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公开(公告)号：WO2008064269A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/085306
申请日：2007-11-20
Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , SHAH, Samip , HINES, Amy Chu, Peishuan , ZHOU, Dao, Min , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , WEILAND, James, D.
Inventor： SHAH, Samip , HINES, Amy Chu, Peishuan , ZHOU, Dao, Min , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , WEILAND, James, D.
CPC classification number: A61N1/0543
Abstract: A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.
Abstract translation: 视网膜假体的关键元件是刺激电极阵列，其被放置在靠近视网膜的位置。 通过该界面，视网膜假体电刺激神经细胞产生光的感知。 电流驱动器所看到的阻抗由组织电阻和复合电极阻抗组成。 结果表明，视网膜的组织电阻显着大于眼玻璃体液的组织电阻。 电极 - 视网膜界面的电路模型用于参数化整个阻抗的不同贡献者。
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公开(公告)号：WO2008064269A8
公开(公告)日：2008-09-18
申请号：PCT/US2007085306
申请日：2007-11-20
Applicant: SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , SHAH SAMIP , HINES AMY CHU PEISHUAN , ZHOU DAO MIN , GREENBERG ROBERT J , HUMAYUN MARK S , WEILAND JAMES D
Inventor： SHAH SAMIP , HINES AMY CHU PEISHUAN , ZHOU DAO MIN , GREENBERG ROBERT J , HUMAYUN MARK S , WEILAND JAMES D
IPC: A61N1/05
CPC classification number: A61N1/0543
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3.发明申请
公开(公告)号：WO2008042278A3
公开(公告)日：2008-07-10
申请号：PCT/US2007020977
申请日：2007-09-28
Applicant: SECOND SIGHT MEDICAL PROD INC , HINES AMY P , ZHOU DAO MIN , ROY ARUP , DAI RONGQING , GREENBERG ROBERT J
Inventor： HINES AMY P , ZHOU DAO MIN , ROY ARUP , DAI RONGQING , GREENBERG ROBERT J
IPC: A61N1/36
CPC classification number: A61N1/36046
Abstract: The present invention is a method for measuring stable and reproducible electrode-tissue impedance, comprising preconditioning an electrode-tissue interface. Further aspect of the invention is a stimulation system for a visual prosthesis generating a stimulation signal to precondition the electrode-tissue interface, comprising a computer; software, loaded in the computer, adapted to perform a stimulating method for a visual prosthesis having a plurality of electrodes; a video processing unit; and an implanted neuron-stimulator.
Abstract translation: 本发明是一种用于测量稳定且可再现的电极组织阻抗的方法，包括预处理电极 - 组织界面。 本发明的另一方面是一种用于视觉假体的刺激系统，其产生用于预处理电极 - 组织界面的刺激信号，所述刺激信号包括计算机; 软件，装在计算机中，适用于执行具有多个电极的视觉假体的刺激方法; 视频处理单元; 和植入的神经元刺激器。
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4.发明申请
公开(公告)号：WO2008042278A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/020977
申请日：2007-09-28
Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. , HINES, Amy, P. , ZHOU, Dao, Min , ROY, Arup , DAI, Rongqing , GREENBERG, Robert, J.
Inventor： HINES, Amy, P. , ZHOU, Dao, Min , ROY, Arup , DAI, Rongqing , GREENBERG, Robert, J.
IPC: A61B5/00
CPC classification number: A61N1/36046 , A61N1/0543
Abstract: The present invention is a method for measuring stable and reproducible electrode-tissue impedance, comprising preconditioning an electrode-tissue interface. Further aspect of the invention is a stimulation system for a visual prosthesis generating a stimulation signal to precondition the electrode-tissue interface, comprising a computer; software, loaded in the computer, adapted to perform a stimulating method for a visual prosthesis having a plurality of electrodes; a video processing unit; and an implanted neuron-stimulator.
Abstract translation: 本发明是一种用于测量稳定且可再现的电极 - 组织阻抗的方法，包括预处理电极 - 组织界面。 本发明的另一方面是一种用于视觉假体的刺激系统，所述视觉假体生成刺激信号以预处理所述电极 - 组织界面，所述刺激系统包括计算机; 装载在计算机中的软件，适于执行具有多个电极的视觉假体的刺激方法; 一个视频处理单元; 和植入的神经元刺激器。
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Patent Agency Ranking
公开(公告)号：WO2008013879A3
公开(公告)日：2008-09-12
申请号：PCT/US2007016783
申请日：2007-07-26
Applicant: SECOND SIGHT MEDICAL PROD INC , ZHOU DAO MIN , HINES AMY , LITTLE JAMES SINGLETON , GREENBERG ROBERT J
Inventor： ZHOU DAO MIN , HINES AMY , LITTLE JAMES SINGLETON , GREENBERG ROBERT J
IPC: C23F13/02
Abstract: The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode, the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
Abstract translation: 本发明涉及一种对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，负偏压通过不对称电流脉冲获得。 通过执行具有较高振幅的负相位来获得不对称电流脉冲。 不对称电流脉冲是通过执行具有比阳极相更宽的脉冲宽度的负相位而获得的。 不对称电流脉冲是通过执行具有比阳极相位更高的幅度和更宽的脉冲宽度的负相位而获得的。 本发明进一步涉及一种用于电极或电极材料的阴极保护的方法，其中负偏压施加在电极上，其中负偏压通过不对称电流脉冲获得，其中不对称电流脉冲通过以较宽的 脉冲宽度比阳极相。 较宽的脉冲宽度由脉冲串获得。
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公开(公告)号：WO2007064916A9
公开(公告)日：2008-05-22
申请号：PCT/US2006046042
申请日：2006-12-01
Applicant: SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
Inventor： GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
CPC classification number: A61N1/0543 , A61N1/36046 , A61N1/37247
Abstract: The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
Abstract translation: 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。
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公开(公告)号：WO2008013879A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016783
申请日：2007-07-26
Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. , ZHOU, Dao, Min , HINES, Amy , LITTLE, James, Singleton , GREENBERG, Robert, J.
Inventor： ZHOU, Dao, Min , HINES, Amy , LITTLE, James, Singleton , GREENBERG, Robert, J.
IPC: C23F13/02
Abstract: The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode, the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
Abstract translation: 本发明涉及一种用于对电极或电极材料进行阴极保护的方法，其中对电极施加负偏压，通过不对称电流脉冲获得负偏压。 通过执行具有较高振幅的负相来获得非对称电流脉冲。 通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。 通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。 本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相 脉冲宽度大于阳极相。 通过脉冲串获得更宽的脉冲宽度。
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公开(公告)号：WO2007064916A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/046042
申请日：2006-12-01
Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , GREENBERG, Robert, J. , ROY, Arup , MCMAHON, Matthew, J. , HUMAYUN, Mark, S. , WEILAND, James, David , HORSAGER, Alan, Matthew , ZHOU, Dao, Min , HINES, Amy , YADAV, Sumit , DAI, Rongqing , FINE, Ione
Inventor： GREENBERG, Robert, J. , ROY, Arup , MCMAHON, Matthew, J. , HUMAYUN, Mark, S. , WEILAND, James, David , HORSAGER, Alan, Matthew , ZHOU, Dao, Min , HINES, Amy , YADAV, Sumit , DAI, Rongqing , FINE, Ione
CPC classification number: A61N1/0543 , A61N1/36046 , A61N1/37247
Abstract: The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
Abstract translation: 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 阻抗测量可用于预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知的阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极位置。
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公开(公告)号：WO2007064916A3
公开(公告)日：2007-08-09
申请号：PCT/US2006046042
申请日：2006-12-01
Applicant: SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
Inventor： GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
CPC classification number: A61N1/0543 , A61N1/36046 , A61N1/37247
Abstract: The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
Abstract translation: 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。
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