中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

194 records (took 0.03 seconds)

    BUCHWALD-HARTWIG ARYLATION PROCESS FOR THE PREPARATION OF TERTIARY ARYL AMINES
    1.
    发明申请
    BUCHWALD-HARTWIG ARYLATION PROCESS FOR THE PREPARATION OF TERTIARY ARYL AMINES 审中-公开
    BUCHWALD-HARTWIG芳基化方法用于生产第三芳基胺

    公开(公告)号：WO2017093427A3

    公开(公告)日：2017-07-27

    申请号：PCT/EP2016079486

    申请日：2016-12-01

    Applicant: UMICORE AG & CO KG

    Inventor： GOOSSEN LUKAS J ,  GRUENBERG MATTHIAS

    IPC: C07D403/12 ,  C07D209/86 ,  C07F15/00 ,  C07F17/02

    CPC classification number: C07D209/86 ,  C07D403/12 ,  C07F15/006 ,  C07F17/02

    Abstract: Disclosed is a selective process for the preparation of a tertiary triaryl amine A-N(B)(C) under the conditions of the Buchwald-Hartwig cross-coupling. Preferably, one of the aryl radicals is a biphenyl derivative. The claimed 2-stage process is characterized in that the two steps are catalyzed by a palladium complex selected from the group consisting of bis(dialkylphosphinoferrocene)palladium complexes or complexes of formula PdX1X2L1L2, wherein X1 and X2 are identical or different halogen ligands, L1 and L2 are identical or different electron donor ligands, or combinations thereof. Preferred are Pd catalysts of the formula PdX1X2L1L2, wherein palladium-NHC complexes (n-heterocyclic carbene complexes) are preferred. Exemplary for the claimed method is example 4a: In the first reaction step, the primary amine 2a is reacted to a secondary amine 3a: formulae 1a, 2a, 3a. In the second reaction step, 3a is then reacted with 4-bromo-1,1'-biphenyl to the tertiary amine 4b: formula (A).

    Abstract translation: 用于制备叔胺三芳基-A-N（B）（C）中，哈特维希-Buchwald偶联的条件下，选择性工艺主张的内容。 优选地，芳基之一是联苯衍生物。 被表征为所要求保护的2阶段过程是，这两个步骤是通过选自由双（Dialkylphosphinoferrocen）钯络合物或式PdX1X2L1L2的复合物的组中选择的钯配合物，其中X1和X2相同或不同的卤素配体L1催化 和L2是相同或不同的电子给体配体或其组合。 式PdX1X2L1L2的钯催化剂是优选的，以钯 - NHC络合物（N-杂环卡宾配合物）是优选的。 示例性所要求的方法实施例4a的：1.在Reaktonsschritt伯胺改组2a至仲胺3A：式1A，2A，3A，在第二反应步骤3a中，然后用4-溴基-1,1'-联苯 转化为叔胺4b：式（A）。

    PHOSPHORUS LIGANDS AND METHODS OF USE
    2.
    发明申请
    PHOSPHORUS LIGANDS AND METHODS OF USE 审中-公开
    磷配体及其使用方法

    公开(公告)号：WO2016094489A1

    公开(公告)日：2016-06-16

    申请号：PCT/US2015/064643

    申请日：2015-12-09

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： LIPSHUTZ, Bruce, H. ,  HANDA, Sachin

    IPC: C07F9/6571 ,  C07F15/00 ,  C07F1/12

    CPC classification number: C07F9/657163 ,  C07F1/12 ,  C07F15/006

    Abstract: In one embodiment, the application discloses ligands, such as a ligand from a dihydrobenzo [1,3] oxaphosphole scaffold, and palladium or other transition metal complexes comprising the ligands and methods for performing cross coupling reactions and asymmetric cross coupling reactions with high selectivity and efficiency, under aqueous micellar catalysis conditions.

    Abstract translation: 在一个实施方案中，本申请公开了配体，例如二氢苯并[1,3]氧杂磷杂胞构架的配体，以及包含配体的钯或其它过渡金属配合物以及用于以高选择性进行交叉偶联反应和不对称交叉偶联反应的方法， 在水性胶束催化条件下的效率。

    SUPRAMETALLOGELS AND USES THEREOF
    5.
    发明申请
    SUPRAMETALLOGELS AND USES THEREOF 审中-公开
    SUPRAMETALLOGELS及其用途

    公开(公告)号：WO2015120391A1

    公开(公告)日：2015-08-13

    申请号：PCT/US2015/015032

    申请日：2015-02-09

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： JOHNSON, Jeremiah, A. ,  HOLTEN-ANDERSEN, Niels ,  GRINDY, Scott, Charles ,  KAWAMOTO, Ken ,  ZHUKHOVITSKIY, Aleksandr, V.

    IPC: C07F15/00 ,  C07F15/02 ,  C07F15/04

    CPC classification number: C07D213/30 ,  A61K47/22 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/02 ,  C07F15/04 ,  C08G83/008

    Abstract: The disclosure provides nanostructures ( e.g. , nanospheres and nano-paddlewheels) formed through transition metal-ligand ( e.g. , Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions ( e.g. , gels) that include the nanostructures or supramolecular complexes and optionally an agent ( e.g. , small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease ( e.g ., a genetic diseases, proliferative disease ( e.g ., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease ( e.g ., liver disease), spleen disease, respiratory disease ( e.g. , lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

    Abstract translation: 本公开提供通过过渡金属配体（例如，式（A）的Pd（II） - ，Ni（II） - 或Fe（II） - 配体）配位和结合形成的纳米结构（例如纳米球和纳米桨轮） 自组装。 本公开还提供包括通过二价连接体Y连接的纳米结构的超分子复合物。所提供的超分子复合物能够形成凝胶（例如水凝胶）。 凝胶是超标记物，表现出优异的机械性能，而不牺牲自愈，显示出高的鲁棒性和储能模量。 本公开进一步提供包含纳米结构或超分子复合物和任选的试剂（例如小分子）的组合物（例如，凝胶），其中超分子复合物的纳米结构和纳米结构部分可以包封并缓慢释放试剂。 纳米结构，超分子复合物和组合物可用于将药物递送至受试者，组织或细胞，作为超吸收材料，以及治疗疾病（例如，遗传性疾病，增殖性疾病（例如癌症或良性） 肿瘤），血液疾病，神经系统疾病，胃肠道疾病（如肝脏疾病），脾脏疾病，呼吸系统疾病（如肺部疾病），疼痛状况，泌尿生殖器疾病，肌肉骨骼疾病，感染性疾病，炎性疾病，自身免疫性疾病，精神疾病 ，或代谢紊乱）。

    DINUCLEAR METAL COMPLEXES COMPRISING CARBENE LIGANDS AND THE USE THEREOF IN OLEDS
    8.
    发明申请
    DINUCLEAR METAL COMPLEXES COMPRISING CARBENE LIGANDS AND THE USE THEREOF IN OLEDS 审中-公开
    包含碳配体的金属复合物及其在OLEDs中的应用

    公开(公告)号：WO2014012972A1

    公开(公告)日：2014-01-23

    申请号：PCT/EP2013/065088

    申请日：2013-07-17

    Applicant: BASF SE ,  BASF SCHWEIZ AG

    Inventor： STRAßNER, Thomas ,  TRONNIER, Alexander ,  HEINEMEYER, Ute

    IPC: C07F15/00 ,  H01L51/00 ,  H05B33/00

    CPC classification number: H01L51/0087 ,  C07F15/006 ,  C07F15/0086 ,  H01L51/5012

    Abstract: The present invention relates to dinuclear metal-carbene complexes comprising a central atom selected from platinum and palladium, where both metal atoms are cyclometalated to the same aromatic group, to OLEDs (Organic Light-Emitting Diodes) which comprise such complexes, to a device selected from the group consisting of illuminating elements, stationary visual display units and mobile visual display units comprising such an OLED, to the use of such a metal-carbene complex in OLEDs, for example as emitter, matrix material, charge transport material and/or charge or exciton blocker.

    Abstract translation: 本发明涉及包含选自铂和钯的中心原子的双核金属 - 卡宾复合物，其中两个金属原子都被二次金属化为相同的芳族基团，这些复合物包含这种复合物的OLED（有机发光二极管）到选定的器件 来自由照明元件，固定视觉显示单元和包含这种OLED的移动视觉显示单元组成的组，在OLED中使用这种金属 - 碳烯复合物，例如作为发射体，基质材料，电荷输送材料和/或电荷 或激子阻滞剂。

Patent Agency Ranking