3个羟基，烷氧基 - 氨基 - 烷基氨基或二烷基氨基取代的-C8烷基，R2独立地为饱和的，直链或支链的C1-C8烷基，-O-C1-C8烷基 ，-OH基团，-OC（O）-C 1 -C 8烷基或-COO（C 1 -C 8烷基）基团，R 3独立地是CH 2，O或CH-（C 1 -C 7烷基），其中增强 毛发的外观选自：恢复头发颜色并延缓头发中的灰白色发作，减轻脱发，恢复发秃后恢复毛发生长，增加头发的厚度，抵抗年龄相关的头发 变薄，防止过早脱发，或延缓年龄相关脱发和变薄的发病或严重程度，保持自然 头发颜色，增加头发光泽，光泽度或体积。

    3,5-DIHYDROXY-2,4-CYCLOHEXADIENONES AND THEIR DERIVATIVES, DIETARY COMPOSITIONS AND FORTIFIED FOOD CONTAINING THEM AND THEIR USES
    5.
    发明申请
    3,5-DIHYDROXY-2,4-CYCLOHEXADIENONES AND THEIR DERIVATIVES, DIETARY COMPOSITIONS AND FORTIFIED FOOD CONTAINING THEM AND THEIR USES 审中-公开
    3,5-DIHYDROXY-2,4-CYCLOHEXADENENESES及其衍生物，膳食组合物和含有它们的食品及其用途

    公开(公告)号：WO2007134868A3

    公开(公告)日：2008-06-12

    申请号：PCT/EP2007004628

    申请日：2007-05-24

    申请人： DSM IP ASSETS BV ,  DE SAIZIEU ANTOINE ,  GORALCZYK REGINA ,  FOWLER ANN ,  SCHUELER GOEDE

    发明人： DE SAIZIEU ANTOINE ,  GORALCZYK REGINA ,  FOWLER ANN ,  SCHUELER GOEDE

    IPC分类号： A23L1/30 ,  A23K1/16 ,  A23K1/18 ,  A61K31/00 ,  A61P25/24

    CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K50/10 ,  A23K50/30 ,  A23K50/42 ,  A23K50/48 ,  A23K50/75 ,  A23L33/105

    摘要： The present invention refers especially to 3,5-dihydroxy-2,4-cyclohexadienones of the general formula(I) wherein R 1 and R 2 are independently from each other C 1-6 -alkyl, C 2-6 -alkenyl or x-oxo-C x -alkyl with x being an integer from 1 to 6, preferably R 1 and R 2 are independently from each other C 2-6 -alkenyl or y-oxo-C y -alkyl with y being an integer from 2 to 5, and wherein R 3 and R 4 are independently from each other hydroxy, C 1-6 -alkyl, C 2-6 -alkenyl or x-oxo-C x -alkyl with x being an integer from 1 to 6, preferably R 3 and R 4 are independently from each other hydroxy or y-oxo-C y -alkyl with y being an integer from 2 to 5, for use as mood balancing agents and stress relievers, as well as to dietary compositions and fortified food/feed/beverages containing such 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I), and their uses.

    摘要翻译： 本发明特别涉及通式（I）的3,5-二羟基-2,4-环己二烯酮，其中R 1和R 2彼此独立地为C C 1-6 - 烷基，C 2-6 - 烯基或x-氧代-C≡C-烷基，其中x是1至 6，优选R 1和R 2彼此独立地为C 2-6 - 烯基或γ-氧代-Cy 其中y为2至5的整数，并且其中R 3和R 4彼此独立地为羟基，C 1〜 6个 - 烷基，C 2-6 - 烯基或x-氧代-C 0 - - - 烷基，x为1至6的整数， SO 3和R 4彼此独立地为羟基或γ-氧代-C 0 - 烷基，y为2至5的整数，对于 用作情绪平衡剂和应激缓解剂，以及含有这种一般的3,5-二羟基-2,4-环己二烯酮的饮食组合物和强化食品/饲料/饮料 公式（I）及其用途。

    NOVEL AGENTS FOR PREVENTING AND TREATING DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION
    7.
    发明申请
    NOVEL AGENTS FOR PREVENTING AND TREATING DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION 审中-公开
    防止和治疗与神经传导障碍有关的新药

    公开(公告)号：WO2006042441A3

    公开(公告)日：2006-07-13

    申请号：PCT/CH2005000621

    申请日：2005-10-21

    申请人： DSM IP ASSETS BV ,  DE SAIZIEU ANTOINE ,  FOWLER ANN ,  GORALCZYK REGINA ,  MUSSLER BERND ,  SCHUELER GOEDE

    发明人： DE SAIZIEU ANTOINE ,  FOWLER ANN ,  GORALCZYK REGINA ,  MUSSLER BERND ,  SCHUELER GOEDE

    IPC分类号： A61K31/37

    CPC分类号： A61K31/37 ,  A23L2/39 ,  A23L7/126 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/322

    摘要： The present invention refers to coumarin ethers of the formula (I), wherein R 1 is H, OH or (E)-3-methyl-but-2-enyl, R 2 is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, R 3 is H, R 1 and R 2 O together for the group -O-C(C(=CH 2 )CH 3 )H-CH 2 -O- or the group -C(H)=C(H)-C(CH 3 ) 2 -O- or R 2 O and R 3 together form the group -O-C(H)(C(CH 3 ) 2 (H)-O-C(O)CH 3 )-CH 2 -, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.

    摘要翻译： 本发明涉及式（I）的香豆素醚，其中R 1是H，OH或（E）-3-甲基 - 丁-2-烯基，R 2是氢， 选自甲基，3-（4,5-二氢-5,5-二甲基-4-呋喃酮-2-基）-2-（E / Z） - 丁烯基，（E / Z） -3,7-二甲基辛-2,6-二烯基，7-羟基-3,7-二甲基-2-辛烯-6-酮基和（E / Z，E / Z）-11-乙酰氧基-3 ，7,11,11-四甲基 - 十一碳-2,7-二烯-10-基 - ，R 3是H，R 1和R 2相同或不同， （C（= CH 2 ）CH 3 ）H-CH 2 -O-或 基团-C（H）= C（H）-C（CH 3）2 -O-或R 2 O和R 2， （H）-C（CH 3）2（H）-OC（O）CH 3（CH 3） ） - CH 2 - ，优选地用作药物，用作药物，特别是用于治疗和/或预防与神经传递受损相关的病症，以及饮食和药物组合物和 含有香豆素醚的植物提取物及其用途 。

    TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE
    9.
    发明申请
    TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE 审中-公开
    在头发护理中使用史蒂芬或衍生物

    公开(公告)号：WO2012010624A3

    公开(公告)日：2012-09-27

    申请号：PCT/EP2011062425

    申请日：2011-07-20

    申请人： DSM IP ASSETS BV ,  GORALCZYK REGINA ,  GRAEUB REMO ,  MAYNE-MECHAN ANNIS OLIVIA ,  PIUSSI JENNY ,  RIEGER HENRY ,  MOHAJERI HASAN

    发明人： GORALCZYK REGINA ,  GRAEUB REMO ,  MAYNE-MECHAN ANNIS OLIVIA ,  PIUSSI JENNY ,  RIEGER HENRY ,  MOHAJERI HASAN

    IPC分类号： A61K8/365 ,  A61K8/60 ,  A61Q5/00 ,  A61Q7/00

    CPC分类号： A61K8/365 ,  A61Q5/00 ,  A61Q5/002 ,  A61Q5/006 ,  A61Q5/06 ,  A61Q5/065 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q17/00

    摘要： The present invention relates to the use of steviol and/or isosteviol, or a salt, ester, a diester, or an ether thereof as depicted in formula (I), formula (I): R1 wherein R1 is hydrogen (H) or a saturated, straight or branched C1-C8 alkyl group non substituted or substituted with up to 3 hydroxyl-, alkoxy-, amino-, alkylamino- or dialkylamino- groups, R2 is independently a saturated, straight or branched C1-C8 alkyl group, -O-C1-C8 alkyl group, -OH group, a -O-C(O)-C1-C8 alkyl, or, -COO(C1-C8 alkyl) group, R3 is independently CH2, O, or CH-(C1-C7 alkyl), wherein the enhancement of the appearance of hair is selected from the group consisting of: restoring hair color and delaying the onset of greyness in hair, lessening hair loss, restoring hair growth after the onset of baldness has occurred, increasing the thickness of hair, counteracting age-associated hair thinning, preventing premature hair loss, or delaying the onset or severity of age-associated hair loss and thinning, maintaining of the natural hair colour, increasing hair shininess, glossiness or volume. In particular, the compound is applied topically.

    摘要翻译： 本发明涉及式（I），式（I）所示的甜菊醇和/或异硬脂醇或其盐，酯，二酯或其醚的用途：其中R1是氢（H）或 未被取代或被至多3个羟基，烷氧基，氨基，烷基氨基或二烷基氨基取代的饱和，直链或支链C 1 -C 8烷基，R 2独立地为饱和的，直链或支链的C 1 -C 8烷基， O-C 1 -C 8烷基，-OH基团，-OC（O）-C 1 -C 8烷基或-COO（C 1 -C 8烷基）基团，R 3独立地是CH 2，O或CH-（C 1 -C 7 烷基），其中提高毛发的外观选自：恢复头发颜色并延迟头发中的灰色发作，减少脱发，恢复发秃后恢复毛发生长，增加毛发的厚度 头发，抵抗年龄相关的头发变薄，防止过早的脱发，或延迟年龄相关脱发和变薄的发作或严重程度，维持 g的天然头发颜色，增加头发光泽，光泽度或体积。 特别地，化合物局部施用。