公开(公告)号：WO2021127586A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/066243

申请日：2020-12-18

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC. ,  VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  KORT, Michael E. ,  NASVESCHUK, Christopher G. ,  DUPLESSIS, Martin

Inventor： VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  NASVESCHUK, Christopher G. ,  DUPLESSIS, Martin

IPC: C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  A61P3/00 ,  A61P35/00 ,  A61K47/00 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K9/0019

Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.

公开(公告)号：WO2013091096A1

公开(公告)日：2013-06-27

申请号：PCT/CA2012/050909

申请日：2012-12-19

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STURINO, Claudio ,  BEAULIEU, Pierre ,  DEROY, Patrick ,  DUPLESSIS, Martin ,  JAMES, Clint ,  LACOSTE, Jean-Eric ,  MINVILLE, Joannie ,  MORENCY, Louis ,  MORIN, Sébastien ,  SIMONEAU, Bruno ,  TREMBLAY, Martin

Inventor： STURINO, Claudio ,  BEAULIEU, Pierre ,  DEROY, Patrick ,  DUPLESSIS, Martin ,  JAMES, Clint ,  LACOSTE, Jean-Eric ,  MINVILLE, Joannie ,  MORENCY, Louis ,  MORIN, Sébastien ,  SIMONEAU, Bruno ,  TREMBLAY, Martin

IPC: C07D491/147 ,  A61K31/519 ,  A61P31/18 ,  C07D491/048

CPC classification number: C07D491/147 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D491/048

Abstract: Compounds of formula (I) and pharmaceutical compositions thereof: wherein A 1 A 2 and A 3 are each independently selected from the group consisting of N and CR 3 , wherein R 1 is an optionally substituted heterocyclyl or an optionally substituted -(C 1-6 )alkyl-heterocyclyl, R 2 is an optionally substituted aryl or an optionally subsisted heteroaryl, R 4 is an optionally substituted aryl, an optionally substituted heterocyclyl or an optionally substituted heteroaryl, useful as an inbitor of HIV replication.

Abstract translation: 式（I）化合物及其药物组合物：其中A1 A2和A3各自独立地选自N和CR 3，其中R 1是任选取代的杂环基或任选取代的 - （C 1-6）烷基 - 杂环基， R2是任选取代的芳基或任选残基的杂芳基，R 4是任选取代的芳基，任选取代的杂环基或任选取代的杂芳基，可用作HIV复制的抑制剂。

公开(公告)号：WO2010115264A1

公开(公告)日：2010-10-14

申请号：PCT/CA2010/000478

申请日：2010-04-07

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GmbH ,  STURINO, Claudio ,  DEROY, Patrick ,  DUPLESSIS, Martin ,  EDWARDS, Paul J. ,  FAUCHER, Anne-Marie ,  HALMOS, Teddy ,  JAMES, Clint ,  LACOSTE, Jean-Eric ,  MALENFANT, Eric ,  MINVILLE, Joannie ,  MORENCY, Louis ,  MORIN, Sebastien ,  TREMBLAY, Martin ,  YOAKIM, Christiane

Inventor： STURINO, Claudio ,  DEROY, Patrick ,  DUPLESSIS, Martin ,  EDWARDS, Paul J. ,  FAUCHER, Anne-Marie ,  HALMOS, Teddy ,  JAMES, Clint ,  LACOSTE, Jean-Eric ,  MALENFANT, Eric ,  MINVILLE, Joannie ,  MORENCY, Louis ,  MORIN, Sebastien ,  TREMBLAY, Martin ,  YOAKIM, Christiane

IPC: C07D491/048 ,  A61K31/519 ,  A61K31/549 ,  A61P31/18 ,  C07D487/04 ,  C07D491/147 ,  C07D513/04

CPC classification number: C07D491/048 ,  C07D487/04 ,  C07D491/147 ,  C07D513/04 ,  C07D519/00

Abstract: Compounds of formula (I): wherein R 1 , R 2 , A 1 , A 2 , A 3 , A 4 , X and Y are as defined herein, are useful as inhibitors of HIV replication.

Abstract translation: 式（I）化合物：其中R1，R2，A1，A2，A3，A4，X和Y如本文所定义，可用作HIV复制的抑制剂。

公开(公告)号：WO2008067644A1

公开(公告)日：2008-06-12

申请号：PCT/CA2007/002155

申请日：2007-12-03

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  BOEHRINGER INGELHEIM PHARMA GmbH & CO KG ,  YOAKIM, Christiane ,  DEROY, Patrick ,  DUPLESSIS, Martin ,  GAGNON, Alexandre ,  GOULET, Sylvie ,  HÜCKE, Oliver ,  LEMKE, Christopher ,  SURPRENANT, Simon

Inventor： YOAKIM, Christiane ,  DEROY, Patrick ,  DUPLESSIS, Martin ,  GAGNON, Alexandre ,  GOULET, Sylvie ,  HÜCKE, Oliver ,  LEMKE, Christopher ,  SURPRENANT, Simon

IPC: C07D405/14 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61P31/18 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.

Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2，R 3和R 4， >如本文所定义，其用于治疗人类免疫缺陷病毒（HIV）感染的组合物和用途。 特别地，本发明提供HIV复制的新型抑制剂，含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法。

公开(公告)号：WO2014070979A1

公开(公告)日：2014-05-08

申请号：PCT/US2013/067674

申请日：2013-10-31

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  FADER, Lee ,  PARISIEN, Mathieu ,  THIBEAULT, Carl ,  MORENCY, Louis ,  DUPLESSIS, Martin ,  JAMES, Clint ,  MORIN, Sebastien ,  GILLARD, James

Inventor： FADER, Lee ,  PARISIEN, Mathieu ,  THIBEAULT, Carl ,  MORENCY, Louis ,  DUPLESSIS, Martin ,  JAMES, Clint ,  MORIN, Sebastien ,  GILLARD, James

IPC: C07D413/12 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  C07D417/12 ,  C07D417/14 ,  A61P31/12 ,  A61P31/22

CPC classification number: C07D277/56 ,  C07D277/82 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds of Formula (I) wherein n, R 1 , R 1A , R 2 , R 4 and Z are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.

Abstract translation: 其中n，R1，R1A，R2，R4和Z在本文中定义的式（I）化合物可用于治疗巨细胞病毒疾病和/或感染。