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公开(公告)号：WO2023086495A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/049581
申请日：2022-11-10
发明人： BOGDAN, Andrew , ECONOMOU, Christos , FROST, Jennifer M. , KYM, Philip R. , SCHOLZ, Spencer O. , XIONG, Zhaoming
IPC分类号： C07D417/04 , C07D417/14 , A61K31/433
摘要： The present invention provides for compounds of Formula (I) wherein R1, has any of the values defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of non-small cell lung cancer.
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公开(公告)号：WO2023019166A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/074758
申请日：2022-08-10
发明人： VEITS, Gesine Kerstin , FITZGERALD, Mark E. , HIRD, Alexander W. , HENDERSON, James A. , VORA, Harit U. , SWEIS, Ramzi F. , KORT, Michael E. , MATULENKO, Mark
IPC分类号： C07D409/14 , A61P35/00 , A61K31/454
摘要： Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
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公开(公告)号：WO2020223538A8
公开(公告)日：2020-11-05
申请号：PCT/US2020/030819
申请日：2020-04-30
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , SHI, Lei , MURAUSKI, Kathleen, J. , XU, Xiangdong , TONG, Yunsong , RANDOLPH, John, T. , DART, Michael, J. , BENELKEBIR, Hanae , EDESON, Steven , STARBUCK, Kathryn
IPC分类号： C07D311/74 , A61P25/00 , A61P35/00 , A61P37/00 , C07C1/00 , C07D213/53 , C07D265/36 , C07D271/10 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , A61K31/165 , A61K31/353 , A61K31/397 , A61K31/4025 , A61K31/403 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/437 , A61K31/4433 , A61K45/06 , A61P25/28 , C07C235/22 , C07C235/36 , C07C235/40 , C07C2601/04 , C07C2602/38 , C07C2602/44 , C07D311/22 , C07D311/24 , C07D471/04 , C07D471/08 , C07D493/08
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2022271727A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034379
申请日：2022-06-21
发明人： VEITS, Gesine Kerstin , FITZGERALD, Mark E. , HIRD, Alexander W. , SWEIS, Ramzi F. , KORT, Michael E.
IPC分类号： C07D417/14 , C07D471/04 , C07D471/10 , A61P1/16 , A61P3/00 , A61P3/10 , A61P35/00 , A61K31/454 , A61K31/496 , A61K31/4995 , A61K31/444
摘要： Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
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公开(公告)号：WO2020077217A1
公开(公告)日：2020-04-16
申请号：PCT/US2019/055850
申请日：2019-10-11
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , DART, Michael, J. , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , MURAUSKI, Kathleen , PLIUSHCHEV, Marina , BROWN, Brian, S. , VOIGHT, Eric , RANDOLPH, John, T.
IPC分类号： C07C235/36 , C07C271/34 , C07C303/34 , C07D221/00 , C07F9/09
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2019245946A1
公开(公告)日：2019-12-26
申请号：PCT/US2019/037433
申请日：2019-06-17
IPC分类号： G01N21/64
摘要： Methods and apparatus for inferring protein binding based on rotational diffusion of a collection of fluorophores. One example of a method includes applying a first light pulse to excite a plurality of fluorophores in the collection of fluorophores to produce a plurality of excited fluorophores, the first light pulse having a first polarization and the plurality of excited fluorophores having a component of their orientation aligned with the first polarization, applying a second light pulse to stimulate emission by the plurality of excited fluorophores, the second light pulse having a second polarization orthogonal to the first polarization, after a time delay following application of the second light pulse, applying a third light pulse of the second polarization to further stimulate emission by the plurality of excited fluorophores, detecting polarized emissions from the plurality of excited fluorophores, and inferring the rate of rotational diffusion of the collection of fluorophores based on the detected polarized emissions.
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公开(公告)号：WO2019090090A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058974
申请日：2018-11-02
发明人： MARTIN, Kathleen Ann , SIDRAUSKI, Carmela , FROST, Jennifer M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , XIONG, Zhaoming
IPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D209/44 , C07D211/18 , A61K31/397 , A61P35/00
CPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D209/44 , C07D211/18
摘要： Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2019090085A8
公开(公告)日：2019-05-09
申请号：PCT/US2018/058969
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , CHUNG, Seungwon , ZHANG, Qingwei, I. , SHI, Lei , MURAUSKI, Kathleen , DART, Michael, J. , RANDOLPH, John, T.
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , A61P19/00 , A61P25/00 , A61P3/00 , A61P21/00 , A61P29/00 , A61P35/00 , A61K31/16 , A61K31/165 , A61K31/538 , A61K31/352 , A61K31/36 , A61K31/498 , C07D311/66 , C07D319/20 , C07D405/12 , C07D413/06 , C07D265/36 , C07D493/04 , C07D207/22 , C07D209/42 , C07D307/84
摘要： Provided herein are compounds of formula (I), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. (Formula I).
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公开(公告)号：WO2019090081A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058963
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , CHUNG, Seungwon , XIONG, Zhaoming , MURAUSKI, Kathleen , ZHANG, Qingwei, I. , BROWN, Brian, S. , DART, Michael, J.
IPC分类号： C07D207/26 , C07D209/46 , C07D207/273 , C07D233/32 , C07D239/88 , C07D239/96 , C07D263/20 , C07D265/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/12 , A61P3/00 , A61P19/00
CPC分类号： C07D207/273 , A61P3/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D207/26 , C07D209/46 , C07D233/32 , C07D239/88 , C07D239/96 , C07D263/20 , C07D265/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/12
摘要： Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2022056281A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/049895
申请日：2021-09-10
发明人： KYM, Philip, R. , FROST, Jennifer, M. , ECONOMOU, Christos , BOGDAN, Andrew , FOSU, Stacy , XIONG, Zhaoming , SCHOLZ, Spencer, O. , VOIGHT, Eric , FARNEY, Elliot, P.
IPC分类号： C07D285/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D493/08 , A61K31/433 , A61P3/10
摘要： Provided herein are compounds including compounds of formula (I), compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
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