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    SELECTABLE STROKE CUTTER
    3.
    发明申请
    SELECTABLE STROKE CUTTER 审中-公开
    可选笔画剪刀

    公开(公告)号：WO2009042991A3

    公开(公告)日：2009-05-22

    申请号：PCT/US2008078087

    申请日：2008-09-29

    Applicant: DOHENY EYE INST ,  DEBOER CHARLES ,  MCCORMICK MATTHEW ,  BHADRI PRASHANT R ,  BARNES AARON ,  KERNS RALPH ,  HUMAYUN MARK S

    Inventor： DEBOER CHARLES ,  MCCORMICK MATTHEW ,  BHADRI PRASHANT R ,  BARNES AARON ,  KERNS RALPH ,  HUMAYUN MARK S

    IPC: A61B17/32

    CPC classification number: A61B17/32002 ,  A61B17/22031 ,  A61B17/320783 ,  A61B2017/00544 ,  A61B2017/320028 ,  A61B2017/32004 ,  A61F9/007 ,  A61F9/00736

    Abstract: Apparatus, systems, and devices are described that utilize an adjustable biological tissue cutting handpiece that is based on selectable settings. The biological tissue cutting handpiece includes a cutter tip that allows multiple duty cycles as well as multiple port configurations. For example, when working next to the retina, the port could be adjusted to be a smaller size, allowing delicate membrane dissection. When working near or in less sensitive tissue, e.g. the center of the eye, the port could be wide open. The port aperture size can be independent of cut speed, allowing a surgeon to work at high speed both next to the retina and away from the retina. High speeds have been shown to have increased tissue (e.g., vitreous) removal, e.g., in 25 and 23-gauge instruments. Duty cycle is not necessarily dependent on cut speed, allowing high cutter performance and varied flow characteristics.

    Abstract translation: 描述了利用基于可选设置的可调节生物组织切割手持件的设备，系统和设备。 生物组织切割手机包括一个刀头，允许多个工作循环以及多个端口配置。 例如，在视网膜旁边工作时，端口可以调整为较小的尺寸，从而可以进行精细的膜解剖。 当在附近或在较不敏感的组织中工作时，例如 眼睛的中心，港口可能是敞开的。 端口孔径大小可以与切割速度无关，允许外科医生在视网膜旁边和远离视网膜的高速下工作。 高速显示具有增加的组织（例如玻璃体）去除，例如在25和23规格的器械中。 占空比不一定取决于切割速度，允许较高的切割性能和不同的流动特性。

    FLEXIBLE CIRCUIT ELECTRODE ARRAY
    5.
    发明申请
    FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
    柔性电路阵列

    公开(公告)号：WO2008109862A2

    公开(公告)日：2008-09-12

    申请号：PCT/US2008/056301

    申请日：2008-03-07

    Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  DOHENY EYE INSTITUTE ,  AGRAWAL, Rajat ,  GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, Singleton ,  MECH, Brian, V. ,  NEYSMITH, Jordan, Matthew ,  TALBOT, Neil, Hamilton ,  ZHOU, Dao, Min

    Inventor： AGRAWAL, Rajat ,  GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, Singleton ,  MECH, Brian, V. ,  NEYSMITH, Jordan, Matthew ,  TALBOT, Neil, Hamilton ,  ZHOU, Dao, Min

    IPC: A61N1/05

    CPC classification number: A61N1/05 ,  A61N1/0541 ,  A61N1/0543

    Abstract: A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

    Abstract translation: 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION
    8.
    发明申请
    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION 审中-公开

    公开(公告)号：WO2008022048A3

    公开(公告)日：2008-02-21

    申请号：PCT/US2007/075746

    申请日：2007-08-10

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TAI, Yu-Chong ,  CHEN, Po-Jui ,  RODGER, Damien, C. ,  HUMAYUN, Mark, S.

    Inventor： TAI, Yu-Chong ,  CHEN, Po-Jui ,  RODGER, Damien, C. ,  HUMAYUN, Mark, S.

    IPC: F16K15/02

    Abstract: Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

    MICROELECTRODE SYSTEMS FOR NEURO-STIMULATION AND NEURO-SENSING AND MICROCHIP PACKAGING AND RELATED METHODS
    10.
    发明申请
    MICROELECTRODE SYSTEMS FOR NEURO-STIMULATION AND NEURO-SENSING AND MICROCHIP PACKAGING AND RELATED METHODS 审中-公开
    用于神经刺激和神经感觉的微电子系统和微型计算机包装及相关方法

    公开(公告)号：WO2007041293A2

    公开(公告)日：2007-04-12

    申请号：PCT/US2006/038061

    申请日：2006-09-29

    Applicant: DOHENY EYE INSTITUTE ,  WHALEN, John, J., III ,  WEILAND, James, D. ,  HUMAYUN, Mark, S.

    Inventor： WHALEN, John, J., III ,  WEILAND, James, D. ,  HUMAYUN, Mark, S.

    IPC: A61N1/05 ,  A61B5/04

    CPC classification number: A61B5/04001 ,  A61B5/685 ,  A61B2562/0215 ,  A61B2562/0217 ,  A61B2562/125 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/37205 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00

    Abstract: Microelectrode assemblies and related methods are disclosed for bio-stimulating and/or bio-sensing a target tissue. The assemblies can include a two-side substrate, an array of microelectrodes, each of the microelectrodes including a nano-wire embedded within the substrate and extending from a proximal end to a distal end and through the substrate, each nano-wire having a diameter preferably less than 1 μm. The substrate can include portions made of nano-porous material(s) through which the microelectrodes pass. The substrate with the embedded nano-wires can effectively be fluid impermeable. The proximal ends of the nano-wires can be adapted to be connected to an electronic device and the distal ends are adapted to be disposed in a biological environment for bio- stimulating a target tissue and/or bio-sensing activities of the target tissue. Suitable alloys such as platinum, platinum-iridium, and/or other noble-metal-alloyed compositions can be used for the nano-wires.

    Abstract translation: 公开了微电极组件和相关方法用于生物刺激和/或生物感测靶组织。 组件可以包括两侧基板，微电极阵列，每个微电极包括嵌入基板内的纳米线，并从近端延伸到远端并穿过基板，每个纳米线具有直径 优选小于1μm。 基板可以包括由微电极通过的纳米多孔材料制成的部分。 具有嵌入式纳米线的基板可以有效地不透液体。 纳米线的近端可以适于连接到电子设备，并且远端适于设置在生物环境中，用于生物刺激靶组织和/或靶组织的生物感测活动。 合适的合金如铂，铂 - 铱和/或其它贵金属合金组合物可用于纳米线。

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