ANTIMICROBIAL AMINO-SALICYLIC ACID DERIVATIVES
    1.
    发明申请
    ANTIMICROBIAL AMINO-SALICYLIC ACID DERIVATIVES 审中-公开
    抗微生物氨基磺酸衍生物

    公开(公告)号:WO2011023573A1

    公开(公告)日:2011-03-03

    申请号:PCT/EP2010/061804

    申请日:2010-08-13

    Abstract: Disclosed is a novel method for achieving an antimicrobial, preservative and/or microorganism adhesion inhibiting effect, for the protection within an article and/or material or on the surface of an article and/or material. The novel method comprises application of a salicylic compound of the formula (I) wherein one of A and A is a residue of the formula (I'): -NH-CO-R 1 while the other is hydrogen; R 1 is C 1 -C 22 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkyl interrupted by O and/or NR 5 , C 4 -C 12 aryl, C 5 -C 18 arylalkyl; R 2 is OR 3 or NHR 4 ; R 3 and R 4 are selected from H, C 1 -C 22 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkyl interrupted by O and/or NR 5 , C 4 -C 12 aryl, C 5 -C 18 arylalkyl; R 5 is H or C 1 -C 8 alkyl; wherein each aryl moiety is unsubstituted or substituted by C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 acyl, C 1 -C 4 acyloxy, C 1 -C 4 acylamino, CF 3 , OH, amino, halogen; or an adduct or salt thereof; to said article and/or material.

    Abstract translation: 公开了一种用于实现在制品和/或材料内或制品和/或材料的表面上的保护的抗微生物,防腐和/或微生物粘附抑制作用的新方法。 该新方法包括施用式(I)的水杨酸化合物,其中A和A之一是式(I')的残基:-NH-CO-R 1,而另一个是氢; R1是C1-C22烷基,C3-C12环烷基,被O和/或NR5,C4-C12芳基,C5-C18芳烷基中断的C3-C12环烷基; R2是OR3或NHR4; R 3和R 4选自H,C 1 -C 22烷基,C 3 -C 12环烷基,被O和/或NR 5,C 4 -C 12芳基,C 5 -C 18芳烷基间隔的C 3 -C 12环烷基; R5是H或C1-C8烷基; 其中每个芳基部分是未取代的或被C 1 -C 4烷基,C 1 -C 4烷氧基,C 1 -C 4酰基,C 1 -C 4酰氧基,C 1 -C 4酰氨基,CF 3,OH,氨基,卤素取代。 或其加合物或其盐; 对所述物品和/或材料。

    MODIFIED HALOGENATED POLYMER SURFACES
    2.
    发明申请
    MODIFIED HALOGENATED POLYMER SURFACES 审中-公开
    改性聚合物表面改性

    公开(公告)号:WO2009130233A1

    公开(公告)日:2009-10-29

    申请号:PCT/EP2009/054785

    申请日:2009-04-22

    CPC classification number: C08J7/16 C08F293/005 C08F2438/01 C08J2327/06

    Abstract: Disclosed is a method of preparing a modified halogenated polymer surface, comprising the steps of (a) activating the surface by modification with a polymerisation initiator by (a 1 ) reacting the halogenated polymer surface with sodium azide and subsequent (a 2 ) 1,3 dipolar cycloaddition with an alkine-functionalized initiator; or (a 3 ) reacting the halogenated polymer surface with mercapto-functionalized initiators; and (b) reacting the activated surface obtained in steps (a 1 )/(a 2 ) or (a 3 ) with polymerizable monomeric units A and/or B. The modified halogenated polymer substrates according to the invention exhibit outstanding properties.

    Abstract translation: 公开了一种制备改性卤化聚合物表面的方法,其包括以下步骤:(a)通过(a1)使卤化聚合物表面与叠氮化钠和随后的(a2)1,3偶极环加成反应,通过用聚合引发剂进行改性来活化表面 用烷基官能化引发剂; 或(a3)使卤代聚合物表面与巯基官能化的引发剂反应; 和(b)使步骤(a1)/(a2)或(a3)中获得的活化表面与可聚合单体单元A和/或B反应。本发明的改性卤化聚合物基材具有突出的性能。

    PRESERVATIVES
    3.
    发明申请
    PRESERVATIVES 审中-公开
    防腐剂

    公开(公告)号:WO2007009879A1

    公开(公告)日:2007-01-25

    申请号:PCT/EP2006/063896

    申请日:2006-07-05

    CPC classification number: A61Q17/005 A61K8/347 A61K2800/524

    Abstract: The present invention relates to the use of compounds of the formula (1 ) wherein all substitutents have the meanings as defined in Claim 1 as preservatives in personal care, pharmaceutical and household; the preservatives can also be used as in-can preservatives.

    Abstract translation: 本发明涉及式(1)化合物的用途,其中所有取代基具有权利要求1中定义的含义作为个人护理,制药和家庭中的防腐剂; 防腐剂也可以作为罐内防腐剂使用。

    ALKOXYPHENYLCARBOXYLIC ACID DERIVATIVES
    4.
    发明申请
    ALKOXYPHENYLCARBOXYLIC ACID DERIVATIVES 审中-公开
    烷氧基苯甲酸衍生物

    公开(公告)号:WO2005079744A1

    公开(公告)日:2005-09-01

    申请号:PCT/EP2005/050605

    申请日:2005-02-11

    CPC classification number: A61K8/368 A61K8/39 A61Q11/00 A61Q15/00 A61Q17/005

    Abstract: Use of compounds of formula (I) wherein R 1 is substituted or unsubstituted C 8 -C 30 alkyl or substituted or unsubstituted C 3 -C 7 cyclo- alkyl, and R 2 is H, COOH or substituted or unsubstituted O-C 1 -C 30 alkyl, in the antimicrobial treatment of surfaces, in the preservation of cosmetics, household products, textiles and plastics, and for use in disinfectants.

    Abstract translation: 在表面的抗微生物处理中,其中R 1为取代或未取代的C 8 -C 30烷基或取代或未取代的C 3 -C 7环烷基,R 2为H,COOH或取代或未取代的O-C 1 -C 30烷基的式(I) 在化妆品,家用产品,纺织品和塑料的保存和用于消毒剂。

    USE OF SUBSTITUTED 2,4-BIS(ALKYLAMINO)PYRIMIDINES
    8.
    发明申请
    USE OF SUBSTITUTED 2,4-BIS(ALKYLAMINO)PYRIMIDINES 审中-公开
    取代的2,4-BIS(亚苄基)嘧啶的使用

    公开(公告)号:WO2005011758A2

    公开(公告)日:2005-02-10

    申请号:PCT/EP2004/051516

    申请日:2004-07-16

    Abstract: The use of 2,4-bis(alkylamino)pyrimidines of formula (1) R 1 is C 1 -C 12 alkyl or C 6 -C 10 laryl; R 2 is hydrogen or C 1 -C 12 alkyl; or R 1 and R 2 together forma radical of formula (1 a) R' and R" are each independently of the other hydrogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, R 3 and R 5 are each independently of the other hydrogen or C 1 -C 8 alkyl; R 4 is C 1 -C 20 alkyl, unsubstituted phenyl, C 6 -C 10 aryl, C 6 -C 10 aryl-C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, di-C 1 -C 6 al-kylamino-C 1 -C 6 aIkyl, mono-C 1 -C 6 alkylamino-C 1 -C 6 alkyl, -(CH 2 )2-(O-(CH 2 ) 2 ) 1-4 -OH or -(CH 2 ) 2 -(O-(CH 2 ) 2 ) 1-4 -NH 2 ; R 6 is C 1 -C 20 alkyl, C 6 -C 10 aryl, C 6 -C 10 aryl-C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, di-C 1 ­C 6 alkylamino-C 1 -C 6 alkyl, mono-C 1 -C 6 alkylamino-C 1 -C 6 alkyl, -(CH 2 ) 2 -(O-(CH 2 ) 2 ) 1-4 -OH or -(CH 2 ) 2 -(O-(CH 2 ) 2 ) 1-4 -NH 2 ; or R 3 and R 4 and/or R 5 and R 6 , together form a pyrrolidine, piperidine, hexamethyleneimine or morpholine ring; in the antimicrobial treatment of surfaces.

    Abstract translation: 式(1)R 1的2,4-双(烷基氨基)嘧啶的用途是C 1 -C 12烷基或C 6 -C 10芳基; R2是氢或C1-C12烷基; 或者R 1和R 2一起形成式(1a)的基团,R'和R“各自独立地为氢,C 1 -C 6烷基或C 1 -C 6烷氧基,R 3和R 5各自独立地为氢或C 1 -C 8烷基; R 4 是C 1 -C 20烷基,未取代的苯基,C 6 -C 10芳基,C 6 -C 10芳基-C 1 -C 6烷基,羟基-C 1 -C 6烷基,二-C 1 -C 6烷基氨基-C 1 -C 6烷基,单-C 1 -C 6烷基氨基-C 1 -C 6烷基, - ( CH2)2-(O-(CH2)2)1-4-OH或 - (CH2)2-(O-(CH2)2)1-4-NH2; R6是C1-C20烷基,C6-C10芳基, C 1 -C 10芳基-C 1 -C 6烷基,羟基-C 1 -C 6烷基,二-C 1 -C 6烷基氨基-C 1 -C 6烷基,单-C 1 -C 6烷基氨基-C 1 -C 6烷基, - (CH 2)2 - (O-(CH 2)2)1-4 -OH或 - (CH2)2-(O-(CH2)2)1-4-NH2;或R3和R4和/或R5和R6一起形成吡咯烷,哌啶,六亚甲基亚胺或吗啉环;在表面的抗微生物处理中。

    PYRIDYL-TRIAZINE DERIVATIVES AS MICROBICIDAL ACTIVE SUBSTANCES
    9.
    发明申请
    PYRIDYL-TRIAZINE DERIVATIVES AS MICROBICIDAL ACTIVE SUBSTANCES 审中-公开
    吡咯并噻嗪衍生物作为微生物活性物质

    公开(公告)号:WO2004013124A1

    公开(公告)日:2004-02-12

    申请号:PCT/EP2003/007975

    申请日:2003-07-22

    CPC classification number: C07D401/04 A01N43/66 A61K8/4966 A61Q11/00

    Abstract: Triazine derivatives of formula (1) wherein R 1 is C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; or C 1 -C 20 perfluoroalkyl; R 2 is hydrogen; C 1 -C 20 alkyl; or C 3 -C 7 cycloalkyl; and R 3 is hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; C 1 -C 20 perfluoroalky; C 1 -C 20 alkyl-carbonyl; C 3 -C 7 cycloalkyl-carbonyl; C 1 -C 20 perfluoroalkyl-carbonyl; or phenylcarbonyl; are described. The compounds exhibit pronounced action against gram-positive and gram-negative bacteria and also against yeasts and moulds. They are also suitable for treating or preventing biofilms on human tooth surfaces and oral mucosa.

    Abstract translation: 式(1)的三嗪衍生物,其中R 1是C 1 -C 20烷基; C3-C7环烷基; 或C 1 -C 20全氟烷基; R2是氢; C1-C20烷基; 或C 3 -C 7环烷基; 并且R 3是氢; C1-C20烷基; C3-C7环烷基; C1-C20perfluoroalky; C1-C20烷基羰基; C3-C7环烷基羰基; C1-C20perfluoroalkyl羰基; 或苯基羰基; 被描述。 化合物对革兰氏阳性和革兰氏阴性细菌以及酵母和霉菌都表现出明显的作用。 它们也适用于治疗或预防人牙齿表面和口腔粘膜上的生物膜。

    SURFACE PATTERNING WITH FUNCTIONAL POLYMERS
    10.
    发明申请
    SURFACE PATTERNING WITH FUNCTIONAL POLYMERS 审中-公开
    带有功能聚合物的表面图案

    公开(公告)号:WO2010054979A1

    公开(公告)日:2010-05-20

    申请号:PCT/EP2009/064695

    申请日:2009-11-05

    Abstract: Disclosed is a method of preparing a modified halogenated polymer surface, comprising the steps of (a) activating the surface by modification with a polymerisation initiator by (a 1 ) reacting the halogenated polymer surface with sodium azide, subsequent (a 2 ) patterning the azidated surface via photolithographic patterning methods, and subsequent (a 3 ) 1, 3 dipolar cycloaddition with an alkine-functionalized initiator; and (b) reacting the activated surface obtained in steps (a 1 )-(a 3 ) with polymerizable monomeric units A and/or B.

    Abstract translation: 公开了一种制备改性卤化聚合物表面的方法,其包括以下步骤:(a)通过(a1)使卤化聚合物表面与叠氮化钠反应,通过用聚合引发剂进行改性来活化表面,随后(a2)将叠氮化表面经过 光刻图案化方法,以及随后(a3)1,3与亚烷基官能化引发剂的偶极环加成反应; 和(b)使步骤(a1) - (a3)中获得的活化表面与可聚合单体单元A和/或B反应。

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