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    CATALYSTS
    1.
    发明申请
    CATALYSTS 审中-公开
    具有作为催化剂的CHIRAL DIAMINE LIGANDS的BIPHOSPHINE RUTHENIUM复合物

    公开(公告)号：WO2005007662A2

    公开(公告)日：2005-01-27

    申请号：PCT/GB2004/002938

    申请日：2004-07-07

    Applicant: JOHNSON MATTHEY PLC ,  HEMS, William, Patrick ,  GRASA, Gabriela, Alexandra

    Inventor： HEMS, William, Patrick ,  GRASA, Gabriela, Alexandra

    IPC: C07F15/00

    CPC classification number: C07D207/14 ,  C07F15/0053

    Abstract: Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group (8) transition metal compound a chiral phosphine and a chiral diamine of formula (1) in which R 1 , R 2 R 3 or R 4 are independently hydrogen, a saturated or unsaturated alkyl, or cycloalkyl group, an aryl group, a urethane or sulphonyl group and R 5 , R 6 , R 7 or R 8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R 1 , R 2 , R 3 or R 4 is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.

    Abstract translation: 描述适用于不对称氢化反应的催化剂，其包括（8）过渡金属化合物手性膦与式（1）的手性二胺的反应产物，其中R 1，R 2，R 3或R 4独立地是氢，饱和或不饱和的烷基或环烷基，芳基，氨基甲酸酯基或磺酰基，R 5，R 6，R 7或R 8独立地是氢， 饱和或不饱和的烷基或环烷基或芳基，R 1，R 2，R 3或R 4中的至少一个是氢，A是包含一个或两个取代的 或未取代的碳原子。

    PREPARATION OF A METAL COMPLEX
    2.
    发明申请
    PREPARATION OF A METAL COMPLEX 审中-公开
    金属复合物的制备

    公开(公告)号：WO2010128316A1

    公开(公告)日：2010-11-11

    申请号：PCT/GB2010/050035

    申请日：2010-01-12

    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY ,  COLACOT, Thomas John ,  GRASA, Gabriela Alexandra ,  LI, Hongbo

    Inventor： COLACOT, Thomas John ,  GRASA, Gabriela Alexandra ,  LI, Hongbo

    IPC: C07F15/00 ,  C07F17/02

    CPC classification number: C07F15/0066 ,  C07F15/006 ,  C07F17/02

    Abstract: The present invention provides a process for the preparation of a Pd(0)L n complex, where L is a ligand and n is 2, 3 or 4, comprising the steps of: (a) reacting a Pd(II) complex in at least one solvent with a base and ligand L; and (b) if required, adding further base, optionally in at least one solvent, to form the Pd(0)L n complex; wherein the at least one solvents in steps a and b are independently the same or different, and provided that when n = 2, the Pd(II) complex is not bis[tri(ortho-tolyl)phosphine] palladium chloride. The invention also provides novel Pd(0)L 2 and Pd(II) complexes.

    Abstract translation: 本发明提供了制备Pd（O）Ln络合物的方法，其中L为配体，n为2,3或4，包括以下步骤：（a）使Pd（II）络合物至少 一种溶剂与碱和配体L; 和（b）如果需要，另外加入碱，任选地在至少一种溶剂中，形成Pd（0）Ln络合物; 其中步骤a和b中的至少一种溶剂独立地相同或不同，条件是当n = 2时，Pd（II）络合物不是双[三（邻 - 甲苯基）膦]氯化钯。 本发明还提供了新颖的Pd（O）L2和Pd（II）络合物。

    CATALYTIC PROCESS FOR ASYMMETRIC HYDROGENATION
    3.
    发明申请
    CATALYTIC PROCESS FOR ASYMMETRIC HYDROGENATION 审中-公开
    不对称加氢催化工艺

    公开(公告)号：WO2008071951A3

    公开(公告)日：2008-10-02

    申请号：PCT/GB2007004756

    申请日：2007-12-12

    Applicant: PORTELA & CA SA ,  LEARMONTH DAVID ALEXANDER ,  ZANOTTI-GEROSA ANTONIO ,  GRASA GABRIELA ALEXANDRA ,  BELIAEV ALEXANDER

    Inventor： LEARMONTH DAVID ALEXANDER ,  ZANOTTI-GEROSA ANTONIO ,  GRASA GABRIELA ALEXANDRA ,  BELIAEV ALEXANDER

    IPC: C07D311/04 ,  C07D405/04 ,  C07F15/00

    CPC classification number: C07D311/58

    Abstract: A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral catalyst and a source of hydrogen, wherein: X is CH 2 , oxygen or sulphur; R- 1 , R 2 and R 3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R 4 is alkyl or aryl, wherein: the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; and the term halogen means fluorine, chlorine, bromine or iodine.

    Abstract translation: 一种制备式A化合物的S或R对映异构体的方法，该方法包括在手性催化剂和氢源存在下使式B化合物进行不对称氢化，其中：X是CH 2 氧，硫; R 1〜R 2，R 2和R 3相同或不同，表示氢，卤素，烷基，烷氧基，羟基，硝基，烷基羰基氨基 ，烷基氨基或二烷基氨基; 并且R 4是烷基或芳基，其中：术语烷基是指含有1-6个碳原子的直链或支链的烃链，任选被芳基，烷氧基，卤素，烷氧基羰基或羟基羰基取代; 术语芳基是指任选被烷氧基，卤素或硝基取代的苯基或萘基; 术语卤素是指氟，氯，溴或碘。

    ASYMMETRIC CATALYTIC REDUCTION OF OXCARBAZEPINE
    4.
    发明申请
    ASYMMETRIC CATALYTIC REDUCTION OF OXCARBAZEPINE 审中-公开
    不对称催化还原氧化腈

    公开(公告)号：WO2007012793A1

    公开(公告)日：2007-02-01

    申请号：PCT/GB2006/001473

    申请日：2006-04-21

    Applicant: PORTELA & C.A., S.A. ,  LEARMONTH, David, Alexander ,  GRASA, Gabriela, Alexandra ,  ZANOTTI-GEROSA, Antonio

    Inventor： LEARMONTH, David, Alexander ,  GRASA, Gabriela, Alexandra ,  ZANOTTI-GEROSA, Antonio

    IPC: C07D223/22

    CPC classification number: C07D223/28 ,  A61K31/55 ,  C07D223/22

    Abstract: A process for preparing (S)-(+)- 10,11 -dihydro-10-hydroxy-5H- dibenz/b,f/azepine-5-carboxamide or (R)-(-)-10,l l-dihydro-10-hydroxy-5H- dibenz/b,f/azepine-5-carboxamide, by reduction of oxcarbazepine in the presence of a catalyst and a hydride source is disclosed. The catalyst is prepared from a combination of [RuX 2 (L)] 2 wherein X is chlorine, bromine or iodine, and L is an aryl or aryl-aliphatic ligand, with a ligand of formula (A) or formula (B): wherein R 1 is chosen from C 1-6 alkoxy and C 1-6 alkyl, n is a number from 0 to 5, and when n is a number from 2 to 5, R 1 can be the same or different, and R 2 is alkyl, substituted alkyl, aryl, substituted aryl, alkaryl or substituted alkaryl. The hydride source is either NR 3 R 4 R 5 and formic acid, [R 3 R 4 R 5 NH][OOCH] and optionally formic acid, or [M][OOCH] x and formic acid, wherein R 3 , R 4 and R 5 are C 1-6 alkyl, M is an alkali metal or alkaline earth metal and x is 1 or 2. A pH from 6.5 to 8 is maintained during the process.

    Abstract translation: 制备（S） - （+） - 10,11-二氢-10-羟基-5H-二苯并/ b，f /吖庚因-5-甲酰胺或（R） - （ - ） - 10,11-二氢 公开了在催化剂和氢化物源的存在下还原奥卡西平的方法，将10-羟基-5H-二苯并/ b，f /吖庚因-5-甲酰胺。 催化剂由[RuX 2（L）] 2 N的组合制备，其中X是氯，溴或碘，L是芳基或芳基 - 脂族配体， 与式（A）或式（B）的配位体反应：其中R 1选自C 1-6烷氧基和C 1-6 - >烷基，n是0至5的数，当n是2至5的数时，R 1可以相同或不同，R 2是 烷基，取代的烷基，芳基，取代的芳基，烷芳基或取代的烷芳基。 氢化物源是NR 3 S 4 R 5和甲酸，[R 3 S 3 R 5] 4 O 5 H] [OOCH]和任选的甲酸或[M] [OOCH] x X和甲酸，其中R 3， R 4，R 4和R 5是C 1-6烷基，M是碱金属或碱土金属，x是1 或2.在该过程中维持6.5至8的pH。

    BIPHOSPHINE RUTHENIUM COMPLEXES WITH CHIRAL DIAMINE LIGANDS AS CATALYSTS
    5.
    发明申请
    BIPHOSPHINE RUTHENIUM COMPLEXES WITH CHIRAL DIAMINE LIGANDS AS CATALYSTS 审中-公开
    以手性二胺配体为催化剂的双膦钌配合物

    公开(公告)号：WO2005007662A3

    公开(公告)日：2005-03-24

    申请号：PCT/GB2004002938

    申请日：2004-07-07

    Applicant: JOHNSON MATTHEY PLC ,  HEMS WILLIAM PATRICK ,  GRASA GABRIELA ALEXANDRA

    Inventor： HEMS WILLIAM PATRICK ,  GRASA GABRIELA ALEXANDRA

    IPC: C07D207/14 ,  C07F15/00

    CPC classification number: C07D207/14 ,  C07F15/0053

    Abstract: Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group (8) transition metal compound a chiral phosphine and a chiral diamine of formula (1) in which R , R R or R are independently hydrogen, a saturated or unsaturated alkyl, or cycloalkyl group, an aryl group, a urethane or sulphonyl group and R , R , R or R are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R , R , R or R is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.

    Abstract translation: 描述了适合于不对称氢化反应的催化剂，其包含组（8）过渡金属化合物，手性膦和式（1）的手性二胺的反应产物，其中R 1，R 2 R 3或R R 4，R 7或R 8独立地为氢，饱和或不饱和的烷基或环烷基，芳基，氨基甲酸酯或磺酰基，并且R 5，R 6，R 7或R 8独立地为氢， 饱和或不饱和的烷基或环烷基，或芳基，R 1，R 2，R 3或R 4中的至少一个为氢且A为包含一个或两个取代基 或未被取代的碳原子。

    PROCESS
    8.
    发明申请
    PROCESS 审中-公开
    处理

    公开(公告)号：WO2008071951A2

    公开(公告)日：2008-06-19

    申请号：PCT/GB2007/004756

    申请日：2007-12-12

    Applicant: PORTELA & C.A., S.A. ,  LEARMONTH, David, Alexander ,  ZANOTTI-GEROSA, Antonio ,  GRASA, Gabriela, Alexandra ,  BELIAEV, Alexander

    Inventor： LEARMONTH, David, Alexander ,  ZANOTTI-GEROSA, Antonio ,  GRASA, Gabriela, Alexandra ,  BELIAEV, Alexander

    IPC: C07D311/04 ,  C07D405/04 ,  C07F15/00

    CPC classification number: C07D311/58

    Abstract: A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral catalyst and a source of hydrogen, wherein: X is CH 2 , oxygen or sulphur; R- 1 , R 2 and R 3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R 4 is alkyl or aryl, wherein: the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; and the term halogen means fluorine, chlorine, bromine or iodine.

    Abstract translation: 一种制备式A化合物的S或R对映异构体的方法，该方法包括在手性催化剂和氢源存在下使式B化合物进行不对称氢化，其中：X是CH 2 氧，硫; R 1〜R 2，R 2和R 3相同或不同，表示氢，卤素，烷基，烷氧基，羟基，硝基，烷基羰基氨基 ，烷基氨基或二烷基氨基; 并且R 4是烷基或芳基，其中：术语烷基是指含有1-6个碳原子的直链或支链的烃链，任选被芳基，烷氧基，卤素，烷氧基羰基或羟基羰基取代; 术语芳基是指任选被烷氧基，卤素或硝基取代的苯基或萘基; 术语卤素是指氟，氯，溴或碘。

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