公开(公告)号：WO2004007489A3

公开(公告)日：2004-03-18

申请号：PCT/IN0300238

申请日：2003-07-10

Applicant: PATEL MAHESH V ,  DESHPANDE PRASAD K ,  SINDKHEDKAR MILIND D ,  GUPTE SHRIKANT V ,  CHUGH YATI ,  SHETTY NITIN ,  SHUKLA MILIND C ,  YEOLE RAVINDRA D ,  DE SOUZA NOEL J

Inventor： PATEL MAHESH V ,  DESHPANDE PRASAD K ,  SINDKHEDKAR MILIND D ,  GUPTE SHRIKANT V ,  CHUGH YATI ,  SHETTY NITIN ,  SHUKLA MILIND C ,  YEOLE RAVINDRA D ,  DE SOUZA NOEL J

IPC: A61P31/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  A61K31/422 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

Abstract translation: 本发明提供了用于预防和治疗感染性疾病的高抗微生物活性的试剂。 因此，本发明提供新的氰基 - （取代） - 亚甲基哌啶基苯基恶唑烷酮衍生物，制备该化合物的方法，以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

公开(公告)号：WO2004108744A3

公开(公告)日：2005-03-24

申请号：PCT/IN2004000137

申请日：2004-05-18

Applicant: DESHPANDE PRASAD K ,  SINDKHEDKAR MILIND D ,  DESAI VIJAYA N ,  GUPTE SHRIKANT V ,  YEOLE RAVINDRA D ,  PATEL MAHESH V ,  DE SOUZA NOEL J

Inventor： DESHPANDE PRASAD K ,  SINDKHEDKAR MILIND D ,  DESAI VIJAYA N ,  GUPTE SHRIKANT V ,  YEOLE RAVINDRA D ,  PATEL MAHESH V ,  DE SOUZA NOEL J

IPC: C07H17/00 ,  C07H17/08 ,  A61K31/7048

CPC classification number: C07H17/00

Abstract: The present invention relates to novel azalides and azaketolides having antimicrobial activity, methods for their preparation, pharmaceutical compositions containing the compounds and methods of treating microbial infections with the compounds.

Abstract translation: 本发明涉及具有抗微生物活性的新型氮杂ides ides ides and az tol tol tol tol for for。。。。。。。。。。。。。。。。。。

公开(公告)号：WO2004007488A2

公开(公告)日：2004-01-22

申请号：PCT/IN2003/000237

申请日：2003-07-10

Applicant: CHUGH, Yati ,  SHETTY, Nitin ,  DESHPANDE, Prasad, K. ,  SINDKHEDKAR, Milind, D. ,  JAFRI, Mohammad, A. ,  YEOLE, Ravindra, D. ,  SHUKLA, Milind, C. ,  GUPTE, Shrikant, V. ,  PATEL, Mahesh, V. ,  DE SOUZA, Noel, J.

Inventor： CHUGH, Yati ,  SHETTY, Nitin ,  DESHPANDE, Prasad, K. ,  SINDKHEDKAR, Milind, D. ,  JAFRI, Mohammad, A. ,  YEOLE, Ravindra, D. ,  SHUKLA, Milind, C. ,  GUPTE, Shrikant, V. ,  PATEL, Mahesh, V. ,  DE SOUZA, Noel, J.

IPC: C07D413/00

CPC classification number: C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyanoalkylpiperidinophenyl oxazolidinone derivatives having antimicrobial activity, favourable pharmacokinetic and safety profiles, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating microbial infections with the said derivatives.

Abstract translation: 本发明提供了用于预防和治疗感染性疾病的具有高抗微生物活性的试剂。 因此，本发明提供了具有抗微生物活性，有利的药代动力学和安全性的新的氰基烷基哌啶子基苯基恶唑烷酮衍生物，制备该化合物的方法，以及含有所述衍生物作为活性成分的抗微生物组合物，以及用所述衍生物治疗微生物感染的方法。 p>

公开(公告)号：WO2005023805A1

公开(公告)日：2005-03-17

申请号：PCT/IN2003/000421

申请日：2003-12-31

Applicant: DESHPANDE, Prasad K ,  DESAI, Vijaya N ,  YEOLE, Ravindra D ,  GUPTE, Shrikant V ,  PATEL, Mahesh V ,  DE SOUZA, Noel J

Inventor： DESHPANDE, Prasad K ,  DESAI, Vijaya N ,  YEOLE, Ravindra D ,  GUPTE, Shrikant V ,  PATEL, Mahesh V ,  DE SOUZA, Noel J

IPC: C07D455/04

CPC classification number: C07D471/06

Abstract: The invention relates to crystalline S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as the active ingredient for use in treating microbial infections.

Abstract translation: 本发明涉及结晶S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H，5H-苯并[i，j ]喹嗪-2羧酸L-精氨酸盐四水合物，其制备方法和将其作为用于治疗微生物感染的活性成分的药物制剂。

公开(公告)号：WO2004058262A1

公开(公告)日：2004-07-15

申请号：PCT/IN2003/000422

申请日：2003-12-31

Applicant: SAOJI, Dilip G ,  NAGORI, Rajendra N ,  SHUKLA, Milind C ,  BHAGWAT, Sachin S ,  GUPTE, Shrikant V ,  PATEL, Mahesh V ,  JHA, Rasendrakumar ,  KUKREJA, Anil ,  DE SOUZA, Noel J

Inventor： SAOJI, Dilip G ,  NAGORI, Rajendra N ,  SHUKLA, Milind C ,  BHAGWAT, Sachin S ,  GUPTE, Shrikant V ,  PATEL, Mahesh V ,  JHA, Rasendrakumar ,  KUKREJA, Anil ,  DE SOUZA, Noel J

IPC: A61K31/473

CPC classification number: A61K31/473

Abstract: This invention relates to topical compositions of an antibacterial benzoquinolizine-2-carboxylic acid, incorporated either as the single therapeutic ingredient in hitherto undescribed pharmaceutical compositions, or as an ingredient in novel combination with at least one agent selected from a retinoid, an antifungal agent, another antibacterial compound and/or a steroid/non-steroid anti-inflammatory agent, to processes for preparation of the compositions, to use of the compositions in preparation of a medicament, and to a method of therapeutic or prophylactic use of such a composition for the treatment of dermal, ophthalmic, otic and nasal infections, with or without attendant inflammation.

Abstract translation: 本发明涉及抗菌苯喹啉-2-羧酸的局部组合物，其作为迄今为止未描述的药物组合物中的单一治疗成分掺入，或作为与至少一种选自维甲酸，抗真菌剂， 另一种抗细菌化合物和/或类固醇/非类固醇抗炎剂，用于制备组合物的方法，组合物在制备药物中的用途，以及治疗或预防性使用这种组合物的方法 治疗皮肤，眼睛，耳鼻喉感染，伴有或不伴有炎症。

公开(公告)号：WO2004007488A3

公开(公告)日：2004-03-18

申请号：PCT/IN0300237

申请日：2003-07-10

Applicant: CHUGH YATI ,  SHETTY NITIN ,  DESHPANDE PRASAD K ,  SINDKHEDKAR MILIND D ,  JAFRI MOHAMMAD A ,  YEOLE RAVINDRA D ,  SHUKLA MILIND C ,  GUPTE SHRIKANT V ,  PATEL MAHESH V ,  DE SOUZA NOEL J

Inventor： CHUGH YATI ,  SHETTY NITIN ,  DESHPANDE PRASAD K ,  SINDKHEDKAR MILIND D ,  JAFRI MOHAMMAD A ,  YEOLE RAVINDRA D ,  SHUKLA MILIND C ,  GUPTE SHRIKANT V ,  PATEL MAHESH V ,  DE SOUZA NOEL J

IPC: A61K31/454 ,  A61P31/04 ,  C07D413/02 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  A61K31/422

CPC classification number: C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyanoalkylpiperidinophenyl oxazolidinone derivatives having antimicrobial activity, favourable pharmacokinetic and safety profiles, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating microbial infections with the said derivatives.

Abstract translation: 本发明提供了用于预防和治疗感染性疾病的高抗微生物活性的试剂。 因此，本发明提供具有抗微生物活性，有利的药代动力学和安全性的新型氰基烷基哌啶基苯基恶唑烷酮衍生物，以及用于制备化合物的方法，以及含有所述衍生物作为活性成分的抗微生物组合物和用所述衍生物治疗微生物感染的方法。

公开(公告)号：WO2004007489A2

公开(公告)日：2004-01-22

申请号：PCT/IN2003/000238

申请日：2003-07-10

Applicant: PATEL, Mahesh V ,  DESHPANDE, Prasad K ,  SINDKHEDKAR, Milind D ,  GUPTE, Shrikant V ,  CHUGH, Yati ,  SHETTY, Nitin ,  SHUKLA, Milind C ,  YEOLE, Ravindra D ,  DE SOUZA, Noel J

Inventor： PATEL, Mahesh V ,  DESHPANDE, Prasad K ,  SINDKHEDKAR, Milind D ,  GUPTE, Shrikant V ,  CHUGH, Yati ,  SHETTY, Nitin ,  SHUKLA, Milind C ,  YEOLE, Ravindra D ,  DE SOUZA, Noel J

IPC: C07D413/00

CPC classification number: C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

Abstract translation: 本发明提供了用于预防和治疗感染性疾病的高抗微生物活性的试剂。 因此，本发明提供新的氰基 - （取代） - 亚甲基哌啶基苯基恶唑烷酮衍生物，制备该化合物的方法，以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

公开(公告)号：WO2004108744A2

公开(公告)日：2004-12-16

申请号：PCT/IN2004/000137

申请日：2004-05-18

Applicant: DESHPANDE, Prasad, K ,  SINDKHEDKAR, Milind, D ,  DESAI, Vijaya, N ,  GUPTE, Shrikant, V ,  YEOLE, Ravindra, D ,  PATEL, Mahesh, V ,  DE SOUZA, Noel, J

Inventor： DESHPANDE, Prasad, K ,  SINDKHEDKAR, Milind, D ,  DESAI, Vijaya, N ,  GUPTE, Shrikant, V ,  YEOLE, Ravindra, D ,  PATEL, Mahesh, V ,  DE SOUZA, Noel, J

IPC: C07H17/00

CPC classification number: C07H17/00

Abstract: The present invention relates to novel azalides and azaketolides having antimicrobial activity, methods for their preparation, pharmaceutical compositions containing the compounds and methods of treating microbial infections with the compounds.

Abstract translation: 本发明涉及具有抗微生物活性的新型氮杂ides ides ides and az tol tol tol tol for for。。。。。。。。。。。。。。。。。

公开(公告)号：WO2003099815A1

公开(公告)日：2003-12-04

申请号：PCT/IN2002/000123

申请日：2002-05-28

Applicant: WOCKHARDT LIMITED ,  DE SOUZA, Noel, J. ,  DESHPANDE, Prasad, K. ,  SHUKLA, Milind, C. ,  MUKARRAM, Siddiqui, M., Jaweed ,  KULKARNI, Dilip, G. ,  YEOLE, Ravindra, D. ,  PATEL, Mahesh, V. ,  GUPTE, Shrikant, V.

Inventor： DE SOUZA, Noel, J. ,  DESHPANDE, Prasad, K. ,  SHUKLA, Milind, C. ,  MUKARRAM, Siddiqui, M., Jaweed ,  KULKARNI, Dilip, G. ,  YEOLE, Ravindra, D. ,  PATEL, Mahesh, V. ,  GUPTE, Shrikant, V.

IPC: C07D455/04

CPC classification number: C07D455/04

Abstract: The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating microbial infections.

Abstract translation: 本发明涉及RS-（+/-） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H的新的精氨酸盐形式， 5H-苯并[i，j]喹嗪-2羧酸，S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代 -1H，5H-苯并[i，j]喹嗪-2羧酸R - （+） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基 - 1-氧代-1H，5H-苯并[i，j]喹嗪-2-羧酸，其制备方法和包含这些精氨酸盐形式的药物制剂，作为其用于治疗微生物感染的活性成分。

公开(公告)号：WO02085886A3

公开(公告)日：2003-05-22

申请号：PCT/IN0200111

申请日：2002-04-24

Applicant: DE SOUZA NOEL J ,  PATEL MAHESH V ,  DESHPANDE PRASAD K ,  AGARWAL SHIV KUMAR ,  GUPTE SHRIKANT V ,  UPADHYAY DILIP J ,  BHAWSAR SATISH B ,  BERI RUPINDER K ,  SREENIVAS KANDEPU ,  NAIR SHEELA C ,  SHUKLA MILIND C ,  CHUGH Y ,  SHETTY NITIN ,  YEOLE RAVINDRA D ,  REDDY MADHAV M

Inventor： DE SOUZA NOEL J ,  PATEL MAHESH V ,  DESHPANDE PRASAD K ,  AGARWAL SHIV KUMAR ,  GUPTE SHRIKANT V ,  UPADHYAY DILIP J ,  BHAWSAR SATISH B ,  BERI RUPINDER K ,  SREENIVAS KANDEPU ,  NAIR SHEELA C ,  SHUKLA MILIND C ,  CHUGH Y ,  SHETTY NITIN ,  YEOLE RAVINDRA D ,  REDDY MADHAV M

IPC: A61K31/095 ,  A61K31/191 ,  A61K31/47 ,  A61K31/4709 ,  A61K45/06 ,  A61P3/04 ,  A61P11/00 ,  A61P13/10 ,  A61P13/12 ,  A61P19/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  C07D215/22 ,  C07D215/233 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00 ,  C07D413/04

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08

Abstract: This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

Abstract translation: 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。