公开(公告)号：WO2006080954A1

公开(公告)日：2006-08-03

申请号：PCT/US2005/027875

申请日：2005-07-28

Applicant: DAS, Biswajit ,  SALMAN, Mohammad ,  HAJARE, Atul, Kashinath ,  VENKATARAMANAN, Ramadass ,  KATOCH, Rita ,  KUMAR, Rajesh ,  KAPKOTI, Gobind, Singh ,  CHAKRABARTI, Anjan ,  BANDYOPADHYAY, Anish ,  KURHADE, Santosh, Haribhau ,  SURASE, Yogesh, Baban ,  RATTAN, Ashok

Inventor： DAS, Biswajit ,  SALMAN, Mohammad ,  HAJARE, Atul, Kashinath ,  VENKATARAMANAN, Ramadass ,  KATOCH, Rita ,  KUMAR, Rajesh ,  KAPKOTI, Gobind, Singh ,  CHAKRABARTI, Anjan ,  BANDYOPADHYAY, Anish ,  KURHADE, Santosh, Haribhau ,  SURASE, Yogesh, Baban ,  RATTAN, Ashok

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing siuch ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌， 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备西罗汉酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：WO2006035301A3

公开(公告)日：2006-04-06

申请号：PCT/IB2005/002894

申请日：2005-09-27

Applicant: RANBAXY LABORATORIES LIMITED ,  DAS, Biswajit ,  KATOCH, Rita ,  HAJARE, Atul, Kashinath ,  BANDYOPADHYAY, Anish ,  KURHADE, Santosh, Haribhau ,  RATHY, Sujata ,  RATTAN, Ashok

Inventor： DAS, Biswajit ,  KATOCH, Rita ,  HAJARE, Atul, Kashinath ,  BANDYOPADHYAY, Anish ,  KURHADE, Santosh, Haribhau ,  RATHY, Sujata ,  RATTAN, Ashok

IPC: C07H17/08 ,  A61K31/7042

Abstract: The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

公开(公告)号：WO2006035301A2

公开(公告)日：2006-04-06

申请号：PCT/IB2005002894

申请日：2005-09-27

Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  KATOCH RITA ,  HAJARE ATUL KASHINATH ,  BANDYOPADHYAY ANISH ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  RATTAN ASHOK

Inventor： DAS BISWAJIT ,  KATOCH RITA ,  HAJARE ATUL KASHINATH ,  BANDYOPADHYAY ANISH ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  RATTAN ASHOK

CPC classification number: C07H17/08

Abstract: The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属，衣原体属。 ，支原体属（Mycoplasm），军团菌属（Legionella spp。），分枝杆菌属（Mycobacterium），幽门螺杆菌属（Clostridium），拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其组合。 还提供了制备本文公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：WO2006117762A8

公开(公告)日：2009-03-05

申请号：PCT/IB2006051397

申请日：2006-05-03

Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  ARORA JASBIR SINGH ,  AHMED SHAHADAT ,  BANDYOPADHYAY ANISH ,  KATOCH RITA ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  GHOSH SOMA ,  KHOJE ABHIJIT DATTA ,  GUJRATI ARTI ,  UPADHYAY DILIP J

Inventor： DAS BISWAJIT ,  ARORA JASBIR SINGH ,  AHMED SHAHADAT ,  BANDYOPADHYAY ANISH ,  KATOCH RITA ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  GHOSH SOMA ,  KHOJE ABHIJIT DATTA ,  GUJRATI ARTI ,  UPADHYAY DILIP J

IPC: C07D333/34 ,  A61K31/381

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia,Rickettsiae, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes,Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract translation: 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌，衣原体，立克次氏体，支原体，军团菌，分枝杆菌，幽门螺杆菌，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮癣菌，亨氏球菌，组织胞浆菌， ，副球菌属，肺孢子虫属，毛癣菌属或Trichosporium。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：WO2006117762A3

公开(公告)日：2007-02-08

申请号：PCT/IB2006051397

申请日：2006-05-03

Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  ARORA JASBIR SINGH ,  AHMED SHAHADAT ,  BANDYOPADHYAY ANISH ,  KATOCH RITA ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  GHOSH SOMA ,  KHOJE ABHIJIT DATTA ,  GUJRATI ARTI ,  UPADHYAY DILIP J

Inventor： DAS BISWAJIT ,  ARORA JASBIR SINGH ,  AHMED SHAHADAT ,  BANDYOPADHYAY ANISH ,  KATOCH RITA ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  GHOSH SOMA ,  KHOJE ABHIJIT DATTA ,  GUJRATI ARTI ,  UPADHYAY DILIP J

IPC: C07D333/34 ,  A61K31/381

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: An audio coding scheme allowing PCM signal to lossless DSD signal expansion for next generation optical disc formats. The encoder (ENC) upsamples a PCM signal to the DSD sample rate. Then a set of -loop filter parameters (LFP) is generated for a noise-shaping loop of a sigma-delta modulator (SDM). A correction signal (CS) indicates the difference between a sigma- delta modulated version of the up-sampled PCM signal (UPCM) and the target DSD signal (IDSD) . The correction signal (CS) may be adapted to be applied to the original PCM signal (PCM), to the up-sampled PCM signal (UPCM) or to the output bit stream (ODSD) . An expansion bit stream (EBS) includes the loop filter parameters (LFP) and the correction signal. The decoder (DEC) can reproduce the original DSD signal based on the PCM signal (PCM) and the expansion bit stream (EBS).

Abstract translation: 音频编码方案允许PCM信号对下一代光盘格式的无损DSD信号扩展。 编码器（ENC）将PCM信号上采样到DSD采样率。 然后为Σ-Δ调制器（SDM）的噪声整形环路生成一组环路滤波器参数（LFP）。 校正信号（CS）指示上采样PCM信号（UPCM）的Σ-Δ调制版本与目标DSD信号（IDSD）之间的差异。 校正信号（CS）可适用于原始PCM信号（PCM），上采样PCM信号（UPCM）或输出比特流（ODSD）。 扩展位流（EBS）包括环路滤波器参数（LFP）和校正信号。 解码器（DEC）可以基于PCM信号（PCM）和扩展位流（EBS）再现原始DSD信号。

公开(公告)号：WO2006117762A2

公开(公告)日：2006-11-09

申请号：PCT/IB2006/051397

申请日：2006-05-03

Applicant: RANBAXY LABORATORIES LIMITED ,  DAS, Biswajit ,  ARORA, Jasbir, Singh ,  AHMED, Shahadat ,  BANDYOPADHYAY, Anish ,  KATOCH, Rita ,  KURHADE, Santosh, Haribhau ,  RATHY, Sujata ,  GHOSH, Soma ,  KHOJE, Abhijit, Datta ,  GUJRATI, Arti ,  UPADHYAY, Dilip, J.

Inventor： DAS, Biswajit ,  ARORA, Jasbir, Singh ,  AHMED, Shahadat ,  BANDYOPADHYAY, Anish ,  KATOCH, Rita ,  KURHADE, Santosh, Haribhau ,  RATHY, Sujata ,  GHOSH, Soma ,  KHOJE, Abhijit, Datta ,  GUJRATI, Arti ,  UPADHYAY, Dilip, J.

IPC: C07D333/34 ,  A61K31/381

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Rickettsiae, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae , and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis , Trichophyton , or Trichosporium . Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract translation: 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌，衣原体，立克次氏体，支原体，军团菌，分枝杆菌，幽门螺杆菌，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮癣菌，亨氏球菌，组织胞浆菌， ，副球菌属，肺孢子虫属，毛癣菌属或Trichosporium。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：WO2006046112A3

公开(公告)日：2006-08-10

申请号：PCT/IB2005003181

申请日：2005-10-25

Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  SALMAN MOHAMMAD ,  KURHADE SANTOSH HARIBHAU ,  VENKATARAMANAN RAMADASS ,  KUMAR RAJESH ,  KAPKOTI GOBIND SINGH ,  KATOCH RITA ,  BANDYOPADHYAY ANISH ,  RATTAN ASHOK

Inventor： DAS BISWAJIT ,  SALMAN MOHAMMAD ,  KURHADE SANTOSH HARIBHAU ,  VENKATARAMANAN RAMADASS ,  KUMAR RAJESH ,  KAPKOTI GOBIND SINGH ,  KATOCH RITA ,  BANDYOPADHYAY ANISH ,  RATTAN ASHOK

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as anti-bacterial agents. Compounds disclosed herein can be used for the treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨卡氏菌，衣原体属， 支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，其合成中使用的中间体，其药物组合物和治疗细菌感染的方法。

公开(公告)号：WO2006013409A1

公开(公告)日：2006-02-09

申请号：PCT/IB2005/001986

申请日：2005-07-13

Applicant: RANBAXY LABORATORIES LIMITED ,  DAS, Biswajit ,  KATOCH, Rita ,  HAJARE, Atul, Kashinath ,  KAPKOTI, Gobind, Singh ,  BANDYOPADHYAY, Anish ,  VENKATARAMANAN, Ramadass ,  KUMAR, Rajesh ,  KURHADE, Santosh, Haribhau ,  RATHY, Sujata ,  CHAKRABARTI, Anjan ,  SURASE, Yogesh, Bahan ,  SALMAN, Mohammad ,  RATTAN, Ashok

Inventor： DAS, Biswajit ,  KATOCH, Rita ,  HAJARE, Atul, Kashinath ,  KAPKOTI, Gobind, Singh ,  BANDYOPADHYAY, Anish ,  VENKATARAMANAN, Ramadass ,  KUMAR, Rajesh ,  KURHADE, Santosh, Haribhau ,  RATHY, Sujata ,  CHAKRABARTI, Anjan ,  SURASE, Yogesh, Bahan ,  SALMAN, Mohammad ,  RATTAN, Ashok

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for the treatment or prevention of a condition caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against bacterium such as Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., My obacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, B ccillus or Enterobactericeae. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating bacterial infections, are also provided.

Abstract translation: 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起的或由其贡献的病症，特别是针对细菌如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨拉氏菌，衣原体 肉豆蔻，军团菌，我的杆菌，幽门螺杆菌，梭菌属，拟杆菌属，棒状杆菌属，B肠杆菌属或肠杆菌属。 还提供了制备所公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：WO2006046112A2

公开(公告)日：2006-05-04

申请号：PCT/IB2005/003181

申请日：2005-10-25

Applicant: RANBAXY LABORATORIES LIMITED ,  DAS, Biswajit ,  SALMAN, Mohammad ,  KURHADE, Santosh, Haribhau ,  VENKATARAMANAN, Ramadass ,  KUMAR, Rajesh ,  KAPKOTI, Gobind, Singh ,  KATOCH, Rita ,  BANDYOPADHYAY, Anish ,  RATTAN, Ashok

Inventor： DAS, Biswajit ,  SALMAN, Mohammad ,  KURHADE, Santosh, Haribhau ,  VENKATARAMANAN, Ramadass ,  KUMAR, Rajesh ,  KAPKOTI, Gobind, Singh ,  KATOCH, Rita ,  BANDYOPADHYAY, Anish ,  RATTAN, Ashok

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as anti-bacterial agents. Compounds disclosed herein can be used for the treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供了可用作抗菌剂的酮内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧菌引起的或由其引起的疾病，更特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉沙拉菌，衣原体属， 支原体，军团菌属，分枝杆菌属，螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，其合成中使用的中间体，其药物组合物以及治疗细菌感染的方法。