公开(公告)号：WO2011009084A3

公开(公告)日：2011-01-20

申请号：PCT/US2010/042340

申请日：2010-07-16

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  HENDERSON, James A. ,  MAXWELL, John ,  VAILLANCOURT, Louis ,  MORRIS, Mark ,  GREY, JR., Ronald ,  GIROUX, Simon ,  KONG, Laval Chan Chun ,  DAS, Sanjoy Kumar ,  LIU, Bingcan ,  POISSON, Carl ,  CADILHAC, Caroline ,  BUBENIK, Monica ,  REDDY, T. Jagadeeswar ,  FALARDEAU, Guy ,  YANNOPOULOS, Constantin ,  WANG, Jian ,  PEREIRA, Oswy Z. ,  BENNANI, Youssef L. ,  PIERCE, Albert C. ,  BHISETTI, Govinda Rao ,  COTTRELL, Kevin M. ,  MARONE, Valerie

Inventor： HENDERSON, James A. ,  MAXWELL, John ,  VAILLANCOURT, Louis ,  MORRIS, Mark ,  GREY, JR., Ronald ,  GIROUX, Simon ,  KONG, Laval Chan Chun ,  DAS, Sanjoy Kumar ,  LIU, Bingcan ,  POISSON, Carl ,  CADILHAC, Caroline ,  BUBENIK, Monica ,  REDDY, T. Jagadeeswar ,  FALARDEAU, Guy ,  YANNOPOULOS, Constantin ,  WANG, Jian ,  PEREIRA, Oswy Z. ,  BENNANI, Youssef L. ,  PIERCE, Albert C. ,  BHISETTI, Govinda Rao ,  COTTRELL, Kevin M. ,  MARONE, Valerie

IPC: C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  A61K31/4184 ,  A61P3/00

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R 1 , R 1 ', R 2 , R 2 ', R 3 , R 3 ', R 5 , R 5 ', R 6 , m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：WO2011009084A2

公开(公告)日：2011-01-20

申请号：PCT/US2010042340

申请日：2010-07-16

Applicant: VERTEX PHARMA ,  HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D403/14 ,  A61K31/506

CPC classification number: C07K5/06052 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R1, R1 ', R2, R2', R3, R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Abstract translation: 其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6，m ，n或p如本文所定义，可用于治疗黄病毒科病毒感染。

公开(公告)号：WO2021127586A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/066243

申请日：2020-12-18

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC. ,  VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  KORT, Michael E. ,  NASVESCHUK, Christopher G. ,  DUPLESSIS, Martin

Inventor： VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  NASVESCHUK, Christopher G. ,  DUPLESSIS, Martin

IPC: C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  A61P3/00 ,  A61P35/00 ,  A61K47/00 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K9/0019

Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.

公开(公告)号：WO2011087776A1

公开(公告)日：2011-07-21

申请号：PCT/US2010/061484

申请日：2010-12-21

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  ARONOV, Alex ,  COME, Jon, H. ,  DAVIES, Robert, J. ,  PIERCE, Albert, C. ,  WANG, Jian ,  NANTHAKUMAR, Suganthini ,  CAO, Jingrong ,  BANDARAGE, Upul, K. ,  KRUEGER, Elaine ,  TIRAN, Amaud, Le ,  LIAO, Yusheng ,  MESSERSMITH, David ,  COLLIER, Philip, N. ,  GREY, Ronald ,  O'DOWD, Hardwin ,  HENDERSON, James, A. ,  GRILLOT, Anne-Laure

Inventor： ARONOV, Alex ,  COME, Jon, H. ,  DAVIES, Robert, J. ,  PIERCE, Albert, C. ,  WANG, Jian ,  NANTHAKUMAR, Suganthini ,  CAO, Jingrong ,  BANDARAGE, Upul, K. ,  KRUEGER, Elaine ,  TIRAN, Amaud, Le ,  LIAO, Yusheng ,  MESSERSMITH, David ,  COLLIER, Philip, N. ,  GREY, Ronald ,  O'DOWD, Hardwin ,  HENDERSON, James, A. ,  GRILLOT, Anne-Laure

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/20 ,  C07D491/20 ,  A61K31/352 ,  A61K31/424 ,  A61K31/429 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07D409/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/20 ,  C07D491/20

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及可用作PI3K抑制剂，特别是PI3Kα的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。