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    NOVEL USE OF ORGANIC COMPOUNDS
    1.
    发明申请
    NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
    有机化合物的新用途

    公开(公告)号：WO2006125651A2

    公开(公告)日：2006-11-30

    申请号：PCT/EP2006005005

    申请日：2006-05-24

    Applicant: DSM IP ASSETS BV ,  FOWLER ANN ,  RAEDERSTORFF DANIEL ,  SCHUELER GOEDE ,  SCHWAGER JOSEPH

    Inventor： FOWLER ANN ,  RAEDERSTORFF DANIEL ,  SCHUELER GOEDE ,  SCHWAGER JOSEPH

    IPC: A61K31/343 ,  A61P11/00 ,  A61P19/02 ,  A61P19/06 ,  A61P29/00

    CPC classification number: A61K31/343

    Abstract: The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R 1 is butyl or butyryl if R 2 is hydroxyl but is butyl if R 2 is hydrogen; or R 1 and R 2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3- (a,ß-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1 , X2, X3, X4, and X5; wherein X is X2, X3or X5 if the dotted line in formula (I) is absent ;and X is X1 , X4 or X5 if the dotted line signifies a bond in formula (I) above; R 3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation. The compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the management of pain, fever and injuries, especially sport injuries. Moreover, the compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the maintenance and regeneration of articular cartilage.

    Abstract translation: 本发明涉及式（I）化合物的用途，其中凝血线是任选的键; 如果R 2是羟基，则R 1是丁基或丁酰基，如果R 2是氢，则是丁基; 或R 1和R 2一起是任选被羟基，甲基或3-（a，β-二甲基丙烯酰氧基） - 戊酰基取代的1-亚丁基; X是选自X1，X2，X3，X4和X5的残基; 其中，如果不存在式（I）中的虚线，X为X 2，X 3或X 5;如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R 3是羟基或丁酰基; 和n为1或2，作为预防，控制和治疗需要调节哺乳动物炎症的病症的药剂。 另一方面，本发明涉及式（I）化合物作为活性成分在制备用于预防，控制和治疗需要调节炎症的病症的药物/组合物中的用途。 如上定义的式（I）化合物也可用于治疗疼痛，发烧和损伤，特别是运动损伤（用于制造组合物）。 此外，如上定义的式（I）化合物也可用于维持和再生关节软骨（用于制备组合物）。

    USE OF COMPOUNDS AND COMBINATIONS OF COMPOUNDS FOR IMPROVING THE PHYSICAL APPEARANCE
    5.
    发明申请
    USE OF COMPOUNDS AND COMBINATIONS OF COMPOUNDS FOR IMPROVING THE PHYSICAL APPEARANCE 审中-公开
    化合物的使用和化合物的组合用于改善物理外观

    公开(公告)号：WO2007112996A3

    公开(公告)日：2010-07-08

    申请号：PCT/EP2007002950

    申请日：2007-04-02

    Applicant: DSM IP ASSETS BV ,  GORALCZYK REGINA ,  SCHWAGER JOSEPH ,  WERTZ KARIN

    Inventor： GORALCZYK REGINA ,  SCHWAGER JOSEPH ,  WERTZ KARIN

    IPC: A61Q19/06 ,  A61K8/31 ,  A61K8/34 ,  A61K8/36 ,  A61K8/97 ,  A61Q19/08

    CPC classification number: A61K8/31 ,  A21D2/36 ,  A23C9/13 ,  A23C9/1322 ,  A23L33/30 ,  A61K8/345 ,  A61K8/347 ,  A61K8/361 ,  A61K8/498 ,  A61K8/97 ,  A61K2800/92 ,  A61Q19/06

    Abstract: The present invention is directed inter alia to the use of at least one compound selected from the group consisting of (-)-epigallocatechin gallate, resveratrol, eicosapentaenoic acid, docosahexaenoic acid, rose hip extract/concentrate, hydroxytyrosol, lycopene, lutein, ß-cryptoxanthin, zeaxanthin and derivatives thereof, for the treatment of cellulite, for the prevention of the development of mild cellulite, for the prevention of the progression of mild cellulite to severe cellulite, for smoothening the micro relief of the skin, for maintaining or increasing the tensile properties of the skin, and/or for reducing the fat mass and the circumference at the hips and thighs, as well as to the corresponding cosmetic and medical methods.

    Abstract translation: 本发明尤其涉及使用至少一种选自（ - ） - 表没食子儿茶素没食子酸酯，白藜芦醇，二十碳五烯酸，二十二碳六烯酸，玫瑰果提取物/浓缩物，羟基酪醇，番茄红素，叶黄素，β- 隐黄质，玉米黄质及其衍生物，用于治疗脂肪团，用于防止轻度脂肪团的发育，用于防止轻度脂肪团进入严重脂肪团的进展，以平滑皮肤的微小浮雕，维持或增加 皮肤的拉伸性能和/或用于降低臀部和大腿处的脂肪量和周长，以及相应的美容和医疗方法。

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