公开(公告)号：WO2014052900A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/062422

申请日：2013-09-27

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  MARSH, David ,  MCCLURE, Kelly, H. ,  GREENBERG, Robert, J. ,  LITTLE, Walter, P. ,  NEYSMITH, Jordan, M. ,  COLEY, Brian ,  LOFTIN, Scott, M.

Inventor： MARSH, David ,  MCCLURE, Kelly, H. ,  GREENBERG, Robert, J. ,  LITTLE, Walter, P. ,  NEYSMITH, Jordan, M. ,  COLEY, Brian ,  LOFTIN, Scott, M.

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372

CPC classification number: A61N1/37211 ,  A61N1/0543 ,  A61N1/36046 ,  A61N1/3605 ,  A61N1/37252 ,  F04C2270/0421

Abstract: It is critical in an inductively linked medical implant, such as a visual prosthesis or other neural stimulator, to adjust the external coil (4) to a position to maximize communication between the external coil and internal coil. Converting the signal strength to a signal easily discernible by a clinician, preferably an audible tone, facilitates the adjustment of the external coil to a preferred position.

Abstract translation: 在诸如视觉假体或其他神经刺激器的感应连接的医疗植入物中，将外部线圈（4）调整到最大化外部线圈和内部线圈之间的连通的位置是至关重要的。 将信号强度转换为临床医生容易识别的信号，优选地是可听见的音调，便于将外部线圈调整到优选位置。

公开(公告)号：WO2011137298A3

公开(公告)日：2011-11-03

申请号：PCT/US2011/034471

申请日：2011-04-29

Applicant: SECOND SIGHT MEDICAL PRODUCTS,INC. ,  FARAJI, Boozarjomehr ,  ZHOU, David, Daomin ,  GREENBERG, Robert, J. ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  LITTLE, James, Singleton

Inventor： FARAJI, Boozarjomehr ,  ZHOU, David, Daomin ,  GREENBERG, Robert, J. ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  LITTLE, James, Singleton

IPC: A61N1/36 ,  A61N1/375 ,  H01L21/60 ,  H01L21/56 ,  A61B5/04

Abstract: The invention is a device and method for connecting a hermetic package to a flexible circuit such as for an electrode array in an implantable device. Attaching metal pads on a flexible circuit to metal pads on a hermetic device by conductive adhesive is known. A smooth metal, such as platinum, does not bond well to conductive epoxy. The invention provides a roughened surface, such as by etching or by applying high surface area platinum gray, to improve adhesion to platinum or other metal pads.

公开(公告)号：WO2009111570A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/036042

申请日：2009-03-04

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  DOHENY EYE INSTITUTE ,  GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M.

Inventor： GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M.

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/0558 ,  H05K1/0281 ,  H05K1/118 ,  H05K1/141 ,  H05K1/189 ,  H05K3/284 ,  H05K3/321 ,  H05K2201/0162 ,  H05K2201/2009 ,  H05K2203/1327

Abstract: An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.

Abstract translation: 附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。 更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。 因此，有利的是在阵列场上获得相等的压力。 在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。

公开(公告)号：WO2008013879A2

公开(公告)日：2008-01-31

申请号：PCT/US2007/016783

申请日：2007-07-26

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  ZHOU, Dao, Min ,  HINES, Amy ,  LITTLE, James, Singleton ,  GREENBERG, Robert, J.

Inventor： ZHOU, Dao, Min ,  HINES, Amy ,  LITTLE, James, Singleton ,  GREENBERG, Robert, J.

IPC: C23F13/02

CPC classification number: C23F13/00 ,  A61N1/05 ,  A61N1/08 ,  C23F13/02

Abstract: The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode, the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.

Abstract translation: 本发明涉及一种用于对电极或电极材料进行阴极保护的方法，其中对电极施加负偏压，通过不对称电流脉冲获得负偏压。 通过执行具有较高振幅的负相来获得非对称电流脉冲。 通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。 通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。 本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相 脉冲宽度大于阳极相。 通过脉冲串获得更宽的脉冲宽度。

公开(公告)号：WO2007149571A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

Inventor： GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/05 ,  H05K2201/053 ,  H05K2201/09063 ,  H05K2201/09409 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2007149465A3

公开(公告)日：2007-12-27

申请号：PCT/US2007/014332

申请日：2007-06-19

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  ZHOU, Dao, Min ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  MECH, Brian, V. ,  LITTLE, James ,  GREENBERG, Robert, J.

Inventor： ZHOU, Dao, Min ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  MECH, Brian, V. ,  LITTLE, James ,  GREENBERG, Robert, J.

IPC: A61N1/05 ,  A61N1/36

Abstract: The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

公开(公告)号：WO2007149291A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/013918

申请日：2007-06-14

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  DOHENY EYE INSTITUTE ,  HORSAGER, Alan, Matthew ,  GREENWALD, Scott, H. ,  HUMAYUN, Mark, S. ,  MCMAHON, Matthew, J. ,  FINE, Ione ,  GREENBERG, Robert, J. ,  BOYNTON, Geoffrey, M.

Inventor： HORSAGER, Alan, Matthew ,  GREENWALD, Scott, H. ,  HUMAYUN, Mark, S. ,  MCMAHON, Matthew, J. ,  FINE, Ione ,  GREENBERG, Robert, J. ,  BOYNTON, Geoffrey, M.

IPC: A61N1/36

CPC classification number: A61N1/36046

Abstract: An apparatus and method for retinal stimulation are shown. The apparatus comprises an implantable and external portion, and the method comprises varied parameters, including frequency, pulse width, and pattern of pulse trains to determine a stimulation pattern and visual perception threshold.

Abstract translation: 显示视网膜刺激的装置和方法。 该装置包括可植入和外部部分，该方法包括变化的参数，包括脉冲序列的频率，脉冲宽度和模式，以确定刺激模式和视觉感知阈值。

公开(公告)号：WO2007050280A2

公开(公告)日：2007-05-03

申请号：PCT/US2006/039572

申请日：2006-10-10

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  ZHOU, Dao, Min ,  GREENBERG, Robert, J.

Inventor： ZHOU, Dao, Min ,  GREENBERG, Robert, J.

IPC: C25D3/50 ,  H01M4/92

CPC classification number: H01M4/8853 ,  B01D53/945 ,  B01D2255/1021 ,  B01J23/08 ,  B01J23/40 ,  B01J23/42 ,  B01J23/44 ,  B01J23/468 ,  B01J35/002 ,  B01J37/0215 ,  B01J37/348 ,  C25D3/50 ,  C25D5/16 ,  C25D21/12 ,  H01M4/8807 ,  H01M4/90 ,  H01M4/92 ,  H01M4/921 ,  H01M4/94 ,  H01M8/00 ,  H01M8/1007 ,  Y02P70/56 ,  Y02T10/22

Abstract: An improved platinum and method for manufacturing the improved platinum wherein the platinum having a fractal surface coating of platinum, platinum gray, with a increase in surface area of at least 5 times when compared to shiny platinum of the same geometry and also having improved resistance to physical stress when compared to platinum black having the same surface area. The process of electroplating the surface coating of platinum gray comprising plating at a moderate rate, for example at a rate that is faster than the rate necessary to produce shiny platinum and that is less than the rate necessary to produce platinum black. Platinum gray is applied to manufacture a fuel cell and a catalyst.

Abstract translation: 一种改进的铂和用于制造改进的铂的方法，其中具有铂的分形表面涂层的铂，白金灰，与相同几何形状的闪亮铂相比，表面积增加至少5倍，并且还具有改善的耐 与具有相同表面积的铂黑相比，物理应力。 电镀铂灰的表面涂层的过程包括以适中的速率镀覆，例如以比产生闪亮铂所需的速率快的速度并且小于生产铂黑所需的速率的速率。 铂灰应用于制造燃料电池和催化剂。

公开(公告)号：WO2007035743A3

公开(公告)日：2007-03-29

申请号：PCT/US2006/036501

申请日：2006-09-18

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  MCCLURE, Kelly, H. ,  ROY, Arup ,  YADAV, Sumit ,  MAKSY, Pishoy ,  MELISTRUP, Peter

Inventor： MCCLURE, Kelly, H. ,  ROY, Arup ,  YADAV, Sumit ,  MAKSY, Pishoy ,  MELISTRUP, Peter

IPC: A61N1/36 ,  A61F9/08 ,  A61N1/05 ,  A61F2/14

Abstract: The present invention is a method of neural stimulation and more specifically an improved method of providing flexible video/image possessing in a visual prosthesis by providing downloadable video filters. In a visual prosthesis, the input video image will, for the foreseeable future, be higher resolution than the output stimulation of the retina, optic nerve or visual cortex. This is due to limits of electrode array technology and the rapid advancement of video camera technology. It is therefore, advantageous to apply video processing algorithms (filters) to help provide the most useful information to the lower resolution electrode array. Different filters are more effective in different environments and for different subjects. Furthermore, filters will continue to improve over time. Examples of situation dependent filters include reverse image, contrast increasing, edge detection, segmentation using chromatic information and motion detection. Filters loaded in the video processing unit may be selected dynamically to suit the situation or the user's preference. It is therefore advantageous to provide flexibility in applying filters. However, it is also important to maintain the security necessary for a medical device. The present invention provides for an external (not implanted) video processing unit with downloadable video filters.

公开(公告)号：WO2006118679A2

公开(公告)日：2006-11-09

申请号：PCT/US2006/010041

申请日：2006-03-20

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert, J. ,  NEYSMITH, Jordan ,  WILKIN, Kevin ,  OK, Jerry

Inventor： GREENBERG, Robert, J. ,  NEYSMITH, Jordan ,  WILKIN, Kevin ,  OK, Jerry

IPC: A61N1/36

CPC classification number: A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

Abstract: The present invention is an improved hermetic package for implantation in the human body. The implantable device of the present invention includes an eclectically non-conductive bass including electrically conductive vias through the substrate. A circuit is flip-chip bonded to a subset of the vias. A second circuit is wire bonded to another subset of the vias. Finally, a cover is bonded to the substrate such that the cover, substrate and vias form a hermetic package.

Abstract translation: 本发明是用于植入人体的改进的密封包装。 本发明的可植入装置包括包含通过基底的导电通路的折衷不导电的低音。 电路倒装芯片结合到通孔的子集。 第二电路被引线接合到通孔的另一子集。 最后，将覆盖物粘合到基底上，使得盖，基底和通孔形成密封包装。